Refine
Has Fulltext
- yes (21)
Is part of the Bibliography
- yes (21)
Year of publication
Document Type
- Doctoral Thesis (9)
- Complete part of issue (5)
- Book (3)
- Jahresbericht (2)
- Journal article (1)
- Master Thesis (1)
Keywords
- Wuerzburg (7)
- Wurzburg (7)
- University (5)
- Universität (5)
- Würzburg (5)
- Bericht (2)
- Europäische Ethnologie (2)
- Hitzeschock-Proteine (2)
- Jahresbericht (2)
- Julius-Maximilians-Universität Würzburg (2)
- Kulturanthropologie (2)
- Multispecies Studies (2)
- annual report (2)
- Achtsamkeit (1)
- Achtsamkeitsbasiertes Training (1)
- Agency (1)
- Aldehydreductase (1)
- Aldose Reductase (1)
- Aldose Reduktase (1)
- Alltagskultur (1)
- Anthropozän (1)
- Antibiotikum (1)
- Antimikrobieller Wirkstoff (1)
- Arzneimittelforschung (1)
- Ausstellung (1)
- Bindemechanismus (1)
- Bindungsaffinität (1)
- CMF-Therapie (1)
- Conflict zones (1)
- Data Fusion (1)
- Emotionales Eßverhalten (1)
- Empirische Kulturwissenschaft (1)
- Enzyminhibitor (1)
- Essgewohnheit (1)
- Essverhalten (1)
- Ethnografie (1)
- Expositionstherapie (1)
- Flexibilität (1)
- Fluoreszenzpolarisation (1)
- Glukose (1)
- Hietzeschockprotein (1)
- High resolution data (1)
- Historische Anthropologie (1)
- Hypertherme Chemotherapie (1)
- Höhenangst (1)
- Kern (1)
- Kernrezeptor (1)
- Kolonkarzinom (1)
- Konsum (1)
- Kulturgeschichte (1)
- Körperkultur (1)
- Lebensreform (1)
- Ligand (1)
- Mammakarzinom (1)
- Menschen-Ratten-Begegnungen (1)
- Mip (1)
- Mip Inhibitoren (1)
- Molekulardesign (1)
- Molekulardynamik (1)
- Multispecies Ethnography (1)
- Museologie (1)
- Museumswissenschaft (1)
- NES (1)
- NLS (1)
- Nachhaltigkeit (1)
- NaturenKulturen (1)
- Nuclear Receptor (1)
- Nukleäre Rezeptoren (1)
- Optical remote sensing data (1)
- Proliferationsmarker (1)
- RS1 (1)
- Ratte (1)
- Regulation (1)
- Remote sensing (1)
- Resistenzentwicklung (1)
- SGLT1 (1)
- Spatial resolution (1)
- Statistische Thermodynamik (1)
- Struktur-Aktivitäts-Beziehung (1)
- Strukturbasiertes Wirkstoffdesign (1)
- Temporal Resolution (1)
- Time Series (1)
- Umwelt (1)
- Umweltanthropologie (1)
- Virtuelle Realität (1)
- Volkskunde (1)
- Zellzyklus (1)
- binding affinity (1)
- binding mechanism (1)
- biology (1)
- cancer (1)
- cell cycle (1)
- clinical genetics (1)
- flexibility (1)
- glucose (1)
- heat shock protein (1)
- low resolution data (1)
- moderate resolution data (1)
- molecular dynamics (1)
- molecular neuroscience (1)
- molekulardynamische Simulationen (1)
- nuclear export signal (1)
- nuclear localization signal (1)
- nucleus (1)
- resistance (1)
- structure-based drug design (1)
- transporter regulator (1)
- university (1)
- virtual screening (1)
- virtuelles Screening (1)
Institute
- Universität - Fakultätsübergreifend (5)
- Institut für deutsche Philologie (4)
- Institut für Pharmazie und Lebensmittelchemie (3)
- Graduate School of Life Sciences (2)
- Institut für Psychologie (2)
- Universität Würzburg (2)
- Graduate School of Science and Technology (1)
- Institut für Anatomie und Zellbiologie (1)
- Institut für Pharmakologie und Toxikologie (1)
- Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) (1)
Sonstige beteiligte Institutionen
EU-Project number / Contract (GA) number
- 115300 (1)
This dissertation focuses on Mip (macrophage infectivity potentiator protein) inhibitors in response to increasing antibiotic resistance. The study follows an antivirulence approach, which aims to inhibit the non-essential Mip protein without exerting too much selective pressure. Three focus areas were (1) development and synthesis of a fluorescent probe for screening Mip inhibitors via fluorescence polarization; (2) design and synthesis of broad spectrum Mip inhibitors bearing a side chain; and (3) understanding the metabolism of Mip inhibitors and identification of active metabolites.
A sub-study addressed the biotinylation of anti-leishmanial compounds from Valeriana wallichii rhizomes, with three tracer molecules synthesized for future pull-down experiments.