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Non-Coding RNAs in Lung Cancer: Contribution of Bioinformatics Analysis to the Development of Non-Invasive Diagnostic Tools
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-147990
- Lung cancer is currently the leading cause of cancer related mortality due to late diagnosis and limited treatment intervention. Non-coding RNAs are not translated into proteins and have emerged as fundamental regulators of gene expression. Recent studies reported that microRNAs and long non-coding RNAs are involved in lung cancer development and progression. Moreover, they appear as new promising non-invasive biomarkers for early lung cancer diagnosis. Here, we highlight their potential as biomarker in lung cancer and present howLung cancer is currently the leading cause of cancer related mortality due to late diagnosis and limited treatment intervention. Non-coding RNAs are not translated into proteins and have emerged as fundamental regulators of gene expression. Recent studies reported that microRNAs and long non-coding RNAs are involved in lung cancer development and progression. Moreover, they appear as new promising non-invasive biomarkers for early lung cancer diagnosis. Here, we highlight their potential as biomarker in lung cancer and present how bioinformatics can contribute to the development of non-invasive diagnostic tools. For this, we discuss several bioinformatics algorithms and software tools for a comprehensive understanding and functional characterization of microRNAs and long non-coding RNAs.…
Autor(en): | Meik Kunz, Beat Wolf, Harald Schulze, David Atlan, Thorsten Walles, Heike Walles, Thomas Dandekar |
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URN: | urn:nbn:de:bvb:20-opus-147990 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften |
Medizinische Fakultät / Lehrstuhl für Tissue Engineering und Regenerative Medizin | |
Medizinische Fakultät / Institut für Experimentelle Biomedizin | |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Genes |
Erscheinungsjahr: | 2016 |
Band / Jahrgang: | 8 |
Heft / Ausgabe: | 1 |
Seitenangabe: | 8 |
Originalveröffentlichung / Quelle: | Genes 2017, 8(1), 8; doi:10.3390/genes8010008 |
DOI: | https://doi.org/10.3390/genes8010008 |
Sonstige beteiligte Institutionen: | Fraunhofer Institute Interfacial Engineering and Biotechnology (IGB) |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
Freie Schlagwort(e): | algorithm; bioinformatics; early diagnosis; lncRNAs; lung cancer; miRNAs; non-invasive biomarkers |
Datum der Freischaltung: | 09.06.2017 |
Sammlungen: | Open-Access-Publikationsfonds / Förderzeitraum 2016 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung |