Förderzeitraum 2019
Refine
Has Fulltext
- yes (198)
Is part of the Bibliography
- yes (198)
Document Type
- Journal article (198)
Language
- English (198)
Keywords
- apoptosis (4)
- inflammation (4)
- ischemic stroke (4)
- measles virus (4)
- sphingolipids (4)
- Meningitis (3)
- Neisseria meningitidis (3)
- Ureaplasma parvum (3)
- Ureaplasma urealyticum (3)
- aging (3)
- blood–brain barrier (3)
- cancer therapy (3)
- deep brain stimulation (3)
- infection (3)
- length of stenosis (3)
- virtual reality (3)
- 3D tissue model (2)
- Alzheimer's disease (2)
- Bees (2)
- Biomedical engineering (2)
- CXCR4 (2)
- Cancer (2)
- Candida albicans (2)
- Exercise capacity (2)
- GABA (2)
- GABAA receptors (2)
- HBMEC (2)
- HeLa cells (2)
- Imaging techniques (2)
- Solution-state NMR (2)
- Stem cells (2)
- TNFR1 (2)
- VEGF (2)
- bacteria (2)
- blood-brain barrier (2)
- carotid atherosclerosis (2)
- carotid stenosis (2)
- carotid ultrasound (2)
- caspase-8 (2)
- chemistry (2)
- children (2)
- death receptors (2)
- degree of stenosis (2)
- genome annotation (2)
- gephyrin (2)
- glioblastoma multiforme (2)
- irradiation (2)
- knockout (2)
- meningitis (2)
- mesencephalic locomotor region (2)
- mouse (2)
- neuroinflammation (2)
- neurology (2)
- neuroprotection (2)
- p53 (2)
- photothrombotic stroke (2)
- presence (2)
- stem cells (2)
- surgery (2)
- theranostics (2)
- (classical and atypical) Werner syndrome (1)
- 3D tissue models (1)
- 3 T (1)
- 4D flow (1)
- ALS mimic (1)
- AMP-activated kinases (1)
- ATP generation (1)
- Adherens junction (1)
- Adolescent (1)
- Adult (1)
- Akt/PKB (1)
- Alcohol dependence (1)
- Alpine habitats (1)
- Animal behavior (1)
- Antioxidants (1)
- Anxiety (1)
- Aortic arch (1)
- Apidae (1)
- Apis mellifera (1)
- Apoptosis (1)
- Applied physics (1)
- Archaeology (1)
- Aspergillus fumigalus (1)
- Associative learning (1)
- Atomic and molecular interactions with photons (1)
- Atrial fibrillation (1)
- Autologous hematopoietic stem cell transplantation (1)
- Axl tyrosine kinase (1)
- B cells (1)
- B-MYB (1)
- B7-H1 (1)
- BCG (1)
- BRAF mutation (1)
- Behavioural ecology (1)
- Bevacizumab (1)
- Binge drinking (1)
- Biomarke (1)
- Biophysics (1)
- Bipolar disorder (1)
- Brain cancer (1)
- Brain diseases (1)
- Brain endothelial cells (1)
- Bronchopulmonary dysplasia (1)
- C-reactive protein (1)
- C3a (1)
- C3aR (1)
- C5a (1)
- C5aR1 (1)
- C5aR2 (1)
- CCI (1)
- CD274 (1)
- CD4+ T cells (1)
- CD8+ T cells (1)
- CD95 (1)
- CIDP (1)
- CRH1 (1)
- CXCL5 (1)
- CXCL8 (1)
- CXCR2 (1)
- Callyspongia siphonella (1)
- Cancer Cell (1)
- Cardiac ventricles (1)
- Cardiovascular diseases (1)
- Cardiovascular risk factors (1)
- Cardiovascular risk prediction (1)
- Carotid intima-media thickness (CIMT) (1)
- Carotid segment (1)
- Carotid ultrasound (1)
- Caspase (1)
- Cell stainin (1)
- Central nervous system (1)
- Characterization and analytical techniques (1)
- Chemical composition (1)
- Children (1)
- Chlamydia trachomatis (1)
- Choice Behavior/physiology (1)
- Circular dichroism (1)
- Clinically silent stroke (1)
- Cognitive behavior (1)
- Cognitive neuroscience (1)
- Computed axial tomography (1)
- Computer modelling (1)
- Confocal microscopy (1)
- Conifers (1)
- Conservation (1)
- Corticosteroids (1)
- Cranial sutures (1)
- Cryo-EM (1)
- Cushing’s disease (1)
- Cutaneous lymphoma (1)
- Cystic fibrosis (1)
- Cytosol (1)
- DC gate (1)
- DNA damage (1)
- DNA methylation (1)
- Data acquisition (1)
- Densovirus (1)
- Developmental biology (1)
- Diagnostic medicine (1)
- Diffusion tensor imaging (1)
- Disease severity (1)
- Dopamine (1)
- Drosophila (1)
- E2 conjugating enzyme (1)
- E3 ligating enzyme (1)
- ECM (1)
- Echinococcosis (1)
- Echinococcus (1)
- Ecology (1)
- Efflux transport (1)
- Eigenvectors (1)
- El Escorial (1)
- Elderly (1)
- Electrical impedance tomography (1)
- Embryonic induction (1)
- Embryos (1)
- Enhancer elements (1)
- Environmental impact (1)
- Epidemiology (1)
- Epigenetic (1)
- Epigenetic regulation (1)
- Equipment (1)
- Evolutionary developmental biology (1)
- Evolutionary emergence (1)
- Exercise testing (1)
- Extracellular matrix (1)
- Extracellular volume (1)
- Eye Movements/physiology (1)
- Eye development (1)
- FKBP5 (1)
- Familial Beckwith-Wiedemann syndrome (1)
- FasL (1)
- Fatigue (1)
- Fats (1)
- Fear (1)
- Fear conditioning (1)
- Female (1)
- Fgf-signalling (1)
- Flavonoids (1)
- Flowering plants (1)
- Flowers (1)
- Fluorescence spectroscopy (1)
- Forces (1)
- Forests (1)
- GAD1 (1)
- GRP78 (1)
- GVHD (1)
- Gene expression analysis (1)
- Gene silencing (1)
- General anaesthesia (1)
- Genome (1)
- Genomics (1)
- Genotype (1)
- Geriatric care (1)
- Geriatrics (1)
- Germline (1)
- Glioblastoma (1)
- Glutathione (1)
- Group B Streptococcus (1)
- HDAC (1)
- HNSCC (1)
- HPA axis (1)
- Haemophilus influenzae (1)
- Heart (1)
- Heart failure (1)
- Heart rate (1)
- Hemipelvectomy (1)
- High grade glioma (1)
- Hindbrain (1)
- Histone deacetylase (1)
- Honey bees (1)
- Humans (1)
- Hunsrueck (1)
- Hypothalamus (1)
- IFN (1)
- IL-10 (1)
- IP3 (1)
- Immune system (1)
- Immune-related adverse event (1)
- Immunology (1)
- Immunoprecipitation (1)
- Impella (1)
- Implicit and explicit reward learning (1)
- In vivo studies (1)
- Incontinentia pigmenti (1)
- Infectious disease (1)
- Inflammatio (1)
- Inflammatory diseases (1)
- Insect flight (1)
- Instructors (1)
- Interleukin-10 (1)
- Ipilimumab (1)
- Ischemic stroke (1)
- JAK2 (1)
- KDELR2 (1)
- Knee (1)
- LC-HRESIMS (1)
- LSD1 (1)
- Laparoscopy (1)
- Learning and memory (1)
- Learning/physiology (1)
- Lifetime spectroscopy (1)
- Limb development (1)
- Limb salvage (1)
- Limestone (1)
- Low risk alcohol use (1)
- Lung disease, (1)
- Lymph nodes (1)
- Lysine-specific methylase (1)
- MDSC (1)
- MGMT promoter methylation (1)
- MOLLI (1)
- MRI spectroscopy (1)
- Magnetic resonance imaging (1)
- Male (1)
- Mastoid process (1)
- Mc4r (1)
- Meat (1)
- Melanoma (1)
- Memory B cells (1)
- Mental health therapies (1)
- Metabolomics (1)
- Methicillin-resistant Staphylococcus aureus (1)
- Mfn2 KO mice (1)
- Microglia (1)
- Minimal change disease (1)
- Minimally invasive surgery (1)
- Mitochondria (1)
- Mobile genetic element (1)
- Motor behaviour (1)
- Mouse (1)
- Muscle function (1)
- Muscle power (1)
- Myb-MuvB (1)
- NFATc1 (1)
- NFκB (1)
- Nanoparticles (1)
- Natural product hybrids (1)
- Necrotizing enterocolitis (1)
- Nectin‐2 (1)
- Neisseria gonorrhoeae (1)
- Neolithic period (1)
- Neural circuits (1)
- Neuroinflammation (1)
- Neurons (1)
- Neuroscience (1)
- Nfatc1 (1)
- Nivolumab (1)
- Non‐ischaemic cardiogenic shock (1)
- Nursing homes (1)
- OSI (1)
- Object recognition (1)
- Oculomotor Muscles/physiology (1)
- Oncology (1)
- Optical spectroscopy (1)
- Oral anticoagulation (1)
- Outer membrane proteins (1)
- P-glycoprotein (1)
- P-gp (1)
- PA-flexed view (1)
- PD-1 (1)
- PD-L1 (1)
- PET/CT (1)
- PIP2 (1)
- PSMA (1)
- PTEN (1)
- Parkinson’s disease (1)
- Parvovirus (1)
- Pathogens (1)
- Pavlovian-to-instrumental transfer (1)
- Pentixafor (1)
- Phenolic acids (1)
- Phenols (1)
- Phosphorylation (1)
- Photic (1)
- Physical activity (1)
- Pilot studies (1)
- Plant signalling (1)
- Plants (1)
- Poplars (1)
- Positron annihilation spectroscopy (1)
- Post-traumatic stress disorder (1)
- Postoperative complications (1)
- Premna (1)
- Preterm birth (1)
- Protein folding (1)
- Proteus vulgaris (1)
- Psychology (1)
- Psychometrics (1)
- Psychomotor Performance/physiology (1)
- Pulmonary function tests (1)
- RCT (1)
- RNA expression (1)
- RNA-seq transcriptome (1)
- RNAi (1)
- RSV-A ON1 (1)
- Radiation exposure (1)
- Radiofluorine (1)
- Radiographs (1)
- Radiotherapy (1)
- Reminder e-mails (1)
- Respiratory tract infection (1)
- Retinopathy (1)
- Robotics (1)
- SASHA (1)
- SB332235 (1)
- SR/mitochondria metabolic feedback (1)
- Saccades/physiology (1)
- Screening (1)
- Secondary stroke prevention (1)
- Sediment (1)
- Self-navigation (1)
- Self-renewal (1)
- Sentinel-1 (1)
- Sentinel-2 (1)
- Serine proteases (1)
- Serotonin (1)
- Sex chromosome (1)
- Sex determination (1)
- Sexual development and function (1)
- ShMOLLI (1)
- Silver (1)
- Simulation (1)
- Skull (1)
- Small interfering RNAs (1)
- Soft tissues (1)
- Somites (1)
- Species delimitation (1)
- Specimen grinding (1)
- Staphylococcus aureus (1)
- Stem cell (1)
- Stem-cell biotechnology (1)
- Stereochemistry (1)
- Stimulation (1)
- Stratigraphy (1)
- Streptococcus agalactiae (1)
- Stroke unit (1)
- Structure elucidation (1)
- Supportive therapy (1)
- Surgical and invasive medical procedures (1)
- Surgical oncology (1)
- Survey (1)
- Survival (1)
- Swine (1)
- Syap1 knockout (1)
- Systemic sclerosis (1)
- T cell (1)
- T cell receptor (1)
- T cell suppression (1)
- T cells (1)
- T-follicular regulatory cell (1)
- T1 mapping (1)
- TDMT (1)
- TGFβ/BMP signaling (1)
- TLR2 (1)
- TLR4 (1)
- TNF (1)
- TNF receptor superfamily (1)
- TNF superfamily (1)
- TNFR family costimulatory receptors (1)
- TNFR2 (1)
- TNFR2 agonists (1)
- TNFR2 antagonism (1)
- TNFα (1)
- TP53 (1)
- TPCA1 (1)
- TRAF1 (1)
- TRAF2 (1)
- TRAIL (1)
- TRAILR1 (1)
- TRAILR2 (1)
- Temozolomide (1)
- Terramechanics (1)
- Time resolved measurements (1)
- Toddler (1)
- Torque (1)
- Tractography (1)
- Transcription (1)
- Transcriptomic (1)
- Transposable element (1)
- Trees (1)
- Tregs (regulatory T cells) (1)
- Tubulin (1)
- UV/Vis spectroscopy (1)
- Ustilago maydis (1)
- VLBW (1)
- VMAT (1)
- Valgus osteoarthritis (1)
- View (1)
- WSS (1)
- Wheel (1)
- X-ray radiography (1)
- YAP (1)
- Yoga (1)
- Young Adult (1)
- Zebrafish (1)
- [68Ga]Pentixafor (1)
- \(^{18}\)F (1)
- \(^{68}\)Ga (1)
- accidents (1)
- acetate (1)
- acid ceramidase (1)
- acid ceramidase inhibitor ceranib-2 (1)
- acrophobia (1)
- actin (1)
- action control (1)
- activation (1)
- adolescents (1)
- adult attention deficit/hyperactivity disorder (adult ADHD) (1)
- aelf-assembly (1)
- age groups (1)
- age-related macular degeneration (1)
- aggregation (1)
- amyloidoma (1)
- analysis of variance (1)
- anime (1)
- anti-cancer drug-like molecules (1)
- anti-contactin-1 (1)
- anti-depressant drug (1)
- antibacterial (1)
- antibiofilm (1)
- antibody (1)
- antibody fusion proteins (1)
- anticancer (1)
- antitrypanosomal (1)
- anti‐aging (1)
- anxiety generalization (1)
- anxiolytics (1)
- artemisinin (1)
- artificial intelligence (1)
- atrial fibrillation (1)
- auto-planning (1)
- autoantibody (1)
- autophagy (1)
- bank mergers (1)
- behavior (1)
- bench press (1)
- benige tumor (1)
- biceps tendon (1)
- bilateral internal carotid artery stenosis (1)
- biomarker (1)
- bisulfite pyrosequencing (1)
- blinking (1)
- blood-cerebrospinal fluid barrier (1)
- boolean modeling (1)
- boreholes (1)
- bottom-up processing (1)
- brain development (1)
- brain disorders (1)
- brain endothelial cell (1)
- brain endothelial cells (1)
- brain tumor (1)
- bronchopulmonary dysplasia (1)
- bullae (1)
- burn severity (1)
- calcium (1)
- calnexin (1)
- cancer (1)
- caveolin-1 (Cav-1) (1)
- cell death (1)
- cell differentiation (1)
- cell migration (1)
- ceramide (1)
- cerebral microbleeds (1)
- cervical dystonia (1)
- channelrhodopsins (1)
- chemokine (1)
- chemokine receptor (1)
- chemotherapy (CH) (1)
- chlamydia (1)
- cholesteryl ester (1)
- cisplatin (1)
- co-culture (1)
- cognitive control (1)
- coherent risk measures (1)
- collybistin (1)
- colorectal cancer (1)
- comparative genomics (1)
- competition (1)
- complement deposition (1)
- computer-mediated communication (1)
- conditioning (1)
- congruency sequences (1)
- conservation (1)
- context-based teaching (1)
- contextual fear conditioning (1)
- continuous theta burst stimulation (cTBS) (1)
- control levels (1)
- copy number variation (1)
- corannulene (1)
- cortical excitability (1)
- cortical silent period (1)
- cross-sectional study (1)
- cytokines (1)
- cytoskeleton (1)
- cytotoxic (1)
- data warehouse (1)
- default-interventionist framework (1)
- dendritic cell (1)
- dendritic cells (1)
- depression (1)
- desk-based (1)
- deubiquitinases (1)
- developmental forms (1)
- diabetes (1)
- diacylglycerol (1)
- dialysis adequacy (1)
- diazepam (1)
- digital health (1)
- dimeric peptide (1)
- distractor-response binding (1)
- document analysis (1)
- dopamine (1)
- double arc (1)
- driving simulation (1)
- drug resistance evolution (1)
- drug transport (1)
- duplication-deficiency (1)
- early brain injury (1)
- ecology (1)
- ectopic lymphoid follicle (1)
- electrical resistivity tomography (1)
- elementary body (1)
- emotion processing (1)
- emotional behavior (1)
- emotions (1)
- en bloc transfer (1)
- end-stage renal disease (1)
- endothelin-1 (1)
- endothelium (1)
- endurance (1)
- energy homeostasis (1)
- enhancer (1)
- eugenol (1)
- expansion microscopy (1)
- expected value of control (1)
- extinction (1)
- extracellular matrix (1)
- eye movement (1)
- eye movements (1)
- face (1)
- face-voice integration (1)
- faces (1)
- fan culture (1)
- fatigue (1)
- fault detection (1)
- fear (1)
- fear learning (1)
- fertility (1)
- fluorescent probes (1)
- food colorings (1)
- foraging patterns (1)
- forest management (1)
- free choice (1)
- full arc (1)
- functional MRI (1)
- fungal rhodopsins (1)
- games (1)
- gangliosides and lipid rafts (1)
- gaze control (1)
- genetic recombination (1)
- genome assembly (1)
- genomic imprinting (1)
- geomorphology (1)
- glioblastoma multiforme (GBM) (1)
- glioma (1)
- global change (1)
- glucocorticoid receptor (1)
- glucose transporter (1)
- glycoprotein Ibα (1)
- glycoprotein VI (1)
- graft vs. host disease (1)
- ground penetrating radar (1)
- growth (1)
- guided bone regeneration (1)
- habit (1)
- habit strength (1)
- head and neck squamous cell carcinoma (1)
- hemodiafiltration (1)
- hemodialysis (1)
- hemorrhagic (1)
- henoch-schönlein purpura (1)
- hip fracture (1)
- hippocampus (1)
- histone H2AX (1)
- historical printings (1)
- honeybees (1)
- human cerebral endothelial cells (1)
- human xenografted mouse models (1)
- hyperpersonal communication (1)
- hypertension (1)
- imaging (1)
- immediate-early gene (1)
- immunotherapy (1)
- in silico simulation (1)
- in vitro (1)
- indole-3-acetic acid (1)
- infection biology (1)
- information extraction (1)
- inhibitor (1)
- inhibitory neurotransmission (1)
- injury (1)
- insect collection (1)
- insurance medicine (1)
- integrin α2 (1)
- interface (1)
- interleukin-8 (1)
- intermittent exercise (1)
- internal carotid artery stenosis (1)
- intracranial bleeding (1)
- iron metabolism (1)
- keratinocytes (1)
- kinesthesia (1)
- late onset sepsis (1)
- late positive potential (1)
- lichen planus (1)
- ligand-receptor promiscuity (1)
- lignan (1)
- linguistic cues (1)
- liquid biopsy (1)
- local field potentials (1)
- long-term potentiation (1)
- low-cost photometer (1)
- lymphoid aggregate (1)
- lyso-phospholipids (1)
- mTOR (1)
- macrophages (1)
- magnetic resonance imaging (1)
- manga (1)
- match load (1)
- maternal separation (1)
- mating (1)
- mating preference (1)
- measurement (1)
- medaka (1)
- medical rehabilitation (1)
- medication extraction (1)
- melt electrospinning writing (1)
- meningeal inflammation (1)
- meningococcal disease (1)
- meningococcus (1)
- mental health (1)
- mesenchymal stem cell (1)
- metabolic adaptation (1)
- metabolic flux (1)
- metabolic modeling (1)
- metabolic modelling (1)
- metabolomic (1)
- metabolomic profiling (1)
- metallo-supramolecular polymer (1)
- metastasis (1)
- metastasis-associated in colon cancer 1 (MACC1) (1)
- methylation array (1)
- methylprednisolone (1)
- microbial rhodopsins (1)
- microfilament (1)
- microtubules (1)
- migration (1)
- minocycline (1)
- mitochondrial genome (1)
- mitochondrial mRyR1 (1)
- mitofusin 2 (1)
- mitotic genes (1)
- mixed methods (1)
- mobile health intervention (1)
- model-based diagnosis (1)
- molecular docking (1)
- molecular dynamics (1)
- molecular imaging (1)
- monocyte-derived DC (1)
- motility (1)
- motor neuron disease (1)
- motor-evoked potentials (MEP) (1)
- movement (1)
- multiple myeloma (1)
- multiple sclerosis (1)
- muscle atrophy (1)
- mutants (1)
- myeloid-derived suppressor cell (MDSC) (1)
- nano-satellite (1)
- native populations (1)
- natural language processing (1)
- naturalistic scenes (1)
- naïve B cells (1)
- necroptosis (1)
- neonatal outcome (1)
- nervous system (1)
- nest microbiota (1)
- neuroborreliosis (1)
- neurodegenerative disease (1)
- neuronal apoptosis (1)
- neurooncology (1)
- neurovascular unit (1)
- neutral sphingomyelinase-2 (1)
- nicknames (1)
- normal distribution (1)
- office environment (1)
- office-workers (1)
- oncolytic virus (1)
- online dating (1)
- online survey (1)
- ontology (1)
- optical character recognition (1)
- optogenetics (1)
- otakuism (1)
- outcome (1)
- outcome devaluation (1)
- ovarian cancer (1)
- overuse injury (1)
- oxidative DNA damage (1)
- oxindole alkaloids (1)
- p21-activated kinase Mbt/PAK4 (1)
- panic disorder (1)
- paranodopathy (1)
- parasexual recombination (1)
- partial arc (1)
- passive transfer (1)
- patch-clamp (1)
- pathogenesis (1)
- pathogenic bacteria (1)
- peatland (1)
- peer review (1)
- peptide inhibitor design (1)
- performance (1)
- person identity processing (1)
- personality judgments (1)
- personalized medicine (1)
- pharmacophore map (1)
- physical saliency (1)
- piRNA (1)
- placebo and nocebo effects (1)
- plan comparison (1)
- plants (1)
- plant–microbe–pollinator triangle (1)
- plaque cross-sectional area (1)
- plasma membrane (1)
- platelet (1)
- platelet degranulation (1)
- pointing task (1)
- pollination (1)
- pollination network (1)
- polycaprolactone (1)
- polynomials (1)
- polyphenols (1)
- position estimation (1)
- powerlifting (1)
- precision medicine (1)
- premature aging (1)
- preterm infants (1)
- prognostic marker (1)
- progressive multiple sclerosis (1)
- prostate cancer (1)
- prostate-specific membrane antigen (1)
- protected forests (1)
- protein-bound uremic toxins (1)
- protein-protein interaction (PPI) (1)
- psychiatric disorders (1)
- psychological pain modulation (1)
- psychometrics (1)
- psychosocial stress (1)
- puberty (1)
- quality assurance (1)
- quantitative analysis (1)
- questionnaires (1)
- radiation (1)
- radiation sensitivity (1)
- radioligand therapy (1)
- radiotherapy (1)
- rational drug design (1)
- reactive oxygen species (1)
- real world evidence (1)
- reciprocal translocation (1)
- recombinant tissue-type plasminogen activator (1)
- reconstructive surgery (1)
- recurrence (1)
- regulatory T cells (Treg) (1)
- regulatory capital (1)
- regulatory dendritic cells (1)
- relapse (1)
- reliability (1)
- repeated sprint (1)
- resistance (1)
- resonance theory (1)
- reticulate body (1)
- retinal pigment epithelium (1)
- ripk1 (1)
- ripk3 (1)
- saccades (1)
- scaffold (1)
- screening (1)
- secreted effectors (1)
- segmental progeria (1)
- sepsis (1)
- sequence analysis (1)
- sequential addition (1)
- serotonin (1)
- serotonin deficiency (1)
- sex robots (1)
- shoulder (1)
- shyness (1)
- signal specification (1)
- signalling (1)
- simulation and modeling (1)
- simultaneous presentation paradigm (1)
- single arc (1)
- single-molecule tracking (1)
- skewness (1)
- slope bogs (1)
- small intestinal submucosa scaffold (1)
- smartphone app (1)
- soccer (football) (1)
- social anxiety disorder (1)
- social attention (1)
- sodium (1)
- solid tumors (1)
- solitary bees (1)
- somatic mutations (1)
- somatosensory evoked potential (1)
- somatosensory temporal discrimination (1)
- sphingomyelinase (1)
- sphingosine kinase (1)
- sphingosine kinase inhibitor SKI-II (1)
- sphingosine-1-phosphate (1)
- sporidia (1)
- standing (1)
- startle response (1)
- static vs. dynamic faces (1)
- statistical distributions (1)
- statistical models (1)
- steering (1)
- stratification (1)
- strength training (1)
- stress (1)
- stress fiber (1)
- stroke (1)
- structure (1)
- structure-activity relationships (1)
- structured illumination microscopy (1)
- subadditivity (1)
- subarachnoid hemorrhage (1)
- submicroscopic chromosome rearrangement (1)
- subsurface hydrology (1)
- subthalamic nucleus (1)
- super resolution microscopy (1)
- super-resolution microscopy (1)
- superresolution (1)
- suppressor mutation (1)
- supramolecular chemistry (1)
- surface transport (1)
- survival (1)
- targeted therapy (1)
- temozolomide (1)
- temporal discrimination threshold (1)
- tendon-derived stem cell (1)
- terrestrial LiDAR (1)
- therapy (1)
- therapy response (1)
- thrombo-inflammation (1)
- tight junctions (1)
- tisindoline (1)
- tissue engineering (1)
- top-down processing (1)
- topminnow (1)
- transcranial magnetic simulation (TMS) (1)
- transcription (1)
- transcription deficiency (1)
- transient ischemic attack (1)
- transient middle cerebral artery occlusion (1)
- transposable elements (1)
- tree cavities (1)
- tryptophan hydroxylase 2 (1)
- tumor microenvironment (1)
- ubiquitin (1)
- uncanny valley (1)
- unmanaged broadleaved forests (1)
- vasculitis (1)
- vestibular schwannoma (1)
- visual orientation (1)
- visual perception (1)
- visual realism (1)
- voice-face matching (1)
- walking (1)
- weightlifting (1)
- white matter lesions (1)
- whole-genome sequencing (1)
- wild bees (1)
- work (1)
- work capacity evaluation (1)
- work engagement (1)
- work performance (1)
- wound healing (1)
- youth (1)
- zinc oxide nanoparticles (1)
- π-π-interactions (1)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (45)
- Neurologische Klinik und Poliklinik (19)
- Institut für Psychologie (14)
- Kinderklinik und Poliklinik (11)
- Medizinische Klinik und Poliklinik I (11)
- Institut für Hygiene und Mikrobiologie (10)
- Institut für Virologie und Immunbiologie (10)
- Lehrstuhl für Tissue Engineering und Regenerative Medizin (10)
- Pathologisches Institut (9)
- Deutsches Zentrum für Herzinsuffizienz (DZHI) (8)
Sonstige beteiligte Institutionen
Abstract
Recent studies reveal the use of tree cavities by wild honeybee colonies in European forests. This highlights the conservation potential of forests for a highly threatened component of the native entomofauna in Europe, but currently no estimate of potential wild honeybee population sizes exists. Here, we analyzed the tree cavity densities of 106 forest areas across Europe and inferred an expected population size of wild honeybees. Both forest and management types affected the density of tree cavities.
Accordingly, we estimated that more than 80,000 wild honeybee colonies could be sustained in European forests. As expected, potential conservation hotspots were identified in unmanaged forests, and, surprisingly, also in other large forest areas across Europe. Our results contribute to the EU policy strategy to halt pollinator declines and reveal the potential of forest areas for the conservation of so far neglected wild honeybee populations in Europe.
The self-assembly of a bowl-shaped naphthalimide-annulated corannulene of high solubility has been studied in a variety of solvents by NMR and UV/Vis spectroscopy. Evaluation by the anti-cooperative K\(_2\)-K model revealed the formation of supramolecular dimers of outstanding thermodynamic stability. Further structural proof for the almost exclusive formation of dimers over extended aggregates is demonstrated by atomic force microscopy (AFM) and diffusion ordered spectroscopy (DOSY) measurements as well as by theoretical calculations. Thus, herein we present the first report of a supramolecular dimer of an annulated corannulene derivative in solution and discuss its extraordinarily high thermodynamic stability with association constants up to > 10\(^6\)M\(^-\) \(^1\) in methylcyclohexane, which is comparable to the association constants given for planar phthalocyanine and perylene bisimide dyes.
Background:
Colonic cancer is the most common cancer of the gastrointestinal tract. The aim of this study was to determine mortality rates following colonic cancer resection and the effect of hospital caseload on in-hospital mortality in Germany.
Methods:
Patients admitted with a diagnosis of colonic cancer undergoing colonic resection from 2012 to 2015 were identifed from a nationwide registry using procedure codes. The outcome measure was in-hospital mortality. Hospitals were ranked according to their caseload for colonic cancer resection, and patients were categorized into five subgroups on the basis of hospital volume.
Results:
Some 129 196 colonic cancer resections were reviewed. The overall in-house mortality rate was 5⋅8 per cent, ranging from 6⋅9 per cent (1775 of 25 657 patients) in very low-volume hospitals to 4⋅8 per cent (1239 of 25 825) in very high-volume centres (P < 0⋅001). In multivariable logistic regression analysis the risk-adjusted odds ratio for in-house mortality was 0⋅75 (95 per cent c.i. 0⋅66 to 0⋅84) in very high-volume hospitals performing a mean of 85⋅0 interventions per year, compared with that in very low-volume hospitals performing a mean of only 12⋅7 interventions annually, after adjustment for sex, age, co-morbidity, emergency procedures, prolonged mechanical ventilation and transfusion.
Conclusion:
In Germany, patients undergoing colonic cancer resections in high-volume hospitals had with improved outcomes compared with patients treated in low-volume hospitals
Tuberculosis patients and mice infected with live Mycobacterium tuberculosis accumulate high numbers of myeloid-derived suppressor cells (MDSCs). Here, we hypothesized that dead M. tuberculosis vaccines also may induce MDSCs that could impair the efficacy of vaccination. We found that repeated injections of M. tuberculosis vaccines (heat-killed M. tuberculosis in incomplete Freund’s adjuvant, such as Montanide) but not single or control vaccines without M. tuberculosis strongly expanded CD11b\(^+\) myeloid cells in the spleen, leading to T cell suppression of proliferation and killing ex vivo. Dead M. tuberculosis vaccination induced the generation of CD11b\(^+\)Ly6C\(^{hi}\)CD115\(^+\) iNOS/Nos2\(^+\) monocytic MDSCs (M-MDSCs) upon application of inflammatory or microbial activation signals. In vivo these M-MDSCs were positioned strategically in the splenic bridging channels and then positioned in the white pulp areas. Notably, within 6–24 hours, in a Nos2-dependent fashion, they produced NO to rapidly kill conventional and plasmacytoid DCs while, surprisingly, sparing T cells in vivo. Thus, we demonstrate that M. tuberculosis vaccine induced M-MDSCs do not directly suppress effector T cells in vivo but, instead, indirectly by killing DCs. Collectively, we demonstrate that M. tuberculosis booster vaccines induce M-MDSCs in the spleen that can be activated to kill DCs. Our data suggest that formation of MDSCs by M. tuberculosis vaccines should be investigated also in clinical trials.
Background
Medication trend studies show the changes of medication over the years and may be replicated using a clinical Data Warehouse (CDW). Even nowadays, a lot of the patient information, like medication data, in the EHR is stored in the format of free text. As the conventional approach of information extraction (IE) demands a high developmental effort, we used ad hoc IE instead. This technique queries information and extracts it on the fly from texts contained in the CDW.
Methods
We present a generalizable approach of ad hoc IE for pharmacotherapy (medications and their daily dosage) presented in hospital discharge letters. We added import and query features to the CDW system, like error tolerant queries to deal with misspellings and proximity search for the extraction of the daily dosage. During the data integration process in the CDW, negated, historical and non-patient context data are filtered. For the replication studies, we used a drug list grouped by ATC (Anatomical Therapeutic Chemical Classification System) codes as input for queries to the CDW.
Results
We achieve an F1 score of 0.983 (precision 0.997, recall 0.970) for extracting medication from discharge letters and an F1 score of 0.974 (precision 0.977, recall 0.972) for extracting the dosage. We replicated three published medical trend studies for hypertension, atrial fibrillation and chronic kidney disease. Overall, 93% of the main findings could be replicated, 68% of sub-findings, and 75% of all findings. One study could be completely replicated with all main and sub-findings.
Conclusion
A novel approach for ad hoc IE is presented. It is very suitable for basic medical texts like discharge letters and finding reports. Ad hoc IE is by definition more limited than conventional IE and does not claim to replace it, but it substantially exceeds the search capabilities of many CDWs and it is convenient to conduct replication studies fast and with high quality.
Abiotic stress by elevated tropospheric ozone and temperature can alter plants’ metabolism, growth, and nutritional value and modify the life cycle of their herbivores. We investigated how the duration of exposure of Sinapis arvensis plants to high ozone and temperature levels affect the life cycle of the large cabbage white, Pieris brassicae. Plants were exposed to ozone-clean (control) or ozone-enriched conditions (120 ppb) for either 1 or 5 days and were afterwards kept in a greenhouse with variable temperature conditions. When given the choice, P. brassicae butterflies laid 49% fewer eggs on ozone-exposed than on control plants when the exposure lasted for 5 days, but showed no preference when exposure lasted for 1 day. The caterpillars took longer to hatch on ozone-exposed plants and at lower ambient temperatures. The ozone treatment had a positive effect on the survival of the eggs. Ozone decreased the growth of caterpillars reared at higher temperatures on plants exposed for 5 days, but not on plants exposed for 1 day. Overall, longer exposure of the plants to ozone and higher temperatures affected the life cycle of the herbivore more strongly. With global warming, the indirect impacts of ozone on herbivores are likely to become more common.
Aims
From the various mechanical cardiac assist devices and indications available, the use of the percutaneous intraventricular Impella CP pump is usually restricted to acute ischaemic shock or prophylactic indications in high‐risk interventions. In the present study, we investigated clinical usefulness of the Impella CP device in patients with non‐ischaemic cardiogenic shock as compared with acute ischaemia.
Methods and results
In this retrospective single‐centre analysis, patients who received an Impella CP at the University Hospital Würzburg between 2013 and 2017 due to non‐ischaemic cardiogenic shock were age‐matched 2:1 with patients receiving the device due to ischaemic cardiogenic shock. Inclusion criteria were therapy refractory haemodynamic instability with severe left ventricular systolic dysfunction and serum lactate >2.0 mmol/L at implantation. Basic clinical data, indications for mechanical ventricular support, and outcome were obtained in all patients with non‐ischaemic as well as ischaemic shock and compared between both groups. Continuous variables are expressed as mean ± standard deviation or median (quartiles). Categorical variables are presented as count and per cent. Twenty‐five patients had cardiogenic shock due to non‐ischaemic reasons and were compared with 50 patients with cardiogenic shock due to acute myocardial infarction. Resuscitation rates before implantation of Impella CP were high (32 vs. 42%; P = 0.402). At implantation, patients with non‐ischaemic cardiogenic shock had lower levels of high‐sensitive troponin T (110.65 [57.87–322.1] vs. 1610 [450.8–3861.5] pg/mL; P = 0.001) and lactate dehydrogenase (377 [279–608] vs. 616 [371.3–1109] U/L; P = 0.007), while age (59 ± 16 vs. 61.7 ± 11; P = 0.401), glomerular filtration rate (43.5 [33.2–59.7] vs. 48 [35.75–69] mL/min; P = 0.290), C‐reactive protein (5.17 [3.27–10.26] vs. 10.97 [3.23–17.2] mg/dL; P = 0.195), catecholamine index (30.6 [10.6–116.9] vs. 47.6 [11.7–90] μg/kg/min; P = 0.663), and serum lactate (2.6 [2.2–5.8] vs. 2.9 [1.3–6.6] mmol/L; P = 0.424) were comparable between both groups. There was a trend for longer duration of Impella support in the non‐ischaemic groups (5 [2–7.5] vs. 3 [2–5.25] days, P = 0.211). Rates of haemodialysis (52 vs. 47%; P = 0.680) and transition to extracorporeal membrane oxygenation (13.6 vs. 22.2%; P = 0.521) were comparable. No significant difference was found regarding both 30 day survival (48 vs. 30%; P = 0.126) and in‐hospital mortality (66.7 vs. 74%; P = 0.512), although there was a trend for better survival in the non‐ischaemic group.
Conclusions
These data suggest that temporary use of the Impella CP device might be a useful therapeutic option for bridge to recovery not only in ischaemic but also in non‐ischaemic cardiogenic shock.
Nectin‐2 is an adhesion molecule that has been reported to play a role in tumor growth, metastasis and tumor angiogenesis. Herein, we investigated Nectin‐2 in ovarian cancer patients and in cell culture. Tumor as well as peritoneal biopsies of 60 ovarian cancer patients and 22 controls were dual stained for Nectin‐2 and CD31 using immunohistochemistry. Gene expression of Nectin‐2 was quantified by real‐time PCR and differences analyzed in relation to various tumor characteristics. In the serum of patients, vascular endothelial growth factor (VEGF) was quantified by ELISA. Effect of VEGF on Nectin‐2 expression as well as permeability was investigated in HUVEC. In tumor biopsies, Nectin‐2 protein was mainly localized in tumor cells, whereas in peritoneal biopsies, clear colocalization was found in the vasculature. T3 patients had a significantly higher percentage of positive lymph nodes and this correlated with survival. Nectin‐2 was significantly upregulated in tumor biopsies in patients with lymph node metastasis and with residual tumor >1 cm after surgery. Nectin‐2 expression was significantly suppressed in the peritoneal endothelium of patients associated with significantly increased VEGF serum levels. In cell culture, VEGF stimulation led to a significant downregulation of Nectin‐2 which was reversed by VEGF‐inhibition. In addition, Nectin‐2 knockdown in endothelial cells was associated with significantly increased endothelial permeability. Nectin‐2 expression in ovarian cancer may support tumor cell adhesion, leading to growth and lymph node metastasis. In addition, VEGF‐induced Nectin‐2 suppression in peritoneal endothelium may support an increase in vascular permeability leading to ascites production.
Werner Syndrome (WS) is an adult‐onset segmental progeroid syndrome. Bisulfite pyrosequencing of repetitive DNA families revealed comparable blood DNA methylation levels between classical (18 WRN‐mutant) or atypical WS (3 LMNA‐mutant and 3 POLD1‐mutant) patients and age‐ and sex‐matched controls. WS was not associated with either age‐related accelerated global losses of ALU, LINE1, and α‐satellite DNA methylations or gains of rDNA methylation. Single CpG methylation was analyzed with Infinium MethylationEPIC arrays. In a correspondence analysis, atypical WS samples clustered together with the controls and were clearly separated from classical WS, consistent with distinct epigenetic pathologies. In classical WS, we identified 659 differentially methylated regions (DMRs) comprising 3,656 CpG sites and 613 RefSeq genes. The top DMR was located in the HOXA4 promoter. Additional DMR genes included LMNA, POLD1, and 132 genes which have been reported to be differentially expressed in WRN‐mutant/depleted cells. DMRs were enriched in genes with molecular functions linked to transcription factor activity and sequence‐specific DNA binding to promoters transcribed by RNA polymerase II. We propose that transcriptional misregulation of downstream genes by the absence of WRN protein contributes to the variable premature aging phenotypes of WS. There were no CpG sites showing significant differences in DNA methylation changes with age between WS patients and controls. Genes with both WS‐ and age‐related methylation changes exhibited a constant offset of methylation between WRN‐mutant patients and controls across the entire analyzed age range. WS‐specific epigenetic signatures occur early in life and do not simply reflect an acceleration of normal epigenetic aging processes.
Life on earth adapted to the daily reoccurring changes in environment by evolving an endogenous circadian clock. Although the circadian clock has a crucial impact on survival and behavior of solitary bees, many aspects of solitary bee clock mechanisms remain unknown. Our study is the first to show that the circadian clock governs emergence in Osmia bicornis, a bee species which overwinters as adult inside its cocoon. Therefore, its eclosion from the pupal case is separated by an interjacent diapause from its emergence in spring. We show that this bee species synchronizes its emergence to the morning. The daily rhythms of emergence are triggered by temperature cycles but not by light cycles. In contrast to this, the bee’s daily rhythms in locomotion are synchronized by light cycles. Thus, we show that the circadian clock of O. bicornis is set by either temperature or light, depending on what activity is timed. Light is a valuable cue for setting the circadian clock when bees have left the nest. However, for pre-emerged bees, temperature is the most important cue, which may represent an evolutionary adaptation of the circadian system to the cavity-nesting life style of O. bicornis.