Nature's Lab for Derivatization: New and Revised Structures of a Variety of Streptophenazines Produced by a Sponge-Derived Streptomyces Strain
Please always quote using this URN: urn:nbn:de:bvb:20-opus-116816
- Eight streptophenazines (A-H) have been identified so far as products of Streptomyces strain HB202, which was isolated from the sponge Halichondria panicea from the Baltic Sea. The variation of bioactivities based on small structural changes initiated further studies on new derivatives. Three new streptophenazines (I-K) were identified after fermentation in the present study. In addition, revised molecular structures of streptophenazines C, D, F and H are proposed. Streptophenazines G and K exhibited moderate antibacterial activity against theEight streptophenazines (A-H) have been identified so far as products of Streptomyces strain HB202, which was isolated from the sponge Halichondria panicea from the Baltic Sea. The variation of bioactivities based on small structural changes initiated further studies on new derivatives. Three new streptophenazines (I-K) were identified after fermentation in the present study. In addition, revised molecular structures of streptophenazines C, D, F and H are proposed. Streptophenazines G and K exhibited moderate antibacterial activity against the facultative pathogenic bacterium Staphylococcus epidermidis and against Bacillus subtilis. All tested compounds (streptophenazines G, I-K) also showed moderate activities against PDE 4B.…
Author: | Anna Lena Kunz, Antje Labes, Jutta Wiese, Torsten Bruhn, Gerhard Bringmann, Johannes F. Imhoff |
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URN: | urn:nbn:de:bvb:20-opus-116816 |
Document Type: | Journal article |
Faculties: | Fakultät für Chemie und Pharmazie / Institut für Organische Chemie |
Language: | English |
Parent Title (English): | Marine Drugs |
ISSN: | 1660-3397 |
Year of Completion: | 2014 |
Volume: | 12 |
Issue: | 4 |
Pagenumber: | 1699-1714 |
Source: | Marine Drugs 2014, 12, 1699-1714; doi:10.3390/md12041699 |
DOI: | https://doi.org/10.3390/md12041699 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/24670532 |
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
Tag: | Baltic Sea; absolute configuration; biosynthesis; halichondria panicea; marine natural product; obstructive pulmonary disease; phenazine; phosphodiesterase-4 inhibitor; rofumilast; streptomyces |
Release Date: | 2015/08/12 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung |