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Alternative Methods for the Replacement of Eye Irritation Testing

Please always quote using this URN: urn:nbn:de:bvb:20-opus-164444
  • In the last decades significant regulatory attempts were made to replace, refine and reduce animal testing to assess the risk of consumer products for the human eye. As the original in vivo Draize eye test is criticized for limited predictivity, costs and ethical issues, several animal-free test methods have been developed to categorize substances according to the global harmonized system (GHS) for eye irritation. This review summarizes the progress of alternative test methods for the assessment of eye irritation. Based on the corneal anatomyIn the last decades significant regulatory attempts were made to replace, refine and reduce animal testing to assess the risk of consumer products for the human eye. As the original in vivo Draize eye test is criticized for limited predictivity, costs and ethical issues, several animal-free test methods have been developed to categorize substances according to the global harmonized system (GHS) for eye irritation. This review summarizes the progress of alternative test methods for the assessment of eye irritation. Based on the corneal anatomy and current knowledge of the mechanisms causing eye irritation, different ex vivo and in vitro methods will be presented and discussed with regard to possible limitations and status of regulatory acceptance. In addition to established in vitro models, this review will also highlight emerging, full thickness cornea models that might be suited to predict all GHS categories.show moreshow less

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Metadaten
Author: Christian Lotz, Freia F. Schmid, Angela Rossi, Szymon Kurdyn, Daniel Kampik, Bart De Wever, Heike Walles, Florian K. Groeber
URN:urn:nbn:de:bvb:20-opus-164444
Document Type:Journal article
Faculties:Medizinische Fakultät / Augenklinik und Poliklinik
Medizinische Fakultät / Lehrstuhl für Tissue Engineering und Regenerative Medizin
Language:English
Parent Title (English):ALTEX - Alternatives to Animal Experimentation
Year of Completion:2016
Volume:33
Issue:1
Pagenumber:55-67
Source:Altex 33(1), 2016, S. 55-67.
DOI:https://doi.org/10.14573/altex.1508241
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 616 Krankheiten
Tag:Draize eye test; OECD guideline; alternatives; corneal equivalent; eye irritation testing
Release Date:2019/09/20
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International