Filtern
Erscheinungsjahr
Dokumenttyp
- Artikel / Aufsatz in einer Zeitschrift (7311) (entfernen)
Sprache
- Englisch (7311) (entfernen)
Schlagworte
- Toxikologie (110)
- Medizin (94)
- inflammation (83)
- Biochemie (81)
- Anorganische Chemie (66)
- gene expression (62)
- Organische Chemie (59)
- Infektionsbiologie (57)
- cancer (56)
- expression (53)
- apoptosis (52)
- Biologie (50)
- Psychologie (49)
- COVID-19 (47)
- Physiologische Chemie (46)
- Hadron-Hadron scattering (experiments) (45)
- breast cancer (44)
- machine learning (44)
- depression (42)
- multiple myeloma (42)
- children (41)
- therapy (40)
- Neurobiologie (39)
- infection (36)
- virtual reality (36)
- ischemic stroke (35)
- mice (35)
- Virologie (34)
- anxiety (34)
- boron (34)
- T cells (32)
- remote sensing (32)
- stroke (32)
- cytokines (31)
- biomarker (30)
- brain (30)
- multiple sclerosis (30)
- prostate cancer (30)
- Germany (29)
- melanoma (29)
- oxidative stress (29)
- SARS-CoV-2 (28)
- biodiversity (28)
- gene (28)
- metabolism (28)
- DNA damage (27)
- evolution (27)
- heart failure (27)
- magnetic resonance imaging (27)
- Chirurgie (26)
- climate change (26)
- in vitro (26)
- macrophages (26)
- High energy physics (25)
- PET (25)
- Parton Distributions (25)
- deep learning (25)
- phosphorylation (25)
- DNA methylation (24)
- MRI (24)
- diagnosis (24)
- genetics (24)
- medicine (24)
- protein (24)
- B cells (23)
- Escherichia coli (23)
- Fabry disease (23)
- identification (23)
- mortality (23)
- survival (23)
- disease (22)
- Candida albicans (21)
- Immunologie (21)
- blood (21)
- obesity (21)
- physics (21)
- positron emission tomography (21)
- 3D printing (20)
- ADHD (20)
- ATLAS detector (20)
- Parkinson’s disease (20)
- activation (20)
- autophagy (20)
- mouse (20)
- neuroinflammation (20)
- quality of life (20)
- Chemie (19)
- chronic kidney disease (19)
- endothelial cells (19)
- immunohistochemistry (19)
- immunotherapy (19)
- management (19)
- mouse model (19)
- physical activity (19)
- prognosis (19)
- radiotherapy (19)
- tissue engineering (19)
- DNA (18)
- Parkinson's disease (18)
- behavior (18)
- binding (18)
- classification (18)
- dendritic cells (18)
- fluorescence (18)
- mouse models (18)
- regulatory T cells (18)
- stem cells (18)
- surgery (18)
- time series (18)
- CXCR4 (17)
- EEG (17)
- Expression (17)
- HIV (17)
- RNA (17)
- antibodies (17)
- biology (17)
- colorectal cancer (17)
- differentiation (17)
- epidemiology (17)
- mitochondria (17)
- pain (17)
- perception (17)
- platelets (17)
- theranostics (17)
- toxicity (17)
- validation (17)
- aging (16)
- artificial intelligence (16)
- biomarkers (16)
- blood pressure (16)
- blood-brain barrier (16)
- cells (16)
- cytotoxicity (16)
- deep brain stimulation (16)
- epithelial cells (16)
- messenger RNA (16)
- metastasis (16)
- model (16)
- myocardial infarction (16)
- prevalence (16)
- psychology (16)
- resistance (16)
- transcriptome (16)
- Decay (15)
- Positronen-Emissions-Tomografie (15)
- cytoskeleton (15)
- escherichia coli (15)
- hadron-hadron scattering (15)
- mutation (15)
- neurons (15)
- proton-proton collision (15)
- signal transduction (15)
- Cytologie (14)
- Drosophila melanogaster (14)
- Extension (14)
- Higgs boson (14)
- P300 (14)
- Sentinel-2 (14)
- Staphylococcus aureus (14)
- angiogenesis (14)
- attention (14)
- bone (14)
- chemotherapy (14)
- foraging (14)
- guidelines (14)
- heart (14)
- immune response (14)
- in vivo (14)
- in-vivo (14)
- luminescence (14)
- mechanisms (14)
- neuropathic pain (14)
- neuroprotection (14)
- osteoporosis (14)
- prediction (14)
- rat (14)
- schizophrenia (14)
- topological insulators (14)
- virulence (14)
- vision (14)
- Apis mellifera (13)
- LHC (13)
- Medicine (13)
- Neisseria meningitidis (13)
- Physics (13)
- adrenocortical carcinoma (13)
- association (13)
- bacteria (13)
- bees (13)
- cell death (13)
- cell staining (13)
- chemistry (13)
- crystal structure (13)
- echocardiography (13)
- extracellular matrix (13)
- flow cytometry (13)
- honey bees (13)
- human (13)
- imaging (13)
- land use (13)
- learning (13)
- mental health (13)
- molecular docking (13)
- monocytes (13)
- ovarian cancer (13)
- proteins (13)
- sepsis (13)
- stress (13)
- transcription (13)
- transcription factors (13)
- Activation (12)
- Drosophila (12)
- MODIS (12)
- Merkel cell carcinoma (12)
- PET/CT (12)
- blood–brain barrier (12)
- circadian clock (12)
- dopamine (12)
- epigenetics (12)
- gene regulation (12)
- genome (12)
- humans (12)
- in-vitro (12)
- inorganic chemistry (12)
- mRNA (12)
- metaanalysis (12)
- microRNA (12)
- nutrition (12)
- proliferation (12)
- recurrence (12)
- risk factors (12)
- structure elucidation (12)
- treatment (12)
- tumor (12)
- ++ (11)
- Aspergillus (11)
- Aspergillus fumigatus (11)
- PRRT (11)
- Squark (11)
- Tanzania (11)
- additive manufacturing (11)
- atherosclerosis (11)
- cancer treatment (11)
- case report (11)
- conservation (11)
- diet (11)
- emotion (11)
- event-related potentials (11)
- fMRI (11)
- fracture (11)
- fungi (11)
- glioblastoma (11)
- glioblastoma multiforme (11)
- hippocampus (11)
- honeybee (11)
- inhibition (11)
- lung cancer (11)
- lymphoma (11)
- mass spectrometry (11)
- measles virus (11)
- membrane proteins (11)
- memory (11)
- metabolomics (11)
- miRNA (11)
- migration (11)
- nervous system (11)
- neurodegeneration (11)
- neurology (11)
- optogenetics (11)
- proteomics (11)
- randomized controlled trial (11)
- reliability (11)
- total knee arthroplasty (11)
- traumatic brain injury (11)
- vitamin D (11)
- Alzheimer’s disease (10)
- BDNF (10)
- DNA repair (10)
- PSMA (10)
- Trypanosoma brucei (10)
- antimicrobial resistance (10)
- cardiomyopathy (10)
- complex (10)
- diabetes (10)
- exercise (10)
- fibrosis (10)
- follow-up (10)
- genome-wide association (10)
- global change (10)
- growth (10)
- lymph nodes (10)
- lymphocytes (10)
- melt electrowriting (10)
- metagenomics (10)
- mushroom body (10)
- neuroendocrine tumor (10)
- neutrophils (10)
- osteoarthritis (10)
- polymers (10)
- pregnancy (10)
- receptor (10)
- relapse (10)
- risk (10)
- safety (10)
- serotonin (10)
- simulation (10)
- sphingolipids (10)
- tight junctions (10)
- transplantation (10)
- tumor microenvironment (10)
- Boron (9)
- Cancer (9)
- Depression (9)
- Google Earth Engine (9)
- Krebs <Medizin> (9)
- RNA-seq (9)
- Schwertkärpfling (9)
- T-cells (9)
- active zone (9)
- adolescents (9)
- age (9)
- animal model (9)
- ants (9)
- asthma (9)
- autoimmunity (9)
- boranes (9)
- central nervous system (9)
- clinical trial (9)
- database (9)
- density functional calculations (9)
- diversity (9)
- dosimetry (9)
- dynamics (9)
- ecology (9)
- ecosystem services (9)
- electronic properties and materials (9)
- emotions (9)
- energy (9)
- enzyme replacement therapy (9)
- fear (9)
- fear conditioning (9)
- forest (9)
- hemodialysis (9)
- hypoxia (9)
- insects (9)
- ischemia (9)
- microbiome (9)
- microglia (9)
- mutations (9)
- neural networks (9)
- olfaction (9)
- outcome (9)
- pancreatic cancer (9)
- performance (9)
- phenotype (9)
- plasticity (9)
- pollination (9)
- polymorphism (9)
- preterm infants (9)
- rats (9)
- reveals (9)
- review (9)
- self-assembly (9)
- systematic review (9)
- systematic uncertainty (9)
- temperature (9)
- tumors (9)
- type 2 diabetes (9)
- ubiquitin (9)
- Adenosine receptors (8)
- Alps (8)
- Apoptosis (8)
- Beyond Standard Model (8)
- Cross-Section (8)
- EAE (8)
- HNSCC (8)
- LASP1 (8)
- Landsat (8)
- MS (8)
- Mass (8)
- Mice (8)
- Model (8)
- Parton distributions (8)
- Sentinel-1 (8)
- TNF (8)
- Therapy (8)
- West Africa (8)
- Xiphophorus (8)
- actin (8)
- amygdala (8)
- analysis of variance (8)
- animal models (8)
- antibiotics (8)
- aromaticity (8)
- atrial fibrillation (8)
- biofabrication (8)
- bipolar disorder (8)
- body size (8)
- borylation (8)
- calcium (8)
- cardiovascular disease (8)
- cell cycle (8)
- cerebrospinal fluid (8)
- chromatin (8)
- cytotoxic T cells (8)
- decay (8)
- decision making (8)
- development (8)
- earth observation (8)
- education (8)
- electroencephalography (8)
- fatigue (8)
- fluorescence microscopy (8)
- forest management (8)
- head and neck cancer (8)
- high energy physics (8)
- hypertension (8)
- immunology (8)
- impact (8)
- in vivo imaging (8)
- jet energy scale (8)
- kidney (8)
- kinematic alignment (8)
- kinetics (8)
- mHealth (8)
- major depression (8)
- mechanism (8)
- mesenchymal stem cells (8)
- molecular biology (8)
- molecular imaging (8)
- nanoparticles (8)
- navigation (8)
- neuroscience (8)
- next generation sequencing (8)
- nitric oxide (8)
- oncolytic virus (8)
- organoids (8)
- pathway (8)
- periodontitis (8)
- platelet activation (8)
- pollen (8)
- polycyclic aromatic hydrocarbons (8)
- prefrontal cortex (8)
- progression (8)
- quality assurance (8)
- radioligand therapy (8)
- reactive oxygen species (8)
- reconstruction (8)
- regulation (8)
- rehabilitation (8)
- replication (8)
- rheumatoid arthritis (8)
- serum (8)
- synaptic plasticity (8)
- technology (8)
- tinnitus (8)
- translation (8)
- transmission (8)
- walking (8)
- ALS (7)
- ATLAS (7)
- Arabidopsis thaliana (7)
- Gehirn (7)
- MYC (7)
- NDVI (7)
- NK cells (7)
- Neisseria gonorrhoeae (7)
- Pain (7)
- Physik (7)
- SAR (7)
- SPECT (7)
- Supersymmetry (7)
- Survival (7)
- Transcription (7)
- Trypanosoma (7)
- acute ischemic stroke (7)
- acute kidney injury (7)
- adolescence (7)
- agriculture (7)
- amyotrophic lateral sclerosis (7)
- animal behavior (7)
- antibacterial activity (7)
- astrocytes (7)
- bioprinting (7)
- biosynthesis (7)
- blood flow (7)
- body mass index (7)
- cell membranes (7)
- central complex (7)
- chemokine receptor (7)
- circadian rhythms (7)
- coherence (7)
- comparative genomics (7)
- cortisol (7)
- dSTORM (7)
- decision-making (7)
- diabetes mellitus (7)
- diborenes (7)
- domain (7)
- drought (7)
- efficacy (7)
- embodiment (7)
- emotion regulation (7)
- experimental autoimmune encephalomyelitis (7)
- extracellular vesicles (7)
- fibromyalgia syndrome (7)
- fluorescent probes (7)
- gastric cancer (7)
- genes (7)
- histology (7)
- hydrogels (7)
- hypophosphatasia (7)
- immersion (7)
- immune evasion (7)
- immunofluorescence (7)
- immunomodulation (7)
- immunoprecipitation (7)
- induced pluripotent stem cells (7)
- inhibitor (7)
- insect (7)
- luciferase (7)
- mechanotransduction (7)
- melt electrospinning writing (7)
- microenvironment (7)
- microscopy (7)
- multicenter (7)
- oncology (7)
- optimization (7)
- panic disorder (7)
- pathogens (7)
- peripheral nervous system (7)
- permafrost (7)
- photocatalysis (7)
- platelet (7)
- platelet aggregation (7)
- population (7)
- prevention (7)
- random forest (7)
- recognition (7)
- responses (7)
- semiconductors (7)
- senescence (7)
- species richness (7)
- spectroscopy (7)
- spinal muscular atrophy (7)
- subthalamic nucleus (7)
- super-resolution microscopy (7)
- symbiosis (7)
- synthesis (7)
- telomeres (7)
- transcriptomics (7)
- trial (7)
- water (7)
- water oxidation (7)
- wearable (7)
- zebrafish (7)
- Alzheimer's disease (6)
- Chrysomelidae (6)
- Covid-19 (6)
- DNA binding (6)
- ELISPOT (6)
- Earth observation (6)
- Echinococcus (6)
- Ernährung (6)
- Europe (6)
- Evolution (6)
- Gluino Production (6)
- Hadron colliders (6)
- HeLa cells (6)
- Higgs physics (6)
- Inflammation (6)
- Large Hadron Collider (6)
- MASS (6)
- Mechanisms (6)
- Monte-Carlo (6)
- N-heterocyclic carbenes (6)
- NAFLD (6)
- NLO Computations (6)
- PD-L1 (6)
- Prevalence (6)
- Schizophrenie (6)
- South Africa (6)
- TRAIL (6)
- UAV (6)
- United States (6)
- X-ray crystallography (6)
- adhesion (6)
- aggregation (6)
- algorithm (6)
- animal behaviour (6)
- antibiotic resistance (6)
- antidepressant (6)
- arabidopsis thaliana (6)
- astrocytoma (6)
- autoantibodies (6)
- bacterial pathogens (6)
- brain development (6)
- brain-computer interface (6)
- carcinoma (6)
- cardiovascular diseases (6)
- catalysis (6)
- cell biology (6)
- cell proliferation (6)
- ceramide (6)
- change detection (6)
- chemokines (6)
- chronic heart failure (6)
- circular dichroism (6)
- communication (6)
- copper (6)
- coronary artery disease (6)
- cytokinins (6)
- deadwood (6)
- dementia (6)
- design (6)
- developmental biology (6)
- down regulation (6)
- drosophila melanogaster (6)
- drug (6)
- drug delivery (6)
- dystonia (6)
- endurance (6)
- evaluation (6)
- exposure (6)
- extinction (6)
- eye movements (6)
- eyes (6)
- factor XII (6)
- family (6)
- genomics (6)
- gephyrin (6)
- glaucoma (6)
- glioma (6)
- glucocorticoid receptor (6)
- glycine receptor (6)
- heart rate (6)
- homogeneous catalysis (6)
- human behaviour (6)
- hyaluronic acid (6)
- hymenoptera (6)
- hyperexpression techniques (6)
- ideomotor theory (6)
- immunity (6)
- immunosuppression (6)
- influenza (6)
- injury (6)
- innate immunity (6)
- insulin (6)
- kidneys (6)
- lesions (6)
- leukemia (6)
- liver (6)
- locomotion (6)
- lung (6)
- malaria (6)
- meiosis (6)
- membrane potential (6)
- meningococcal disease (6)
- meta-analysis (6)
- metapopulation (6)
- methylation (6)
- microbiology (6)
- molecular dynamics (6)
- monitoring (6)
- motivation (6)
- mushroom bodies (6)
- myelin (6)
- near-infrared spectroscopy (6)
- neuromuscular junction (6)
- organic chemistry (6)
- outcomes (6)
- p53 (6)
- pediatric (6)
- pediatrics (6)
- personalized medicine (6)
- pharmacokinetics (6)
- phylogenetic trees (6)
- plasmodium falciparum (6)
- precision medicine (6)
- presence (6)
- primary care (6)
- psoriasis (6)
- psychiatric disorders (6)
- public health (6)
- quantum dots (6)
- radiation (6)
- radicals (6)
- receptors (6)
- recombination (6)
- repair (6)
- sRNA (6)
- secondary prevention (6)
- secretion (6)
- segmentation (6)
- sequence alignment (6)
- sex differences (6)
- signaling (6)
- sleep (6)
- small interfering RNAs (6)
- smoking (6)
- social cognition (6)
- social interaction (6)
- staphylococcus aureus (6)
- states (6)
- susceptibility (6)
- target (6)
- therapeutic drug monitoring (6)
- thermodynamics (6)
- thrombosis (6)
- tool (6)
- vaccinia virus (6)
- variability (6)
- 53BP1 (5)
- Akt (5)
- BRCA1 (5)
- Biology (5)
- Breaking (5)
- Burkina Faso (5)
- CD95 (5)
- CML (5)
- CMV (5)
- CSF (5)
- Chlamydia trachomatis (5)
- Durchblutung (5)
- Energy (5)
- Enzyme replacement therapy (5)
- Gene-expression (5)
- Genotoxicity (5)
- Heart failure (5)
- Higgs bosons (5)
- IL-10 (5)
- Immunotherapy (5)
- In-vivo (5)
- MSC (5)
- Magnetic resonance imaging (5)
- Metapopulation (5)
- Multiple myeloma (5)
- Multiple sclerosis (5)
- NF-KAPPA-B (5)
- NLO computations (5)
- PCR (5)
- PD-1 (5)
- Quality of life (5)
- RNA sequencing (5)
- RNA-binding proteins (5)
- Radiotherapy (5)
- Rat (5)
- T cell (5)
- T lymphocytes (5)
- TNF-α (5)
- TNFR2 (5)
- TerraSAR-X (5)
- Top physics (5)
- Top quark (5)
- VEGF (5)
- absorption (5)
- actinomycetes (5)
- acute myeloid leukemia (5)
- adaptation (5)
- adults (5)
- allergy (5)
- altitudinal gradient (5)
- anatomy (5)
- annotation (5)
- antennal lobe (5)
- antigen (5)
- antimicrobial stewardship (5)
- bariatric surgery (5)
- basal ganglia (5)
- behavioral conditioning (5)
- biocompatibility (5)
- bioinformatics (5)
- biological locomotion (5)
- blood brain barrier (5)
- body weight (5)
- bone mineral density (5)
- boronate esters (5)
- brain tumor (5)
- bronchopulmonary dysplasia (5)
- caloric restriction (5)
- cancer therapy (5)
- carbenes (5)
- cardiac surgery (5)
- cardiovascular events (5)
- cartilage (5)
- cell cultures (5)
- cell cycle and cell division (5)
- cell differentiation (5)
- cell wall (5)
- ceramides (5)
- cerebellum (5)
- cerebral ischemia (5)
- circadian rhythm (5)
- coagulation (5)
- cognition (5)
- cognitive decline (5)
- cognitive impairment (5)
- collagens (5)
- comparison (5)
- competition (5)
- complexes (5)
- computed tomography (5)
- condensed matter physics (5)
- coping (5)
- cuticular hydrocarbons (5)
- damage (5)
- density functional theory (5)
- dental education (5)
- detoxification (5)
- diagnostics (5)
- drug design (5)
- drug discovery (5)
- dyes (5)
- eHealth (5)
- ecological momentary assessment (5)
- electron microscopy (5)
- electronic structure (5)
- endocytosis (5)
- enzyme-linked immunoassays (5)
- experimental design (5)
- eye tracking (5)
- facial expression (5)
- fluorine (5)
- food-cues (5)
- forensic neuropathology (5)
- fungal infection (5)
- gait (5)
- galactomannan (5)
- gastrointestinal tract (5)
- gender (5)
- gene-expression (5)
- generation (5)
- genotoxicity (5)
- glaucoma surgery (5)
- global warming (5)
- glycoprotein VI (5)
- grazing (5)
- guideline adherence (5)
- health-related quality of life (5)
- hearing loss (5)
- heterochromatin (5)
- heterocycles (5)
- human-computer interaction (5)
- immune cells (5)
- implementation (5)
- incidence (5)
- inflammatory bowel disease (5)
- iron (5)
- larvae (5)
- leaf-cutting ants (5)
- lipids (5)
- localization (5)
- long-term outcome (5)
- mapping (5)
- masked priming (5)
- mechanical thrombectomy (5)
- membrane (5)
- meningitis (5)
- mental disorders (5)
- methionine (5)
- mineralization (5)
- models (5)
- molecular medicine (5)
- motor control (5)
- movement disorders (5)
- movement ecology (5)
- mutualism (5)
- neuroanatomy (5)
- neuronal differentiation (5)
- neuropathy (5)
- norepinephrine (5)
- nuclear envelope (5)
- object detection (5)
- octopamine (5)
- oilseed rape (5)
- oncolysis (5)
- organization (5)
- parasitic diseases (5)
- pathogenesis (5)
- permeability (5)
- phenology (5)
- plant-insect interactions (5)
- plants (5)
- polyomavirus (5)
- protein kinase (5)
- pulmonary hypertension (5)
- quantification (5)
- radial (5)
- recombinant proteins (5)
- recovery (5)
- recruitment (5)
- refractory (5)
- regenerative medicine (5)
- regression analysis (5)
- reward (5)
- salt stress (5)
- scale (5)
- secondary structure (5)
- selection (5)
- sequence (5)
- signaling pathway (5)
- single-crystal X-ray study (5)
- skeletal muscle (5)
- small RNA (5)
- social anxiety (5)
- software (5)
- solar cells (5)
- somatic mutations (5)
- spinal cord (5)
- stem-cell transplantation (5)
- structural biology (5)
- structure (5)
- superconductivity (5)
- supramolecular chemistry (5)
- survey (5)
- sympathetic nervous system (5)
- synaptic vesicles (5)
- system (5)
- systems biology (5)
- taxonomy (5)
- thrombo-inflammation (5)
- tomography (5)
- trabeculectomy (5)
- training (5)
- transcriptional regulation (5)
- translational research (5)
- transverse momentum (5)
- vaccination (5)
- vaccine (5)
- valence (5)
- vancomycin (5)
- variants (5)
- winter wheat (5)
- working memory (5)
- 3D tissue model (4)
- AI (4)
- AdS-CFT Correspondence (4)
- Adenylate cyclase (4)
- Adult (4)
- Alzheimers disease (4)
- Anaphylaxis (4)
- Anura (4)
- Asthma (4)
- Atlas detector (4)
- B-cell lymphoma (4)
- BRAF (4)
- Bordetella pertussis (4)
- Boson (4)
- Botanik (4)
- Brain (4)
- C-MYC (4)
- CNS (4)
- CRISPR/Cas9 (4)
- CT (4)
- Cancer genetics (4)
- Candida auris (4)
- Children (4)
- China (4)
- Cushing’s syndrome (4)
- DNA transcription (4)
- DNA-binding proteins (4)
- Dendritische Zelle (4)
- Diagnosis (4)
- Distributions (4)
- EGFR (4)
- EMG (4)
- ERP (4)
- Earth Observation (4)
- Electroweak interaction (4)
- FDG (4)
- FGFR (4)
- G proteins (4)
- GABA (4)
- GFAP (4)
- GVHD (4)
- Gene (4)
- Geschichte (4)
- Glioblastoma (4)
- Hierarchy (4)
- Hypothalamus (4)
- IL-2 (4)
- IL-4 (4)
- ITS2 (4)
- Immunobiologie (4)
- InSAR (4)
- IoT (4)
- Krebs (4)
- LPS (4)
- Lepidoptera (4)
- MRSA (4)
- Models (4)
- NASH (4)
- NET (4)
- NFATc1 (4)
- NFκB (4)
- NGS (4)
- NLRP3 (4)
- NMR (4)
- NPY (4)
- NSCLC (4)
- Neurons (4)
- Neurospora crassa (4)
- Parkinson disease (4)
- Pathway (4)
- Pflanzenfressende Insekten (4)
- Pharmakologie (4)
- Protein (4)
- Quantitative anatomy (4)
- RCT (4)
- RNA interference (4)
- ROS (4)
- RapidEye (4)
- Rituximab (4)
- Roux-en-Y gastric bypass surgery (4)
- SSTR (4)
- Salmonella (4)
- Surgery (4)
- TLR4 (4)
- Th17 (4)
- Transport (4)
- Treatment (4)
- UV/Vis spectroscopy (4)
- Ureaplasma parvum (4)
- Zoologie (4)
- accumulation (4)
- accuracy (4)
- acid sphingomyelinase (4)
- action (4)
- adalimumab (4)
- adenosine (4)
- age-related macular degeneration (4)
- agency (4)
- aggression (4)
- algorithms (4)
- alignment (4)
- alkaloids (4)
- allogeneic stem cell transplantation (4)
- amyotrophic-lateral-sclerosis (4)
- animals (4)
- anorexia nervosa (4)
- antagonists (4)
- antibody (4)
- antidepressants (4)
- antifungals (4)
- antimicrobials (4)
- antiretroviral therapy (4)
- antisense RNA (4)
- anxiety disorders (4)
- aorta (4)
- apis mellifera (4)
- arousal (4)
- arrhythmia (4)
- arthritis (4)
- aspergillosis (4)
- aspergillus fumigatus (4)
- athletes (4)
- atopic dermatitis (4)
- attention-deficit/hyperactivity disorder (ADHD) (4)
- augmented reality (4)
- autonomic nervous system (4)
- balance (4)
- bevacizumab (4)
- binding analysis (4)
- biodiversity conservation (4)
- biofilms (4)
- bioink (4)
- biokinetics (4)
- biomass (4)
- biophysics (4)
- bismuth (4)
- blood plasma (4)
- body composition (4)
- bone marrow (4)
- bone regeneration (4)
- bone-mineral density (4)
- brain computer interface (4)
- burden (4)
- cGMP (4)
- calcium phosphate (4)
- cancer patients (4)
- cancer stem cells (4)
- capsaicin (4)
- carcinomas (4)
- cardiac hypertrophy (4)
- cardiorespiratory fitness (4)
- cardiovascular genetics (4)
- cardiovascular risk factors (4)
- care (4)
- cell-cycle arrest (4)
- chirality (4)
- chlamydia (4)
- chondrocytes (4)
- chondrogenic differentiation (4)
- ciliary neurotrophic factor (4)
- cisplatin (4)
- classical conditioning (4)
- climate (4)
- clinical trials (4)
- co-culture (4)
- cochlear implant (4)
- cognitive control (4)
- colony-stimulating factor (4)
- consortium (4)
- coronary heart disease (4)
- critical illness (4)
- cross-coupling (4)
- crowdsensing (4)
- cystic fibrosis (4)
- cytokine (4)
- cytokinesis (4)
- deficiency (4)
- degradation (4)
- dehydrocoupling (4)
- democracy (4)
- demyelination (4)
- dentate gyrus (4)
- dermatology (4)
- dexamethasone (4)
- dialysis (4)
- diborynes (4)
- diffusion (4)
- disability (4)
- disease severity (4)
- dispersal (4)
- eating disorders (4)
- economic growth (4)
- ecosystem function (4)
- editorial (4)
- ejection fraction (4)
- elderly (4)
- electrospinning (4)
- emission (4)
- empathy (4)
- energy metabolism (4)
- enzyme (4)
- enzymes (4)
- epithelial-mesenchymal transition (4)
- ethanol (4)
- excitons (4)
- experience (4)
- fNIRS (4)
- facial expressions (4)
- fatty acids (4)
- ferroptosis (4)
- fluorescence imaging (4)
- fluorescence resonance energy transfer (4)
- fluoroarene (4)
- follow up (4)
- food security (4)
- forensic neurotraumatology (4)
- fullerenes (4)
- functional characterization (4)
- functional diversity (4)
- functional magnetic resonance imaging (4)
- fungal structure (4)
- genetic loci (4)
- genome annotation (4)
- genotype (4)
- geography (4)
- geomorphology (4)
- glucocorticoids (4)
- glucose transporter (4)
- glycolysis (4)
- gynecology (4)
- habitats (4)
- head (4)
- healthy volunteers (4)
- hematology (4)
- hepatitis C virus (4)
- homeostasis (4)
- homologous recombination (4)
- honeybees (4)
- hospitalization (4)
- host cells (4)
- host-pathogen interaction (4)
- hybrid materials (4)
- hydroboration (4)
- hydrogen bonding (4)
- hypercortisolism (4)
- hyperekplexia (4)
- imaging techniques (4)
- immune checkpoint blockade (4)
- immune system (4)
- immunization (4)
- immunohistochemistry techniques (4)
- impulsivity (4)
- in vitro selection (4)
- individual-based model (4)
- induction (4)
- infectious diseases (4)
- inflammasome (4)
- inpatient rehabilitation (4)
- insect brain (4)
- insulin resistance (4)
- integrins (4)
- interaction (4)
- intervention (4)
- invasion (4)
- invasive aspergillosis (4)
- iron oxide nanoparticles (4)
- jet energy resolution (4)
- juvenile idiopathic arthritis (4)
- knockout (4)
- knockout mice (4)
- land cover (4)
- latency (4)
- learning and memory (4)
- lines (4)
- linkage (4)
- lipid bilayer (4)
- living cells (4)
- lysosome (4)
- man-computer interface (4)
- marine sponges (4)
- mast cells (4)
- matrix metalloproteinases (4)
- medaka (4)
- medical education (4)
- medical research (4)
- megakaryocytes (4)
- melatonin (4)
- metabarcoding (4)
- methylphenidate (4)
- microRNAs (4)
- microarray (4)
- microglomeruli (4)
- micronuclei (4)
- middle cerebral artery occlusion (4)
- migrants (4)
- mindfulness (4)
- minimally invasive surgery (4)
- mitosis (4)
- mobility (4)
- modulation (4)
- molecular modelling (4)
- molecular neuroscience (4)
- monoclonal antibodies (4)
- multisensory processing (4)
- mycotoxin (4)
- myelination (4)
- nanostructures (4)
- natural disturbance (4)
- natural products (4)
- neisseria meningitidis (4)
- neural stem cells (4)
- neurogenesis (4)
- neuroimaging (4)
- neuroimmunology (4)
- neuropeptides (4)
- neuropsychiatric disorders (4)
- neurotrophins (4)
- nickel (4)
- norepinephrine transporter (4)
- nutrients (4)
- oligodendrocytes (4)
- opioids (4)
- optical spectroscopy (4)
- organoid (4)
- oxidation (4)
- paraganglioma (4)
- pathogenicity (4)
- pathways (4)
- patient (4)
- patient blood management (4)
- perception and action (4)
- perioperative management (4)
- periprosthetic infection (4)
- persistence (4)
- perylene bisimide (4)
- pheochromocytoma (4)
- phosphorescence (4)
- photoelectron spectroscopy (4)
- phylogeny (4)
- physiology (4)
- plasma cells (4)
- plasma membrane (4)
- polarization (4)
- polycaprolactone (4)
- polygenic risk score (4)
- polymerase chain reaction (4)
- post-traumatic stress disorder (4)
- preclinical research (4)
- prognostic marker (4)
- prospective (4)
- protein domains (4)
- protein expression (4)
- protein synthesis (4)
- psychiatry (4)
- quantum dot (4)
- radar (4)
- radical (4)
- radioiodine therapy (4)
- reaction time (4)
- rectal cancer (4)
- regeneration (4)
- renal function (4)
- replacement (4)
- resilience (4)
- resolution (4)
- response inhibition (4)
- revision (4)
- risk assessment (4)
- risk factor (4)
- saproxylic beetles (4)
- sarcopenia (4)
- scaffold (4)
- screening (4)
- seasonality (4)
- sequence motif analysis (4)
- serotonin transporter (4)
- sex (4)
- sex chromosomes (4)
- shear stress (4)
- singlet oxygen (4)
- skin (4)
- small fiber neuropathy (4)
- smartwatch (4)
- social systems (4)
- sodium (4)
- solubility (4)
- somatostatin receptor (4)
- spacer (4)
- sphingomyelinase (4)
- sponges (4)
- startle reflex (4)
- stem cell transplantation (4)
- streptomyces (4)
- stromal cells (4)
- subarachnoid hemorrhage (4)
- substantia nigra (4)
- sulfur (4)
- supersymmetry (4)
- surface water (4)
- surfactants (4)
- surgical and invasive medical procedures (4)
- surgical oncology (4)
- surveillance (4)
- systemic sclerosis (4)
- systems (4)
- targeted therapy (4)
- teeth (4)
- tight junction (4)
- time series analysis (4)
- titanium (4)
- toe (4)
- tolerance (4)
- top quark mass (4)
- total knee replacement (4)
- transient ischemic attack (4)
- translocation (4)
- transport (4)
- transposable elements (4)
- tremor (4)
- triarylborane (4)
- tryptophan (4)
- two-dimensional materials (4)
- ubiquitination (4)
- uveal melanoma (4)
- vestibular schwannoma (4)
- viruses (4)
- visual system (4)
- visualization (4)
- vitamin C (4)
- zinc oxide nanoparticles (4)
- γ-H2AX (4)
- 1 (3)
- 18F-FDG (3)
- 18F-FDG PET/CT (3)
- 3D reconstruction (3)
- 5-HT1A (3)
- 5-HT2C (3)
- 5-Methylcytosine (3)
- ACTH (3)
- AIDS (3)
- ARIA (3)
- AVHRR (3)
- Acyrthosiphon pisum (3)
- Alzheimer disease (3)
- Ameisen (3)
- Amphibian oocytes (3)
- Antarctica (3)
- Anxiety (3)
- Autonomous UAV (3)
- B cell (3)
- B-cells (3)
- B7-H1 (3)
- BCI (3)
- BRAF mutation (3)
- Bevacizumab (3)
- Biomarker (3)
- Biomarkers (3)
- Biomedical engineering (3)
- Bipolar disorder (3)
- Bosons (3)
- C-reactive protein (3)
- C5aR1 (3)
- CD4(+) (3)
- CD40 (3)
- CMR (3)
- COPD (3)
- COVID-19 pandemic (3)
- COVID‐19 (3)
- CRMO (3)
- Caenorhabditis elegans (3)
- Carcinogenesis (3)
- Carcinogenicity (3)
- Central nervous system (3)
- Cerebellar cortex (3)
- Chemotherapy (3)
- Chlamydia (3)
- Coexpression (3)
- Coleoptera (3)
- Cystic fibrosis (3)
- DNA double-strand breaks (3)
- DNA replication (3)
- Deep learning (3)
- Design (3)
- Diabetes mellitus (3)
- EBV (3)
- ERK1/2 (3)
- ESS (3)
- Electron microscopy (3)
- Enterobacteriaceae (3)
- Enzyme induction (3)
- Enzymes (3)
- Epichloë (3)
- Events (3)
- FMRI (3)
- Fabry-associated pain (3)
- Fitness (3)
- Fluorescence (3)
- Fn14 (3)
- Formicidae (3)
- GWAS (3)
- Gauge-gravity correspondence (3)
- Gaussian approximation (3)
- Genetik (3)
- Genome (3)
- Gibbs free energy of binding (3)
- HBMEC (3)
- HUWE1 (3)
- Hadron Colliders (3)
- Helicobacter pylori (3)
- Hfq (3)
- Hirschsprung disease (3)
- Hodgkin lymphoma (3)
- Humans (3)
- Hymenoptera (3)
- IGRT (3)
- IgE (3)
- In-vitro (3)
- Insulin (3)
- Kenyon cells (3)
- Käfer (3)
- LC-HRESIMS (3)
- LC/MS (3)
- Legionella pneumophila (3)
- Leishmania (3)
- Lewis acids (3)
- LiDAR (3)
- Listeria monocytogenes (3)
- Lolium perenne (3)
- Lung cancer (3)
- Lymphozyt (3)
- MC simulation (3)
- MDD (3)
- MIZ1 (3)
- MSCs (3)
- MYCN (3)
- Macaranga (3)
- Macrophage (3)
- Mathematik (3)
- Maus (3)
- Measuring Masses (3)
- Meningitis (3)
- Methylation (3)
- Micronuclei (3)
- Mortality (3)
- Muscarinic receptor subtypes (3)
- Muscarinic receptors (3)
- Mycobacterium tuberculosis (3)
- Myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) (3)
- N170 (3)
- NMR spectroscopy (3)
- NRF2 (3)
- Neurodegeneration (3)
- Neuromyelitis optica spectrum disorders (NMOSD) (3)
- Neurotrophic factors (3)
- Nrf2 (3)
- Nude-mice (3)
- Oncology (3)
- Onkogen (3)
- Optic neuritis (3)
- Osteoarthritis (3)
- Outcome survey (3)
- Oxygen (3)
- P-glycoprotein (3)
- PER (3)
- PTEN (3)
- Pair Production (3)
- Parkinsons disease (3)
- Particle data analysis (3)
- Physical activity (3)
- Plants (3)
- PolSAR (3)
- Polymerase chain reaction (3)
- Promoter (3)
- Prostaglandine (3)
- Protein-Tyrosin-Kinasen (3)
- Proton-Proton Collisions (3)
- Psychiatrie (3)
- QCD (3)
- Quadrocopter (3)
- Quadrotor (3)
- RADS (3)
- RNA modification (3)
- RNA polymerase II (3)
- RNA structure (3)
- RNA-SEQ (3)
- RNA-Seq (3)
- RNA-sequencing (3)
- RNAseq (3)
- RNS (3)
- Radarsat-2 (3)
- Radiosurgery (3)
- Regulatory T cells (3)
- Relapse (3)
- SGLT1 (3)
- SM background (3)
- SOAT1 (3)
- Saccharomyces cerevisiae (3)
- Salmonella enterica (3)
- Salmonella typhimurium (3)
- Scattering (3)
- Schizophrenia (3)
- Schlaganfall (3)
- Search (3)
- Serotonin (3)
- Skin (3)
- Stem cells (3)
- Strahlentherapie (3)
- Streptomyces (3)
- Stroke (3)
- Supersymmetric models (3)
- Symmetry (3)
- T cell receptor (3)
- T cell receptors (3)
- T-lymphocytes (3)
- TEM (3)
- TGF-beta (3)
- TNF-alpha (3)
- TNFR1 (3)
- TRAF2 (3)
- TRH (3)
- TWEAK (3)
- Tourette syndrome (3)
- Tumor-necrosis-factor (3)
- USP28 (3)
- Ureaplasma urealyticum (3)
- VMAT (3)
- Vaccination (3)
- W boson (3)
- Weak (3)
- Wilms tumor (3)
- Wilms' tumor (3)
- X-ray (3)
- Z boson (3)
- Zebrafish (3)
- ab initio calculations (3)
- abnormalities (3)
- absolute configuration (3)
- accelerometer (3)
- acetylcholine (3)
- acrophobia (3)
- actins (3)
- active galactic nuclei (3)
- acute respiratory distress syndrome (3)
- adaption (3)
- adaptive immunity (3)
- adenocarcinoma of the lung (3)
- adipose tissue (3)
- adrenocortical cancer (3)
- adsorption (3)
- adverse events (3)
- aerobic fitness (3)
- african trypanosomes (3)
- age groups (3)
- alcohol (3)
- alkaline phosphatase (3)
- alternative splicing (3)
- altitudinal gradients (3)
- amino acid (3)
- anaemia (3)
- anastomotic leakage (3)
- anemia (3)
- aneurysm (3)
- angiography (3)
- animal sociality (3)
- antagonist (3)
- anticipation (3)
- anticoagulants (3)
- anticoagulation (3)
- antigenic variation (3)
- antimicrobial (3)
- antimicrobial peptides (3)
- applied physics (3)
- approach (3)
- architecture (3)
- arctic (3)
- arrhythmogenic cardiomyopathy (3)
- arthropods (3)
- artificial photosynthesis (3)
- assistive technology (3)
- attention deficit/hyperactivity disorder (3)
- auditory (3)
- autism (3)
- autoantibody (3)
- autoimmune disease (3)
- automation (3)
- avatars (3)
- axons (3)
- azobenzenes (3)
- bacillus subtilis (3)
- back pain (3)
- bacterial infection (3)
- bacterial meningitis (3)
- bee (3)
- bee decline (3)
- beta-D-glucan (3)
- binding protein (3)
- bioactivity (3)
- biogenic amines (3)
- biological models (3)
- biomaterials (3)
- bioreactor (3)
- biosensors (3)
- birth cohort (3)
- black holes (3)
- bladder cancer (3)
- blood vessel (3)
- bone cement (3)
- bone disease (3)
- bone morphogenetic proteins (3)
- bone-marrow (3)
- boronate (3)
- brain cancer (3)
- breast-tumors (3)
- bumblebees (3)
- c-Fos (3)
- c-Myc (3)
- cAMP (3)
- calcification (3)
- calcium phosphate cement (3)
- cancer cells (3)
- cancer metabolism (3)
- canine cancer therapy (3)
- canola (3)
- carbene ligands (3)
- carbohydrates (3)
- cardiac (3)
- cardiac magnetic resonance imaging (3)
- cardiolipin (3)
- cardiomyocytes (3)
- cardiovascular magnetic resonance (3)
- cartilage regeneration (3)
- caspase-3 (3)
- catecholamines (3)
- cationic species (3)
- cations (3)
- cell binding (3)
- cell fusion (3)
- cell imaging (3)
- cell migration (3)
- central-nervous-system (3)
- cerebellar tDCS (3)
- cerebrovascular disorders (3)
- cervical dystonia (3)
- charge transfer (3)
- chlamydia infection (3)
- chlamydia trachomatis (3)
- chromophore (3)
- chronic pain (3)
- chronic stress (3)
- citrus (3)
- click chemistry (3)
- clinical practice (3)
- clinical study (3)
- cloning (3)
- closed head injury (3)
- cochlea (3)
- cochlear implantation (3)
- collagen (3)
- colonoscopy (3)
- combination therapy (3)
- comet assay (3)
- community (3)
- complications (3)
- computational chemistry (3)
- conditioned response (3)
- consciousness (3)
- conversion (3)
- convolutional neural networks (3)
- copy number variation (3)
- corticosteroids (3)
- count time series (3)
- criteria (3)
- critical care (3)
- critically ill (3)
- crosstalk (3)
- cryptochrome (3)
- culture (3)
- cysteine protease (3)
- cytosol (3)
- data acquisition (3)
- deadwood enrichment (3)
- death receptors (3)
- decellularization (3)
- defects (3)
- deficient mice (3)
- definition (3)
- degeneration (3)
- density (3)
- derivatives (3)
- desmin (3)
- desmosomes (3)
- detrended fluctuation analysis (3)
- diabetic nephropathy (3)
- diagnostic markers (3)
- diagnostic medicine (3)
- diazepam (3)
- diborane (3)
- dilated cardiomyopathy (3)
- dimerization (3)
- disease progression (3)
- disorder (3)
- diversity gradients (3)
- division of labor (3)
- docking (3)
- dogs (3)
- double-blind (3)
- drug adverse reaction (3)
- drug allergy (3)
- drug hypersensitivity (3)
- drug metabolism (3)
- drug resistance (3)
- drug therapy (3)
- drugs (3)
- dyes/pigments (3)
- ecological intensification (3)
- electrical and electronic engineering (3)
- electrohydrodynamic (3)
- electrohydrodynamics (3)
- electron (3)
- electron tomography (3)
- electrophysiology (3)
- elevated plus-maze (3)
- embryos (3)
- emotional regulation (3)
- emphysema (3)
- end-stage renal disease (3)
- endoscopy (3)
- endothelium (3)
- endovascular (3)
- endurance exercise (3)
- entropy production (3)
- environment (3)
- environmental health (3)
- epidermis (3)
- essential tremor (3)
- estrogens (3)
- evidence-based medicine (3)
- exciton coupling (3)
- exome sequencing (3)
- exosomes (3)
- experimental stroke (3)
- face (3)
- fatty liver disease (3)
- feeding (3)
- female (3)
- fibrin (3)
- fish (3)
- flowers (3)
- fluorescence spectroscopy (3)
- force (3)
- formicidae (3)
- frontotemporal dementia (3)
- fully convolutional neural networks (3)
- functional training (3)
- fungal pathogens (3)
- fungal rhodopsins (3)
- fusion (3)
- gait initiation (3)
- games (3)
- gametogenesis (3)
- gefitinib (3)
- gender differences (3)
- gene therapy (3)
- genetic modifiers (3)
- genetic variation (3)
- genome integrity (3)
- genome sequence (3)
- geoarchaeology (3)
- germinal center (3)
- gingivitis (3)
- glomerular filtration rate (3)
- glucose (3)
- glutamate (3)
- growth cone (3)
- guard cell (3)
- hands (3)
- healing (3)
- healthcare (3)
- heat transfer (3)
- hematopoietic stem cells (3)
- hemolysin (3)
- hepatitis B virus (3)
- herbivores (3)
- herpesvirus (3)
- high-intensity interval training (3)
- hip (3)
- histone H2AX (3)
- histones (3)
- historical document analysis (3)
- honey bee (3)
- host-pathogen interactions (3)
- human brain (3)
- human immunodeficiency virus (3)
- human learning (3)
- humidity (3)
- hydrodynamics (3)
- hydrology (3)
- hypertrophic cardiomyopathy (3)
- hypofractionation (3)
- image processing (3)
- image segmentation (3)
- immunoreactive neurons (3)
- immunosenescence (3)
- impedance spectroscopy (3)
- in vitro model (3)
- incisional hernia (3)
- indication for surgery (3)
- individual differences (3)
- infections (3)
- inflammatory diseases (3)
- information (3)
- innovation (3)
- instrument (3)
- insulin receptor (3)
- integration (3)
- intelligence (3)
- intensive care (3)
- intentional binding (3)
- interactome (3)
- interface (3)
- interferon (3)
- interleukin-6 (3)
- interleukins (3)
- interoception (3)
- interview (3)
- intestine (3)
- invasive pulmonary aspergillosis (3)
- investigators (3)
- involvement (3)
- ion channels (3)
- ionic liquids (3)
- irradiation (3)
- jet energy scale uncertainty (3)
- ketogenic diet (3)
- kidney function (3)
- kinase (3)
- kinematics (3)
- knee (3)
- knee arthroplasty (3)
- land-use change (3)
- laparoscopic ventral hernia repair (3)
- learning curve (3)
- leaves (3)
- left ventricular hypertrophy (3)
- leishmania major (3)
- leishmaniasis (3)
- lenalidomide (3)
- length of stenosis (3)
- leukemic cells (3)
- leukocytes (3)
- library screening (3)
- life history (3)
- ligand binding (3)
- light quark jet (3)
- lipidomics (3)
- liquid crystals (3)
- liraglutide (3)
- lithium (3)
- liver metastasis (3)
- local field potentials (3)
- localization microscopy (3)
- locomotor activity (3)
- locus coeruleus (3)
- loneliness (3)
- low back pain (3)
- lung and intrathoracic tumors (3)
- lung fibrosis (3)
- lung injury (3)
- macrophage (3)
- magnesium phosphate cement (3)
- magnetic properties and materials (3)
- main group elements (3)
- major depressive disorder (3)
- major histocompatibility complex (3)
- malignant melanoma (3)
- malignant tumors (3)
- marine natural products (3)
- marine sponge (3)
- mastocytosis (3)
- mathematics (3)
- measles (3)
- mechanics (3)
- medical rehabilitation (3)
- melanogaster (3)
- melt electrowriting (MEW) (3)
- memory B cells (3)
- meningioma (3)
- mesencephalic locomotor region (3)
- mesenchymal stromal cells (3)
- mesoscopics (3)
- messenger-RNA (3)
- metabolic adaptation (3)
- metabolic modeling (3)
- methionine restriction (3)
- miRNAs (3)
- microarrays (3)
- microbial rhodopsins (3)
- microbiota (3)
- microvascular endothelial cells (3)
- minimally invasive (3)
- mitotane (3)
- mixed methods (3)
- mobile health (3)
- monoclonal antibody (3)
- morbidity (3)
- morphology (3)
- morphometry (3)
- mothers (3)
- motoneurons (3)
- multijet background (3)
- multilocularis (3)
- multiple linear regression (3)
- multiple system atrophy (3)
- multisensory integration (3)
- muscarinic receptor subtypes (3)
- muscle (3)
- muscle strength (3)
- music (3)
- myocarditis (3)
- myofibroblast (3)
- natural history (3)
- natural variation (3)
- necroptosis (3)
- necrosis-factor-alpha (3)
- negative affect (3)
- nephroblastoma (3)
- nephrotoxicity (3)
- nerve fibers (3)
- network (3)
- network analysis (3)
- networks (3)
- neuroblastoma (3)
- neurodevelopment (3)
- neurological disorders (3)
- neuromelanin (3)
- neuropathology (3)
- neurotrophic factor (3)
- niche (3)
- non-prompt lepton (3)
- nonsmooth optimization (3)
- nucleolus (3)
- nucleotide excision repair (3)
- nucleus (3)
- obstructive pulmonary disease (3)
- oncogenes (3)
- oncolytic viruses (3)
- ontology (3)
- open abdomen (3)
- opioid receptors (3)
- optimal control (3)
- oral anticancer drugs (3)
- organic light emitting diodes (3)
- organic photodiodes (3)
- organic semiconductors (3)
- oscillation (3)
- osteoblasts (3)
- osteogenesis (3)
- osteogenic differentiation (3)
- outbreak (3)
- output elasticities (3)
- oxygenation (3)
- parasite (3)
- pasture (3)
- patch-clamp (3)
- pathophysiology (3)
- pemphigus (3)
- pemphigus vulgaris (3)
- peptide (3)
- peptide receptor radionuclide therapy (3)
- performance monitoring (3)
- perfusion (3)
- personality (3)
- phagocytosis (3)
- pharmacogenetics (3)
- pharmacology (3)
- phenomenology (3)
- phenotypic plasticity (3)
- phosphoantigen (3)
- photodynamic therapy (3)
- photoinduced electron transfer (3)
- photoluminescence (3)
- photoperiodism (3)
- photophysics (3)
- photothrombotic stroke (3)
- phylogenetic analysis (3)
- phylogenetics (3)
- phytic acid (3)
- platinum (3)
- pluripotency (3)
- polarized training (3)
- pollinator (3)
- pollution (3)
- poly(2-oxazine) (3)
- polycycles (3)
- polymerization (3)
- polyneuropathy (3)
- polyphenols (3)
- poor prognosis (3)
- population pharmacokinetics (3)
- positron-emission-tomography (3)
- posture (3)
- potassium (3)
- predictors (3)
- preschool children (3)
- preterm (3)
- preterm birth (3)
- principal component analysis (3)
- process mining (3)
- prognostic value (3)
- prospective study (3)
- prostate-specific membrane antigen (3)
- prostate-specific membrane antigen (PSMA) (3)
- protease inhibitors (3)
- protected areas (3)
- protein binding (3)
- protein kinases (3)
- protein structure (3)
- protein-protein interaction (3)
- psychometrics (3)
- pulse wave velocity (3)
- punishment (3)
- purification (3)
- quality (3)
- quality control (3)
- quality indicators (3)
- quality of democracy (3)
- quantum mechanics (3)
- quantum optics (3)
- quantum physics (3)
- questionnaire (3)
- radiation therapy (3)
- radical reactions (3)
- radionuclide therapy (3)
- radiosensitivity (3)
- randomized controlled-trial (3)
- real-time (3)
- receptor tyrosine kinases (3)
- recommendations (3)
- red blood cells (3)
- regulator genes (3)
- renal cell carcinoma (3)
- reoperation (3)
- reporter gene (3)
- research (3)
- response regulator (3)
- retinal pigment epithelium (3)
- rhinitis (3)
- rhodesain (3)
- rhodopsin (3)
- ribosomal RNA (3)
- ribosome (3)
- risk stratification (3)
- robustness (3)
- rotator cuff (3)
- saccades (3)
- salvage radiotherapy (3)
- sample (3)
- satellite data (3)
- scanning electron microscopy (3)
- schistosomiasis (3)
- school (3)
- scleroderma (3)
- secondary lung tumors (3)
- self-organization (3)
- semantic segmentation (3)
- sensitivity (3)
- sensory neurons (3)
- sentinel (3)
- sequence databases (3)
- sequestration (3)
- seroprevalence (3)
- serotonin transporter gene (3)
- sexual selection (3)
- shape (3)
- shock (3)
- signal peptides (3)
- silver (3)
- single top quark (3)
- skin punch biopsy (3)
- sleeping sickness (3)
- social attention (3)
- social media (3)
- specialization (3)
- specificity (3)
- sperm (3)
- spiders (3)
- spillover (3)
- spintronics (3)
- spleen (3)
- stability (3)
- startle disease (3)
- statistical data (3)
- stemness (3)
- stereotactic body radiotherapy (3)
- stereotactic irradiation (3)
- stimulation (3)
- stomach (3)
- stomata (3)
- strains (3)
- strategies (3)
- strategy (3)
- substituent (3)
- subtypes (3)
- subunit (3)
- subventricular zone (3)
- sucrose (3)
- sucrose responsiveness (3)
- sudden cardiac death (3)
- super-resolution (3)
- superresolution (3)
- surface (3)
- surgical site infection (3)
- susceptibility loci (3)
- swine (3)
- synapse (3)
- synapses (3)
- synaptic inhibition (3)
- synaptic transmission (3)
- synchrotron radiation (3)
- tMCAO (3)
- teaching (3)
- team sport (3)
- telemedicine (3)
- temozolomide (3)
- temporal bone (3)
- text comprehension (3)
- thermogenesis (3)
- thermoregulation (3)
- threat (3)
- three-dimensional imaging (3)
- thrombin (3)
- thymus (3)
- tissue (3)
- top quark pair (3)
- topography (3)
- total hip arthroplasty (3)
- toxins (3)
- trafficking (3)
- tranexamic acid (3)
- transcranial direct current stimulation (3)
- transcription factor (3)
- transgenic mice (3)
- transient absorption (3)
- transmission electron microscopy (3)
- treatment outcome (3)
- treatment response (3)
- triglycerides (3)
- troponin (3)
- trypanosoma (3)
- tsetse fly (3)
- tumor heterogeneity (3)
- tumor necrosis factor (3)
- tundra (3)
- tyrosine kinase (3)
- ultimatum game (3)
- ultrasound (3)
- ultrastructure (3)
- unconscious processing (3)
- urbanization (3)
- uremic toxins (3)
- urinary tract infections (3)
- user experience (3)
- user-centered design (3)
- validity (3)
- vasculitis (3)
- velocity (3)
- vesicles (3)
- viral infection (3)
- viral load (3)
- viral replication (3)
- virotherapy (3)
- virtual environments (3)
- virus (3)
- visual orientation (3)
- visual perception (3)
- wall shear stress (3)
- weight gain (3)
- weight loss (3)
- well-being (3)
- wild bees (3)
- women (3)
- "-omics" (2)
- 123I-mIBG (2)
- 123I-metaiodobenzylguanidine (2)
- 177Lu (2)
- 18F-FDS (2)
- 18F-LMI1195 (2)
- 2B (2)
- 3D fluoroscopy (2)
- 3D model generation (2)
- 3D models (2)
- 3D scaffolds (2)
- 4D flow (2)
- 5-Azacytidine (2)
- 5-Fluorouracil (2)
- 5-HT transporter (2)
- 5-HT1A receptor (2)
- 5-HTTLPR (2)
- 5-fluorouracil (2)
- A1 adenosine receptors (2)
- AAA (2)
- ABCG2 (2)
- AKT (2)
- ALCL (2)
- AMD (2)
- AML (2)
- AMPK (2)
- ARONJ (2)
- ARPES (2)
- ASC (2)
- Abwehr (2)
- Acromyrmex fracticornis (2)
- Acute lymphocytic leukaemia (2)
- Acute myeloid leukemia (2)
- Africa (2)
- African Trypanosomes (2)
- Agalsidase beta (2)
- Agent (2)
- Albino rats (2)
- Algorithm (2)
- Allogeneic stem cell transplantation (2)
- Alter Orient (2)
- Ames test (2)
- Amino acids (2)
- Amplification (2)
- Analysis (2)
- Animal models (2)
- Annotation (2)
- Antarctic ice sheet (2)
- Anthropocene (2)
- Anti-k Jet (2)
- Antibody (2)
- Antisense RNA (2)
- Ants (2)
- Arabidopsis (2)
- Araneae (2)
- Association (2)
- Assyriologie (2)
- Atomic and molecular interactions with photons (2)
- Ausbreitung (2)
- Autism spectrum disorders (2)
- Autoantibodies (2)
- Autoimmunity (2)
- Autologous hematopoietic stem cell transplantation (2)
- Autoradiography (2)
- Axon degeneration (2)
- Axonal degeneration (2)
- B cell receptors (2)
- B chromosomes (2)
- B lymphocytes (2)
- BBCH (2)
- BCG (2)
- BCL6 (2)
- BDG (2)
- BGK approximation (2)
- BMP (2)
- BMP-2 (2)
- BN compounds (2)
- BRCA2 (2)
- BRENDA (2)
- BTN3 (2)
- Bacillus (2)
- Bacterial pathogens (2)
- Barth syndrome (2)
- Bavaria (2)
- Bees (2)
- Biene (2)
- Big Five (2)
- Bioinformatik (2)
- Biokinetics (2)
- Blattkäfer (2)
- Blood-brain barrier (2)
- Body weight (2)
- Bone marrow (2)
- Bone marrow transplantation (2)
- Bone morphogenetic protein-2 (2)
- Bone-marrow-transplantation (2)
- Bor (2)
- Brassica napus (2)
- Breast-cancer (2)
- Breast-tumors (2)
- Bruchpilot (2)
- C-X-C motif chemokine receptor 4 (2)
- C. elegans (2)
- C57BL/6 mice (2)
- C5a (2)
- CA19-9 (2)
- CADe (2)
- CAR T cells (2)
- CCL4 (2)
- CCR2 (2)
- CD117 (2)
- CD274 (2)
- CD28 (2)
- CD30 (2)
- CD39 (2)
- CD4(+) T-cells (2)
- CD40L (2)
- CD73 (2)
- CD8 (2)
- CD9 (2)
- CNN (2)
- CNO (2)
- CNS cancer (2)
- CNS disease (2)
- CNS disorders (2)
- CNV (2)
- COMT (2)
- CORDEX Africa (2)
- CRC (2)
- CSVD (2)
- CT angiography (2)
- CTLA-4 (2)
- CYP2W1 (2)
- Ca\(^{2+}\) signalling (2)
- Calibration (2)
- Cambrian (2)
- Camponotus floridanus (2)
- Campylobacter jejuni (2)
- Cancer treatment (2)
- Carcinogen (2)
- Carcinogens (2)
- Cardiovascular disease (2)
- Cardiovascular diseases (2)
- Cardiovascular risk factors (2)
- Cell therapy (2)
- Cells (2)
- Central Asia (2)
- Cerebellum (2)
- Cerebrospinal fluid (2)
- Chagas disease (2)
- Charcot-Marie-Tooth (2)
- Childhood (2)
- Childhood medulloblastoma (2)
- Chili RNA Aptamer (2)
- Chromatin structure (2)
- Chronic heart failure (2)
- Chronic kidney disease (2)
- Circular dichroism (2)
- Cisplatin (2)
- Cl Lowe limit (2)
- Climate change (2)
- Clinical Neuroradiology (2)
- Clinical trial (2)
- Colombia (2)
- Colonization (2)
- Combination (2)
- Computersimulation (2)
- Concealed Information Test (2)
- Conservation (2)
- Consistent partial least squares (2)
- Constraints (2)
- Costa Rica (2)
- Crohn's disease (2)
- Crohn’s disease (2)
- Cross-section (2)
- Cryo-EM (2)
- Cu(111) (2)
- CubeSat (2)
- Cushing’s disease (2)
- Cyanobacteria (2)
- Cys-loop receptor (2)
- Cytokines (2)
- DAPI staining (2)
- DFT (2)
- DHAP (2)
- DIRA (2)
- DLBCL (2)
- DM-domain gene (2)
- DNA Methylation (2)
- DNA antibodies (2)
- DNA barcoding (2)
- DNA helicase (2)
- DNA storage (2)
- DNA-PK (2)
- DNA-repair (2)
- DNA/RNA sensors (2)
- DNS-Schädigung (2)
- DOTATOC (2)
- DSG2 (2)
- DUB (2)
- DYT1 (2)
- Dark-Matter (2)
- Dendritic cells (2)
- Deoxyribozymes (2)
- Deutschland (2)
- Diagnose (2)
- Diagnostic medicine (2)
- Diethylstilbestrol (2)
- Difenidol (2)
- Differential effects of stressors (2)
- Dionaea muscipula (2)
- Disease (2)
- Diseases (2)
- Dopamine (2)
- Dose response (2)
- Dose-response relationship (2)
- Down syndrome (2)
- Drug development (2)
- Drug resistance (2)
- Duchenne muscular dystrophy (2)
- Dyes (2)
- Dynamics (2)
- E. coli serotype 06 (2)
- ECM (2)
- EDA-NOCV (2)
- EF-1A (2)
- EMT (2)
- EPR spectroscopy (2)
- ERK (2)
- EUROASPIRE (2)
- EW (2)
- EZH2 (2)
- Early-onset (2)
- Echinococcosis (2)
- Ecology (2)
- Egypt (2)
- Eiablage (2)
- Eiparasitismus (2)
- Elderly (2)
- Electropermeabilization (2)
- Emotion regulation (2)
- Emotional processing (2)
- Endosymbiont (2)
- Endothelium (2)
- Entanglement (2)
- Environment (2)
- Epidemiology (2)
- Epitope (2)
- Epitranscriptomics (2)
- Estrogen (2)
- European beech (2)
- Evaluation (2)
- Event-related potential (2)
- Event-related potentials (2)
- Exercise capacity (2)
- Exercise testing (2)
- Expansion microscopy (2)
- Extensions of gauge sector (2)
- F-actin (2)
- F8 fimbriae (2)
- FAAH (2)
- FDG PET/CT (2)
- FDG-PET/CT (2)
- FGF-pathway (2)
- FGFR1 (2)
- FIB-4 (2)
- FISH (2)
- FKBP5 (2)
- FSHD (2)
- FTIR spectroscopy (2)
- Fabry (2)
- Fabry genotype (2)
- Fabry nephropathy (2)
- Fabry phenotype (2)
- Factor receptor (2)
- Fagus sylvatica (2)
- Female (2)
- Festkörperphysik (2)
- Fibroblasts (2)
- Fibromyalgia syndrome (2)
- Fish (2)
- Flow cytometry (2)
- Fluorescence spectroscopy (2)
- Fokker–Planck equation (2)
- Foxp3 (2)
- Frosch (2)
- Fusarium (2)
- Fusion proteins (2)
- G protein-coupled receptors (2)
- G-protein (2)
- G-quadruplexes (2)
- GABAA receptors (2)
- GIS (2)
- GLUT2 (2)
- GLUT3 (2)
- GLV-1H68 (2)
- GPCR (2)
- GPVI (2)
- Galeruca tanaceti (2)
- Gamma (2)
- Gedächtnisleistung (2)
- Gen (2)
- Gene cloning (2)
- Gene regulation (2)
- Genes (2)
- Genetics research (2)
- Geographie (2)
- Geologie (2)
- German Hepatitis C-Registry (2)
- German people (2)
- Glatiramer acetate (2)
- Gluino production (2)
- Glutathione (2)
- Golgi (2)
- Grad-seq (2)
- Gram-positive bacteria (2)
- Group B Streptococcus (2)
- Growth (2)
- Grundvorstellung (2)
- Guidelines (2)
- Guillain-Barre-Syndrome (2)
- Guinea-pig uterus (2)
- GvHD (2)
- H-1-NMR spectroscopy (2)
- HBV (2)
- HFQ (2)
- HFpEF (2)
- HGF (2)
- HIV-1 (2)
- HKT transporter (2)
- HPA axis (2)
- HPP (2)
- HPV (2)
- HSC (2)
- HUVEC (2)
- Habichtskraut (2)
- Habitat fragmentation (2)
- Haemophilus influenzae (2)
- Halcyon (2)
- Hamburg (2)
- Healthy subjects (2)
- Heart (2)
- Hemolysin (2)
- Heterocycles (2)
- Hexahydro-sila-difenidol analogues (2)
- Hieracium (2)
- Higgs (2)
- Hill numbers (2)
- Hippo signaling (2)
- Holothuria spinifera (2)
- Hormone (2)
- Hospitalization (2)
- Host-parasite interaction (2)
- Host-parasite interactions (2)
- Hsp90 (2)
- Human behaviour (2)
- Human brain (2)
- Human papillomavirus (2)
- Hypothetical gauge bosons (2)
- I-tasser (2)
- IAPS (2)
- IFN-γ (2)
- IL-17 (2)
- IL-6 (2)
- ILEX (2)
- IMAT (2)
- IMRT (2)
- IN-VIVO (2)
- IR (2)
- IR spectroscopy (2)
- Identification (2)
- IgG (2)
- Image-guidance (2)
- Imaging techniques (2)
- Imatinib (2)
- Immunbiologie (2)
- Immunosuppression (2)
- Impact (2)
- In vitro (2)
- Induced apoptosis (2)
- Infections (2)
- Infectious disease (2)
- Inhibitor (2)
- Insects (2)
- Insekten (2)
- Interleukin-4 (2)
- Interleukin-6 (2)
- Internet of Things (2)
- Invasion (2)
- Iran (2)
- JES uncertainty (2)
- JNK (2)
- Japankärpfling (2)
- Jena Experiment (2)
- Jets (2)
- Josephson junctions (2)
- J‐aggregates (2)
- KDIGO (2)
- KEAP1 (2)
- KIT (2)
- Kaposi sarcoma (2)
- Kenya (2)
- Ketogenic diet (2)
- Ki67 (2)
- Kidney function (2)
- Kilombero (2)
- Kultur (2)
- L-arginine (2)
- L929 (2)
- LC-MS/MS (2)
- LINC complex (2)
- LMHFV (2)
- LPP (2)
- LST (2)
- Lampbrush chromosomes (2)
- Landsat time series (2)
- Langerhans cells (2)
- Langerhans-Inseln (2)
- Larvae (2)
- Latin America (2)
- Lebendgebärende Zahnkarpfen (2)
- Lewis acidity (2)
- Lichtheimia (2)
- Ligand (2)
- Lipofuscin (2)
- Longitudinally extensive transverse myelitis (LETM) (2)
- Lung-cancer (2)
- MAG3 (2)
- MAPK signaling cascades (2)
- MASK (2)
- MATQ-seq (2)
- MC event generator (2)
- MCPH1 (2)
- MDSC (2)
- ME/CFS (2)
- MEG (2)
- MIBG (2)
- MPFL (2)
- MPI (2)
- MPS1 (2)
- MRI criteria (2)
- Machine learning (2)
- Malaysia (2)
- Malignant hyperthermia (2)
- Malignant melanoma (2)
- Masernvirus (2)
- Matlab (2)
- Mc4r (2)
- Measurement (2)
- Mekong (2)
- Melanom (2)
- Melanoma (2)
- Merkel cell polyomavirus (2)
- Mesenchymal stem cells (2)
- Mesenchymal stem/stromal cells (2)
- Mesenteric circulation (2)
- Met (2)
- Metabolic pathways (2)
- Metabolism (2)
- Metabolomics (2)
- Metastatic breast cancer (2)
- Methotrexate (2)
- Microarray (2)
- Microcirculation (2)
- Microglia (2)
- Microtubules (2)
- Mitochondria (2)
- Molecular biology (2)
- Molecular neuroscience (2)
- Molecules (2)
- Monte Carlo (2)
- Mouse (2)
- Mouse model (2)
- Mouse-brain (2)
- Multiple Myeloma (2)
- Multiple bonds (2)
- Multivariate analysis (2)
- Muscarinic receptor antagonists (2)
- Mushroom bodies (2)
- Mutations (2)
- Mycobacterium (2)
- Myeloma (2)
- N ligands (2)
- N-Myc (2)
- N-formyl peptides (2)
- N-heterocyclic carbene (2)
- NEUROWIND (2)
- NF-Kappa-B (2)
- NF-kappa-B (2)
- NF-κB (2)
- NFAT (2)
- NFkB (2)
- NHC (2)
- NMDAR (2)
- NOAC (2)
- NONO (2)
- NOTCH (2)
- NRPS (2)
- NSG (2)
- NSSI (2)
- NVP-BEZ235 (2)
- Nanoparticles (2)
- Nervenzelle (2)
- Netzwerk (2)
- Neuronal ceroid lipofuscinosis (2)
- Neuropathy (2)
- Neurophysiologie (2)
- Neuroprotection (2)
- Neutrino Telescope (2)
- New Zealand (2)
- Nfatc1 (2)
- Niger (2)
- Non-coding RNAs (2)
- Nucleolus (2)
- OCD (2)
- Olea (2)
- Omega-3-Fettsäuren (2)
- Oocytes (2)
- Oomyzus galerucivorus (2)
- Optical spectroscopy (2)
- Orthoptera (2)
- Oxidative stress (2)
- P53 (2)
- PALM (2)
- PAPA (2)
- PARK2 (2)
- PDE (2)
- PI3K (2)
- PIP2 (2)
- PML (2)
- PMMA (2)
- PSA (2)
- PSMA I&T (2)
- PSMA-RADS (2)
- PTCL (2)
- PTSD (2)
- Paediatric (2)
- Pair production (2)
- Pakistan (2)
- Parasit (2)
- Parkinson (2)
- Parkinsonism (2)
- Pathogens (2)
- Patron Distributions (2)
- Patterns (2)
- Pharmazie (2)
- Phase-II (2)
- Phonologische Bewusstheit (2)
- Phosphorylation (2)
- Photochemistry (2)
- Physiologie (2)
- Placebo (2)
- PlanetScope (2)
- Plasma-membrane (2)
- Plus plus (2)
- Pollen (2)
- Positron emission tomography (2)
- Pp Collision (2)
- Prognose (2)
- Program (2)
- Proliferation (2)
- Prostate Cancer (2)
- Pseudomonas aeruginosa (2)
- Psychiatric disorders (2)
- Pulmonary imaging (2)
- Purkinje cells (2)
- Pädiatrie (2)
- R factor = 0.027 (2)
- RCC (2)
- RFID (2)
- RHO (2)
- RKIP (2)
- RNA extraction (2)
- RNA secondary structure (2)
- RNA splicing (2)
- RNA synthesis (2)
- RNA-SEQ data (2)
- RNA-dependent RNA polymerase (2)
- RNA-polymerase-II (2)
- RSK (2)
- RT-PCR (2)
- RT-qPCR (2)
- Radiative-corrections (2)
- Radioligand binding (2)
- Radionuclide Therapy (2)
- Raf kinases (2)
- Randomized controlled trial (2)
- Randomized controlled-trial (2)
- Rashba effect (2)
- Rats (2)
- Ratte (2)
- Reaction kinetics and dynamics (2)
- Rectal cancer (2)
- Reduction (2)
- Regression (2)
- Rehabilitation (2)
- Renal cell carcinoma (2)
- Repair (2)
- Reproductive toxicity (2)
- Rezension (2)
- Rhabdomyosarcoma (2)
- Rheumatologie (2)
- Rhizopus (2)
- Rhodobacter sphaeroides (2)
- Risk (2)
- Risk factors (2)
- Ruthenium (2)
- Ruthenium complexes (2)
- Ruxolitinib (2)
- S-ADAPT (2)
- S. aureus (2)
- SAH (2)
- SARS‐CoV‐2 (2)
- SEM (2)
- SEQ (2)
- SGLT2 inhibitor (2)
- SHRSP (2)
- SLC2A3 (2)
- SLX4 (2)
- SMAD signaling (2)
- SMN (2)
- SNP (2)
- SOX9 (2)
- SPECT/CT (2)
- STR profile (2)
- SUV (2)
- SWOT (2)
- Salmonella Typhimurium (2)
- Salmonella-containing vacuole (SCV) (2)
- Salmonella/microsome assay (2)
- Salmonellosis (2)
- Scale (2)
- Scarabaeidae (2)
- Schwann cells (2)
- Selective attention (2)
- Sensitivity (2)
- Signal transduction (2)
- Silicones (2)
- Simulation (2)
- Skorpion (2)
- SnRK1 (2)
- Solution-state NMR (2)
- Sonic hedgehog (2)
- Spermatogenesis (2)
- Squalius alburnoides (2)
- Staphylococcus (2)
- Stem cell (2)
- Stereology (2)
- Stereoselectivity (2)
- Stereotactic body radiotherapy (2)
- Stimuli (2)
- Strains (2)
- Streptomyces axinellae (2)
- Stress (2)
- Structural Biology (2)
- Struktur (2)
- Subarachnoid hemorrhage (2)
- Succinylcholine (2)
- Surveillance (2)
- Swine (2)
- Symmetry-breaking (2)
- System (2)
- Systematic review (2)
- Systemic sclerosis (2)
- Systems (2)
- T = 100 K (2)
- T cell activation (2)
- T cell receptor excision circles (2)
- T-cadherin (2)
- T-cell (2)
- T-cell lymphoma (2)
- TAVI (2)
- TB (2)
- TCR signaling cascade (2)
- TGF-BETA (2)
- TGFβ signaling (2)
- TGN1412 (2)
- TIMELINE (2)
- TKA (2)
- TKI (2)
- TLR2 (2)
- TNAP (2)
- TNF receptor superfamily (2)
- TNF superfamily (2)
- TNFα (2)
- TP53 (2)
- TanDEM-X (2)
- Tell Karrana (2)
- Temozolomide (2)
- Theoretische Ökologie (2)
- Thyroid cancer (2)
- Tian Shan (2)
- Time-course (2)
- Tissue (2)
- Tissue engineering (2)
- Top-Quark (2)
- Tranquillizer (2)
- Transcriptome (2)
- Transgenic mice (2)
- Translational research (2)
- Transporter (2)
- Trees (2)
- Tregs (2)
- Tregs (regulatory T cells) (2)
- Tuberculosis (2)
- Tumor Treating Fields (TTFields) (2)
- Uganda (2)
- Ulcerative colitis (2)
- Uzbekistan (2)
- VACV (2)
- VAL66MET polymorphism (2)
- VSOP (2)
- Vaccine (2)
- Vaccinia virus (2)
- Validation (2)
- Variability (2)
- Variants (2)
- Vasodilatator-stimuliertes Phosphoprotein (2)
- Vesicles (2)
- WH2 domain (2)
- WNT (2)
- WSS (2)
- WZ (2)
- West Gondwana (2)
- Western Cape (2)
- Western Europe (2)
- Western diet (2)
- Wilms tumour (2)
- Wirt (2)
- Wnt (2)
- Wnt signalling (2)
- X-ray computed (2)
- XR (2)
- Xenopus oocytes (2)
- Y chromosome (2)
- YAP (2)
- Yoga (2)
- YouTube (2)
- Zambia (2)
- Zelldifferenzierung (2)
- [68Ga]PentixaFor (2)
- abandonment (2)
- ablation (2)
- abscisic acid (2)
- abscisic acid (ABA) (2)
- absorption spectra (2)
- abundance (2)
- acceptance (2)
- acceptance time efficiency (2)
- accretion (2)
- acetylsalicylic acid (2)
- acid ceramidase inhibitor ceranib-2 (2)
- acoustic signals (2)
- acoustic startle (2)
- actin cytoskeleton (2)
- action control (2)
- action effects (2)
- action planning (2)
- action potential (2)
- action potentials (2)
- activity (2)
- activity rhythm (2)
- acupuncture (2)
- acute graft-versus-host disease (2)
- acute heart failure (2)
- acute lymphoblastic leukemia (2)
- acute myeloid leukaemia (2)
- adaptive immune system (2)
- addiction (2)
- adenocarcinoma (2)
- adenomas (2)
- adenosine receptors (2)
- adenovirus (2)
- adenylate cyclase toxin (2)
- adhesion molecules (2)
- adipose-derived stromal cells (2)
- adjuvant treatment (2)
- adolescent (2)
- adoptive transfer (2)
- adrenal insufficiency (2)
- adrenal tumours (2)
- adrenocortical tumors (2)
- adult (2)
- adult-onset (2)
- adulthood (2)
- adverse drug reaction (2)
- adverse effects (2)
- adversity (2)
- affect (2)
- age-related hearing loss (2)
- aged 80 and over (2)
- ageing (2)
- agonist (2)
- agreement (2)
- agrobacterium tumefaciens (2)
- agroecology (2)
- agroecosystems (2)
- aldosterone (2)
- alleles (2)
- allelic replacement (2)
- allergic rhinitis (2)
- alliance (2)
- allogeneic hematopoietic stem cell transplantation (2)
- allometric scaling (2)
- alloreactive T cells (2)
- allostatic load (2)
- alpaca (2)
- alpha (2)
- alpha-synuclein (2)
- altruism (2)
- altruistic compensation (2)
- alveolar bone loss (2)
- alveolar echinococcosis (2)
- amino acid restriction (2)
- amino acid sequence (2)
- amino acid transporter (2)
- amino acids (2)
- aminotroponiminates (2)
- ampicillin (2)
- amplicon sequencing (2)
- amyloidosis (2)
- amyotrophic lateral sclerosis (ALS) (2)
- anaesthetics (2)
- analgesia (2)
- anaphylaxis (2)
- anaplastic large cell lymphoma (2)
- anchoring (2)
- androgen deprivation therapy (2)
- anesthetics (2)
- angle-resolved photoemission spectroscopy (2)
- anhedonia (2)
- anion channel (2)
- anions (2)
- ankle (2)
- annulation (2)
- anomaly detection (2)
- ant (2)
- ant brain (2)
- antenna (2)
- anterior cingulate cortex (2)
- anterior insula (2)
- anthocyanins (2)
- anti-k jet (2)
- anti-parasitic (2)
- anti-trypanosomal (2)
- anti-tumor agents (2)
- antibacterial (2)
- antibiotic (2)
- antibody fusion proteins (2)
- anticancer activity (2)
- antigen presentation (2)
- antigen testing (2)
- antigens (2)
- antimicrobial activities (2)
- antimicrobial activity (2)
- antimony (2)
- antioxidant (2)
- antioxidants (2)
- antirheumatic agents (2)
- antisense RNAs (2)
- antiviral treatment (2)
- anxiety-like behavior (2)
- aortic arch (2)
- aphasia (2)
- app (2)
- approach-avoidance (2)
- arabidopsis (2)
- archaea (2)
- areas (2)
- artemisinin (2)
- arteriovenous loop (2)
- arthrography (2)
- ascites (2)
- aspiration (2)
- assay (2)
- assistive devices (2)
- asymmetry (2)
- atmospheric circulation (2)
- atomic-force microscopy (2)
- attention capture (2)
- attentional bias (2)
- auditory cortex (2)
- auditory pathway (2)
- autobiographical memory (2)
- autoimmune (2)
- autoinhibition (2)
- autologous stem cell transplantation (2)
- autologous transplantation (2)
- autonomous (2)
- auxin (2)
- auxins (2)
- avatar embodiment (2)
- avoidance (2)
- avoidance learning (2)
- awareness (2)
- axonal degeneration (2)
- axonal transport (2)
- azulene (2)
- bZIP (2)
- background knowledge (2)
- bacterial genetics (2)
- bacterial genomics (2)
- baghdadite (2)
- barbiturates (2)
- bark beetles (2)
- barrier (2)
- base of support (2)
- basic mental models (2)
- bats (2)
- beech forests (2)
- behavioral plasticity (2)
- beta diversity (2)
- beta oscillations (2)
- beta-oxidation (2)
- bias correction (2)
- biased signaling (2)
- big five (2)
- bile (2)
- bioconjugation (2)
- biodosimetry (2)
- bioengineering (2)
- biofeedback (2)
- biofilm (2)
- biofilm formation (2)
- biogenesis (2)
- biological sciences (2)
- biological techniques (2)
- biologics (2)
- bioluminescence imaging (2)
- biomechanics (2)
- biomedical engineering (2)
- biomedical materials (2)
- biomedicine, general (2)
- biopsy (2)
- biosensor (2)
- biradicals (2)
- birds (2)
- bisphosphonates (2)
- bisulfite pyrosequencing (2)
- blastocysts (2)
- blazars (2)
- bleeding (2)
- blood coagulation (2)
- blood gas analysis (2)
- blood platelets (2)
- blood-brain barrier (BBB) model (2)
- blood-nerve barrier (2)
- blood-stream forms (2)
- blood–labyrinth barrier (2)
- body ownership (2)
- body representation (2)
- body weight modification (2)
- body weight perception (2)
- bonding (2)
- bone formation (2)
- bone fractures (2)
- bone imaging (2)
- bone loss (2)
- bone marrow edema (2)
- bone marrow immune-microenvironment (2)
- bone marrow stromal cells (2)
- bone metastasis (2)
- bone remodeling (2)
- boronateesters (2)
- boronic acid (2)
- bortezomib (2)
- borylene (2)
- borylenes (2)
- brain disorders (2)
- brain edema (2)
- brain endothelial cells (2)
- brain metastases (2)
- brain pathology (2)
- brain potentials (2)
- brain stem (2)
- brain-computer interface (BCI) (2)
- brain-computer interfaces (2)
- breed predisposition (2)
- brucei (2)
- butterflies (2)
- butyrophilin (2)
- butyrophilin 3 (2)
- butyrylcholinesterase (2)
- c-MYC (2)
- c-myc (2)
- c-reactive protein (2)
- cAArC (2)
- cEND (2)
- caenorhabditis elegans (2)
- caffeine (2)
- cage compounds (2)
- calcium signaling (2)
- calipered (2)
- calorie content (2)
- calorimeter (2)
- calprotectin (2)
- cancer detection and diagnosis (2)
- cancer diagnosis (2)
- cancer immunotherapy (2)
- cancer microenvironment (2)
- cancer risk (2)
- cancer risk factors (2)
- cancers and neoplasms (2)
- candidate gene (2)
- candidemia (2)
- canine (2)
- canine cancer cell lines (2)
- canine soft tissue sarcoma (CSTS) (2)
- capacitance (2)
- capillary electrophoresis (2)
- carabid beetles (2)
- carbon (2)
- carbon dioxide (2)
- carbon nanotubes (2)
- carborane (2)
- carboxylation (2)
- carcinogenesis (2)
- cardiac MRI (2)
- cardiac innervation imaging (2)
- cardiac magnetic resonance (2)
- cardiac metabolism (2)
- cardiac nerve (2)
- cardiac output (2)
- cardiac rehabilitation (2)
- cardinality constraints (2)
- cardiology (2)
- cardiovascular (2)
- cardiovascular arousal (2)
- cardiovascular morbidity (2)
- caregiver burden (2)
- caries (2)
- carotid atherosclerosis (2)
- carotid stenosis (2)
- carotid ultrasound (2)
- carpenter ant (2)
- caspase-8 (2)
- catalytic (2)
- cathepsin (2)
- causality (2)
- cell adhesion (2)
- cell binding assay (2)
- cell culture (2)
- cell cycle arrest (2)
- cell division (2)
- cell fate (2)
- cell labeling (2)
- cell metabolism (2)
- cell of origin (2)
- cell signalling (2)
- cell surface (2)
- cellular physiology (2)
- cellular signalling networks (2)
- cement (2)
- ceramics (2)
- cerebEND (2)
- cerebral autoregulation (2)
- cerebral blood flow (2)
- cerebrosides (2)
- chalcogens (2)
- change vector analysis (2)
- channel (2)
- channelrhodopsin (2)
- chaperone (2)
- characterization (2)
- chemical bonding (2)
- chemical communication (2)
- chemical ecology (2)
- chemical mimicry (2)
- chemokine (2)
- chemotaxis (2)
- child (2)
- child development (2)
- childhood (2)
- childhood asthma (2)
- childhood cancer (2)
- childhood maltreatment (2)
- chimeric antigen receptor (2)
- chirality transfer (2)
- chloroquine (2)
- cholestasis (2)
- cholesterol (2)
- cholinergic system (2)
- chondrogenesis (2)
- chromatin structure (2)
- chromosomes (2)
- chronic cerebrovascular disease (2)
- chronic hepatitis C (2)
- chronic kidney-disease (2)
- chronic myelogenous leukemia (2)
- chronic myeloid leukemia (2)
- chronic non-bacterial osteomyelitis (2)
- chronic nonbacterial osteomyelitis (2)
- chronic recurrent multifocal osteomyelitis (2)
- chronic thromboembolic pulmonary hypertension (2)
- chronobiology (2)
- chronophin (2)
- chronotype (2)
- cigarette smoking (2)
- circulation patterns (2)
- circulation type (2)
- cirrhosis (2)
- claudin-1 (2)
- clinical (2)
- clinical diagnosis (2)
- clinical outcome (2)
- clinical-practice (2)
- clothing (2)
- coastal erosion (2)
- coated vesicles (2)
- coatings (2)
- coexistence (2)
- cognitive conflict (2)
- cognitive function (2)
- cognitive neuroscience (2)
- cognitive psychology (2)
- cohort studies (2)
- cold stress (2)
- colloids (2)
- colon (2)
- colonization (2)
- colorectal carcinoma (2)
- combined therapy (2)
- common variants (2)
- communities (2)
- community structure (2)
- comparability (2)
- comparative genomic hybridization (2)
- complement (2)
- complement system (2)
- complementary alternative medicine (2)
- complementary medicine (2)
- complexity (2)
- complication (2)
- components (2)
- compound eye (2)
- compressive strength (2)
- computational biology and bioinformatics (2)
- computational physics (2)
- computer software (2)
- cone beam CT (2)
- conjugation (2)
- connective tissue (2)
- consensus (2)
- conservation biology (2)
- consolidation (2)
- contact-kinin system (2)
- context (2)
- contextual fear conditioning (2)
- contrast (2)
- convection volume (2)
- conversational agents (2)
- convolutional neural network (2)
- cooperation (2)
- coordination polymers (2)
- copeptin (2)
- corannulene (2)
- cord blood (2)
- coronavirus (2)
- correction (2)
- correlates (2)
- cortex (2)
- cortical activation (2)
- cortical neurons (2)
- cost-effectiveness (2)
- costs (2)
- coupling strength (2)
- covalent inhibitors (2)
- craving (2)
- creatine kinase (2)
- creatinine (2)
- cropping systems (2)
- cross-cultural comparison (2)
- cross-link repair (2)
- cross-sectional studies (2)
- crowdsourcing (2)
- crystal engineering (2)
- crystal-structure (2)
- cultivation (2)
- cultures (2)
- curcumin (2)
- cyanoborate (2)
- cyanoborates (2)
- cybersickness (2)
- cycle (2)
- cyclic (alkyl)(amino)carbenes (2)
- cycling (2)
- cycloaddition (2)
- cyclodextrin (2)
- cyclophanes (2)
- cystic fibrosis patients (2)
- cytochrome P450 3A4 (CYP3A4) (2)
- cytokine production (2)
- cytokine release (2)
- cytokine secretion (2)
- cytosolic pH (2)
- cytotoxic (2)
- cytotoxic activity (2)
- dRNA-Seq (2)
- daratumumab (2)
- dark matter (2)
- data analysis (2)
- data fusion (2)
- data mining (2)
- data visualization (2)
- data warehouse (2)
- ddPCR (2)
- deafness (2)
- death (2)
- death rates (2)
- decline (2)
- decomposition (2)
- deficit hyperactivity disorder (2)
- deformation (2)
- degree of stenosis (2)
- delineation (2)
- demography (2)
- dendritic cell (2)
- dendrobates pumilio (2)
- dental trauma (2)
- dependent protein-kinase (2)
- dereplication (2)
- derivation (2)
- dermatitis (2)
- desirable difficulties (2)
- desk-based (2)
- desmosome (2)
- developmental dyslexia (2)
- developmental plasticity (2)
- diabetic retinopathy (2)
- dialysis adequacy (2)
- diapause (2)
- diazadiborinines (2)
- diboration (2)
- dictator game (2)
- dieting success (2)
- differential diagnosis (2)
- differential expression (2)
- differentiation potential (2)
- diffuse large B-cell lymphoma (2)
- diffusion tensor imaging (2)
- digital health (2)
- dimensions (2)
- diode (2)
- direct anterior approach (2)
- direct gaze (2)
- direct-acting antivirals (2)
- discovery (2)
- discussion report (2)
- diseases (2)
- diseases of the nervous system (2)
- disembodiment (2)
- disorders (2)
- dispersal ability (2)
- dispersal rate (2)
- distance measurement (2)
- distributed control (2)
- distribution (2)
- dog (2)
- dopaminergics (2)
- dorsal root ganglion (2)
- dorsolateral prefrontal cortex (2)
- double intentionality (2)
- doxorubicin (2)
- drug repurposing (2)
- drug–drug interactions (DDIs) (2)
- dual function (2)
- dual polarimetry (2)
- dual-stage crosslinking (2)
- duchenne muscular dystrophy (2)
- dunce (2)
- dynamic covalent chemistry (2)
- dynamic programming (2)
- dysfunction (2)
- dysphagia (2)
- dysplasia (2)
- dyspnea (2)
- early diagnosis (2)
- early intervention (2)
- early recognition (2)
- echinococcus multilocularis (2)
- ecosystem service (2)
- edema (2)
- edge states (2)
- editorial board (2)
- education for sustainable healthcare (2)
- effectiveness (2)
- effects (2)
- efficiency (2)
- elbow joint (2)
- electroactive (2)
- electrocardiography (2)
- electrochemistry (2)
- electroencephalogram (2)
- electrolytes (2)
- electronic health records (2)
- electrophilic substitution (2)
- electroporation (2)
- element (2)
- elements (2)
- elevation (2)
- elevation gradient (2)
- elongation (2)
- embodied cognition (2)
- embryo (2)
- embryonic stem cells (2)
- emissions (2)
- emotion recognition (2)
- emotional experience (2)
- emotional facial expressions (2)
- emotional pictures (2)
- empagliflozin (2)
- emulsions (2)
- enantiomers (2)
- encephalitis (2)
- endocannabinoid (2)
- endochondral ossification (2)
- endoglin (2)
- endoluminal (2)
- endophenotype (2)
- endophyte (2)
- endoplasmic reticulum (2)
- endoradiotherapy (2)
- endosomes (2)
- endothelial cell (2)
- endothelin-1 (2)
- endotoxemia (2)
- endovascular therapy (2)
- endovascular treatment (2)
- endurance training (2)
- energy homeostasis (2)
- energy transfer (2)
- engineering (2)
- enteric nervous system (2)
- enteric pathogens (2)
- enterica serovar typhimurium (2)
- entomology (2)
- entropy (2)
- envelopment (2)
- environmental exposure (2)
- environmental impact (2)
- environmental justice (2)
- environments (2)
- enzyme activation (2)
- enzyme inhibitors (2)
- epidemology (2)
- epidermal growth factor (2)
- epithelium (2)
- epitope mapping (2)
- establishment (2)
- estimation error (2)
- ethics (2)
- etymology (2)
- eudaimonia (2)
- eugenol (2)
- evapotranspiration (2)
- evolutionary biology (2)
- evolutionary genetics (2)
- exact matching (2)
- excimer formation (2)
- excitations (2)
- excited states (2)
- exciton (2)
- exercise intervention (2)
- exhaustion (2)
- expansion microscopy (2)
- experiment (2)
- experimental models of disease (2)
- expertise (2)
- exposure therapy (2)
- expression signature (2)
- extinction risk (2)
- extracorporeal membrane oxygenation (2)
- extramedullary disease (2)
- face perception (2)
- face processing (2)
- facial electromyography (2)
- factor H (2)
- factor XI (2)
- factor-I (2)
- failure (2)
- fake lepton (2)
- familial DCM (2)
- families (2)
- fatty liver (2)
- fear generalization (2)
- fear-potentiated startle (2)
- feasibility (2)
- feature selection (2)
- features (2)
- femur (2)
- fermions (2)
- ferromagnetism (2)
- fertility (2)
- fetal programming (2)
- fibers (2)
- fibrinogen (2)
- fibroblast activation protein (2)
- fibromyalgia (2)
- field (2)
- films (2)
- fire (2)
- fish model (2)
- fission yeast (2)
- fitness (2)
- fixation (2)
- flagellar pocket (2)
- flagellum (2)
- flood (2)
- flow (2)
- flowering plants (2)
- fluid (2)
- fluorescence correlation spectroscopy (2)
- fluorescent dyes (2)
- fluorescent probe (2)
- fluorescent protein (2)
- fluorescent proteins (2)
- fluorescent-probes (2)
- fluoroscopy (2)
- flupyradifurone (2)
- flux (2)
- flux balance analysis (2)
- foamy virus (2)
- foamy viruses (2)
- focal cerebral-ischemia (2)
- follicular lymphoma (2)
- food allergy (2)
- food consumption (2)
- food safety (2)
- foot (2)
- forecast (2)
- forest degradation (2)
- forest ecology (2)
- forest health (2)
- forests (2)
- formation control (2)
- fpVCT (2)
- fracture healing (2)
- frailty (2)
- framework (2)
- free choice (2)
- free energy (2)
- frontal cortex (2)
- fruit set (2)
- functional analysis (2)
- functional traits (2)
- functionalization (2)
- fungal infections (2)
- fused deposition modeling (FDM) (2)
- future directions (2)
- gain (2)
- gait analysis (2)
- gambling (2)
- gametocyte (2)
- gamma (2)
- gamma rays (2)
- gas (2)
- gastric bypass (2)
- gastroenterology (2)
- gastrointestinal infections (2)
- gels (2)
- gemcitabine (2)
- gene cloning (2)
- gene conversion (2)
- gene expression profiling (2)
- gene mutations (2)
- gene targeting (2)
- gene-environment interaction (2)
- general anaesthesia (2)
- general practice (2)
- general relativity (2)
- generalization (2)
- generalized anxiety disorder (2)
- generalized cerebral edema (2)
- generation effect (2)
- genetic diagnostics (2)
- genetic polymorphisms (2)
- genetic susceptibility (2)
- genetic testing (2)
- genetic variants (2)
- genetically modified plants (2)
- genome analysis (2)
- genome assembly (2)
- genome sequencing (2)
- genome wide (2)
- genome-wide association study (2)
- genomic analysis (2)
- genomic databases (2)
- genomic imprinting (2)
- genomic libraries (2)
- genotyping (2)
- geometry (2)
- germline mutation (2)
- gestational diabetes mellitus (2)
- giant cell arteritis (2)
- giant ventral hernia (2)
- glaciers (2)
- glial fate modulation (2)
- glial fibrillary acidic protein (2)
- glioblastoma multiforme (GBM) (2)
- globotriaosylceramide (2)
- glucose metabolism (2)
- glutathione (2)
- glycemic control (2)
- glycine (2)
- glycopeptide antibiotics (2)
- glycoprotein Ib (2)
- glycoprotein receptor Ib (2)
- go/no-go task (2)
- gold nanoparticles (2)
- grading (2)
- graft (2)
- graft versus host disease (2)
- gram-negative bacteria (2)
- granules (2)
- granulocytes (2)
- grassland (2)
- grasslands (2)
- green fluorescent protein (2)
- gridle muscular-dystrophy (2)
- growth factor (2)
- growth factor beta (2)
- growth hormone deficiency (2)
- guard cells (2)
- guided bone regeneration (2)
- gut bacteria (2)
- gynogenesis (2)
- gyroscope (2)
- habits (2)
- haemophilus influenzae (2)
- haemostasis (2)
- halogenation (2)
- hand (2)
- haploinsufficiency (2)
- harmonization (2)
- head and neck squamous cell carcinoma (2)
- head-mounted display (2)
- health (2)
- health care (2)
- health care workers (2)
- health economics (2)
- health monitoring (2)
- health policy (2)
- hearing (2)
- hearing impairment (2)
- hearing preservation (2)
- heart failure with mid-range ejection fraction (2)
- heat shock response (2)
- heat stress (2)
- helicase (2)
- helicene (2)
- helicenes (2)
- helminths (2)
- hematologic malignancies (2)
- hematopoietic (2)
- hematopoietic stem cell transplantation (2)
- heme oxygenase-1 (2)
- hemicraniectomy (2)
- hemodiafiltration (2)
- hemoglobin (2)
- hepatic stellate cell (2)
- hepatocellular carcinoma (2)
- herbivore (2)
- herbivory (2)
- hereditary breast and ovarian cancer (2)
- hereditary motor and sensory neuropathy (2)
- heritability (2)
- herpes simplex virus (2)
- herpes virus (2)
- heterogeneity (2)
- heterosis (2)
- hiPSC (2)
- hiPSC-CM (2)
- hierarchy (2)
- high performance liquid chromatography (2)
- high risk (2)
- high-risk prostate cancer (2)
- high-throughput screening (2)
- hip fracture (2)
- hippocampal neurogenesis (2)
- histamine (2)
- histopathology (2)
- history (2)
- holography and condensed matter physics (AdS/CMT) (2)
- homogenous catalysis (2)
- homologous chromosomes (2)
- homology modeling (2)
- hormones (2)
- hospitalizations (2)
- human adipose-derived stromal cells (2)
- human african trypanosomiasis (2)
- human breast (2)
- human cells (2)
- human exposure (2)
- human genetics (2)
- human interleukin-4 (2)
- human macrophages (2)
- human pathogenic fungi (2)
- human rights (2)
- human-centered design (2)
- humanized mice (2)
- hybridogenesis (2)
- hybridomas (2)
- hydrogel (2)
- hydrogen (2)
- hyperactivity (2)
- hyperalgesia (2)
- hypercholesterolemia (2)
- hyperoxia (2)
- hypersensitivity (2)
- hyphae (2)
- hypogammaglobulinemia (2)
- hypothalamus (2)
- hypotonic (2)
- idiopathic inflammatory myopathies (2)
- ileocecal resection (2)
- illness (2)
- image analysis (2)
- image-guided radiation therapy (2)
- imaging the immune system (2)
- imidazolate (2)
- immediate early genes (2)
- immersive technologies (2)
- immune cell infiltration (2)
- immune escape (2)
- immune reconstitution (2)
- immune suppression (2)
- immune therapy (2)
- immunoassay (2)
- immunoblotting (2)
- immunodeficiency (2)
- immunoglobulin superfamily (2)
- immunostaining (2)
- immunosurveillance (2)
- implant (2)
- implant positioning (2)
- implantation (2)
- in silico analysis (2)
- in situ hybridization (2)
- in vitro models (2)
- inactivation (2)
- incentives (2)
- individual‐based model (2)
- infection control (2)
- inferior vena cava (2)
- inflammatory cytokines (2)
- inflammatory response (2)
- informal caregiving (2)
- information extraction (2)
- infrared spectroscopy (2)
- inhibitors (2)
- inhibitory neurotransmission (2)
- injury prevention (2)
- innate immune response (2)
- innate immune system (2)
- inner ear (2)
- insect decline (2)
- insect flight (2)
- insect monitoring (2)
- insect vision (2)
- insecticide (2)
- insecticides (2)
- insights (2)
- insulin signaling (2)
- integral (2)
- intellectual disability (2)
- intensity distribution (2)
- intensity zones (2)
- interaction networks (2)
- interacts (2)
- interband cascade lasers (2)
- interferometry (2)
- interleukin 6 (2)
- interleukin-8 (2)
- internalization (2)
- internet of things (2)
- interpolation (2)
- interval timing (2)
- interval training (2)
- intestinal epithelial barrier (2)
- intracellular bacterial pathogens (2)
- intracellular membranes (2)
- intracellular pathogens (2)
- intraoperative imaging (2)
- introgressive hybridization (2)
- intuition (2)
- invasive fungal infections (2)
- inventory (2)
- ion channel (2)
- iron deficiency (2)
- irrigation (2)
- ischaemic stroke (2)
- ischemia-reperfusion injury (2)
- ischemia/reperfusion injury (2)
- ischemic penumbra (2)
- islet transplantation (2)
- islets of Langerhans (2)
- isocenter (2)
- isolation (2)
- isomerization (2)
- isothermal titration calorimetry (2)
- isotonic (2)
- isotopes (2)
- jet channel (2)
- jet reconstruction efficiency (2)
- jet transverse momentum (2)
- jets (2)
- joint aspiration (2)
- joint instability (2)
- judgements (2)
- juvenile hormone (2)
- keratinocytes (2)
- kidney cancer (2)
- kidney disease (2)
- kinase inhibitors (2)
- kinesin (2)
- kinetic model (2)
- knee osteoarthritis (2)
- knee replacement (2)
- laboratory techniques and procedures (2)
- lactate dehydrogenase (2)
- lactation (2)
- land surface (2)
- land surface temperature (2)
- land-use intensity (2)
- landsat (2)
- landscape heterogeneity (2)
- landscape metrics (2)
- language (2)
- language acquisition (2)
- laparostomy (2)
- large T antigen (2)
- large vessel occlusion (2)
- laser spectroscopy (2)
- late positive potential (2)
- late-onset (2)
- laterality (2)
- left ventricular ejection fraction (2)
- left ventricular mass (2)
- left-ventricular function (2)
- length of stay (2)
- lepidoptera (2)
- lessons learned (2)
- life (2)
- life cycle (2)
- life events (2)
- lifestyle (2)
- ligand (2)
- ligands (2)
- light pulses (2)
- lineage (2)
- linear regression analysis (2)
- linguistic morphology (2)
- lipid bilayer membrane (2)
- lipid metabolism (2)
- liquid biopsy (2)
- liquid chromatography/mass spectrometry (2)
- literature review (2)
- liver resection (2)
- lncRNAs (2)
- load management (2)
- locked-in state (2)
- locked-in syndrome (2)
- locust outbreak (2)
- long non-coding RNA (2)
- long-term potentiation (2)
- long-term survivors (2)
- longitudinal studies (2)
- loss (2)
- low-grade glioma (2)
- lower body (2)
- lower extremity (2)
- lung-cancer (2)
- lying (2)
- lymph node dissection (2)
- lymphocyte differentiation (2)
- lyso-Gb3 (2)
- lysosomal storage disease (2)
- mTOR (2)
- macrocycles (2)
- macrophage polarization (2)
- magic (2)
- magnesium (2)
- magnetic compass (2)
- magnetic resonance (2)
- main group element halides (2)
- maize (2)
- malignant hyperthermia (2)
- mammalian cells (2)
- mammalian genomics (2)
- maps (2)
- marcophages (2)
- marine bacteria (2)
- marine natural product (2)
- markers (2)
- mass (2)
- mass casualties (2)
- match load (2)
- materials for optics (2)
- maternal exposure (2)
- mathematical modelling (2)
- mating success (2)
- matrix metalloproteinase (2)
- matrix protein porin (2)
- maturation (2)
- meadow (2)
- mean-field theory (2)
- measels virus (2)
- measurement (2)
- measures (2)
- media equation (2)
- mediated apoptosis (2)
- medical nutrition therapy (2)
- medical students (2)
- medieval manuscripts (2)
- medullary thyroid cancer (2)
- medullary thyroid carcinoma (2)
- medulloblastoma (2)
- megavoltage computed-tomography (2)
- melanomas (2)
- membrane receptor signaling (2)
- membrane skeleton (2)
- membrane vesicles (2)
- memory formation (2)
- men (2)
- men who have sex with men (2)
- mentalizing (2)
- merocyanines (2)
- mesenchymal stem cell (2)
- metabolic flux (2)
- metabolic flux analysis (2)
- metabolic syndrome (2)
- metabolomic profiling (2)
- metacognitive prompting (2)
- metacomprehension (2)
- metallic trace elements (2)
- metals (2)
- metamorphic buffer layer (2)
- metaproteomics (2)
- metastasis-directed therapy (2)
- methodological pluralism (2)
- methods (2)
- miR (2)
- miR-182-5p (2)
- miR-21 (2)
- micelles (2)
- microbial spectrum (2)
- microcephaly (2)
- microclimate (2)
- micronutrients (2)
- microparticles (2)
- microswimmer (2)
- microtubules (2)
- microvascular complications (2)
- microvasculature (2)
- midazolam (2)
- migraine (2)
- mimicry (2)
- mineral metabolism (2)
- minimal invasive surgery (2)
- mismatch (2)
- mitochondrial DNA (2)
- mixed hearing loss (2)
- mobile apps (2)
- mobile laser scanning (2)
- modeling (2)
- moderate (2)
- modifiers (2)
- modulation spectroscopy (2)
- molecular alterations (2)
- molecular beam epitaxy (2)
- molecular characterization (2)
- molecular cloning (2)
- molecular epidemiology (2)
- molecular evolution (2)
- molecular mass (2)
- molecular mechanisms (2)
- molecular modeling (2)
- molecular phylogeny (2)
- molecular structure (2)
- molecular subtypes (2)
- monocyte (2)
- mood (2)
- morphogenesis (2)
- morphogenetic protein (2)
- morris water maze (2)
- mosquito (2)
- motility (2)
- motivated reasoning (2)
- motoneuron (2)
- motor proteins (2)
- mouse-brain (2)
- movement (2)
- mtDNA (2)
- mucoepidermoid carcinoma (2)
- multi-fluid mixture (2)
- multi-jet background (2)
- multi-sensor (2)
- multidrug resistance (2)
- multidrug-resistant bacteria (2)
- multimodal (2)
- multiparticle collision dynamics (2)
- multiple bonds (2)
- multiple-sclerosis (2)
- muon channel (2)
- murine model (2)
- muscarinic receptors (2)
- muscle degeneration (2)
- muscle disease (2)
- musculoskeletal system (2)
- mutants (2)
- myasthenia gravis (2)
- mycotoxins (2)
- myeloid (2)
- myeloma (2)
- myocardial sympathetic innervation imaging (2)
- myocardial work (2)
- myocardial-infarction (2)
- myocardium (2)
- myofibrillar myopathy (2)
- myopathy (2)
- nab-paclitaxel (2)
- naloxone (2)
- nano rods (2)
- nanographene (2)
- nanomedicine (2)
- nanophotonics and plasmonics (2)
- nanotechnology (2)
- national park (2)
- national parks (2)
- natriuretic peptide (2)
- natural enemies (2)
- natural language processing (2)
- natural pest control (2)
- nature conservation (2)
- necrobiome (2)
- necrotic cell death (2)
- negative pressure (2)
- neisseria gonorrhoeae (2)
- neoadjuvant (2)
- neonates (2)
- nervous-system (2)
- nesting habits (2)
- networking (2)
- neume notation (2)
- neural circuits (2)
- neural crest (2)
- neural network (2)
- neural stem cell (2)
- neurite outgrowth (2)
- neuroendocrine tumor (NET) (2)
- neuroethology (2)
- neurofilament light chain (2)
- neurofilaments (2)
- neuromodulation (2)
- neuronal dendrites (2)
- neuronal network (2)
- neuronal plasticity (2)
- neuroplasticity (2)
- neuropsychology (2)
- neurosphere (2)
- neurosurgery (2)
- neurotoxicity (2)
- neurotransmitter release (2)
- neurotrophic factors (2)
- neutral sphingomyelinase-2 (2)
- neutralino (2)
- neutrino astronomy (2)
- neutrino emission (2)
- neutrino telescope (2)
- neutrophil (2)
- next generation sequencing (NGS) (2)
- next-generation sequencing (2)
- nicotine addiction (2)
- nicotinic receptors (2)
- nilotinib (2)
- non-invasive ventilation (2)
- non-penetrating glaucoma surgery (2)
- non-small cell lung cancer (2)
- non-verbal communication (2)
- noncoding RNA (2)
- noncoding RNAs (2)
- noncovalent interactions (2)
- noradrenaline (2)
- normal distribution (2)
- nuclear import (2)
- nuclear magnetic resonance (2)
- nuclear medicine (2)
- nuclear organization (2)
- nucleophilic addition (2)
- nucleosomes (2)
- nucleotide excision-repair (2)
- nucleotide sequence (2)
- nude-mice (2)
- numerical analysis (2)
- numerical cognition (2)
- nurses (2)
- o-methoxy-sila-hexocyclium (2)
- object-based classification (2)
- object-based image analysis (2)
- occupational medicine/industrial medicine (2)
- oestrogen receptor signalling (2)
- office-workers (2)
- olfactory memory (2)
- oligodendrocyte (2)
- oligorecurrence (2)
- olive (2)
- omega-3 fatty acids (2)
- oncogene-induced senescence (2)
- oncolytic virotherapy (2)
- one-electron oxidation (2)
- onset (2)
- open spaces (2)
- opioid peptides (2)
- optical (2)
- optical coherence tomography (2)
- optical remote sensing (2)
- optics and photonics (2)
- oral mucositis (2)
- organ-on-a-chip (2)
- organic electronics (2)
- organic solar cells (2)
- orientation (2)
- orthopedic surgery (2)
- oscillations (2)
- osteoclasts (2)
- osteonecrosis of the jaw (2)
- osteopontin (2)
- osteoradionecrosis (2)
- otitis media (2)
- outcomes research (2)
- outer membrane protein (2)
- outer membrane proteins (2)
- outer-membrane proteins (2)
- outpatients (2)
- oxaliplatin (2)
- oxidative addition (2)
- oxygen uptake (2)
- oxygen/glucose deprivation (2)
- oxytocin (2)
- pCa (2)
- paediatrics (2)
- paleogeography (2)
- palladium (2)
- palliative care (2)
- pandemic (2)
- panel sequencing (2)
- parallel evolution (2)
- parasitic cell cycles (2)
- parasitology (2)
- paraspeckles (2)
- parastomal hernia (2)
- parasympatholytics (2)
- parietal hypoactivation (2)
- parotid gland (2)
- parthenogenesis (2)
- partial agonists (2)
- partial decay width (2)
- particles (2)
- pathogen (2)
- pathogenic bacteria (2)
- pathology (2)
- pathway analysis (2)
- patient education (2)
- patient reported outcome measures (2)
- patient survival (2)
- patient-specific (2)
- peak oxygen uptake (2)
- pediatric adrenocortical cancer (2)
- pediatric adrenocortical tumor (2)
- pediatric patients (2)
- peer review (2)
- pelvic examination (2)
- pelvic palpation (2)
- pemphigus foliaceus (2)
- penicillin allergy (2)
- penicillin hypersensitivity (2)
- pentacene (2)
- people (2)
- peptide tyrosine tyrosine (PYY) (2)
- peptide vaccination (2)
- peptides (2)
- perfusion culture (2)
- periodization (2)
- perioperative care (2)
- peripartum (2)
- peripheral nerve (2)
- peripheral neuropathy (2)
- periprosthetic joint infection (2)
- peritoneal carcinomatosis (2)
- peroxisomes (2)
- personalised medicine (2)
- personalized treatment (2)
- perspective taking (2)
- perspectives (2)
- perylene bisimides (2)
- phage (2)
- pharmaceutical applications (2)
- pharmacology/toxicology (2)
- pharmacotherapy (2)
- pharmacovigilance (2)
- phasic affective modulation (2)
- phenprocoumon (2)
- pheromones (2)
- phosphatidylserine (2)
- phosphodiesterase (2)
- phosphorus (2)
- photoemission (2)
- photoemission spectroscopy (2)
- photolysis (2)
- photon statistics (2)
- photon-counting (2)
- photonic devices (2)
- photoreceptor (2)
- photoswitchable organic fluorophores (2)
- photosynthesis (2)
- photothrombosis (2)
- phototransduction (2)
- physical fitness (2)
- physical performance (2)
- physical properties (2)
- physiologically based pharmacokinetic (PBPK) modeling (2)
- phytochemicals (2)
- phytohormones (2)
- piRNA (2)
- piperacillin/tazobactam (2)
- piperidines (2)
- placebo-controlled trial (2)
- planning (2)
- plant cuticle (2)
- plant defence (2)
- plant defenses (2)
- plant diversity (2)
- plant–insect interactions (2)
- plaque (2)
- plasma (2)
- plasma proteins (2)
- plasminogen (2)
- plasmonics (2)
- platelet physiology (2)
- platelet receptors (2)
- platyhelminthes (2)
- plausibility (2)
- pleomorphic adenoma (2)
- pneumolysin (2)
- pneumonia (2)
- point of care testing (2)
- pointing gestures (2)
- policy (2)
- pollen tube (2)
- pollination network (2)
- pollinator decline (2)
- poly(2- oxazoline) (2)
- poly(2-ethyl-2-oxazoline) (2)
- polycationic peptides (2)
- polymavirus (2)
- polymer processing (2)
- polymorphisms (2)
- polyploidy (2)
- pomalidomide (2)
- population genetics (2)
- populations (2)
- pore formation (2)
- porin (2)
- positive selection (2)
- positron emission tomography/computed tomography (2)
- posterior parietal cortex (2)
- postmenopausal women (2)
- postnatal development (2)
- postoperative care (2)
- postoperative nausea and vomiting (2)
- posttranslational modifications (2)
- postural control (2)
- potassium channel (2)
- power training (2)
- pp Collisions (2)
- pp collisions (2)
- pre-messenger RNA (2)
- precision agriculture (2)
- predation risk (2)
- predictive factors (2)
- predictive marker (2)
- predictive value (2)
- preexisting bias (2)
- prenatal exposure (2)
- presynaptic inhibition (2)
- preterm infant (2)
- primary cells (2)
- primary healthcare (2)
- primary prevention (2)
- primary ventral hernia (2)
- primary vertex (2)
- priming (2)
- printability (2)
- printed tooth (2)
- pro-inflammatory cytokines (2)
- probability (2)
- probes (2)
- proboscis extension response (PER) (2)
- processing fluency (2)
- prodrug (2)
- productivity (2)
- progenitor cells (2)
- progenitors (2)
- prognostic factors (2)
- projection neurons (2)
- promoter (2)
- promoter methylation (2)
- propensity score matching (2)
- propulsion (2)
- prosocial behavior (2)
- prospective studies (2)
- prostate-cancer (2)
- prostatic neoplasms (2)
- prosthesis (2)
- protease (2)
- protease inhibition (2)
- protein aggregation (2)
- protein interactions (2)
- protein phosphorylation (2)
- protein-coupled receptors (2)
- protein-interaction networks (2)
- protein-protein interactions (2)
- proteinuria (2)
- proteomes (2)
- proteomic (2)
- proton-proton collisions (2)
- proton-proton-collision (2)
- proton–proton collisions (2)
- proximal gradient method (2)
- psycho-oncology (2)
- psycholinguistics (2)
- psychological variables (2)
- psychopathology (2)
- psychophysics (2)
- psychotherapy (2)
- puberty (2)
- public speaking (2)
- pulmonary artery pressure (2)
- pulmonary embolism (2)
- pupae (2)
- pyrene (2)
- pyrolysis (2)
- qPCR (2)
- quality evaluation (2)
- quality of experience (2)
- quality of life (QoL) (2)
- quantitative analysis (2)
- quantum wells (2)
- qubits (2)
- quinine (2)
- quinoa (2)
- radiation sensitivity (2)
- radiation-therapy (2)
- radical cystectomy (2)
- radical prostatectomy (2)
- radii (2)
- radiography (2)
- radiology (2)
- radiomics (2)
- radiopharmaceuticals (2)
- radiotherapy (RT) (2)
- radiotracer (2)
- rainforest (2)
- raman spectroscopy (2)
- random forest classification (2)
- randomised controlled trial (2)
- rapid prototyping (2)
- rare (2)
- rare diseases (2)
- rat brain membranes (2)
- rat hepatocytes (2)
- rat model (2)
- re-irradiation (2)
- reaction mechanism (2)
- reaction mechanisms (2)
- reactivation (2)
- reactive electrophilic species (2)
- reactive intermediates (2)
- reading comprehension (2)
- reading disability (2)
- real time PCR (2)
- real world evidence (2)
- real-time PCR (2)
- receptor beta (2)
- receptor signalling (2)
- receptor tyrosine kinase (2)
- reconstructed human epidermis (2)
- rectum (2)
- red fluorescent protein (2)
- redox (2)
- reflection (2)
- reflex (2)
- refugees (2)
- regenerative capacity (2)
- regional development (2)
- register (2)
- registries (2)
- registry (2)
- regulator (2)
- regulatory RNA (2)
- regulatory T cell (2)
- regurgitation (2)
- reinforcement learning (2)
- relativistic jets (2)
- relaxation (2)
- release (2)
- religion (2)
- remyelination (2)
- renal cancer (2)
- renal disease (2)
- renal failure (2)
- renal system (2)
- renewable energy (2)
- renewable fuels (2)
- repair and replication (2)
- reperfusion (2)
- reperfusion injury (2)
- replacement therapy (2)
- replica (2)
- replication crisis (2)
- reporter genes (2)
- reporting and data system (2)
- repositories (2)
- reproductive success (2)
- resin (2)
- resonant tunneling diode (2)
- resource use (2)
- respiratory chain (2)
- respiratory syncytial virus (2)
- restrictive cardiomyopathy (2)
- resveratrol (2)
- retention interval (2)
- retinitis pigmentosa (2)
- retinoblastoma protein (2)
- retinoic acid (2)
- retrospective (2)
- retroviral vectors (2)
- reverse shoulder arthroplasty (2)
- reverse transcriptase (2)
- reverse transcriptase-polymerase chain reaction (2)
- reversible posterior leukoencephalopathy syndrome (2)
- revision arthroplasty (2)
- rheology (2)
- ribonucleases (2)
- ribosome biogenesis (2)
- riboswitch (2)
- rice (2)
- ring-expansion reaction (2)
- robotic surgery (2)
- roentgenographic assessment (2)
- rolipram (2)
- room temperature (2)
- root (2)
- root growth (2)
- rotation (2)
- ruthenium (2)
- ruthenium complexes (2)
- saccharomyces cerevisiae (2)
- safety behavior (2)
- salicylic acid (2)
- salinity stress (2)
- salivary gland (2)
- salivary gland tumors (2)
- sampling method (2)
- sarcoidosis (2)
- satellite (2)
- satellite remote sensing (2)
- satisfaction with life (2)
- scaffolds (2)
- scalability (2)
- scapula (2)
- sciatic nerve (2)
- scientific guidelines (2)
- sclerostin (2)
- scoping review (2)
- search (2)
- second hit (2)
- secondary metabolites (2)
- secretion systems (2)
- sectoral planning (2)
- sedentary behavior (2)
- sedimentology (2)
- see (2)
- selective attention (2)
- self-adaptive systems (2)
- self-aware computing (2)
- self-help (2)
- self-management (2)
- self-renewal (2)
- semantic coherence (2)
- semi-natural habitats (2)
- sense of agency (2)
- sensitivity analysis (2)
- sensor (2)
- sensor fusion (2)
- sensory cues (2)
- sensory neuropathy (2)
- sensory perception (2)
- sentinel-2 (2)
- septic (2)
- sequence analysis (2)
- serum concentration (2)
- serum creatinine (2)
- sevoflurane (2)
- sex chromosome evolution (2)
- sex determination (2)
- sex differentiation (2)
- sexual development (2)
- shape fidelity (2)
- shedding (2)
- short-term memory (2)
- shoulder (2)
- shoulder arthroplasty (2)
- shoulder surgery (2)
- sialic acid (2)
- signal cross section (2)
- signal filtering (2)
- signal inhibition (2)
- signal to noise ratio (2)
- signaling pathways (2)
- signalling pathways (2)
- signals (2)
- signature (2)
- signs and symptoms (2)
- silahexocyclium (2)
- simulated signal event (2)
- simultaneous integrated boost (2)
- single photon (2)
- single top event (2)
- single top production (2)
- single top quark production (2)
- single-cell RNA-seq (2)
- single-molecule biophysics (2)
- single-nucleotide polymorphisms (2)
- single-sided deafness (2)
- site-specific RNA cleavage (2)
- sizing (2)
- sleep disorders (2)
- small RNAs (2)
- small nucleolar RNAs (2)
- small-molecule activation (2)
- smart speaker (2)
- smartphone app (2)
- smooth muscle cells (2)
- social capital (2)
- social context (2)
- social decision-making (2)
- social features (2)
- social influence (2)
- social psychology (2)
- sodium channel (2)
- sodium channels (2)
- sofosbuvir (2)
- soil (2)
- solid tumors (2)
- solid-state NMR (2)
- solid-state emitters (2)
- solitary bee (2)
- solitary bees (2)
- solvent effects (2)
- somatic mosaicism (2)
- somatostatin receptor (SSTR) (2)
- soybean (2)
- spacing effect (2)
- spatial attention (2)
- spatial navigation (2)
- spatial presence (2)
- speciation (2)
- species concept (2)
- species diversity (2)
- spectral karyotyping (2)
- speech perception (2)
- speed (2)
- sperm DNA methylation (2)
- spermatocytes (2)
- spermatogenesis (2)
- sphingolipid (2)
- sphingosine kinase inhibitor SKI-II (2)
- sphingosine-1-phosphate (2)
- spider (2)
- spider phobia (2)
- spin (2)
- spin polarization (2)
- spinal-cord (2)
- spinal-cord-injury (2)
- spine (2)
- spine radiosurgery (2)
- spin–orbit coupling (2)
- spiral ganglion neuron (2)
- splicing (2)
- split-belt treadmill (2)
- spontaneous symmetry breaking (2)
- sporidia (2)
- squaraine dyes (2)
- stage renal-disease (2)
- standardization (2)
- startle (2)
- state (2)
- stem cell niche (2)
- stenosis (2)
- stent (2)
- stereochemistry (2)
- stereotypes (2)
- stiffness (2)
- stimuli (2)
- streptozotocin (2)
- stress resilience (2)
- stress resistance (2)
- stress response (2)
- strong coupling (2)
- strongly correlated materials (2)
- structural basis (2)
- structural synaptic plasticity (2)
- structure prediction (2)
- structure-activity (2)
- structure-activity relationship (2)
- structure-activity relationships (2)
- structured illumination (2)
- structured illumination microscopy (2)
- student training (2)
- study design (2)
- sturgeon (2)
- subcutaneous animal model (2)
- substantia nigra pars compacta (2)
- succession (2)
- suicide prevention (2)
- sulfates (2)
- sun exposure (2)
- supervisors (2)
- support vector machines (2)
- suppressor cells (2)
- supraglacial lakes (2)
- supraparticles (2)
- surgical site infections (2)
- surgical therapy (2)
- surgical treatment (2)
- survival analysis (2)
- survivors (2)
- susceptibility gene (2)
- sustainability (2)
- sustainable agriculture (2)
- sustainable intensification (2)
- sustained inflammation (2)
- swarming (2)
- swimming (2)
- symptoms (2)
- synapse formation (2)
- synapsis (2)
- synaptonemal complex (2)
- syndrome (2)
- synergistic effect (2)
- synovial fluid (2)
- synthetic aperture RADAR (2)
- synthetic aperture radar (2)
- synthetic biology (2)
- synthetic mesh (2)
- synthetic methods (2)
- systematics (2)
- targeting (2)
- targets (2)
- task force (2)
- taste (2)
- teacher education (2)
- telecommunication spectral range (2)
- temporal binding (2)
- temporal processing (2)
- temporal-lobe epilepsy (2)
- temporoparietal junction (2)
- tendon (2)
- tension (2)
- teriparatide (2)
- terror attack (2)
- testes (2)
- testis (2)
- testosterone (2)
- tetraspanin (2)
- tetromycin (2)
- textile (2)
- the rich (2)
- theory (2)
- theory of mind (2)
- thin films (2)
- thinking (2)
- thorax (2)
- thromboembolism (2)
- thromboinflammation (2)
- thrombolysis (2)
- thrombopoiesis (2)
- thyroid cancer (2)
- time (2)
- time perception (2)
- time-resolved spectroscopy (2)
- time-series (2)
- timing (2)
- tissue saturation index (2)
- tocilizumab (2)
- tolerability (2)
- toll-like receptors (2)
- tool use (2)
- tooth extraction (2)
- top quark (2)
- top quark decay (2)
- total joint arthroplasty (2)
- toxicology (2)
- toxin (2)
- trabectome (2)
- trabecular meshwork (2)
- trace elements (2)
- tracking (2)
- trade-offs (2)
- transactivation (2)
- transcription factor MIZ-1 (2)
- transcriptional control (2)
- transcriptional profiling (2)
- transcriptome analysis (2)
- transfection (2)
- transformation (2)
- transformative education (2)
- transforming growth factor-beta 1 (2)
- transient middle cerebral artery occlusion (2)
- transition (2)
- transition metal oxides (2)
- transition radiation (2)
- translation initiation (2)
- translational initiation (2)
- translational regulation (2)
- transportation (2)
- transposition (2)
- trap (2)
- trap nests (2)
- trastuzumab (2)
- treatment guidelines (2)
- treatment options (2)
- treatment resistance (2)
- trees (2)
- trend analysis (2)
- triple in situ hybridization (2)
- triple-negative breast cancer (2)
- tropical forest (2)
- trust (2)
- trypanosoma brucei (2)
- tuberculosis (2)
- tumor cells (2)
- tumor growth (2)
- tumor immunity (2)
- tumor immunology (2)
- tumor necrosis factor (TNF) (2)
- tumor stem cells (2)
- tumor-infiltrating lymphocytes (2)
- tumour immunology (2)
- two-photon absorption (2)
- two-photon excited fluorescence (2)
- two-stage exchange (2)
- type VII secretion system (2)
- tyrosine (2)
- tyrosine kinase inhibitor (2)
- tyrosine kinase inhibitors (2)
- umbilical hernia (2)
- unconventional superconductivity (2)
- unexpressed needs (2)
- unfolded protein response (2)
- unmanned aerial vehicles (2)
- unpleasant pictures (2)
- up-regulation (2)
- update (2)
- urban (2)
- urine (2)
- urticaria (2)
- user study (2)
- vaccines (2)
- vacuum conditioning (2)
- vacuum-assisted closure (2)
- vandetanib (2)
- vascular access (2)
- vascular permeability (2)
- vascular surgery (2)
- vasculature (2)
- vasculogenesis (2)
- vasopressin (2)
- vegetative state (2)
- venous system (2)
- ventilation (2)
- ventral hernia (2)
- vertebral metastases (2)
- vertigo (2)
- very-long-baseline interferometry (2)
- vibration (2)
- vicinal surfaces (2)
- video analysis (2)
- virology (2)
- virtual agent (2)
- virtual body ownership (2)
- virulence factors (2)
- viscosity (2)
- visible cross section (2)
- vitamin D deficiency (2)
- vitamins (2)
- volatile anesthetics (2)
- volume regulation (2)
- voluntary movement (2)
- von Willebrand factor (2)
- vulnerability (2)
- vulnerability curve (2)
- wR factor = 0.068 (2)
- water load test (2)
- wave functions (2)
- weakly coordinating anions (2)
- wetland (2)
- white blood cells (2)
- whole exome sequencing (2)
- whole genome sequencing (2)
- whole-exome sequencing (2)
- whole-genome duplication (2)
- wind speed (2)
- wood anatomy (2)
- wood-inhabiting fungi (2)
- work capacity evaluation (2)
- work engagement (2)
- workplace (2)
- wound healing (2)
- xenotransplantation (2)
- xylem loading (2)
- yam (2)
- yellow fluorescent protein (2)
- yoga (2)
- young children (2)
- youth (2)
- zinc (2)
- zinc oxide (2)
- zoology (2)
- γδ T cell (2)
- γδ T cells (2)
- π-conjugated systems (2)
- ( L. ivanovii ) (1)
- ( L. selligeri) (1)
- (+)-limonene (1)
- (13)C (1)
- (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium chloride/pharmacology (1)
- (AB)\(_{n}\) segmented copolymers (1)
- (Mouse L-cell) (1)
- (Nucleotide sequence (1)
- (R)- and (S)-hexahydro- / Antimuscarinic properties / Muscarinic receptor subtypes (1)
- (Rat brain membrane) (1)
- (Rat liver) (1)
- (Salmonella) (1)
- (approximate) functional equation (1)
- (cardiac) surgery (1)
- (classical and atypical) Werner syndrome (1)
- (dis-)embeddedness (1)
- (± )-dioncophyllacine A (1)
- + (1)
- 0 antigen (1)
- 1,2-additionreaction (1)
- 1,2-azaborinine (1)
- 1,2-benzisothiazolinone (1)
- 1,25-dihydroxyvitamin D\(_{3}\) (1)
- 1,4-Diborabenzene (1)
- 1,4-naphthoquinone (1)
- 1/N expansion (1)
- 11C-HED (1)
- 11C-Hydroxyephedrine (1)
- 11C-Methionine PET/CT (1)
- 11C-hydroxyephedrine (1)
- 12-oxo-phytodienoic acid (1)
- 123I-Ioflupane (1)
- 14.7K (1)
- 15-Deoxyspergualin (1)
- 1550 nm (1)
- 16S metabarcoding (1)
- 16S ribosomal-RNA (1)
- 177Lu SPECT/CT imaging (1)
- 18-F-fluorothymidine uptake (1)
- 18F-DCFPL (1)
- 18F-DCFPyL (1)
- 18F-flurpiridaz (1)
- 18FDG-PET/CT (1)
- 18FFBnTP (1)
- 18S (1)
- 1960s (1)
- 1H-Magnetic resonance spectroscopy (1H-MRS) (1)
- 1p13.3 (1)
- 1p36 deletion syndrome (1)
- 1q21 (1)
- 1st International Workshop (1)
- 1st-line treatment (1)
- 2 Jets (1)
- 2 PM (1)
- 2',7'-dichlorofluorescin (1)
- 2,5-diketopiperazines (1)
- 2- deoxy-2-(18F)fluoro-D-glucose (1)
- 2-APB (1)
- 2-Acetylaminofluorene (1)
- 2-DG (1)
- 2-Dichloroethane (1)
- 2-Dioxetane (1)
- 2-Generation reproduction (1)
- 2-Thiazaphospholidines (1)
- 2-alkylbranched acids (1)
- 2-chloro (1)
- 2-component system (1)
- 2-deoxy-2-(18F)fluoro-D-glucose (1)
- 2-deoxy-2-18F-fluoro-D-sorbitol (1)
- 2-deoxy-D-glucose (1)
- 2-dimensional speckle tracking (1)
- 2-halo (1)
- 2-imino- (1)
- 2-loop level (1)
- 2-photon absorption (1)
- 2-photon microscopy (1)
- 2-pore potassium channel (1)
- 2-step IMRT (1)
- 2015 (1)
- 21q22.2-q22.3 (1)
- 223Ra (1)
- 224Ra (1)
- 22q11.2 deletion syndrome (1)
- 25-hydroxycholesterol 7 alpha-hydroxylase (1)
- 26S RDNA Data (1)
- 26S proteasome (1)
- 28 (1)
- 2D-perfusion angiography (1)
- 2Dimensionale Spektroskopie (1)
- 2ϕ\(_0\) periodicity (1)
- 3 (1)
- 3 D rotational fluoroscopy (1)
- 3-coordinate boron (1)
- 3-coordinate organoboron compounds (1)
- 3-dimensional MRI (1)
- 3-dimensional structure (1)
- 3-dimensional visualization (1)
- 316L stainless-steel (1)
- 360° videos (1)
- 3D (1)
- 3D GIS analysis (1)
- 3D Printing (1)
- 3D X-ray microscopy (1)
- 3D analysis (1)
- 3D cell culture (1)
- 3D cell cultures (1)
- 3D collation (1)
- 3D conformal silicone bolus (1)
- 3D culture (1)
- 3D echocardiography (1)
- 3D electrophysiology (1)
- 3D ex vivo models (1)
- 3D in vitro model (1)
- 3D in vitro models (1)
- 3D lung tumor tissue models (1)
- 3D mapping (1)
- 3D microfiber (1)
- 3D model systems (1)
- 3D modeling (1)
- 3D neuronal networks (1)
- 3D object recognition (1)
- 3D organoids (1)
- 3D powder printing (1)
- 3D printer (1)
- 3D remote sensing (1)
- 3D tissue models (1)
- 3D tumor model (1)
- 3D viewer (1)
- 3D-printed tooth (1)
- 3D-reconstruction methods (1)
- 3DTK toolkit (1)
- 3R (1)
- 3 T (1)
- 3‐D electrical resistivity imaging (1)
- 3′ UTR (1)
- 4'-hydroxylation (1)
- 4-(p-nitrobenzyl)pyridine (1)
- 4-dimethylamino-4′-cyanodiphenylacetylene (1)
- 4D (1)
- 4D flow MRI (1)
- 4D flow cardiovascular magnetic resonance (1)
- 4D-GIS (1)
- 4D-MRI (1)
- 4H (1)
- 5-HT (1)
- 5-HT receptors (1)
- 5-HTT (1)
- 5-HTT knockout mice (1)
- 5-HTTLPR polymorphism (1)
- 5-bromodeoxyuridine (1)
- 5-methyl cytosine (1)
- 5-methylcytosine (1)
- 5HTTLPR (1)
- 5IA-SPECT (1)
- 6-benzylaminopurine (1)
- 6-percent hydroxyethyl starch (1)
- 60-nucleotide duplication (1)
- 65-kda isoform (1)
- 68Ga-DOTATATE (1)
- 68Ga-DOTATATE/-TOC (1)
- 68Ga-PSMA ligand PET/CT (1)
- 68Ga-Pentixafor PET/CT (1)
- 6S RNA (1)
- 7 T (1)
- 7000 GeV-cms (1)
- 77-LH-28-1 (1)
- 7T (1)
- 7q11.2 (1)
- 8 TEV (1)
- 8-Hydroxy-deoxyguanosine (1)
- 8-oxoguanine (1)
- 99mTc-DTPA (1)
- <sup>18</sup>F-FDG (1)
- <sup>68</sup>Ga-Pentixafor (1)
- A chromosomes (1)
- A(2B) receptors (1)
- A-D (1)
- A-delta fibers (1)
- A-type lamins (1)
- A. thaliana (1)
- A1 (1)
- A1 Adenosine receptors (1)
- A20 (1)
- A2a-R receptor (1)
- A375 (1)
- A53T (1)
- A549 cell line (1)
- A<sub>2</sub> Adenosine receptor (1)
- AAA+ ATPase p97 (1)
- AAPA (1)
- ABA receptors (1)
- ABL gene (1)
- ABP1 (1)
- AC Stark effect (1)
- ACC (1)
- ACC deaminase (1)
- ACC/AHA classification (1)
- ACE inhibitor (1)
- ACH-2 (1)
- ACID (1)
- ACKR4 (1)
- ACM (1)
- ACP5 (1)
- ACPC (1)
- ACR practice guidelines (1)
- AChE inhibitor (1)
- AD mouse modele (1)
- AD pathogenesis (1)
- AD-AID (1)
- AD5 mutation (1)
- ADAM10 (1)
- ADAM9 (1)
- ADAMTS (1)
- ADCC (1)
- ADME analysis (1)
- ADP-ribosylation toxins (1)
- ADP-ribosyltransferases (1)
- AF-DX 116 (1)
- AFLP (1)
- AG(110) (1)
- AGP (1)
- AGT (1)
- AHRR (1)
- AICDA (1)
- AID-ΔE4a (1)
- AIE (1)
- AIME (1)
- AIModules (1)
- AIRWAYS ICPs (1)
- AKI (1)
- AKT-signaling (1)
- AKT1 (1)
- ALAN (1)
- ALI culture (1)
- ALK-1 (1)
- ALMT (1)
- ALOS (1)
- ALOS-2 (1)
- ALPH (1)
- ALPH1 (1)
- ALPL (1)
- ALS mimic (1)
- ALS treatment (1)
- ALSIN gene (1)
- ALT (1)
- ALiOS (1)
- AMADEUS (1)
- AMP-activated kinases (1)
- ANOVA (1)
- ANTARES telescope (1)
- AP-1 (1)
- APC (1)
- APERIO (1)
- APERIO Hybrid (1)
- APEX2 (1)
- API (1)
- APOBEC3G (1)
- APRI (1)
- ARCI (1)
- ARCI EM type III (1)
- ARDS (1)
- ARDS (acute respiratory distress syndrome) (1)
- ARF (1)
- ARF tumor-suppressor induced lymphomagenes (1)
- ART outcome (1)
- ARVC (1)
- AS clavicle plate (1)
- ASAR (1)
- ASCAT (1)
- ASCs (1)
- ASE formula (1)
- AT/RT (1)
- ATF6 (1)
- ATG (1)
- ATG proteins (1)
- ATG12-ATG5 conjugate (1)
- ATG7 (1)
- ATG8 (1)
- ATLAS experiment (1)
- ATM (1)
- ATM gene (1)
- ATMP (1)
- ATP carrier (1)
- ATP generation (1)
- ATP synthase (1)
- ATP-DnaA complex (1)
- ATP-adenosine triphosphate (1)
- ATP-binding cassette transporter (1)
- ATPase activity (1)
- ATPase mutants (1)
- ATRX (1)
- ATTRv amyloidosis (1)
- AUX1 (1)
- AVA (1)
- AVHRR data (1)
- AYAs (1)
- AZD4547 (1)
- AZD6244 (1)
- A\(_{2A}\) adenosine receptor antagonist (1)
- Aaskäfer (1)
- Ab interno trabeculectomy (1)
- Abatacept (1)
- Abelson helper integration-1 (AHI1) (1)
- Ableitung (1)
- Abstandsmessung (1)
- Accelerator modelling and simulations (multi-particle dynamics; single-particle dynamics) (1)
- Accelerometry (1)
- Accidental coincidence (1)
- Accountability (1)
- Accumulative Femtosecond Spectroscopy (1)
- Accurate (1)
- Acene (1)
- Acer platanoides (1)
- Acetabularia (1)
- Acetylated tubulin (1)
- Achilles (1)
- Achilles tendinopathy (1)
- Acids (1)
- Acipenser baerii (1)
- Acoustics (1)
- Acquisition of literacy (1)
- AcrAB-TolC efflux pump (1)
- Acromesomelic dysplasias (1)
- Acromyrmex ambiguus (1)
- Acromyrmex heyeri (1)
- Actin nucleation (1)
- Actinokineospora (1)
- Actinomycin D (1)
- Action feedback (1)
- Action potentials (1)
- Active disease (1)
- Acute Myocardial Infarction (1)
- Acute lymphoblastic leukemia (1)
- Acute myeloid leukemia (AML) (1)
- Acute osteomyelitis (1)
- Acute tryptophan depletion (1)
- AdS-CFT correspondence (1)
- Adamantiades-Behçet disease (1)
- Adaptation (1)
- Adaptive cell transfer (1)
- Addison's disease (1)
- Addisons disease (1)
- Adenocarcinomas (1)
- Adenosine receptor (1)
- Adenosine receptor antagonists (1)
- Adenosinrezeptor (1)
- Adenovirus (1)
- Adenylate cyclase toxin (1)
- Adherence (1)
- Adherens junction (1)
- Adhesion (1)
- Adhäsion (1)
- Adipokine (1)
- Adipositas (1)
- Adolescence (1)
- Adolescent (1)
- Adolescents (1)
- Adrenocortial carcinomas (1)
- Adrenocortical Carcinoma (1)
- Adult head (1)
- Adult patients (1)
- Adults (1)
- Advanced snowmelt (1)
- Affective processing (1)
- Afferent nerve stimulation (1)
- Afghanistan (1)
- Aflatoxin (1)
- Aflatoxin B1 (1)
- Africa south of the equator (1)
- African agriculture (1)
- African sleeping sickness (1)
- African trypanosome (1)
- African trypanosomes (1)
- African-americans (1)
- Ag(111) (1)
- Ag-DNA (1)
- Agalsidase beta therapy (1)
- Age (1)
- Ageing (1)
- Aggeneys (1)
- Aggression (1)
- Aggressive behaviour (1)
- Aging (1)
- Agoraphobia (1)
- Agricultural intensification (1)
- Agricultural soil science (1)
- Agro-ecology (1)
- Agrobacterium (1)
- Ahmed (1)
- Akt/PKB (1)
- Akutes Nierenversagen (1)
- Albino rat (1)
- Alcohol dependence (1)
- Aldehyde Bioconjugation (1)
- Aldehyde Complexes (1)
- AldoA (1)
- Alemtuzumab (1)
- Alento hydrological observatory (1)
- Alkaline phosphatase (1)
- Alkekengi (1)
- Alkohol (1)
- Alkyl(amino)carbene (1)
- Alkylation (1)
- Alkyltransferase Ribozyme SAMURI (1)
- Alkyne (1)
- Allelic loss (1)
- Allergic rhinitis (1)
- Allergie (1)
- Allergy (1)
- Allogeneic transplantation (1)
- Allophrynidae (1)
- Allorhizobium vitis (1)
- Allotransplantation (1)
- Alpelisib (1)
- Alpen (1)
- Alpha galactosidase (1)
- Alpha therapy (1)
- Alpha-Galactosidase (1)
- Alpha-dependent apoptosis (1)
- Alpha-galactosidase (1)
- Alpha-synuclein oligomers (1)
- Alpine habitats (1)
- Altenpflege (1)
- Alternaria (1)
- Alternative test methods (1)
- Aluminium-copper (1)
- Alvis (1)
- Alzheimer's diseas (1)
- Alzheimer-Krankheit (1)
- Alzheimers-disease (1)
- Alzheimer’s dementia (1)
- Alzheimer′s disease (1)
- AmGr1 (1)
- AmGr2 (1)
- AmGr3 (1)
- Amazon Molly (1)
- Amazonia (1)
- Amazonian forest (1)
- American Thyroid Association (1)
- American foulbrood (1)
- Amino acid composition (1)
- Aminosäuren (1)
- Ampfer (1)
- Amphibia (1)
- Amphibians (1)
- Amplitude (1)
- Amu Darya (1)
- Amygdala (1)
- Amyloid-beta oligomers; (1)
- Amyotrophic Lateral Sclerosis (ALS) (1)
- Amyotrophic Lateral Sclerosis Assessment Questionnaire 5 (ALSAQ-5) (1)
- Amyotrophic-lateral-sclerosis (1)
- Anabolieagent (1)
- Analgesia (1)
- Analytical Quality by Design (1)
- Anaphylactic shock (1)
- Anas crecca (1)
- Anatomic reattachment (1)
- Anchimeric assistance in solvolysis (1)
- Ancistrocladus ealaensis (1)
- Ancistrocladus likoko (1)
- Andalusian varieties (1)
- Anderson-Fabry Disease (1)
- Aneuploidy (1)
- Angiopoietin-2 (1)
- Angiopoietin-like 4 (1)
- Angiosperms ; Ant-plant interactions ; domatia ; Flora of Malaysia (1)
- Angola (1)
- Angst (1)
- Aniline derivatives (1)
- Animal Tracking (1)
- Animal behavior (1)
- Animal studies (1)
- Ankyrin (1)
- Anomalous magnetic-moment (1)
- Anoplolepis gracilipes (1)
- Anorexia nervosa (1)
- Ant-following birds (1)
- Ant-plant interactions (1)
- Ant-plant interactions ; Herbivory Macaranga ; Mutualism ; Myrmecophytes (1)
- Ant/plant interaction (1)
- Anterior chamber perfusion model (1)
- Anterior inferotemporal cortex (1)
- Anthraquinone glycosides (1)
- Anti-TNF-alpha agents (1)
- Anti-tank rocket (1)
- Anti-tank weapon (1)
- Antibacterial therapy (1)
- Antibacterials (1)
- Antibiotic resistance (1)
- Antibiotics (1)
- Antibodies (1)
- Antibody index (1)
- Anticoagulants (1)
- Antidepressants (1)
- Antigen 4 (1)
- Antioxidants (1)
- Antiparanodal Autoantibodies (1)
- Antisense (1)
- Antisocial behavior (1)
- Antiviral nucleoside analogues (1)
- Anxiety sensitivity (1)
- Anxiety-like behavior (1)
- Anxiolysis (1)
- Any Evil (1)
- Anästhesiologie (1)
- Aorta (1)
- Aortic arch (1)
- ApaH (1)
- ApaH like phosphatase (1)
- Aphthae (1)
- Apicomplexan (1)
- Apidae (1)
- Apis dorsata (1)
- Aplastic anemia (1)
- ApoE\(^{(-/-)}\) (1)
- Apple Watch 7 (1)
- Applied physics (1)
- Aquaporin-4 antibodies (AQP4-Ig, NMO-IgG)G (1)
- Aquaporin-4 antibodies (AQP4-IgG) (1)
- Aquaporin-4 antibodies (AQP4-IgG, NMO-IgG) (1)
- Aqueous Solution Photochemistry (1)
- Arabidopsis-thaliana (1)
- Araneidae (1)
- Araneus diadematus (1)
- ArcCHECK (1)
- Archaea (1)
- Archaeology (1)
- Arctic (1)
- Arena experiment (1)
- Argentina (1)
- Arginine (1)
- Argonaute (1)
- Aromatic-hydrocarbon (1)
- Aromaticity (1)
- Arp2/3 complex (1)
- Arrhenius equation (1)
- Arterial Diameters (1)
- Arterial water (1)
- Arterioles (submucosal) (1)
- Arthrography (1)
- Arthroleptis amphibia (1)
- Arthropod (1)
- Arthropods (1)
- Arthur Hailey (1)
- Articular afferent (1)
- Articular-Cartilage (1)
- Artificial Nuclear Pores (1)
- Aryl hydrocarbon rnonooxygenase (1)
- Arylborylene Complexes (1)
- Asc-1 transporter (1)
- Ascaris lumbricoides (1)
- Aseptic loosening (1)
- Asia (1)
- Asian Englishes (1)
- Aspartate Aminotransferases (1)
- Aspergillus fumigalus (1)
- Aspergillus medium (1)
- Aspergillus niger (1)
- Aspergillus sp. (1)
- Assay (1)
- Assemblages (1)
- Association study (1)
- Associative learning (1)
- Astrocytes ; Schwann cells ; Interferon-gamma ; Fibroblast growth factor ; Cyclic AMP (1)
- Astrocytic tumor (1)
- Astrophysical neutrino sources (1)
- Asymmetrie (1)
- Atacama (1)
- Ataxia (1)
- Atharvaveda (1)
- Atherosclerosis (1)
- Atherosclerosis, intracranial arteries (1)
- Atherosclerotic plaque (1)
- Atmospheric muons (1)
- Atomic force microscopy (1)
- Atria (1)
- Atrial fibrillation (1)
- Atrial natriuretic peptide (1)
- Attention (1)
- Attention Deficit Hyperactivity Disorder (ADHD) (1)
- Attention-deficit/hyperactivity disorder (1)
- Attentional performance (1)
- Attitude (1)
- Attitude Heading Reference System (AHRS) (1)
- Au/Ge(111) (1)
- Auditory pathway (1)
- Auditory targets (1)
- Augenkrankheit (1)
- Aulonocara (1)
- Aureobasidium (1)
- AurisID (1)
- Australian stingless bees (1)
- Autism (1)
- Auto-antibodies (1)
- Autoimmune diseases (1)
- Autoimmune-Diseases (1)
- Autoinflammation (1)
- Autologous (1)
- Automated analysis (1)
- Automatization (1)
- AuxRE (1)
- Auxin-regulated transcription (1)
- Available soil water capacity (1)
- Aversive events (1)
- Aversive tension (1)
- Aviophobia (1)
- Avirulent Salmonella (1)
- Avoidance behavior (1)
- Axl tyrosine kinase (1)
- Axon growth (1)
- Axon guidance (1)
- Axonal transport (1)
- Azathioprine (1)
- Aziridines (1)
- Aššur (1)
- Aδ- and C-fibers (1)
- B (1)
- B 37 CAG repeat locus (1)
- B cell culture (1)
- B cell malignancies (1)
- B neisseria meningitidis (1)
- B physics (1)
- B,N-heterocycles (1)
- B,N-heterocylcles (1)
- B-0 (1)
- B-B bond (1)
- B-B bond activation (1)
- B-MYB (1)
- B-cell (1)
- B-lymphocytes (1)
- B-tagged jet (1)
- B4GALT7 gene (1)
- B7-H1 Antigen (1)
- BAL (1)
- BARF-mutated melanoma (1)
- BB/OKL rats (1)
- BBC3 (1)
- BCL-X-L P53 (1)
- BCOR (1)
- BCORL1 (1)
- BCR-ABL (1)
- BCR‐ABL (1)
- BDNF Val66Met (1)
- BDNF stimulation (1)
- BET Inhibitor (1)
- BETA(2)-adrenergic receptor (1)
- BH3 domains (1)
- BH3-only proteins (1)
- BIRC7 (1)
- BK channel (1)
- BK virus (1)
- BM (1)
- BMI (1)
- BMP antagonist (1)
- BMP signaling (1)
- BMP-2 delivery (1)
- BMP-6 (1)
- BMPR1B (1)
- BN 52021 (1)
- BNIP3 (1)
- BON-1 (1)
- BP180 (1)
- BPD (1)
- BPM (1)
- BPMN (1)
- BRAF mutations (1)
- BRAF(V600E) mutation (1)
- BRCA1 positive (1)
- BRCA1/2 (1)
- BRCA1/2 negative (1)
- BRCA2 positive (1)
- BRD4 (1)
- BRIP1 gene (1)
- BRM (1)
- BRN-3A (1)
- BSA (1)
- BSM Higgs boson (1)
- BSS directive (1)
- BSTA (1)
- BTN (1)
- BTN2 (1)
- BTN2A1 (1)
- BTN3A1 (1)
- BT_1884 (1)
- BV-2 (1)
- BaPb\(_{1-X}\)Bi\(_{X}\)O\(_{3}\) (1)
- Babylon (1)
- BacT/ALERT (1)
- Bacillus megaterium (1)
- Bacillus subtilis (1)
- Bacillus-Calmette-Guerin (1)
- Bacillus-subtilis (1)
- Background Epithelioid haemangioma (1)
- Bacteria (1)
- Bacterial conjugation (1)
- Bacterial meningitis (1)
- Bacterial symbionts (1)
- Bacteriaophage AR9 (1)
- Baerveldt (1)
- Baja California [(PNN) Mexico] (1)
- Bakterien (1)
- Balints-Syndrome (1)
- Ballistics (1)
- Baltic Sea (1)
- Barbed suture (1)
- Barbed suture material (1)
- Barbiturates (1)
- Barcodes (1)
- Barkhof criteria (1)
- Barratt Impulsiveness Scale (1)
- Barrett-Ösophagus (1)
- Barrier (1)
- Bartak (1)
- Barthel-Index (1)
- Base composition (1)
- Basophil activation test (1)
- Batf3 (1)
- Bavarian Forest (1)
- BayPass (1)
- Bayesian approach (1)
- Bayesian inverse problems (1)
- Bayesian methods (1)
- Bcl-2 proteins (1)
- Beauveria bassiana (1)
- Becker naevus (1)
- Becker naevus syndrome (1)
- Bee abundance (1)
- Beer-lambert law (1)
- Behavior (1)
- Behavioural ecology (1)
- Behçet’s disease (1)
- Bembix (1)
- Benzefuran dioxetane (1)
- Benzefuran epoxide (1)
- Benzene (1)
- Benzimidazole (1)
- Benzimidazoles (1)
- Benzo(a)pyrene-DNA binding (1)
- Benzyne (1)
- Berberine (1)
- Berchtesgaden (1)
- Berchtesgaden NP (1)
- Berenil (1)
- Berger-Parker (1)
- Bernstein-type inequality (1)
- Berry phase (1)
- Beryllium (1)
- Bessle functions (1)
- Beta(1)-adrenergic receptor (1)
- Beta(2)-adrenergic receptor (1)
- Beta-blocker (1)
- Beta-catenin (1)
- Beta-glucocerebrosidase (1)
- Bethe–Salpeter equation (1)
- Bewegungsfixateur (1)
- Bhabha Scattering (1)
- Bi-Fidelity method (1)
- Bialowieza (1)
- Bias (1)
- Biased gene conversion (1)
- Bicyclo[1.1.0]butylcarbinyl sulfonates (1)
- Bienenverhalten (1)
- Big picture (1)
- Bilma <Region> (1)
- Bindungsaktivierung (1)
- Binge drinking (1)
- BioID (1)
- BioVaSc (1)
- Biochemical-Diagnosis (1)
- Biochemistry (1)
- Biocompatibility (1)
- Biodegradable polymer scaffolds (1)
- Biogenic (1)
- Biohazard (1)
- Biological identifications (1)
- Bioluminescence (1)
- Bioluminescence imaging (1)
- Biomarke (1)
- Biomechanical Properties (1)
- Bioorganosilicon chemistry (1)
- Bioorthogonal Tag (1)
- Biophysics (1)
- Biopsy (1)
- Bioreaktor (1)
- Biostratigraphy (1)
- Biowissenschaften (1)
- Biradicals (1)
- Biradikale (1)
- Birds (1)
- Bismuth (1)
- Bisphosphonates (1)
- Bistability (1)
- Black Holes in String Theory (1)
- Black Scholes equation (1)
- Black-hole (1)
- Bland–Altman (1)
- Blattschneiderameisen (1)
- Blepharoplastik (1)
- Bloch oscillations (1)
- Blood (1)
- Blood pressure (1)
- Blood stream infection (1)
- Blood-brain-barrier (1)
- Blood–brain barrier (1)
- Bloom setting (1)
- Blue Spot Analysis (1)
- Blut (1)
- Blut-Hirn-Schranke (1)
- Blutdruck (1)
- Bocas-del-Toro (1)
- Bodenwasser (1)
- Body composition (1)
- Body schema (1)
- Body size (1)
- Bombesin ; Bombesin receptor ; Chromosomal localization (1)
- Bombus (1)
- Bombus Spp. Hymenoptera (1)
- Bombus terrestris (1)
- Bone Mineral Density (1)
- Bone chips (1)
- Bone disease (1)
- Bone graft (1)
- Bone health (1)
- Bone marrow cells (1)
- Bone marrow transplantantation (1)
- Bone regeneration (1)
- Bone tissue engineering (1)
- Bone tumor (1)
- Boolean function (1)
- Boolean tree (1)
- Bootstrap (1)
- Boranes (1)
- Bordeiella pertussis (1)
- Borylation (1)
- Borylene (1)
- Bose gas (1)
- Bose-Einstein Correlations (1)
- Bose-Einstein condensation (1)
- Bose-Fermi (1)
- Bound-states (1)
- Bovis (1)
- Bowen’s disease, periungual (1)
- Braak (1)
- Bradyrhizobium (1)
- Bragg-reflection waveguide (1)
- Brahma (1)
- Brain Computer Interface (1)
- Brain atrophy (1)
- Brain cancer (1)
- Brain diseases (1)
- Brain edema (1)
- Brain endothelial cells (1)
- Brain ischemia (1)
- Brain mappins (1)
- Brain stem (1)
- Brain μ-opioid receptors (1)
- Brain-Computer Interface (BCI) (1)
- Brain-computer interface (1)
- Brain-derived neurotrophic factor (1)
- Brainstem encephalitis (1)
- Brain–computer interfaces (BCI) (1)
- Branching fractions (1)
- Brassicaceae (1)
- Brassicogethes spp. (1)
- Brazil (1)
- BrdU replication banding pattern (1)
- BrdU-Hoechst (1)
- BrdU/dT replication banding (1)
- Breast cancer (1)
- Breast cancer cells (1)
- Breath tests (1)
- Breathing (1)
- Breeding system (1)
- Broca (1)
- Brockett (1)
- Broken Hill (1)
- Brombeere (1)
- Bromodeoxyuridine labeling (1)
- Bronchopulmonary dysplasia (1)
- Brownian ratchet (1)
- Brownsche Bewegung (1)
- Brucei (1)
- Brugia Malayi (1)
- Brushite (1)
- Bruton Tyrosine Kinase (1)
- Bruton's tyrosine kinase inhibitor CC-292 (1)
- Bryophyta (1)
- Buche (1)
- Bull-Headed Demon (1)
- Bullous pemphigoid (1)
- Bumblebee (1)
- Bunnell (1)
- Buntbarsche (1)
- Burma (1)
- Burmese Days (1)
- Business Process Models (1)
- Butadien (1)
- By-Light Scattering (1)
- B‐cell lymphoma (1)
- B−H activation (1)
- C virus (1)
- C(-1019)G polymorphism (1)
- C-11-methionine pet (1)
- C-13 NMR (1)
- C-13-metabolic flux analysis (1)
- C-6-H (1)
- C-60 fullerene (1)
- C-C coupling (1)
- C-H activation (1)
- C-IAP1 (1)
- C-MYC PUMA (1)
- C-Myc (1)
- C-Terminus (1)
- C-elegans (1)
- C-tactile fibers (1)
- C-terminal domain (1)
- C.376A>G (p.S126G) (1)
- C1-inhibitor (1)
- C1q/TNF related protein (CTRP) (1)
- C2-toxin (1)
- C3 (1)
- C3a (1)
- C3aR (1)
- C57BL/KALWRIJ mouse (1)
- C5aR2 (1)
- C6 (1)
- C60 fullerene (1)
- C9orf72 (1)
- CA2+ channels (1)
- CA3 (1)
- CA3 pyrimidal cells (1)
- CA4 (1)
- CAD (1)
- CAD detection (1)
- CAGSSS (1)
- CAM (1)
- CAPA (1)
- CAPS (1)
- CAR T (1)
- CAR T cell (1)
- CAR T-cell (1)
- CAR-T cells (1)
- CAR-T-cell (1)
- CARAT (1)
- CASP (1)
- CASPASE-3 (1)
- CB1 receptor antagonists (1)
- CBF (1)
- CBT (1)
- CCAP (1)
- CCD (1)
- CCD, charge-coupled device (1)
- CCDC79 (1)
- CCHamide1 (1)
- CCI (1)
- CCL2 (MCP-1) (1)
- CCL3 (1)
- CCL5 (1)
- CCN1 (1)
- CCN2 (1)
- CCR4 (1)
- CCR7 (1)
- CCS (1)
- CCl\(_4\) (1)
- CD coreceptors (1)
- CD/metabolism (1)
- CD10 (1)
- CD105 (1)
- CD105 antigen (1)
- CD11b+ myeloid cells (1)
- CD133 (1)
- CD147 (1)
- CD20 (1)
- CD23 (1)
- CD27 (1)
- CD28 costimulation (1)
- CD28 superagonists (1)
- CD2AP (1)
- CD3/19 depletion (1)
- CD319 (1)
- CD34 antigen (1)
- CD34 selection (1)
- CD38 (1)
- CD4 (1)
- CD4 T cells (1)
- CD4(+)CD25(+) (1)
- CD4+ T cells (1)
- CD4+ T-cells (1)
- CD4+T cells (1)
- CD40 ligand (1)
- CD44 (1)
- CD46 (1)
- CD4\(^{+}\) T cells (1)
- CD4\(^{+}\) T helper cells (1)
- CD52 (1)
- CD56 (1)
- CD62L (1)
- CD70 (1)
- CD74 (1)
- CD8 T cell (1)
- CD8(+) (1)
- CD8+ T cells (1)
- CD8+T cells (1)
- CD8\(^+\) T cells (1)
- CDC14A (1)
- CDH13 (1)
- CDH13 Expression (1)
- CDH13 mRNA (1)
- CDL (1)
- CDR3 sequences (1)
- CEF (1)
- CENP-A (1)
- CERN (1)
- CERN LHC Coll (1)
- CETCH cycle (1)
- CGG repeat (1)
- CHIP (1)
- CHRODIS (1)
- CIAP1 (1)
- CIB1 (1)
- CIDP (1)
- CIED malfunction; pacemaker (PM) (1)
- CIN (1)
- CIR aerial imagery (1)
- CIS+ (1)
- CIT (1)
- CK5 (1)
- CKD (1)
- CLAVATA3 (1)
- CLEC-2 ITAM (1)
- CLIP (1)
- CLIP-seq (1)
- CLL (1)
- CLN3 (1)
- CLRN2 (1)
- CLV3p (1)
- CMSSM Point (1)
- CMV reactivation (1)
- CMV-specific cellular immunity (1)
- CNG channel (1)
- CNS Myelination (1)
- CNS diseases (1)
- CNS imaging (1)
- CNS infection (1)
- CNS injury (1)
- CNS integrity (1)
- CNVs (1)
- CO sensing (1)
- CO2 (1)
- CO2 gas exchange (1)
- CO2-sequestration (1)
- COD movements (1)
- COH29 (1)
- COI (1)
- COMPLEX 1 (1)
- COMT VAL(158)MET polymorphism (1)
- COPD diagnosis (1)
- CORONATINE INSENSITIVE 1 (1)
- COS cell expression (1)
- COU254 (1)
- COVID 19 (1)
- COVID-19 testing (1)
- COVID‐19 vaccination (1)
- COX-2 (1)
- COX2 expression (1)
- CO\(_{2}\) exposure (1)
- CO\(_{2}\) signaling (1)
- CO‐releasing molecules (CORMs) (1)
- CP-690,550 (1)
- CPAF activation (1)
- CPF (1)
- CPFE (1)
- CPG Island (1)
- CPG binding domain (1)
- CRAC (1)
- CRH stimulation test (1)
- CRH1 (1)
- CRISPR (1)
- CRISPR-Cas Systems (1)
- CRISPR-Cas system (1)
- CRISPR-Cas9 (1)
- CRISPRs (1)
- CRKL (1)
- CRLs (1)
- CRPS (1)
- CRY evolution (1)
- CS1 (1)
- CSE4, CENP-A (1)
- CSI (1)
- CT perfusion (1)
- CT, circadian time (1)
- CT-angiography (1)
- CTCAE (1)
- CTGF (1)
- CTLA-4 Antigen (1)
- CTNNB1 (1)
- CTSE (1)
- CUL4-DDB1 ubiquitin ligase (1)
- CVID (1)
- CX3CL1 (1)
- CX5461 (1)
- CXCL10 (1)
- CXCL12-abundant reticular (CAR)-cells (1)
- CXCL13 (1)
- CXCL4 (1)
- CXCL5 (1)
- CXCL7 (1)
- CXCL8 (1)
- CXCL8 (IL-8) (1)
- CXCR2 (1)
- CXCR4-targeting (1)
- CXCR4/SDF-1 (1)
- CXCR7 (1)
- CXorf44 (1)
- CYP induction (1)
- CYP inhibition (1)
- CYP11B enzymes (1)
- CYP1B1 (1)
- CYP24A1 (1)
- CYP2B6 (1)
- CYP2C9 (1)
- CYP3A4 (1)
- CYR61 (1)
- C\(_{60}\) fullerene (1)
- Ca cycling (1)
- Ca2+ (1)
- Ca2+ homeostasis (1)
- Ca2+ ion analysis (1)
- Ca2+ leak (1)
- Ca2+ oscillation (1)
- Ca2+ release activated Ca2+ channel (1)
- Ca2+i handling (1)
- CaMKII (1)
- Ca\(^{2+}\) channels (1)
- Ca\(^{2+}\) indicator (1)
- Ca\(^{2+}\)-Imaging (1)
- Ca\(_{v}\)2.2 (1)
- Cabozantinib (1)
- Caco-2 (1)
- Caco2 cells (1)
- Cadherin (CDH13) (1)
- Cadherin-13 (CDH13) (1)
- Caenorhabditis elegans (C. elegans) (1)
- Calcineurin-NFATsignaling (1)
- Calcium (1)
- Calcium Citrate (1)
- Callyspongia siphonella (1)
- Calu-3 (1)
- Canada (1)
- Canaloplasty (1)
- Cancellous bone (1)
- Cancer Cell (1)
- Cancer models (1)
- Cancer prevention (1)
- Cancer risk factors (1)
- Cancer therapeutic resistance (1)
- Candida (1)
- Candida lusitaniae (1)
- Candida sp. (1)
- Candidate Phylum Poribacteria (1)
- Canis lupus familiaris (1)
- Capicua transcriptional repressor (1)
- Capillaries (1)
- Capsaicin (1)
- Capsaicin receptor (1)
- Caputo fractional derivative (1)
- CarO (1)
- Carabidae (1)
- Carbachol-induced drinking (1)
- Carbene (1)
- Carbon (1)
- Carbon Metabolism (1)
- Carbon Monoxide (1)
- Carbon-11 (1)
- Carcinogen risk Individual susceptibili (1)
- Carcinogenic potency (1)
- Carcinoma (1)
- Carcinoma cells (1)
- Carcinomatosis (1)
- Cardiac autonomic regulation (1)
- Cardiac dysfunction| Brain natriuretic peptide (1)
- Cardiac magnetic resonance imaging (1)
- Cardiac myocyte ; Beta-Receptor ; Muscarinic receptor ; cAMP ; G-protein ; Serum (1)
- Cardiac rehabilitation (1)
- Cardiac resynchronization therapy defibrillator (1)
- Cardiac ventricles (1)
- CardioMEMS™ HF system (1)
- CardioMEMS™ HF-System (1)
- Cardiology (1)
- Cardiomyopathy (1)
- Cardiovascular (1)
- Cardiovascular Magnetic Resonance (1)
- Cardiovascular biology (1)
- Cardiovascular hospitalizations (1)
- Cardiovascular magnetic-resonance (1)
- Cardiovascular risk prediction (1)
- Cardiovascular system (1)
- Care-Arbeit (1)
- Career choice (1)
- Carleson embedding theorem (1)
- Carotid intima-media thickness (CIMT) (1)
- Carotid segment (1)
- Carotid ultrasound (1)
- Carpinus betulus (1)
- Cartilage (1)
- Cartilage regeneration (1)
- Cas9 (1)
- Case report (1)
- Case-Control Studies (1)
- Caspase (1)
- Caspase 3/7 activity (1)
- Caspase-8 activation (1)
- Cataglyphis (1)
- Cataglyphis-fortis (1)
- Catechine (1)
- Catheter Lock Solution (1)
- Catheter-related Bloodstream Infections (CRBSI) (1)
- Cauchy-Born rule (1)
- Caudate nucleus (1)
- Cav2.2 (1)
- Cavity quantum electrodynamics (1)
- Cayley graph (1)
- Cdc48 (1)
- Cdu1 (1)
- Cecropia telenitida (1)
- Celebrity Autobiography (1)
- Cell (1)
- Cell Index (1)
- Cell Motility (1)
- Cell binding (1)
- Cell death and comet assay (1)
- Cell lung canger (1)
- Cell permeability (1)
- Cell replacement therapy (1)
- Cell reprogramming (1)
- Cell signalling (1)
- Cell stainin (1)
- Cell surface (1)
- Cell surface proteomics (1)
- Cell transformation (1)
- Cell viability, (1)
- Cell-based assays (1)
- Cell-line (1)
- Cellular imaging (1)
- Cellular prion protein (1)
- Central complex (1)
- Central hyperactivity (1)
- Central nervous system infection (1)
- Central venous access (1)
- Central venous-pressure (1)
- Centrolenidae (1)
- Ceramide (1)
- Cerebellar nuclei (1)
- Cerebellitis (1)
- Cerebral Ischemia (1)
- Cerebral blood flow (1)
- Cerebral small vessel disease (1)
- Cerebral vasospasm (1)
- Cerebral-ischemia (1)
- Cerebrolysin (1)
- Cervical cancer (1)
- Cestoda (1)
- Cestoda Taeniidae (1)
- Cestode (1)
- ChAT (1)
- ChIP-seq (1)
- ChIP-sequencing (1)
- ChT1 (1)
- Chagas diagnosis (1)
- Chagas monitoring (1)
- Chagas real time PCR (1)
- Chains (1)
- Chambers (1)
- Channelrhodopsin-2 (1)
- Characterization and analytical techniques (1)
- Charcot-Marie-Tooth disease (1)
- Charcot-Marie-Tooth neuropathy 1A (1)
- Charcot–Marie–Tooth disease (1)
- Charcot–Marie–Tooth disease type 1A (1)
- Charged Scalar Field (1)
- Charged aerosol detector (CAD) (1)
- Charged-Particles (1)
- Charm quark (1)
- Charmonia (1)
- Checkpoints (1)
- Chemerin (1)
- Chemerin processing (1)
- Chemical carcinogenesis (1)
- Chemical composition (1)
- Chemical modification (1)
- Chemical nature (1)
- Chemicals (1)
- Chemische Ökologie (1)
- Chemistry (1)
- Chemosensory neurons (1)
- Chemotactic receptors (1)
- Chemotaxis (1)
- Cherenkov detectors (1)
- Cherenkov underwater neutrino telescope (1)
- Chernobyl (1)
- Childhood cancer survivors (1)
- Children-at-Risk (1)
- Childrens-cancer (1)
- Chile (1)
- Chimeric Antigen Receptor T cells (1)
- Chinese family (1)
- Chinese politics (1)
- Chinese state media (1)
- Chl (1)
- ChlaDUB1 (1)
- Chlamydia pneumoniae (1)
- Chlamydiales (1)
- Chlamydomonas reinhardtii (1)
- Chlorophyll fluorescence (1)
- Choice Behavior/physiology (1)
- Choline deficiency (1)
- CholinomiRs (1)
- Chondrogenesis (1)
- Chondrosarcoma (1)
- Chorioamnionitis (1)
- Christianity (1)
- Chromatin and Epigenetics (1)
- Chromatin-remodeling complexes (1)
- Chromophore Assembly (1)
- Chromophores (1)
- Chromosomal instability (1)
- Chromosome aberration (1)
- Chromosome distribution (1)
- Chromosomes (1)
- Chronic Kidney-disease (1)
- Chronic disease (1)
- Chronic heart-failure (1)
- Chronic kidney-disease (1)
- Chronic lymphoblastic leukemia (1)
- Chronic myeloid leukaemia (1)
- Chronic myeloid leukemia (1)
- Chronic neuropathic pain (1)
- Chronic obstrusive pulmonary disease (1)
- Chronic respiratory diseases (1)
- Chronic rhino‑sinusitis (1)
- Chronic stress (1)
- Chrysididae (1)
- Cigarette smoking (1)
- Cimex lectularius (1)
- Circadian rhythms and sleep (1)
- Circinella (1)
- Cis-elements (1)
- Cisterna magna (1)
- Citrus (1)
- Class II antigen blockade (1)
- Claudin2 (1)
- Clay mineralogy (1)
- ClearSight\(^®\) (1)
- Clever Hans Phenomenon (1)
- Climate Change (1)
- Climatic water balance (1)
- Clinical Genetics (1)
- Clinical manifestations (1)
- Clinical practice guidelines (1)
- Clinical prediction rule (1)
- Clinical proteomics (1)
- Clinical remission (1)
- Clinical trials (1)
- Clinical-trials (1)
- Clinically silent stroke (1)
- Clonality (1)
- Clostridioides binary toxins (1)
- Cluster-RCT (1)
- Co (1)
- Co-Crystal Structures of Chili RNA (1)
- Co-option (1)
- CoA (1)
- CoPt (1)
- Coagulation factor IX (1)
- Coahuila (1)
- Cobl domain (1)
- Cocalodinae (1)
- Cochlear duct length (1)
- Cochlear planning software (1)
- Coefficient (1)
- Coffin-Lowry syndrome (1)
- Coffin–Lowry syndrome (1)
- Cognitive (1)
- Cognitive Remediation (1)
- Cognitive Therapy (1)
- Cognitive behavior (1)
- Cognitive control (1)
- Cognitive decline (1)
- Cognitive neuroscience (1)
- Cognitive representation (1)
- Cohort study (1)
- Cold (1)
- Cold War (1)
- Coleoptera: Chrysomelidae (1)
- Collaboration (1)
- Collagen (1)
- Collagen membrane (1)
- Collective effects in quantum optics (1)
- Collicions (1)
- Colloids (1)
- Colonial volvocales chlorophyta (1)
- Colony growth (1)
- Color (1)
- Combination therapy (1)
- Combinatorial Background (1)
- Commercial preparations (1)
- Community-acquired methicillin-resistant Staphylococcus aureus (1)
- Comorbidities (1)
- Comorbidity survey replication (1)
- Complex (1)
- Complex medium (1)
- Complexity (1)
- Components (1)
- Compound 3k (1)
- Compressive Properties (1)
- Computational and Systems Biology (1)
- Computed axial tomography (1)
- Computer modelling (1)
- Computer science (1)
- Computer software (1)
- Computertomographie (1)
- Concealed Information Test (CIT) (1)
- Condensed matter (1)
- Conditioning evidence (1)
- Conditioning regimen (1)
- Conduct disorder (1)
- Cone-beam CT (1)
- Cone-beam computed tomography (1)
- Confidence interval (1)
- Confocal microscopy (1)
- Conformal Field Theory (1)
- Confucianism; East Asia; Traditional Values (1)
- Congo Basin (1)
- Conifers (1)
- Conjugate arc therapy (1)
- Conjugated polymers (1)
- Connective tissue (1)
- Conrad Hilton (1)
- Contaminants (1)
- Context (1)
- Contextual fear (1)
- Contrast-enhanced CT (1)
- Cooperative UAV (1)
- Coordinated Regional Climate Downscaling Experiment (CORDEX)-South Asia (1)
- Copal\(^®\) spacem (1)
- Copaxone® (1)
- Copeptin (1)
- Coptic (1)
- Copy number changes (1)
- Copy number variation (1)
- Corannulene (1)
- Coreidae (1)
- Corneal confocal microscopy (1)
- Coronary artery bypass graft (1)
- Coronary artery disease (1)
- Coronavirus Disease 2019 (1)
- Correlates (1)
- Cortex (1)
- Cortical plasticity (1)
- Corticosteroids (1)
- Corynebacterium urealyticum (1)
- Cosmic-rays (1)
- Cotransporter 2 inhibition (1)
- Couch tracking (1)
- Coulomb interaction (1)
- Coumarin (1)
- Couplings (1)
- Covalent DNA binding (1)
- Covalent binding (1)
- Covalent binding index - Diethylstilbestrol (1)
- Coverage (1)
- Covid19 (1)
- Covid‐19 (1)
- Cox proportional regression analysis (1)
- CpG (1)
- CpG island hypermethylation (1)
- Cranial sutures (1)
- Cranial window (1)
- CreERT2 (1)
- Creatine Kinase (1)
- Crematogaster borneensis (1)
- Crespi effect (1)
- Critically-ill patients (1)
- Crohn disease (1)
- Crohns-disease (1)
- Crohn’s Disease (1)
- Crop seed (1)
- Cross-bridges (1)
- Cross-species analyses (1)
- CrossQuery (1)
- Cruzi (1)
- Cryoelectron Microscopy (1)
- Cryoelectron microscopy (1)
- Cryolesion (1)
- Cryptic species (1)
- Crystalloids (1)
- CsrA (1)
- CubeSat GNSS (1)
- Cultural studies (1)
- Cumulative incidence function (1)
- Curculionidae (1)
- Cuscuta (1)
- Cushing (1)
- Cushing syndrome (1)
- Cushing's (1)
- Cushing's disease (1)
- Cushings syndrome (1)
- Cutaneous hyperemia (1)
- Cutaneous leishmaniasis (1)
- Cutaneous lymphoma (1)
- Cutaneous metastatic Crohn’s disease (1)
- Cvi-0 (1)
- Cx3cr1 (1)
- Cx43 (1)
- CyaA (1)
- Cyclic AMP (1)
- Cyclic GMP (1)
- Cyclic electron transport (1)
- Cyclic nucleotides (1)
- Cyclization (1)
- Cycloaddition (1)
- Cyclobutylcarbinyl sulfonates (1)
- Cyclooxygenase-2 (1)
- Cyclophilin A (1)
- Cyclophosphamide (1)
- Cynoglossus semilaevis (1)
- CysLTR1 (1)
- Cysteine: motif (1)
- Cysteine‐Rich Domain (CRD) (1)
- Cystic-fibriosis (1)
- Cytochrome P 450 pathway (1)
- Cytochrome b5 (1)
- Cytokine GM-CSF (1)
- Cytokine receptors (1)
- Cytoskeleton (1)
- Cytosol (1)
- Cytotoxic (1)
- Cytotoxic T lymphocytes (1)
- Côte d’Ivoire (1)
- D insufficiency (1)
- D serum-levels (1)
- D-amino acid oxidase activator (1)
- D-norm (1)
- D2 receptors (1)
- D313Y genotype (1)
- D4Z4 partial deletion (1)
- D665 (1)
- DAMGO (1)
- DARPA (1)
- DAS28 (1)
- DASA-58 (1)
- DASH (1)
- DAT (1)
- DBH (1)
- DBS biomarkers (1)
- DBS programming (1)
- DBT (1)
- DC gate (1)
- DC vaccination (1)
- DCGAN (1)
- DD, constant darkness (1)
- DECAY (1)
- DEL(5Q) (1)
- DEM (1)
- DES (1)
- DETC (1)
- DEUQUA (1)
- DExD/H-Box RNA helicase (1)
- DFNB32 (1)
- DFNB68 (1)
- DFT+U (1)
- DFT-LDA (1)
- DIA-MS (1)
- DIMBOA (1)
- DIRK method (1)
- DLS and AFM measurements (1)
- DLX5/6 (1)
- DM2 (1)
- DMARD (1)
- DMRT1 (1)
- DNA Binding (1)
- DNA Breaks (1)
- DNA Damage Repair (1)
- DNA adduct . Repair endonuclease (1)
- DNA barcodes (1)
- DNA binching (1)
- DNA catalysis (1)
- DNA complex (1)
- DNA damage repair (1)
- DNA damage response (1)
- DNA double strand breaks (1)
- DNA double-strand break (1)
- DNA electronic transport (1)
- DNA electrophoresis (1)
- DNA fingerprinting (1)
- DNA fragments (1)
- DNA glycosation (1)
- DNA hybridization (1)
- DNA hypermethylation (1)
- DNA immunolocalization (1)
- DNA lang range mapping (1)
- DNA mediated gene transfer (1)
- DNA metabarcoding (1)
- DNA metabolism (1)
- DNA methylation dynamics (1)
- DNA methylferase homolog (1)
- DNA methyltransferase gene (1)
- DNA methyltransferases (1)
- DNA nanotechnology (1)
- DNA origami (1)
- DNA recognition (1)
- DNA recombination (1)
- DNA repair defect (1)
- DNA repair protraction (1)
- DNA repeat expansion (1)
- DNA replication initiation (1)
- DNA sensing (1)
- DNA sequence (1)
- DNA sequences (1)
- DNA sequencing (1)
- DNA structures (1)
- DNA transfection (1)
- DNA traps (1)
- DNA vaccination (1)
- DNA weight (1)
- DNA-based species delimitation (1)
- DNA-binding (1)
- DNA-binding domain (1)
- DNA-binding vesicles (1)
- DNA-damage checkpoint (1)
- DNA-encapsulated silver nanoclusters (1)
- DNA-repair genes (1)
- DNA/RNA binding (1)
- DNMT3A (1)
- DNMT3B (1)
- DNS-Reparatur (1)
- DOACs (1)
- DOPA-responsive-dystonia (1)
- DOT1 (1)
- DOT1B (1)
- DOTA-EB-TATE (1)
- DPF3a (1)
- DPP III enzyme (1)
- DRD2 (1)
- DRD4 (1)
- DSA (1)
- DSB damage (1)
- DSB focus substructure (1)
- DSC (1)
- DSC2 (1)
- DSM (1)
- DSM-5 (1)
- DSM-IV (1)
- DSM-IV disorders (1)
- DT40 cells (1)
- DTI (1)
- DUB inhibitor (1)
- DWI (1)
- DYNC1I1 (1)
- DaTscan (1)
- Damage (1)
- Danio-rerio (1)
- Danish hernia database (1)
- Dara-KDT-P(A)CE (1)
- Dark Factor of Personality (1)
- Dark Matter (1)
- Dark matter (1)
- Dark-matter (1)
- Dark-matter production (1)
- Dasycladales chlorophyta (1)
- Data Fusion (1)
- Data acquisition (1)
- Database searching (1)
- Dauer formation (1)
- Davis gun (1)
- De-novo (1)
- DecaWave (1)
- Decay sequence (1)
- Decays (1)
- Deep Inelastic-scattering (1)
- DeepSqueak (1)
- Deficit/hyperactivity disorder (1)
- Defined burkitts lymphoma (1)
- Deflazacort (1)
- Delayed cerebral infarction (1)
- Delayed ischemic neurological deficit (1)
- Delayed snowmelt (1)
- Delbruck Scattering (1)
- Deletion (1)
- Deletion analysis (1)
- Deliberate practice (1)
- Delphi procedure (1)
- Delta Repertoire (1)
- Democracy Matrix (1)
- Democratic People's Republic of Korea (1)
- Demyelinating peripheral neuropathy (1)
- Dendritic Cells (1)
- Dendritic cell tumor (1)
- Denoising (1)
- Densities (1)
- Densovirus (1)
- Dentate granule cells (1)
- Dentistry (1)
- Deoxyribozyme (1)
- Dependence (1)
- Depression treatment (1)
- Depressive symptomatology (1)
- Der Granatapfelbaum (1)
- Der p 23 (1)
- Dermatologie (1)
- Desert ant navigation (1)
- Design patterns (1)
- Desmoplakin (1)
- Desmoplastic fibroma (1)
- Deterioration (1)
- Deutsche Forschungsgemeinschaft (1)
- Developmental biology (1)
- Devic syndrome (1)
- Devic’s syndrome (1)
- Dextran sulphate (1)
- Diabetes (1)
- Diabetes history (1)
- Diabetic nephropathies (1)
- Diabetic polyneuropathy (1)
- Diabetic-nephropathy (1)
- Diagnostic approach (1)
- Diagnostic radiopharmaceuticals (1)
- Dialogue Board (1)
- Diaphragmatic breathing (1)
- Diarrhea (1)
- Diastocic Dysfunction (1)
- Diborane (1)
- Diboryne (1)
- Dichte (1)
- Dickblattgewächse (1)
- Dickkopf proteins (1)
- Dictyostelium discoideum (1)
- Dictyota (1)
- Dictyotaceae (1)
- Dicyclohexylcarbodiimid (1)
- Diels–Alder reaction (1)
- Dietary process-related contaminants (1)
- Differential Cross-Sections (1)
- Differential GPS (DGPS) (1)
- Differential RNA-sequencing (1)
- Differentiation (1)
- Diffusion tensor imaging (1)
- Digital platforms (1)
- Dihydroboranes (1)
- Diisononyl phthalate (1)
- Diktat (1)
- Dilated Cardiomyopathy with Ataxia (1)
- Dimers (1)
- Dionaea-muscipula ellis (1)
- Dioncophyllaceae (1)
- Dioncophyllaceae leaves (1)
- Dioscorea (1)
- Dipeptidyl-peptidase IV inhibitors (1)
- Diplopia Internuclear ophthalmoplegia (INO) (1)
- Dirac points (1)
- Direct care workers (1)
- Directed Flight (1)
- Disaster response (1)
- Discovery (1)
- Discrete-to-continuum limits (1)
- Disease gene prioritization (1)
- Disease genetics (1)
- Disease network (1)
- Disease prevalence (1)
- Disease progression (1)
- Disease severity (1)
- Disease-modifying therapies (1)
- Disorders (1)
- Distal biceps tendon repair (1)
- Distal outflow trac (1)
- Distinct (1)
- Distress (1)
- Distributed Control (1)
- Diversity (1)
- Division (1)
- Dixon (1)
- Diät (1)
- Dmrt1bY (1)
- Dociostaurus maroccanus (1)
- Doctor (1)
- Domain-specific approach (1)
- Dongting Lake (1)
- Donor lymphocytes (1)
- Donor−acceptor dyads (1)
- Dopaminergic PAM cluster neurons (1)
- Dorsolateral prefrontal cortex (1)
- Dorylinae (1)
- Dose reduction (1)
- Dosimetry (1)
- Double hemorrhage model (1)
- Double sensitization (1)
- Double-Beta Decay (1)
- Double-blind (1)
- Down-regulation (1)
- Doxorubicin (1)
- Draize eye test (1)
- Drinfel’d twists (1)
- Drosha (1)
- Drosophila Antennal Lobe (1)
- Drosophila melanogaster motoneuron (1)
- Drosophila model (1)
- Drosophilia (1)
- Drought (1)
- Drug Therapy, Combination (1)
- Drug allergy (1)
- Drug delivery (1)
- Drug discovery (1)
- Drug metabolism (1)
- Drug reaction (1)
- Drug-free remission (1)
- Dsg2 (1)
- Dual 3'seq (1)
- Dual-PAM-100 (1)
- Duchenne dystrphy (1)
- Dufours gland (1)
- Dunce isoforms (1)
- Durchflusscytometrie (1)
- Dynamic Causal Modeling (1)
- Dynamic stopping (1)
- Dynamical Supersymmetry Breaking (1)
- Dyson orbitals (1)
- Dystonia (1)
- Dünndarm (1)
- E(+)E(-) collicions (1)
- E-H bond activation (1)
- E. coli (1)
- E. coli atp operon (1)
- E. coli hemolysin (1)
- E. coli virulence (1)
- E/e’ (1)
- E1 (1)
- E2 conjugating enzyme (1)
- E3 14.7-kilodalton protein (1)
- E3 enzyme (1)
- E3 ligase (1)
- E3 ligating enzyme (1)
- E3 ubiquitin ligase (1)
- EAHP/SH bone marrow workshop (1)
- EANM (1)
- EANM dosage card (1)
- EAU guidelines (1)
- EBER in situ hybridization (1)
- EBM (1)
- EBRT (1)
- ECG (1)
- ECG-recording (1)
- ECM coating (1)
- ECM remodeling (1)
- ECORN-CF Projekt (1)
- ED2 (1)
- EDS (1)
- EDX spectra (1)
- EEA (1)
- EEG data (1)
- EEG frequency band analysis (1)
- EEG preprocessing (1)
- EEG processing (1)
- EEG/ERP (1)
- EEOS (1)
- EGF (1)
- EGF receptor (1)
- EGR1 (1)
- EHS classification (1)
- EHT (1)
- EHT1864 (1)
- EIP on AHA (1)
- EJMA-D-19-00287 (1)
- EMMA (1)
- EMMPRIN (1)
- ENV (1)
- ENVISAT ASAR WSM (1)
- EO data (1)
- EORTC-BN20 (1)
- EORTC-QLQ-C15-PAL (1)
- EP Procedures (1)
- EPM (1)
- EPR (1)
- EQ-5D (1)
- ER Ca2+ imaging (1)
- ER Ca2+ store (1)
- ER signaling (1)
- ER stress (1)
- ER-Stress (1)
- ERBB receptors (1)
- ERCC1-XPF (1)
- ERCC4 (1)
- ERG (1)
- ERI (1)
- ERK map kinease (1)
- ERK signaling (1)
- ERK signaling cascade (1)
- ERM proteins (1)
- ERP-BCI (1)
- ERPS (1)
- ERPs (1)
- ERPs (Event-Related Potentials) (1)
- ERT (1)
- ESAT‐6‐like secretion system (1)
- ESBL (1)
- ESC (1)
- ESCAlife (1)
- ESM (1)
- ESPED (1)
- ESTARFM (1)
- ESTARFM framework (1)
- ETR (1)
- EU (1)
- EU member states (1)
- EU-RHAB registry (1)
- EULAR guidelines (1)
- EUROASPIRE survey (1)
- EU‐RHAB Registry (1)
- EVER1 (1)
- EVER2 (1)
- EVI (1)
- EVT (1)
- EVs (1)
- EWAS (1)
- EZH1 (1)
- EZH2 differentiation trichostatin (1)
- Early posterior negativity (1)
- Eating disorder (1)
- Eccentricities (1)
- Ecological momentary assessment (1)
- Ecologically important traits (1)
- Ecosystem services (1)
- Ectopic bone formation (1)
- Edema (1)
- Edema formation (1)
- Edmund Husserl (1)
- Effective dose (1)
- Effectors in plant pathology (1)
- Efflux transport (1)
- Egfr (1)
- Ehlers-Danlos syndrome (1)
- Eigenvectors (1)
- Einfluss (1)
- El Escorial (1)
- El Niño (1)
- Elbow (1)
- Elbow joint (1)
- Elderly patients (1)
- Elective cesarean-section (1)
- Electric Field (1)
- Electrical breakdown (1)
- Electrical impedance tomography (1)
- Electrochemistry (1)
- Electroencephalography (1)
- Electron (1)
- Electron Microscopy (1)
- Electron demand in ditosylates (1)
- Electron transfer (1)
- Electrophiles (1)
- Electrophysiology (1)
- Electroweak Measurements (1)
- Electroweak Phase-Transition (1)
- Elektronisches Publizieren (1)
- Elissen-Palm flux (1)
- Elite Rowers (1)
- Ellenbogengelenk (1)
- Embolism resistance (1)
- Embryo (1)
- Embryonic induction (1)
- Embryonic stem cell (1)
- Embryos (1)
- Emergence (1)
- Emery-Dreifuss muscular dystrophy (1)
- Emission (1)
- Emodin (1)
- Emotion (1)
- Emotional behavior (1)
- Emotional expression (1)
- Emotional labor (1)
- Emotionality (1)
- Emotionsregulation (1)
- EndoVAC and small bowel (1)
- Endogenous genotoxicity (1)
- Endogenous opioids (1)
- Endoplasmic-Reticulum Stress (1)
- Endothelial growth-factor (1)
- Endothelzelle (1)
- Energies (1)
- Energy depletion (1)
- Energy transfer (1)
- England (1)
- English version (1)
- Enhancer (1)
- Enhancer elements (1)
- Enoxaparin (1)
- Enrichment analysis (1)
- Enrique Gaspar y Rimbau (1)
- Enteric nervous system (1)
- Enteric neuropathies (1)
- Enterica serovar typhimurium (1)
- Enterococcus faecalis (1)
- Enterococcus faecium (1)
- Enterovirus (1)
- Entomology (1)
- Entwicklung (1)
- Environmental enrichment (1)
- Environmental impact (1)
- Environmental isolate (1)
- Envisat (1)
- Enzyme Regulation (1)
- Enzyme immunoassay (1)
- Enzyme kinetics (1)
- Enzyme metabolism (1)
- Enzyme regulation (1)
- Enzyme-Linked Immunospot assay (ELISPOT) (1)
- Enzyme‐Linked Immunosorbent Assay (1)
- EpCAM (1)
- Epicardium-derived cells (1)
- Epichloë spp. (1)
- Epidemiological study (1)
- Epidermal growth-factor (1)
- Epidermaler Wachstumsfaktor-Rezeptor (1)
- Epidermis (1)
- Epidural Analgesia (1)
- Epigenesis (1)
- Epigenetic (1)
- Epigenetic regulation (1)
- Epigenetics (1)
- Epilepsy (1)
- Episkin (1)
- Epitaxy (1)
- Eplerenone (1)
- Epoxide hydrolase (1)
- Epstein-Barr virus (1)
- Epstein-Barr virus-induced gene 2 (1)
- Epstein-Barr-virus (1)
- Equipment (1)
- Erbendorf (1)
- Erigone atra (1)
- Eriodictyon californicum (1)
- Erwachsener (1)
- Erwinia amylovora (1)
- EsaA (1)
- Escberichia coli (1)
- Escherichia coli AlkA (1)
- Escherichia coli K1 (1)
- Escherichia coli infections (1)
- Escherichia coli-Hfq (1)
- Escherichia coli-derived recombinant human bone morphogenetic protein-2 (1)
- Escherichia-coli K-12 (1)
- Ester (1)
- Estivation (1)
- Estrone (1)
- Ethanol (1)
- Ethionine (1)
- Ethiopia (1)
- Eukaryoten (1)
- Eukaryotic cell (1)
- Eulen <Schmetterlinge> (1)
- Euler system (1)
- Euler–Bernoulli damped beam (1)
- Eulophidae (1)
- EuroQol Five Dimension Five Level Scale (EQ-5D-5L) (1)
- European Innovation Partnership on Active and Healthy Ageing (1)
- European Property Law (1)
- European Society (1)
- European Spanish (1)
- European countries (1)
- European experience (1)
- European experts (1)
- European foulbrood (1)
- European group (1)
- European orchard bee (Osmia cornuta) (1)
- Evans syndrome (1)
- Event (1)
- Event builder (1)
- Evoked potentials (1)
- Evolutionary developmental biology (1)
- Evolutionary emergence (1)
- Exacerbation (1)
- Examensklausur (1)
- Examination (1)
- Excision (1)
- Excited states (1)
- Exciton-polariton condensate (1)
- Excitons (1)
- Exercise (1)
- Exercise intervention (1)
- Exons (1)
- Exosome (1)
- Exotic mesons (1)
- Exotics (1)
- Expected MOS (1)
- Expected QoE (1)
- Experimental brain trauma (1)
- Experimental intracerebral hemorrhage (1)
- Experimental stroke (1)
- Experimental study (1)
- Expert chess players (1)
- Explorative analyses (1)
- Exposure therapy (1)
- Expresses genes (1)
- Expression of mood states (1)
- Extended field irradiation (1)
- Extensions of Higgs sector (1)
- External exposure assessment (1)
- Extra-anatomical (1)
- Extracellular domain (1)
- Extracellular matrix (1)
- Extracellular volume (1)
- Extracorporeal Membrane Oxygenation (1)
- Extracorporeal membrane oxygenation (1)
- Extramedullary disease (1)
- Extraocular eye muscles (1)
- Extreme flows (1)
- Exziton (1)
- Eye Movement Modeling Examples (1)
- Eye Movements/physiology (1)
- Eye development (1)
- Eye gaze (1)
- Eyjafjallajökull 2010 (1)
- E−X bond activation (1)
- F-18-FDG PET (1)
- F-18-FDG PET/CT (1)
- F-19 MRI (1)
- F1 (1)
- FADD (1)
- FADS (1)
- FAIR (1)
- FAM104A (1)
- FAM104B (1)
- FANCA (1)
- FANCD2 (1)
- FANCM (1)
- FANCP (1)
- FAP (1)
- FAPI PET/CT (1)
- FARS1 (1)
- FAS (1)
- FBXW7 (1)
- FCS (1)
- FDG-PET (1)
- FDG-PET/MRI (1)
- FDM (1)
- FE (1)
- FFPE (1)
- FGF (1)
- FGF/FGFR signalling (1)
- FGF21 (1)
- FGFR signaling (1)
- FGFR-inhibitors (1)
- FIB-SEM (1)
- FINCA (1)
- FISH-CLEM (1)
- FL spectroscopy (1)
- FLIMbee (1)
- FLJ14775 (1)
- FLJ20434 (1)
- FLS2 receptor (1)
- FLT-PET (1)
- FMR1 (1)
- FMR2 (1)
- FNIRS (1)
- FOLFIRI (1)
- FOLFOX (1)
- FOSMN (1)
- FP-CIT SPECT (1)
- FPG protein (1)
- FRET (1)
- FRET sensors (1)
- FRG (1)
- FRG calculations (1)
- FRN (1)
- FT-IR spectroscopy (1)
- FTY720 (1)
- FTY720-P (1)
- FV45 (1)
- FWGE (1)
- FXII (1)
- FXIIa inhibitor rHA-Infestin (1)
- FXR1 (1)
- FXR2 (1)
- Fabaceae (1)
- Fabry Disease (FD) (1)
- Fabry cardiomyopathy (1)
- Fabry patient (1)
- Faces and scenes (1)
- Facial Nerve Transection (1)
- Facial expression (1)
- Facial nerve palsy (1)
- Factor gene PRPF31 (1)
- Factor messenger-RNA (1)
- Factor sigma(B) (1)
- Factor-alpha (1)
- Fagus orientalis (1)
- Fak regulation (1)
- Faktor (1)
- False Vacuum (1)
- False positive reactions (1)
- Familial Alzheimers-disease (1)
- Familial Beckwith-Wiedemann syndrome (1)
- Family (1)
- Family Investigation of Nephropathy and Diabetes (1)
- Fanconi Anemia (1)
- Fanconi anaemia (1)
- Fanconi anemia (1)
- Fanconi-Anämie (1)
- Fanconi-anemia subtype (1)
- FasL (1)
- Fascia transversalis (1)
- Fatigue (1)
- Fats (1)
- Fatty acids (1)
- Fbw7 (1)
- Fc-receptor (1)
- FcγR receptor (1)
- FeS proteins (1)
- Fear (1)
- Fear conditioning (1)
- Fehleridentifikation (1)
- Female patients (1)
- Feminisation (1)
- Femoral vein (1)
- Femtosecond Mid-Infrared Study (1)
- Fermi liquid (1)
- Fernerkundung (1)
- Ferrite (1)
- Fetal brain development (1)
- Fettgehalt (1)
- Fettsucht (1)
- Fgf-signalling (1)
- Fibrin glue (1)
- Fibroblast Growth Factor (1)
- Fibroblast Growth Factor-21 (1)
- Fibromyalgia (1)
- Fibromyalgie (1)
- Ficaria ambigua (1)
- Ficaria calthifolia (1)
- Ficaria verna (1)
- Field sting (1)
- Fiels-effect transistors (1)
- Fifth Dynasty (1)
- Filial piety/xiao (1)
- Fimbria (1)
- Fimbriae (1)
- FinO family (1)
- First G-APD Cherenkov Telescope (1)
- Fische (1)
- Fischer 344 rats (1)
- Fisher Z-score transformation (1)
- Fitbit Sense (1)
- Fks1 (1)
- Flagellum (1)
- Flash relaxation kinetics (1)
- Flavonoids (1)
- Flavor Violation (1)
- Flavour changing neutral currents (1)
- Flexor tendon repair (1)
- Flowering (1)
- Flowering plants (1)
- Flowers (1)
- Flt3L (1)
- Fludarabine (1)
- Fludarabine-treosulfan (FT) (1)
- FluidFM technology (1)
- Fluorescein angiography (1)
- Fluorescence Microscopy (1)
- Fluorescence and Crosslinking (1)
- Fluorescence in situ hybridization (1)
- Fluorescence microscopy (1)
- Fluorescence resonance energy transfer (1)
- Fluoreszenzresonanz-Energietransfer (1)
- Fluoro(perfluoroalkyl) phosphoranes (1)
- Fluorogenic RNA Aptamers (1)
- Fluorouracil (1)
- Flussufer (1)
- Foamy virus (1)
- Foc protein (1)
- Follicular lymphoma (1)
- Follow-up (1)
- Fontan’s Operation (1)
- Food Carvings Questionnaire (1)
- Food Cravings Questionnaires (1)
- Food craving (1)
- Foragers (1)
- Foraging behaviour (1)
- Forces (1)
- Forecasting (1)
- Forensische Anthropologie (1)
- Forensische Osteologie (1)
- Forests (1)
- FormCalc8 (1)
- Fortran code (1)
- Fourier-transform spectroscopy (1)
- Fourthcorner analysis (1)
- FoxO3 (1)
- FoxP3 Expression (1)
- FoxQ2 (1)
- Frabin/Fgd4 (1)
- Fractional cover analysis (1)
- Fragmentation (1)
- Fragmentierung (1)
- Frame-based (1)
- Frame-less (1)
- Framingham (1)
- Fraser syndrome (1)
- Fraxinus excelsior (1)
- Freeze-etching (1)
- Fremdsprachenlernen (1)
- Fremdsprachenunterricht (1)
- French-Canadian patients (1)
- Frequency (1)
- Frequency-response areas (1)
- Fresh Freeze Plasma (1)
- Frontal cortex (1)
- Fruits (1)
- Frustrated Lewis Pairs (1)
- Ftsz (1)
- Fulgurite (1)
- Full body ownership illusion (1)
- Function knowledge (1)
- Functional diversity (1)
- Functional magnetic resonance imaging (1)
- Functional modules (1)
- Functional nucleic acids (1)
- Functionalization (1)
- Fungal (1)
- Fungal cell-walls (1)
- Fungal host response (1)
- Fungal traits (1)
- Fungiplex Candida Auris (1)
- Fungus (1)
- Fusarium fujikuroi (1)
- Förster Resonance Energy Transfer (1)
- Förster resonance energy transfer (1)
- G Protein (1)
- G protein coupled receptor (GPCR) (1)
- G protein coupled receptors (1)
- G protein-coupled receptor (1)
- G-2 (1)
- G-protein coupled receptor (1)
- G-protein coupled receptors (1)
- G-protein-coupled receptor (1)
- G-protein-coupled receptors (1)
- G-quadruplex motifs (1)
- G3BP (1)
- GAAS (1)
- GABA(A) receptors (1)
- GABA-A receptor (1)
- GABA-receptor complex (1)
- GABAA (1)
- GABAB receptor agonists (1)
- GABA\(_A\) (1)
- GABA\(_{A}\) (1)
- GABA\(_{A}\) receptor (1)
- GABA\(_{A}\) receptors (1)
- GABA\(_{B}\) (1)
- GABAergic neurons (1)
- GABBR1 (1)
- GABP (1)
- GAD1 (1)
- GAG (1)
- GAMMA (1)
- GAN (1)
- GAP (1)
- GATA-3 (1)
- GA\(^2\)LEN (1)
- GBM (1)
- GBR (1)
- GBS (1)
- GC-Content (1)
- GCA (1)
- GCC (1)
- GCH1 (1)
- GDNF (1)
- GDNF5 (1)
- GEDI (1)
- GFAP-astrocytopathies (1)
- GFP (1)
- GH response (1)
- GHQ-28 (1)
- GI (1)
- GI-101A tumor xenografts (1)
- GIS-analysis (1)
- GIST (1)
- GLA mutation (1)
- GLA protein UCMGP (1)
- GLDN variant (1)
- GLP-1 (1)
- GLUT1 (1)
- GLUT4 (1)
- GLUT5 (1)
- GLUTs (1)
- GLV-1 h153 (1)
- GM (1)
- GM-CSF (1)
- GMP (1)
- GMPcGMP-dependent protein kinase I (1)
- GMSB model (1)
- GNA11 (1)
- GNAQ (1)
- GNSS/INS integrated navigation (1)
- GO1 (1)
- GOLD (1)
- GP41 cytoplasmic tail (1)
- GPCRs (1)
- GPI-anchor (1)
- GPS (1)
- GPS Reciever (1)
- GPS tracking (1)
- GPVI shedding (1)
- GPX4 (1)
- GRAID (1)
- GRAPPA (1)
- GRN (1)
- GRO alpha (1)
- GRP78 (1)
- GSK-3β (1)
- GSK3 (1)
- GSTP1 (1)
- GSV (1)
- GTL2 (1)
- GUT (1)
- GUT-directed hypnotherapy (1)
- GVL (1)
- Ga-68 (1)
- GaAs (1)
- GaAsSb (1)
- GagPol fusion protein (1)
- Galactic Ridge (1)
- Galactic sources (1)
- Galactosidase-A gene (1)
- Galectin-1 (1)
- Gallium (1)
- Gamma-convergence (1)
- Gamma-ray bursts (1)
- Gamsberg (1)
- Ganglia (1)
- Ganglia (rat) (1)
- GapN (1)
- Garcinia biflavonoids (1)
- Garmin Fenix 6 Pro (1)
- Gaseous detectors (1)
- Gastric carcinogenesis (1)
- Gastroenteritis (1)
- Gastrointestinal (1)
- Gauge bosons (1)
- Gauge-dependent Quantity (1)
- Gaze behavior (1)
- Gaze perception (1)
- Gb3 and lyso-Gb3 biomarkers (1)
- Gecko (1)
- Gedächtnis (1)
- Gefäßpflanzen (1)
- Geitonogamy (1)
- Gelenkinstabilität (1)
- Gender (1)
- Gene Regulation (1)
- Gene Transfer (1)
- Gene duplication (1)
- Gene expression (1)
- Gene expression analysis (1)
- Gene expression profiling (1)
- Gene expression vectors (1)
- Gene mapping (1)
- Gene sets (1)
- Gene silencing (1)
- Gene therapy (1)
- Gene transfer (1)
- Gene-transfer (1)
- General anaesthesia (1)
- General-population (1)
- Generation (1)
- Generic questionnaire (1)
- Genetic (1)
- Genetic causes of cancer (1)
- Genetic instability (1)
- Genetics (1)
- Genitoanal region (1)
- Genom (1)
- Genom / Genkartierung / Genanalyse (1)
- Genome analysis (1)
- Genome assembly (1)
- Genome comparison (1)
- Genome evolution (1)
- Genome re-annotation (1)
- Genome wide analysis (1)
- Genome-wide association studies (1)
- Genomic profile (1)
- Genomics (1)
- Genomics data sets (1)
- Genotype (1)
- Genotype-phenotype association (1)
- Genotype–phenotype correlations (1)
- Gentransfer (1)
- Georgre Orwell (1)
- Geriatric care (1)
- Geriatrics (1)
- German Research Foundation (1)
- German Stroke Registers Study Group (1)
- German healthcare system (1)
- German population (1)
- German translation (1)
- German/French/Italian (1)
- Germanium (1)
- Germanium telluride (1)
- Germination (1)
- Germinative cell (1)
- Germline (1)
- Germylenes (1)
- Gerontologie (1)
- Geruch (1)
- Geschlechtsbestimmung (1)
- Getz Ice Shelf (1)
- Gewebe (1)
- Ghana (1)
- Giant cell arteritis (GCA (1)
- GibS (1)
- Gibbs activation energy (1)
- Gifsy-1 (1)
- Gimbaled tracking (1)
- Gland (1)
- Gleason score (1)
- Gletscher (1)
- Glial fibrillary acidic protein (1)
- Glioblastom (1)
- Glioblastoma cell line (1)
- Glioblastoma multiforme (1)
- Glioblastomas (1)
- Glioma stem cells (1)
- GlobALS (1)
- Global Ecosystem Dynamics Investigation (1)
- Global Navigation Satellite System (GNSS) (1)
- Global Positioning System (GPS) (1)
- Globotriaosylceramide (1)
- Glomerular filtration (1)
- Glomerular-filtration-rate (1)
- Glucagon (1)
- Glucose metabolism (1)
- Glucose transport (1)
- Glucose uptake (1)
- Glucosetransportproteine (1)
- Glucosyltransferase (1)
- Gluon (1)
- Gluon Fusion (1)
- Glut1DS (1)
- Glutamate-induced excitotoxicity (1)
- Glutamate-receptor (1)
- Glutamatergic synapses (1)
- Glutamic-acid decarboxylase anxiety (1)
- Glutathione Stransferase (1)
- GlyR receptors (1)
- GlyRs (1)
- Glycaemic control (1)
- Glycosyltransferase (1)
- Goldbrasse (1)
- Golgi apparatus (1)
- Good Practices (1)
- Good-or-Better (GoB) (1)
- Google Earth (1)
- Google Earth Engine (GEE) (1)
- Government research funding (1)
- Gradient boosted trees (GBT) (1)
- Gradients (1)
- Graft versus Tumor (1)
- Graft-versus-host disease (1)
- Graft-versus-leukemia (1)
- Gram points (1)
- Gram’s law (1)
- Granular layer (1)
- Graph eigenvalues (1)
- Graph products (1)
- Graphene nanoribbons (1)
- Graphnullity (1)
- Graptolithoidea (1)
- Grasses (1)
- Graves disease (1)
- Grave’s disease (1)
- Gravitons (1)
- Graßmannians (1)
- Grebe dysplasia (1)
- Green's function (1)
- Greenland (1)
- Greenland ice sheet (1)
- Green’s functions (1)
- Grenzflächenaktiver Stoff (1)
- Grippe (1)
- Groin infection (1)
- Group dynamics (1)
- Growth-factor receptor (1)
- Growth; BMP-2 (1)
- Gruppo-italiano (1)
- Guanylyl cyclase-A (1)
- Guideline (1)
- Guillain-Barré syndrome (1)
- Guillain-Barré-Syndrom (1)
- Guinea pig model (1)
- Guinean rain forest (1)
- Guinier-Preston zones (1)
- Göttingen (1)
- Gα\(_{i1}\), Gα\(_{i2}\) and Gα\(_{i3}\) activation (1)
- H+-atpase (1)
- H-infinity (1)
- H3K27me3 (1)
- H441 (1)
- H7N9 influenza virus (1)
- HA modifiedCNF membranes (1)
- HAND (1)
- HAQ (1)
- HB-EGF (1)
- HBO (1)
- HCMV infection (1)
- HCV (1)
- HCV cure (1)
- HCV genotype 2 (1)
- HCV genotype-2 (1)
- HCV infection (1)
- HCW (1)
- HD (1)
- HDAC (1)
- HDBSCAN (1)
- HE-3 diffusion MRI (1)
- HECT (1)
- HECT Ligase (1)
- HEK cells (1)
- HEMA (1)
- HER2 (1)
- HER2 conversion (1)
- HER2 targeted therapy (1)
- HER2-low (1)
- HERV-K (1)
- HES (1)
- HEV (1)
- HEY repressors (1)
- HFmrEF (1)
- HFrEF (1)
- HGPS (1)
- HHV-6 (1)
- HHblits (1)
- HIGGS (1)
- HIP osteoarthritis (1)
- HIV diagnosis and management (1)
- HIV infection (1)
- HIV infections (1)
- HIV neurocognitive impairment (1)
- HIV-1 protease (1)
- HIV-1 subtype AG (1)
- HIV-1-infected patients (1)
- HIV-1-infected subjects (1)
- HIV-1; subtype C; proviral plasmid; viral replication; resistance assays; Vpu; CD317; CD4 (1)
- HIV-Infektion (1)
- HIV-infected patients (1)
- HKT1 (1)
- HLA (1)
- HLA antigens (1)
- HLA class II (1)
- HLA class ll (1)
- HLA peptidome (1)
- HLA-E matching (1)
- HLA-G gene (1)
- HMD (Head-Mounted Display) (1)
- HMDP hydroxymethylene diphosphonate (1)
- HMG-Proteine (1)
- HMGB1 (1)
- HNSC (1)
- HPLC-MS/MS method (1)
- HPLC/UPLC methods (1)
- HPLC–MS (1)
- HPc (1)
- HPβCD (1)
- HRAS (1)
- HRMS (1)
- HRQL (1)
- HRQOL (1)
- HRTEM (1)
- HRV (1)
- HSAB principle (1)
- HSTC outcome (1)
- HT-29 colon carcinoma cells (1)
- HT29 cells (1)
- HTLV-I (1)
- HTTP adaptive video streaming (1)
- HaCaT cells (1)
- Habitats (1)
- Hadron Collider (1)
- Hadron Hadron scattering (experiments) (1)
- Hadron-Hadron Scattering (1)
- Hadron-hadron interactions (1)
- Haematogenous (1)
- Haematology (1)
- Haemodialysis (1)
- Haemolysin (1)
- Haftung (1)
- Halbleiter (1)
- Halictidae (1)
- Hall effect (1)
- Halobacterium halobium (1)
- Haloferax volcanii (1)
- Halothane (1)
- Hamman's syndrome (1)
- Hans algorithm (1)
- Haploidentical (1)
- Harnwegsinfekt (1)
- Harold Garnet Callan (1)
- Hautflügler (1)
- Hautkrebs (1)
- Hautus test (1)
- Hazards (1)
- Head (1)
- Head and neck cancer (1)
- Head and neck cancers (1)
- Head-injury (1)
- Health (1)
- Health care service research (1)
- Health promotion (1)
- Health-determinants (1)
- Healthcare Cost (1)
- Healthcare Economics (1)
- Healthcare research (1)
- Hearing loss (1)
- Hearing-loss (1)
- Heart failure with preserved ejection fraction (1)
- Heart failure with reduced ejection fraction (1)
- Heart rate (1)
- Heart rate variability (1)
- Heat Hyperalgesia (1)
- Heat Wave Magnitude Index (HWMI) (1)
- Heavy-Particles (1)
- Hecke L-functions (1)
- Hecke eigenforms (1)
- Hegyi competition index (1)
- Hela Cells (1)
- Helicobacterpylori (1)
- Hemagglutination inhibition (1)
- Hematopoietic Stem (1)
- Hematopoietic cell transplant (1)
- Hematopoietic stem cell transplantation (1)
- Heme-regulated inhibitor (1)
- Hemipelvectomy (1)
- Hemodialysis-patients (1)
- Hemodynamic depression (1)
- Hemoglobin A1C (1)
- Hemolysin excretion (1)
- Hemorrhage (1)
- Hemospermia (1)
- Heparan-sulfate (1)
- Heparin (1)
- Hepatitis B Virus (1)
- Hepatitis B virus (1)
- Hepatitis B virus reactivation (1)
- Hepatitis C (1)
- Hepatitis C infection (1)
- Hepatitis E (1)
- Herbivory (1)
- Hereditary breast cancer (1)
- Herodotus (1)
- Herpes (1)
- Herpes simplex encephalitis (1)
- Herpes simplex virus (1)
- Herzthoraxchirurgie (1)
- Hesse (1)
- Heterocyclen (1)
- Heterocyclische Verbindungen (1)
- Heteroptera (1)
- Heubacillus (1)
- HeuristicsMiner algorithm (1)
- Hexadehydro-Diels-Alder (1)
- Hexahydro-difenidol (1)
- Hexahydro-difenidol analogues (1)
- Hexahydro-procyclidine (1)
- Hexbutinol (1)
- Hexocyclium/sila-hexocyclium derivatives (1)
- Hg1-xCdxTe (1)
- HgTe (1)
- HiGHmed (1)
- Hibernation (1)
- Hickman catheter (1)
- Hierarchy problem (1)
- Higgs Boson (1)
- Higgs Mass (1)
- Higgs boson decays (1)
- Higgs boson mass (1)
- Higgs boson signal (1)
- Higgs-boson (1)
- Higgy-Boson (1)
- High efficiency (1)
- High fat diet (1)
- High grade glioma (1)
- High mobility group (1)
- High performance (1)
- High-Energies (1)
- High-Frequency Ventilation (1)
- High-dose chemotherapy (1)
- High-energy jets (1)
- High-fat diet (1)
- High-jump photographs (1)
- High-performance liquid chromatography (HPLC) (1)
- High-resolution (1)
- High-spontaneous rate (1)
- High-throughput data (1)
- High-throughput screening (1)
- Higher rates (1)
- Highlights Lecture (1)
- Hill's powers (1)
- Himalaya Karakoram (1)
- Hindbrain (1)
- Hip joint (1)
- Hippocampus (1)
- Hirnhautentzündung (1)
- Hirschsprung disease liability (1)
- Histologic grade (1)
- Histone deacetylase (1)
- Histone deacetylase inhibition (1)
- Histone gamma H2AX (1)
- Hittitology (1)
- Hodgkin-lymphoma (1)
- Hoechst 33258 dye (1)
- Hoechst 33342 (1)
- Hoffa (1)
- Holliday junction reolvass (1)
- Holocene (1)
- Holography and condensed matter physics (AdS/CMT) (1)
- Holozän (1)
- Home monitoring (1)
- Homebox gene (1)
- Homeostatic plasticity (1)
- Homoarginine (1)
- Homology (1)
- Homoptera aphididae (1)
- Homotopy Continuation Method (1)
- Honey bee (1)
- Honey bees (1)
- Honey-bees (1)
- Honeybee (1)
- Hordeum vulgare (1)
- Horizontal transfer (1)
- Hormesis (1)
- Horowitz Quotient (1)
- Hospital emergency plan (1)
- Hospital water system (1)
- Hospitalisation (1)
- Host adaptation (1)
- Host cells (1)
- Host-pathogen interactions (1)
- Hotel (1)
- Htr1a (1)
- Htr2a (1)
- Htr2c (1)
- Hubbard model (1)
- Hubbard-model (1)
- Hueter interval (1)
- Human (1)
- Human CDH13 (1)
- Human Knee (1)
- Human Medial Meniscus (1)
- Human Muse Cells (1)
- Human Physiome (1)
- Human Resource Management (1)
- Human Sodium/Iodide symporter (1)
- Human and murine cancer cells (1)
- Human atrial stromal cells (1)
- Human endogenous retrovirus (1)
- Human entorhinal area (1)
- Human foamy virus bel-l transactivator; Expression in insect cells (1)
- Human genome (1)
- Human immunodefiency virus (1)
- Human lung-cancer (1)
- Human platelets (1)
- Human prefrontal cortex (1)
- Human-immunodeficiency-virus (1)
- Hunsrueck (1)
- Huntington's disease . Human cerebral cortex (1)
- Hurst Exponent (1)
- Hurwitz zeta function (1)
- Hybridisierung <Biologie> (1)
- Hybridoma (1)
- Hydraulic conductivity (1)
- Hydraulic plasticity (1)
- Hydroarylation (1)
- Hydrogen-deuterium (1)
- Hydrogen-peroxide (1)
- Hydroxymethyluracil (1)
- Hymenoptera venom (1)
- Hyperalgesia (1)
- Hypercortisolism (1)
- Hyperfine coupling constants (1)
- Hyperkalaemia (1)
- Hyperkalemia (1)
- Hyperolius viridiflavus (1)
- Hyperosmotic Stress (1)
- Hypersensitivity (1)
- Hypertonic (1)
- Hypertonic saline 7.5-percent (1)
- Hypertrophic cardiomyopathy (1)
- Hypertrophic pyloric-stenosis (1)
- Hypertrophy (1)
- Hypnales (1)
- Hypopharyngeal glands (1)
- Hypophosphatasia (1)
- Hypothetical particle physics models (1)
- Hypoxia (1)
- Hyrcanian forest (1)
- Hyrtios (1)
- Hämolysin (1)
- I-lactate (1)
- IA (1)
- IABP (1)
- IACS (1)
- IARS2 (1)
- IBA-1 (1)
- ICD (1)
- ICD-10 (1)
- ICD-CRT (1)
- ICD-coding of CKD (1)
- ICEP (1)
- ICF (1)
- ICF2 (1)
- ICL (1)
- ICM (1)
- ICM cells (1)
- ICP27 (1)
- ICP4 (1)
- ICRS (1)
- ICSI (1)
- ICT (1)
- ICU staff (1)
- ICU treatment (1)
- IDH (1)
- IDH1/2 (1)
- IDO-1 (1)
- IDSA (1)
- IFN (1)
- IFN-gamma (1)
- IFN-γ ELISpot (1)
- IFNG (1)
- IGF-I (1)
- IGF1 (1)
- IGF2-H19 (1)
- IGFBP2 (1)
- II citrullinemia (1)
- II type-2 receptor (1)
- II-VI semiconductor (1)
- III adenylyl cyclases (1)
- III secretion (1)
- III secretion system (1)
- III–V quantum dot (1)
- III–V semiconductor devices (1)
- IL-1 beta (1)
- IL-1 blockade (1)
- IL-10 expression (1)
- IL-12 family (1)
- IL-12 production (1)
- IL-12B (1)
- IL-12p40 (1)
- IL-15 (1)
- IL-17A-inhibition (1)
- IL-1ß (1)
- IL-22 binding protein isoform (1)
- IL-4 antagonists (1)
- IL-4-receptor (1)
- IL-5 (1)
- IL-7 (1)
- IL12B (1)
- IL1RA (1)
- IL2 branching (1)
- IL22RA2 (1)
- IL28B (1)
- IL28B polymorphisms (1)
- IL6 (1)
- IL‐10 (1)
- IL‐1β (1)
- IMA2.1 (1)
- IMD (1)
- IMR-90 (1)
- IMSI (1)
- IMpACT (1)
- INR rebound (1)
- INS/LIDAR integrated navigation (1)
- IP3 (1)
- IPND criteria (1)
- IRF4 (1)
- IS education (1)
- ISBI (1)
- ISS (1)
- IT security (1)
- IVF-methods (1)
- IVIg (1)
- Ibrutinib (1)
- Ibuprofen (1)
- IcaR (1)
- Icecube (1)
- Icosanoid (1)
- IctP (1)
- Identifizierung (1)
- Ifn-gamma (1)
- IgE sensitazion (1)
- IgG glycosylation (1)
- Ighmbp2 (1)
- Ileal Crohns-disease (1)
- Ileal conduit (1)
- Ileum-Conduit (1)
- Ileum; Atrium (1)
- Illumina Human Exome Bead Chip (1)
- Image Aesthetic Assessment (1)
- Image interpretation (1)
- Image processing (1)
- ImageJ (1)
- ImageJ plugin (1)
- Images (1)
- Imaging (1)
- Imaging Air Cherenkov Telescope (1)
- Imaging pitfalls (1)
- Imd pathway (1)
- Imidates (1)
- Imidoyl halides (1)
- Immediate-type (1)
- Immune receptor signaling (1)
- Immune system (1)
- Immune tolerance (1)
- Immune-System (1)
- Immune-related adverse event (1)
- Immunization (1)
- Immunoadsorption (1)
- Immunoapheresis (1)
- Immunocompromised patient (1)
- Immunodeficiency (1)
- Immunogenicity (1)
- Immunoglobulin E (1)
- Immunohistochemistry (1)
- Immunological Self-Tolerance (1)
- Immunology (1)
- Immunopanning (1)
- Immunoprecipitation (1)
- Immunosenescence (1)
- Immunostimulatory adjuvant (1)
- Immunstimulation (1)
- Impact-Faktor (1)
- Impaired vision (1)
- Impella (1)
- Implicit and explicit reward learning (1)
- Improved survival (1)
- Impulsivity (1)
- In Situ Nick-End Labeling (1)
- In vitro contracture test (1)
- In vitro models (1)
- In vitro skin irritation testing (1)
- In vitro toxicity testing (1)
- In vivo (1)
- In vivo imaging (1)
- In vivo studies (1)
- In-Vivo (1)
- In-vivo dia lysis (1)
- InSAR height (1)
- Inactivation (1)
- Inbreeding depression (1)
- Inc (1)
- IncRNA (1)
- Incidence (1)
- Inclusion (1)
- Inclusion Rate (1)
- Incomplete contracts (1)
- Incontinentia pigmenti (1)
- IncuCyte\(^®\)S3 (1)
- Indian muntjac (1)
- Indirect and direct contributions to A<sub>iso</sub> (1)
- Indirekte Abwehr (1)
- Induced Pluripotent Stem Cells (1)
- Induced senescence (1)
- Inducible Clindamycin Resistance (1)
- Indus-Ganges-Brahmaputra-Meghna (1)
- Infarct Zone (1)
- Infection (1)
- Infection control (1)
- Infectious Diseases (1)
- Infectious complications (1)
- Inferior Vena Cava (1)
- Inferior colliculus (1)
- Inferior vena cava (1)
- Inflammatio (1)
- Inflammatory bowel disease (1)
- Inflammatory diseases (1)
- Inflammatory pain (1)
- Infliximab (1)
- Influence of excitation classes (1)
- Influenza (1)
- Influenza vaccination (1)
- Influenzae type B (1)
- Information (1)
- Information Integration Theory (1)
- Inhalation (1)
- Inhibition (1)
- Inhibitory glycine receptor (1)
- Injuries (1)
- Inner hair cell (1)
- Innervation (1)
- Inoculum production (1)
- Insect flight (1)
- Insect hosts (1)
- Insect pests (1)
- Insect symbiois (1)
- Insekt (1)
- Insensitivity (1)
- Instability (1)
- Instructors (1)
- Insulating thin films (1)
- Insulator surfaces (1)
- Insulin Degrading Enzyme (1)
- Insulin therapy (1)
- Insulinlike Growth Factor (1)
- Integrase (1)
- Integrated network analysis (1)
- Intellectual disability (1)
- IntelliCage (1)
- Intelligent Virtual Agents (1)
- Intelligent mobile system (1)
- Intensity (1)
- Inter-observer variability (1)
- InteractionSuitcase (1)
- Interactive Tree Of Life (iTOL) (1)
- Interactive Ventilatory Support (1)
- Interband cascade lasers (1)
- Interference microscopy (1)
- Interferon beta (1)
- Interferon-alpha (1)
- Interieukin-1ß (1)
- Interleukin (1)
- Interleukin 2 (1)
- Interleukin 4 (1)
- Interleukin 4 (human) (1)
- Interleukin 7 (1)
- Interleukin IL-6 (1)
- Interleukin-1 (1)
- Interleukin-10 (1)
- Interleukin-18 (1)
- Interleukin-2 (1)
- Interleukin-4 (IL-4) (1)
- Interleukin-5 (1)
- Interleukin-6-Deficient mice (1)
- Intermediate filaments (1)
- Internal transcription start site (1)
- International Physical Activity Questionnaire (1)
- International consensus diagnostic criteria for neuromyelitis optica spectrum disorders (1)
- Internet (1)
- Internet Behaviour (1)
- Intestinal Intraepithelial Lymphocy (1)
- Intestinal pseudoobstruction (1)
- Intracellular domain (1)
- Intractable nausea and vomiting (1)
- Intravascular coagulation (1)
- Intravital imaging (1)
- Intrinsic charm (1)
- Invasion genes (1)
- Invasive Aspergillosis (1)
- Invasive fungal-infections (1)
- Inzisionale Hernie (1)
- Inzisionalhernie (1)
- IoT-driven processes (1)
- Ionizing radiation (1)
- Iowa Gambling Task (1)
- Ipilimumab (1)
- Ips typographus (1)
- Ire1 (1)
- Iron Oxide Nanoparticle (1)
- Iron-oxide (1)
- Iron-uptake (1)
- IronChip Evaluation Package (1)
- Irradiation (1)
- Irritable bowel syndrome (1)
- Ischemia (1)
- Ischemia/reperfusion (1)
- Ischemic stroke (1)
- Isheru (1)
- Islam (1)
- Islets of Langerhans (rat) (1)
- Isoenzym (1)
- Isomorphe Nukleobasen-Analoga (1)
- IsrK (1)
- J-aggregate behavior (1)
- J-aggregates (1)
- JA/JA-Ile transport protein JAT1 (1)
- JAK2 (1)
- JAQ1 (1)
- JCV (1)
- JES (1)
- JIA (1)
- JOL reactivity (1)
- JQ1 (1)
- JR11 (1)
- JUN (1)
- Jacobian matrix (1)
- Jahn–Teller effect (1)
- Jak kinases (1)
- Janus fibers (1)
- Janus kinase (1)
- Japanese population (1)
- Jasmonate perception (1)
- Jasmonic acid (1)
- Java 3D (1)
- Jaynes-Cummings ladder (1)
- Jet physics (1)
- Jmjd6 (1)
- Johnstons organ (1)
- Joint capsule (1)
- Joint ownership (1)
- Joint pain (1)
- Josephson effect (1)
- Joubert syndrome (1)
- Journal of Nuclear Cardiology (1)
- Judaism (1)
- Jugend (1)
- Julia line (1)
- Jurkat T cells (1)
- Jurkat cells (1)
- Juvenile biventricular cardiomyopathy (1)
- Juvenile idiopathic arthritis (1)
- K + -channels (1)
- K band ranging (KBR) (1)
- K* µ+μ− (1)
- K+ channel (1)
- K+ channels (1)
- K-PG radiation (1)
- K-RAS (1)
- K-region (1)
- K279a (1)
- K2P channels (1)
- K2–K model (1)
- KAT/HAT (1)
- KATP channel (1)
- KCNK5 (1)
- KDELR2 (1)
- KEA (1)
- KFZA (1)
- KIF (1)
- KIF11 (1)
- KM3NeT (1)
- KRAS (1)
- KRAS biomarker signatures (1)
- KWIC (1)
- K\(_{2P}\)5.1 (1)
- Kaiser test (1)
- Kaliumkanal (1)
- Kappa-B activation (1)
- Kappa-B pathway (1)
- Karyotyp (1)
- Karyotype; chromosome banding; Desertellio elongatus; Crustacea; Isopoda; Oniscidea (1)
- Katayama fever (1)
- Keller–Segel model (1)
- Keras (1)
- Kerinokeratosis papulosa (1)
- Kerneldensity estimation (1)
- Ketogene Kost (1)
- Keuchhusten (1)
- KhpB protein (1)
- Kidney (perfused (1)
- Kidney cancer (1)
- Kidneys (1)
- Killer cell immunoglobulin-like receptors (1)
- Kinase inhibitor (1)
- Kinase pathway (1)
- Kindergarten (1)
- Kinetochore (1)
- Kinetochores (1)
- Kinetoplastea (1)
- Kinetoplastida (1)
- Kirchhoff's law (1)
- Klebsiella pneumoniae (1)
- Klima (1)
- Klotho-related molecules (1)
- Knee (1)
- Knieschmerzen (1)
- Knock-out mice (1)
- Knotless tendon repair (1)
- Koenigs function (1)
- Kohlberg (1)
- Kohlenhydrate (1)
- Kongress (1)
- Kono-S anastomosis (1)
- Konservierung (1)
- Krebskranker (1)
- Kristallographie (1)
- Kristallstruktur (1)
- Krylow matrix (1)
- Krüppel-like factor (1)
- Kunduz River Basin (1)
- L cells (1)
- L-3,4-Dihydroxyphenylalanine-induced dyskinesia (1)
- L-DOPA (1)
- L-Lactate Dehydrogenase (1)
- L. reuteri (1)
- L5178Y cells (1)
- LAALO3/SRTIO3 interfaces (1)
- LAD (1)
- LAMN (1)
- LATE DEATHS (1)
- LC-ESI/MS/MS (1)
- LC3 lipidation (1)
- LCCS11 (1)
- LCNEC (1)
- LCP (1)
- LCST (1)
- LC–HRESIMS (1)
- LC–MS/MS (1)
- LD, light:dark (1)
- LDA (1)
- LDL cholesterol (1)
- LED (1)
- LESA (1)
- LFA-1 (1)
- LGMDR5 (1)
- LHS (1)
- LI-rTMS (1)
- LIF (1)
- LIMP-2 (1)
- LIN-5 (1)
- LINC complexes (1)
- LINE-1 retrotransposition (1)
- LINGO-1 (1)
- LITAF (1)
- LMNA (1)
- LMNA mutations (1)
- LMX (1)
- LNCaP (1)
- LND (1)
- LNE (1)
- LOGIC study (1)
- LPHN3 (1)
- LRIG1 (1)
- LRP6 (1)
- LS-MIDA (1)
- LSD1 (1)
- LSVT-big therapy (1)
- LTB4 receptor (1)
- LTD (1)
- LTR retrotransposons (1)
- LULCC (1)
- LUMEN (1)
- LV dilatation (1)
- LV mass (1)
- LVNC (1)
- Labial glands (1)
- Labour Analgesia (1)
- Labour Pain (1)
- Lacking neurofilaments (1)
- Lactated ringers solution (1)
- Lag time (1)
- Lamarckian genetic algorithms (1)
- Lambda5-Germanate (1)
- Lamto Reserve (1)
- Land Change Modeler (1)
- Land Surface Temperature (1)
- Land Surface Temperature (LST) (1)
- Land Use/Land Cover (1)
- Land plants (1)
- Land-use change (1)
- Landau Gauge (1)
- Landau level (1)
- Landmarken (1)
- Landsat 8 (1)
- Landsat archive (1)
- Landsat-8 (1)
- Landscape ecology (1)
- Landschaft (1)
- Landwirtschaft (1)
- Langerhans cell (1)
- Langlebigkeit (1)
- Language comprehension (1)
- Lantana camara (1)
- Lao PDR (1)
- Laparoscopy (1)
- Laplace approximation (1)
- Laplace transform (1)
- Large T antigen (1)
- Large detector systems for particle and astroparticle physics (1)
- Large loop excision of the transformation zone (LLETZ) (1)
- Large multicenter ADHD (1)
- Large vessel vasculitides (LVV) (1)
- Larval development (1)
- Laser Doppler vibrometer (1)
- Late mortality (1)
- Late-effects (1)
- Latency (1)
- Lateral suboccipital craniectomy (1)
- Lateralitity (1)
- Laterality (1)
- Latimeria menadoensis (1)
- Latrophilin (1)
- Leaderless transcript (1)
- Leaf cutting ants (1)
- Learner Autonomy (1)
- Learning and memory (1)
- Learning/physiology (1)
- Leaves (1)
- Lebensalter (1)
- Lebensqualität (1)
- Lebenszyklus (1)
- Lectins (1)
- Legionella (1)
- Legionella ssp. (1)
- Legionellae (1)
- Legume crops (1)
- Legumes (1)
- LeishBASEedit (1)
- Leishmania major (1)
- Leistenhernie (1)
- Leonhard cIassification (1)
- Leonhard classification (1)
- Leptin (1)
- Lepton (1)
- Leptonic (1)
- Leptons (1)
- Lerch zeta function (1)
- Lernerautonomie (1)
- Lernkurve (1)
- Lese- und Schreibfähigkeit (1)
- Lese-Rechtschreibstörung (1)
- Lesefähigkeit (1)
- Lesen (1)
- Lesions (1)
- Leukemia Inhibitory Factor (1)
- Leukocyte/endothelium interaction (1)
- Level (1)
- Lewis acid (1)
- Lewis acid/base adducts (1)
- Lewis adducts (1)
- Lewy-like pathology (1)
- Li-Fraumeni syndrome (1)
- Lie group actions (1)
- Lie groups (1)
- Lie n-algebroids (1)
- Lieberoser Heide (1)
- Life expectancy (1)
- Lifetime spectroscopy (1)
- Ligamentum capitis femoris (1)
- Ligand <Biochemie> (1)
- Ligand effects (1)
- Light (1)
- Light Supersymmetric Particle (1)
- Light stimulation (1)
- Light-emitting diodes (1)
- Limb development (1)
- Limb girdle muscular dystrophy (LGMD) (1)
- Limb salvage (1)
- Limestone (1)
- Limit (1)
- Linagliptin (1)
- Linea alba (1)
- Lines (1)
- Lipid (1)
- Lipid metabolism (1)
- Lipom (1)
- Lipophilicity (1)
- Lipopolysaccharide (1)
- Liposomal amphotericin-B (1)
- Lipoxin (1)
- Lippert–Mataga plot (1)
- Liquid-crystalline (1)
- Listeria (1)
- Listeriolysin O (1)
- Lithium niobate (1)
- Live cells (1)
- Liver cirrhosis (1)
- Living cells (1)
- Llullaillaco Volcano (1)
- Ln-MOFs (1)
- LoRaWAN (1)
- Local governance (1)
- Local rings (1)
- Localized states (1)
- Location-based algorithms (1)
- Locked-in syndrome (1)
- Locomotion compensator (1)
- Locomotor activity (1)
- Locoregional recurrence (1)
- Locus (1)
- Locus coeruleus (1)
- Logged forests (1)
- Long bones (1)
- Long-range order (1)
- Long-term care (1)
- Long-term depression (1)
- Long-term follow-up (1)
- Longitudinal analysis (1)
- Longitudinally extensive transverse myelitis (1)
- Loop electrosurgical excision procedure (LEEP) (1)
- Lov domain (1)
- Low risk alcohol use (1)
- Low-dose acyclovir (1)
- Low-fat diet (1)
- Lower Reference Value (1)
- Lower extremity reconstruction (1)
- LpxC inhibitors (1)
- Lu-177 (1)
- Luminescence (1)
- Lung (1)
- Lung Injury (1)
- Lung disease, (1)
- Lungenkrebs (1)
- Lutetium (1)
- Luxembourg (1)
- LyP (1)
- Lyapunov functions (1)
- Lycopersicon esculentum (1)
- Lymantria dispar (1)
- Lymph nodes (1)
- Lymph2Cx assay (1)
- Lymphocytes (1)
- Lymphoma (1)
- Lymphomas (1)
- Lynx lynx (1)
- Lysine (1)
- Lysine-specific methylase (1)
- Lysis (medicine) (1)
- Lyso-Gb3 (1)
- Lysosomal storage disease (1)
- M1/M2 macrophages (1)
- M14 carboxypeptidasses (1)
- M2 (1)
- M2 muscarinic receptors (1)
- M30 (1)
- M4 receptors (1)
- MACE (1)
- MACVIA (1)
- MAINZPouch (1)
- MALDI imaging (1)
- MAP kinase pathway (1)
- MAP1B (1)
- MAPK pathway (1)
- MAPK signaling (1)
- MAPKAPK2 (1)
- MARC effect (1)
- MAS (1)
- MAX (1)
- MC expectation (1)
- MC program (1)
- MCC (1)
- MCC950 (1)
- MCL-1 (1)
- MCP1 (1)
- MCPyV (1)
- MCV-negative (1)
- MDL-28170 (1)
- MDR (1)
- MDS (1)
- MDSCs (1)
- MED-EL cochlear implant (1)
- MEDAS (1)
- MEK/ERK-signaling (1)
- MEMS IMU (1)
- MEN1 (1)
- MET receptor (1)
- METTL8 (1)
- MFM (1)
- MGL (1)
- MGMT (1)
- MGMT promoter methylation (1)
- MHC I (1)
- MHC II (1)
- MHC Klasse II (1)
- MHC class I chain-related protein (1)
- MHC molecules (1)
- MI-2/NURD complex (1)
- MIBG scintigraphy (1)
- MIC ligands (1)
- MIND estimator (1)
- MIP-1β (1)
- MIR-155 (1)
- MITE (1)
- MITF (1)
- MITF-low (1)
- MK801 (1)
- MLC tracking (1)
- MLLE domain (1)
- MLST (1)
- MMN (1)
- MMP (1)
- MMP-1 (1)
- MMP9 (1)
- MMQ cells (1)
- MNV type 3 (1)
- MOC fibers (1)
- MOD13Q1 (1)
- MODIS image (1)
- MODIS time-series (1)
- MOG-IgG (1)
- MOLLI (1)
- MOPC315.BM (1)
- MOR202 (1)
- MORN-repeat (1)
- MPACT (1)
- MPK12 (1)
- MPO (1)
- MPS (1)
- MR (1)
- MR angiography (1)
- MR guidance (1)
- MR neurography (1)
- MRI reporter (1)
- MRI spectroscopy (1)
- MRONJ (1)
- MRSA - methicillin-resistant Staphylococcus aureus (1)
- MS-18 (1)
- MSC 11M35 (1)
- MSC: 14M15 (1)
- MSC: 49M37 (1)
- MSC: 53C22 (1)
- MSC: 53C35 (1)
- MSC: 65K05 (1)
- MSC: 90C30 (1)
- MSC: 90C40 (1)
- MSCI (1)
- MSCT (1)
- MSIS (1)
- MSSM (1)
- MSSS (1)
- MTB (1)
- MTCH2 (1)
- MTH1 (1)
- MTL30 (1)
- MTOR (1)
- MTX (1)
- MU-M (1)
- MUD (1)
- MUST-Score (1)
- MV receptor (1)
- MV transcription (1)
- MVT (1)
- MYB (1)
- MYCNv (1)
- Macaque monkey (1)
- Macrophage Migration Inhibitory Factor (MIF) (1)
- Macrophages (1)
- Mactel 2 (1)
- Maculinea butterfly (1)
- Mad Men (1)
- Madagascar (1)
- Magnesium (1)
- Magnetfeld (1)
- Magnetic resonance imaging(MRI) (1)
- Magnetic-resonance (1)
- Magnetic-resonance microscopy (1)
- Magnetresonanztomografie (1)
- Main-group chemistry (1)
- Maintenance (1)
- Maintenance treatment (1)
- Mais (1)
- Majeed (1)
- Majeed-Syndrome (1)
- Major abdominal surgery (1)
- Major depression (1)
- Major splice donor (1)
- Majorana fermions (1)
- Makrophage (1)
- Malaise trap (1)
- Malaria (1)
- Malaya (1)
- Male (1)
- Male breast cancer (1)
- Male intromittent organ (1)
- Malignancies (1)
- Malignant effusion (1)
- Malignant neoplasms (1)
- Malvaviscus arboreus (1)
- Mamestra brassicae (1)
- MammaJian mutagenicity test (1)
- Mammakarzinom (1)
- Mammalian genomes (1)
- Mammalian target (1)
- Management (1)
- Mandibular condyle (1)
- Mandibular continuity defects (1)
- Manganese (1)
- Manganese Carbonyl ligands (1)
- Mania (1)
- Manifestation (1)
- Mann-Kendall test (1)
- Mansoni infection (1)
- Mantle cell lymphoma (1)
- Marcus inverted region (1)
- Marfan syndrome (1)
- Markarian 501 (1)
- Markov chains (1)
- Marrakech (1)
- Marrow stromal cells (1)
- Martensit (1)
- Mass Spectrum (1)
- Mass critical care (1)
- Mass-spectrometry (1)
- Mast cells (1)
- Masticatory mucosa (1)
- Mastocytosis (1)
- Mastoid process (1)
- Materials chemistry (1)
- Materials science (1)
- Mato Grosso (1)
- Matrix (1)
- Matrix metalloproteinases (1)
- Matter (1)
- Maxwell demon (1)
- Mbt (1)
- McDonald criteria (1)
- McN-A-343 analogs (1)
- Mcl-1 (1)
- MeDALL (1)
- Measurement error correlation (1)
- Measurement invariance (1)
- Measuring masses (1)
- Meat (1)
- Mechanical strain (1)
- Mechanism of action (1)
- Mechanistic model (1)
- Medaka - Genetransfer - Transient expression - DNA fate - Fish developmental biology (1)
- Medaka fish (1)
- Media (1)
- Mediated Inflammatory Hyperalgesia (1)
- Medicago truncatula (1)
- Medical education (1)
- Medical history (1)
- Medical implants (1)
- Medical journals (1)
- Medical overuse (1)
- Medical research (1)
- Medical student (1)
- Medical students (1)
- Medicalization (1)
- Mediterranean environment (1)
- Medulloblastoma (1)
- Medullärer Schilddrüsenkrebs (1)
- Meeresschwämme (1)
- Megalobrama amblycephala (1)
- Megaponera analis (1)
- Mehrskalenmodell (1)
- Meiosis (1)
- Meisenheimer complex (1)
- Mekong-Delta (1)
- Melanocortin 4 receptor (MC4R) (1)
- Melanocyte stimulating hormones MSH (1)
- Melanoma B16 (1)
- Melanoma-cells (1)
- Melatonin (1)
- Meliponini (1)
- Mellitus (1)
- Melophorus-bagoti (1)
- Membranes (1)
- Memory (1)
- Memory B cells (1)
- Memory capacity (1)
- Memory dysfunction (1)
- Men (1)
- Mena/VASP (1)
- Meniere’s disease (1)
- Meningioma (1)
- Meningococcal infection (1)
- Meningococcal polysaccharide caccine (1)
- Meningococcal serogroup C (1)
- Meningococci (1)
- Mental arithmetic (1)
- Mental health therapies (1)
- Merkel cell density (1)
- Merlin (1)
- Merocyanine (1)
- Merogone experiments (1)
- Mesenchymal stem cell (1)
- Mesenchymal transition (1)
- Mesh Augmentation (1)
- Mesoarchaean (1)
- Mesocestoides corti (1)
- Mesoskopisches System (1)
- Messenger RNA (1)
- Messenger Ribonucleoprotein Particles (1)
- Messenger-RNA (1)
- Messenger-RNAs (1)
- Messenger-RNS (1)
- Metaanalysis (1)
- Metabolic profiles (1)
- Metabolism saturation (1)
- Metabolismus (1)
- Metacestode (1)
- Metalloproteinasen (1)
- Metalloradicals (1)
- Metanephrine (1)
- Metapleural gland (1)
- Metarhizium anisopliae (1)
- Metastases (1)
- Metastatic melanoma (1)
- Meta‑analysis (1)
- Methanosarcina mazei (1)
- Methicillin resistant Staphylococcus aureus (1)
- Methicillin-resistant Staphylococcus aureus (1)
- Methicillin-resistant staphylococcus aureus (1)
- Methoctramine (1)
- Methodological quality (1)
- Methylome (1)
- Mexican coffee plantations (1)
- Mexico City (1)
- Mexico [North America] (1)
- Mfn2 KO mice (1)
- MgAl LDH (1)
- MiMIC (1)
- MicroRNAs (1)
- Microarray analysis (1)
- Microarray data (1)
- Microbiology and Infectious Disease (1)
- Microcavity (1)
- Microcavity devices (1)
- Microenvironment (1)
- Microinjection (1)
- Micromonospora (1)
- Micronucleus formation (1)
- Micronucleus test (1)
- Microorganisms (1)
- Mid-infrared photoluminescence (1)
- Middle cerebral-artery (1)
- Midline (1)
- Midollo-Osseo (1)
- Mig1 (1)
- Migration (1)
- Migräne (1)
- Mikroarray (1)
- Mikrobiologie (1)
- Military shooting (1)
- Millisecond-timescale (1)
- Milnesium tardigradum (1)
- Mindfulness (1)
- Mini Unmanned Aerial Vehicle (1)
- Minimal Surface Tension (1)
- Minimal change disease (1)
- Minimal supersymmetric model (1)
- Minimalinvasiv (1)
- Minimalinvasive Leistenhernienversorgung (1)
- Minimally invasive surgery (1)
- Minischwein (1)
- Minor histocompatibility antigen mismatch transplantation (1)
- Minor subunits (1)
- MircoRNA (1)
- Missense mutation (1)
- Missing Energy (1)
- MitoQ (1)
- Mitochondrial Matrix Protein (1)
- Mitomycin C (1)
- Mitosis (1)
- Mitotane (1)
- MitraClip (1)
- Mitsunobu (1)
- Mitteleuropa (1)
- Miyoshi myopathy (1)
- Mobile Sensor Network (1)
- Mobile application engineering (1)
- Mobile augmented reality (1)
- Mobile augmented reality game (1)
- Mobile genetic element (1)
- Model specification (1)
- Modell (1)
- Modified Nucleotides in tRNAs (1)
- Modifizierte Sugarbaker-Technik (1)
- Molecular Biophysics (1)
- Molecular Channel Transport (1)
- Molecular Imaging (1)
- Molecular beam epitaxy (1)
- Molecular biophysics (1)
- Molecular imaging (1)
- Molecular mechanism (1)
- Molecular pathogenesis (1)
- Molecular systematics (1)
- Molecular-dynamics (1)
- Molecular-genetics (1)
- Molecular-weight heparin (1)
- Molecularly targeted therapy (1)
- Molekulare Infektionsbiologie (1)
- Molekularpathologie (1)
- Molekularpharmakologie (1)
- Molekül (1)
- Molnupiravir (1)
- Molnupiravir-Induced RNA Mutagenesis Mechanism (1)
- Monoamine Oxidase/genetics (1)
- Monoclonal antibody (1)
- Monocytes and macrophages (1)
- Monopolar depression (1)
- Monte Carlo methods (1)
- Monte Carlo simulation (1)
- Monte-Carlo-Simulation (1)
- Mood disorders (1)
- Moose (1)
- Morbidity (1)
- Morbus Fabry (1)
- Morocco (1)
- Motion (1)
- Motion detection (1)
- Motivation (1)
- Motoneuron disease (1)
- Motor behaviour (1)
- Motor cortex (1)
- Motor nerve biopsy (1)
- Motor neuron disease; Ciliary neurotrophic factor; Brain-derived neurotrophic factor; Animal models; Neurotrophic factors (1)
- Motor plasticity (1)
- Mott–Schottky analysis (1)
- Mouse models (1)
- Movement (1)
- Movement behavior (1)
- Mozambique (1)
- Mt. Kinabalu (1)
- Mucin (1)
- Mucopolysaccharidosis IIIa (1)
- Mucor (1)
- Mucorales (1)
- Mud (1)
- Multibranched structures (1)
- Multicenter randomized-trial (1)
- Multidetector computed tomography (1)
- Multimorbidity (1)
- Multiparameter predictor (1)
- Multiple (1)
- Multiple Sklerose (1)
- Multiple drug resistance (1)
- Multiple-Scattering (1)
- Multiple-Sclerosis (1)
- Multiplex PCR (1)
- Multipolar mitosis (1)
- Mund-Kiefer-Gesichts-Chirurgie (1)
- Munigua (1)
- Muon spectrometers (1)
- Mus spretus (1)
- Muscarinic M1 receptors (1)
- Muscarinic M1 receptors; Muscarinic M2 receptors (1)
- Muscarinic M3 receptor subtypes (1)
- Muscarinic M3selective antagonists (1)
- Muscarinic antagonist (1)
- Muscarinic receptor agonists (1)
- Muscarinic receptor antagonists (M 3-selective) (1)
- Muscarinic receptor antagonists (selective) (1)
- Muscarinic receptor subtype (1)
- Muscarinic receptor subtypes; Muscarinic rcceptor agonists (M 1-selective) (1)
- Muscarinie M2 receptors (1)
- Muscidifurax (1)
- Muscle function (1)
- Muscle power (1)
- Musearinic M4 receptors (1)
- Musearlnie M1 (1)
- Musearlnie aeetyleholine receptor agonists (1)
- Musearlnie aeetyleholine receptor antagonists (1)
- Musearlnie receptor subtypes (1)
- Mutagenicity (1)
- Mutagenicity assay (1)
- Mutagens (1)
- Mutant (1)
- Mutation assay (1)
- Mutation screening (1)
- Mwanza (1)
- Myanmar (1)
- Myb-MuvB (1)
- Myc (1)
- Myc Transcription (1)
- Mycobacterium avium (1)
- Mycobacterium caprae (1)
- Mycobacterium marinum (1)
- Mycobacterium tuberculosis complex (1)
- Mycoplasma (1)
- Myelin oligodendrocyte glycoprotein (MOG) antibodies (1)
- Myelitis (1)
- Myeloma cells (1)
- Myelomas (1)
- Myocardial fibrosis (1)
- Myocardial infarction (1)
- Myocardial perfusion (1)
- Myocardial-Infarction (1)
- Myocardial-perfusion SPECT (1)
- Myofibroblast differentiation (1)
- Myokarditis (1)
- Myrmecophytes (1)
- Myrmecophytism ; Malaysia ; trophobionts ; colony foundation ; Cladomyrma (1)
- Myrmica ant non-equilibrium dynamics (1)
- Müller cells (1)
- N-Acetyl-leukotriene E4 (1)
- N-CAM (1)
- N-Heterocyclic Carbene Adducts (1)
- N-Heterocyclic Carbenes (1)
- N-Heterocyclic carbenes (1)
- N-Myc down regulated gene 1 (1)
- N-functionalization (1)
- N-glycans (1)
- N-heterocyclic olefins (1)
- N-methyl-N-nitrosourea (1)
- N-methylpyridinium pyrene (1)
- N-oleoyl serinol (1)
- N-terminal domain (1)
- N100 (1)
- N1E 115 cells (1)
- N400 (1)
- NA (1)
- NA+/I-symporter (1)
- NA/I symporter (1)
- NAD (1)
- NAD(P)H-dehydrogenase (1)
- NAD(P)H-plastoquinone-oxidoreductase (1)
- NADH-dehydrogenase (1)
- NADPH (1)
- NADPH oxidase (1)
- NADPH oxidase 2 (NOX2) (1)
- NADPH oxidase inhibitors (1)
- NADPH oxidases (NOX) (1)
- NAKO (1)
- NAP-2 (1)
- NAS (1)
- NCAM1 (1)
- NCH93 (1)
- NCI-60 (1)
- NCI-H295R (1)
- ND10 complex (1)
- NDH-H (1)
- NDH-I (1)
- NDH-J (1)
- NDH-K (1)
- NDI-H (1)
- NDVI thresholds (1)
- NEAT1 (1)
- NEC (1)
- NEIL2 (1)
- NETs (1)
- NEXAFS spectroscopy (1)
- NF-\(\kappa\)B (1)
- NF-\(\kappa\)B pathway (1)
- NF-κB/NFAT reporter cells (1)
- NFE2L2 (1)
- NFKB (1)
- NFkB-relatedgenes (1)
- NFkappaB (1)
- NFκB-activation (1)
- NHC Complexes (1)
- NHCs (1)
- NHLRC2 (1)
- NHX1 (1)
- NH\(_{3}\) (1)
- NI(111) (1)
- NIHSS (1)
- NIPAL4 (1)
- NIR OLED (1)
- NIRS (1)
- NK cell (1)
- NK-cells (1)
- NKG2D (1)
- NKG2D ligands (1)
- NLO QCD (1)
- NLPHL (1)
- NMD (1)
- NMDA receptor subunits NR2A and NR2B (1)
- NMDA-Antagonist (1)
- NMDA-Rezeptor (1)
- NMJ–neuromuscular junction (1)
- NMO-IGG (1)
- NMO-IgG (1)
- NMOSD (1)
- NMR fingerprint (1)
- NMR relaxation (1)
- NMR-Tomographie (1)
- NMR-spectroscopy (1)
- NNLO (1)
- NO (1)
- NOP10 (1)
- NP-hard (1)
- NP-hardness (1)
- NPC1 gene (1)
- NPC2 gene (1)
- NPSI (1)
- NPSR1 (1)
- NPU (1)
- NPWT (1)
- NR3C1 (1)
- NRAS mutation (1)
- NRG1 (1)
- NS1608 (1)
- NSAIDs (1)
- NSG animals (1)
- NSG mice (1)
- NSG-UC (1)
- NT-proBNP (1)
- NTCDA (1)
- NTP-binding-properties (1)
- NT‐proBNP (1)
- NVP-BGT226 (1)
- NaCl transport (1)
- NaV1.8 (1)
- NaV1.9 (1)
- Nail unit (1)
- Naive T cells (1)
- Namibia (1)
- Nampt (1)
- Nanda-Hamner (1)
- NanoFEEP (1)
- Nanog protein (1)
- Nanos (1)
- Naphthylisoindolinone alkaloids (1)
- Nasal Carriage (1)
- Nash equilibrium (1)
- Nasonia (1)
- Nasonia courtship (1)
- Natalizumab (1)
- National Science Foundation (1)
- Natural product hybrids (1)
- Natural-history data (1)
- Ndrg1 (1)
- Neanderthal (1)
- Necrosis (1)
- Necrosis-factor-Alpha (1)
- Necrotizing enterocolitis (1)
- Nectin‐2 (1)
- Negative geotaxis (1)
- Neisseria (1)
- Nekrose (1)
- Nematode Caenorhabditis-elegans (1)
- Neoblast (1)
- Neolithic (1)
- Neolithic agriculture (1)
- Neolithic period (1)
- Neomycin Resistance (1)
- Neostriatum (1)
- Nephroblastoma (1)
- Neprilysin inhibition (1)
- Nerve fibers (1)
- Nerve growth factor (1)
- Nerve growth-factorcopy (1)
- Nervous system (1)
- Nesplora Aquarium (1)
- Nestin (1)
- Nesting resources (1)
- Netarsudil (1)
- Netherlands (1)
- Netrin (1)
- Network (1)
- Neugeborenes (1)
- Neural Differentiation (1)
- Neural basis (1)
- Neural circuits (1)
- Neural crest cells (1)
- Neural precursor cells (1)
- Neuralgie (1)
- Neuritis (1)
- Neuro-blastoma (1)
- Neuroblastoma (1)
- Neuroendocrine (1)
- Neuroendocrine Tumor (1)
- Neurofilament (1)
- Neurogenic inflammation (1)
- Neurogenie inflammation (1)
- Neuroinfectiology (1)
- Neuroinflammation (1)
- Neuromuscular junctions (1)
- Neuromyelitis optica (NMO) (1)
- Neuromyelitis optica antibodies (NMO-IgG) (1)
- Neuronal plasticity (1)
- Neuronal survival (1)
- Neuronales Netz (1)
- Neurone number (1)
- Neuropeptide (1)
- Neuropeptides (1)
- Neuroscience (1)
- Neurosciences (1)
- Neurotropathic Factor (1)
- Neurotrophin (1)
- Neutrino (1)
- Neutrino Detectors and Telescopes (experiments) (1)
- Neutrino Mass (1)
- Neutrino data (1)
- Neutrino detectors (1)
- Neutrino emission (1)
- Neutrino mass mixing (1)
- Neutrino telescope (1)
- Neutrophil (1)
- Neutrophils (1)
- New Species (1)
- New mexico (1)
- NfL (1)
- Nicandra (1)
- Nicardipine (1)
- Nickel ComplexCyclic (1)
- Nickel Complexes (1)
- Niedere Wirbeltiere (1)
- Niemann–Pick disease type C (1)
- Niere (1)
- Nierenfunktionsstörung (1)
- Niger <Ost> (1)
- Nile Delta (1)
- Nile Delta (Egypt) (1)
- Nile delta (1)
- Nile flow (1)
- Nissl stain (1)
- Nitric oxide (NO) (1)
- Nitric-oxide (1)
- Nitrogen metabolism (1)
- Nitrosation (1)
- Nitrosierung (1)
- Nivolumab (1)
- Njassasee (1)
- Nodo-parandopathy (1)
- Nodule (1)
- Nogo-A (1)
- Noise stimulation (1)
- Non-penetrating glaucoma surgery (1)
- Non-phototrophic bacteria (1)
- Non-reactive Measurement (1)
- Non-rigid image registration (1)
- Non-simultaneous bilateral distal biceps tendon rupture (1)
- Non-steroidal anti-inflammatory drug (1)
- Nonlinear Dynamics (1)
- Nonpathogenic Escherichia-coli (1)
- Nonverbal communications (1)
- Non‐ischaemic cardiogenic shock (1)
- Norbert Groeben (1)
- Normal Distribution (1)
- Normal breast (1)
- Normal tissue tolerance (1)
- Normetanephrine (1)
- North American (1)
- Northeastern Costa Rica (1)
- Northern Bald Ibis (1)
- Northern Xinjiang (1)
- Notch1 (1)
- Nothotaxa (1)
- Novel PI3K (1)
- Novobiocin (1)
- Npy (1)
- Npyr1 (1)
- Npyr2 (1)
- NuMA (1)
- Nuclear (1)
- Nuclear RDNA (1)
- Nuclear envelope (1)
- Nuclear expression (1)
- Nuclear pore complex (1)
- Nuclear pores (1)
- Nucleic Acids (1)
- Nucleobase Analogue (1)
- Nucleocytoplasmic exchange (1)
- Nucleocytoplasmic transport (1)
- Nucleolus-DNA (1)
- Nucleus (1)
- Nucleus accumbens (1)
- Nurses (1)
- Nursing homes (1)
- N‐Heterocyclic Carbenes (1)
- OAT1 (1)
- OAT3 (1)
- OBF-1 OCA-B (1)
- OCB (1)
- OCSVM (1)
- OCT angiography (1)
- OCT-1-deficient mice (1)
- ODE (1)
- OECD guideline (1)
- OEG chains (1)
- OGG1 (1)
- OHIP-49 (1)
- OHIP-G14 (1)
- OHRQoL (1)
- OK cells (1)
- OLED (1)
- OLEDs (1)
- OLFM4 (1)
- ONJ (1)
- OPS201 (1)
- OPT (1)
- OPUS (1)
- OSC (1)
- OSCC (1)
- OSI (1)
- OSM (1)
- OXPHOS (1)
- OXTR (1)
- Obesity history (1)
- Object recognition (1)
- Observational study (1)
- Obturator bypass (1)
- Ockham (1)
- Oct4 (1)
- Octavalen (1)
- Oculomotor Muscles/physiology (1)
- Oesling (1)
- Ofatumumab (1)
- Oil (1)
- Oilseed rape (1)
- Oldenburg burnout inventory (1)
- Olefin Complexes (1)
- Olfr1393 (1)
- Olig2 (1)
- Oligoclonal bands (1)
- Oligofructoside (1)
- Omp85 (1)
- Oncogene (1)
- Oncolysis (1)
- Oncolytic action (1)
- Oncolytic vaccinia virus (1)
- Oncolytic virotherapy (1)
- Oncostatin-M-Receptor (1)
- OncotypeDX\(^{®}\) (1)
- One Health (1)
- One-loop Effective Potential (1)
- One-photon (1)
- Onset hypertrophic cardiomyopathy (1)
- Ontogeny (1)
- Oogenesis (1)
- Open source reconstructed epidermis (1)
- Open-source tool (1)
- Openfield test (1)
- Opioid receptor (1)
- OprO (1)
- OprP (1)
- OpsA (1)
- Opsins (1)
- Optical Activity (1)
- Optical Flow (1)
- Optical Music Recognition (1)
- Optical Spectroscopy (1)
- Optical coherence tomography (1)
- Optical control (1)
- Optical properties (1)
- Optogenetics (1)
- Orai2 (1)
- Oral anticoagulation (1)
- Oral antidiabetic drugs (1)
- Oral squamous cell carcinoma (1)
- Oralchirurgie (1)
- Oralsekret (1)
- Ordination methods (1)
- Organ motion (1)
- Organelles (1)
- Organoazides (1)
- Organoids (1)
- Orobanche crenata (1)
- Orthogonal field attenuation gel electrophoresis (1)
- Orthopädische Chirurgie (1)
- Oryza sativa (1)
- Oscillation (1)
- Oshana (1)
- Osmia (1)
- Osmia bicornis (1)
- Osmoregulation (1)
- Osmunda regalis (1)
- Osseointegration (1)
- Ostasien (1)
- Osteoarthrosis (1)
- Osteogeneration (1)
- Osteogenic precursor cells (1)
- Osteology (1)
- Osteomyelitis of the humerus (1)
- Osteopontin (1)
- Osteoporosis (1)
- Otolaryngolgy (1)
- Outcome (1)
- Outcomes (1)
- Outer membrane proteins (1)
- Outlier detection (1)
- Ovarian (1)
- Overdiagnosis (1)
- Overeating (1)
- Own-name (1)
- Oxford knee score (1)
- Oxide synthase gene (1)
- OxyR (1)
- Oxygen radical (1)
- Oxygen uptake (1)
- Oxyphencyclimine (1)
- O–I 1 fluorescence rise (1)
- P(P) over-bar collisions (1)
- P(P)over-bar collicions (1)
- P-cresyl sulfate (1)
- P-fimbriae (1)
- P-glycoprotein expression (1)
- P-gp (1)
- P-gp inhibitors (1)
- P. aeruginosa (1)
- P. falciparum (1)
- P100 (1)
- P14ARF (1)
- P15(INK4B) (1)
- P21 (1)
- P300 speller (1)
- P300 topography (1)
- P300-Speller (1)
- P515 (1)
- P67(PHOX) (1)
- P75 Neurotrophin receptor (1)
- P97 (1)
- PA-flexed view (1)
- PABC1 (1)
- PABP (1)
- PABPs (1)
- PAF-acether (1)
- PAH formation (1)
- PAI-1 (1)
- PAK4 (1)
- PALS (1)
- PAM2 (1)
- PAM2w (1)
- PAPA syndrome (1)
- PAR (1)
- PAR-CLIP (1)
- PARM (1)
- PARROT (1)
- PB-PB Collisions (1)
- PBEF (1)
- PBI cyclophane (1)
- PBM (1)
- PBPK/PBTK model (1)
- PC-1 blockade (1)
- PCDHGC3 (1)
- PCI (1)
- PCI-32765 (1)
- PCL retention (1)
- PCLS (1)
- PCR analysis (1)
- PCR diagnostics (1)
- PCa (1)
- PDE2 (1)
- PDE4-I (1)
- PDE4-inhibitor roflumilast (1)
- PDE4d (1)
- PDF set (1)
- PDGF (1)
- PDH (1)
- PD‐L1 (1)
- PEComa (1)
- PEGylation (1)
- PER-TIM complex (1)
- PEST (1)
- PET imaging (1)
- PET-1 (1)
- PET/MR systems (1)
- PETRI-seq (1)
- PF-05231023 (1)
- PF4 (1)
- PFA in ethanol (1)
- PFS25 (1)
- PGAS (1)
- PI stacking (1)
- PI-3-kinase (1)
- PI3K isoforms (1)
- PI3K/Akt/mTOR (1)
- PIA/ica (1)
- PICD (1)
- PIK3CA mutations (1)
- PIK3R1 (1)
- PKA (1)
- PKB/Akt phosphorylation (1)
- PKCζ, (1)
- PKM2 (1)
- PKS I (1)
- PKS II (1)
- PLAG1 rearrangement (1)
- PLEKHG5 (1)
- PML nuclear-bodies (1)
- PMMA bone cement (1)
- PMNs (1)
- PMR (1)
- PNA (peptide nucleic acid) (1)
- PO (1)
- POEM (1)
- POLO-chart (1)
- POLSCORE (1)
- POTRA domain (1)
- POU6F2-AS2 (1)
- POZ domain (1)
- PP Collicions (1)
- PP collisions (1)
- PP2A (1)
- PPAR-gamme (1)
- PPGL (1)
- PPGPP (1)
- PRAME (1)
- PROM’s (1)
- PRPF31 (1)
- PSA response (1)
- PSI-blast (1)
- PSMA PET/CT (1)
- PSMA-617 (1)
- PSMA-PET (1)
- PSMA-TV (1)
- PSMA‐617 (1)
- PSMC2 (1)
- PSP (1)
- PTA (1)
- PTCDA (1)
- PU.1 (1)
- PUFA (1)
- PUMP (1)
- PWV (1)
- PYY3-36 (1)
- Pacific Ocean (1)
- Paenibacillus (1)
- Paenibacterin (1)
- Paeonia (1)
- Pain questionnaire (1)
- Pain threshold ; Smoking ; Nicotine ; Acute tolerance ; Deprivation ; Psychophysiologicat measures (1)
- Pain-related evoked potentials (1)
- Pair Prodution (1)
- Pair-Production (1)
- Paleopedology (1)
- Palladium-catalyzed silaboration (1)
- Palliativmedizin (1)
- Palmoplantar keratoderma (1)
- Pamir (1)
- Pan1 (1)
- Pancreatic islet (1)
- Panic Disorder/genetics (1)
- Panic Disorder/therapy (1)
- Paprosky (1)
- Paradoxical heat sensation (1)
- Paraganglioma (1)
- Parallel fiber synapses (1)
- Parametric down-conversion (1)
- Parasite (1)
- Parasite development (1)
- Parastomale Hernie (1)
- Parataxonomy (1)
- Parent Piano-Stool Complex (1)
- Parent-of-origin (1)
- Parent–Child Interaction Therapy (PCIT) (1)
- Parietal cortex (1)
- Parkinsons diesease (1)
- Parkinsons-disease (1)
- Parkionson's disease (1)
- Partially parallel acquisitions (1)
- Particle accelerators (1)
- Particle dark matter (1)
- Particle physics (1)
- Particle production (1)
- Particle properties (1)
- Particle tracking detectors (Gaseous detectors) (1)
- Particle-acceleration (1)
- Particles (1)
- Partnership (1)
- Parton Ditributions (1)
- Parvovirus (1)
- Path-integraton (1)
- Pathogenesis (1)
- Pathogenicity (1)
- Pathologic neovascularization (1)
- Pathology (1)
- Patient Blood Management (PBM) (1)
- Patient Controlled Analgesia (1)
- Patient Satisfaction (1)
- Patient education (1)
- Patient-centered care (1)
- Patient-centered registry (1)
- Patient’s needs (1)
- Pattern classification (1)
- Pauli procedure (1)
- Pauli-Verfahren (1)
- Pavlovian-to-instrumental transfer (1)
- Pearson correlation coefficient (1)
- Pediatric (1)
- Pediatric malignancy (1)
- Pedicled perforator flap (1)
- Pelvic tumors (1)
- Pelvisio® (1)
- Pentastomiasis (1)
- Pentixafor (1)
- Peptidase inhibitor 16 (PI16) (1)
- Peptide receptor radionuclide therapy (1)
- Peptide-leukotrienes (1)
- Peptidoglycan recognition (1)
- Perception (1)
- Performance (1)
- Perfusion (1)
- Perinatal Asphyxia (1)
- Period (1)
- Peripheral Inflammation (1)
- Peripheral blood lymphocytes (1)
- Peripheral nervous system (1)
- Perovskite (1)
- Personality (1)
- Personalized medicine (1)
- Perturbative QCD (1)
- Perugia-Kärpfling (1)
- Peter Singer (1)
- Petropedetidae (1)
- Peyer's patches (1)
- PfAMA1 (1)
- PfCCp protein (1)
- Pfam domain (1)
- Pflanzen (1)
- Pflanzeninhaltsstoff (1)
- Pfs230 (1)
- Phacocanaloplasty (1)
- Phacotrabeculectomy (1)
- Phaeophyceae (1)
- Pharmacokinetics (1)
- Pharmacological management (1)
- Phase II trial (1)
- Phase II trials (1)
- Phase- (1)
- Phasenumwandlung (1)
- Phedimus middendorffianus, var. diffusus (1)
- Phedimus spurius subsp. oppositifolius (1)
- PhenoCam (1)
- Phenolic acids (1)
- Phenols (1)
- Pheromone (1)
- Phoenix dactylifera (1)
- Phonological awareness (1)
- Phosphatidylinositol metabolism (1)
- Phosphodiesterase (1)
- Photic (1)
- Photoactivated localization microscopy (1)
- Photoaffinity labelling (1)
- Photocatalysis (1)
- Photoelektron (1)
- Photoelektronenspektroskopie (1)
- Photon detectors for UV, visible and IR photons (vacuum) (1)
- Photon migration (1)
- Photons (1)
- Photosystem I (1)
- Phrynobatrachus amphibia (1)
- Phylogenetics (1)
- Phylogenie (1)
- Physalis (1)
- Physical Activity (1)
- Physical Sciences (1)
- Physical fitness (1)
- Physical impairment (1)
- Physical sciences (1)
- Physics and instrumentation (1)
- Physiological functions (1)
- Physiologically based kinetic models (1)
- Picea mariana (1)
- Pigmentarchitectonics (1)
- Pilot studies (1)
- Pilus (1)
- Pilzbefall (1)
- Pinus sylvestris L. (1)
- Pirenzepine (1)
- Pitfall (1)
- Pithed rat (1)
- Pitrakinra (1)
- Pityriasis lichenoides (1)
- PknB (1)
- Placebo-controlled trial (1)
- Planetary Health (1)
- Planetary Health Education (1)
- Plant growth promotion (1)
- Plant root endophyte (1)
- Plant signalling (1)
- Plant utricularia-gibba (1)
- Plant-herbivore interactions (1)
- Plant-insect interactions (1)
- Plantation forests (1)
- Plasma (1)
- Plasma extravasation (1)
- Plasmid (1)
- Plastid DNA (1)
- Plataspidae (1)
- Platelet-derived growthfactor (1)
- Platform economy (1)
- Pleckstrin homology containing family member 5 (Plekhg5) (1)
- Pleistocene (1)
- Pleistozän (1)
- Plumbylenes (1)
- Pluripotency (1)
- Plus (1)
- Plus Plus (1)
- Pneumococcal vaccination (1)
- Pneumococci (1)
- Pneumocystis-carinii-pneumonia (1)
- Pnictogen reduction (1)
- Po (1)
- Podocarpus National Park (1)
- Poecilia (Teleostei: Poeciliidae) (1)
- Poecilia reticulata (1)
- Poeciliid fish (1)
- Pointing error (1)
- Pointmutation (1)
- Poisson algebras (1)
- Poisson surface reconstruction (1)
- Pol II (1)
- Polanyi (1)
- Polarimetric Synthetic Aperture Radar (PolSAR) (1)
- Polarity index (1)
- Polistine wasps (1)
- Politik (1)
- Pollination (1)
- Pollinators (1)
- Poly(A) binding protein (1)
- Polyadenylation (1)
- Polyadenylierung (1)
- Polycistronic mRNA (1)
- Polygonum cuspidatum (1)
- Polylactide-co-glycolide (1)
- Polymer-drug interaction (1)
- Polymerase chain raction (1)
- Polymers (1)
- Polymorphisms (1)
- Polyoma-Virus (1)
- Polyphasic fluorescence rise (1)
- Polyphenols (1)
- Polyspermy (1)
- Pompe disease (1)
- Pom‐PAD‐Dara (1)
- Pontryagin maximum principle (1)
- Poor-prognosis (1)
- Poplars (1)
- PorB (1)
- Porcine eye (1)
- Porifera (1)
- Porphyrin arrays (1)
- Port (1)
- Portland cement (1)
- Positioning (1)
- Positive-Pressure Respiration (1)
- Positron Emission Tomography (1)
- Positron annihilation spectroscopy (1)
- Positron-Emission Tomography (1)
- Positron-emission-tomography (1)
- Positronenemissionstomografie (1)
- Post-traumatic stress disorder (1)
- Posteriore Komponentenseparation (1)
- Postmarketing Experience (1)
- Postoperative complications (1)
- Potential-energy curves (1)
- Potentials (1)
- Pou2af1 (1)
- Practice (1)
- Practitioner's guide (1)
- Precipitation gradient (1)
- Preclinical evaluation (1)
- Predict fluid responsiveness (1)
- Prediction (1)
- Predictions (1)
- Predictive toxicology (1)
- Predictive value of tests (1)
- Predictors (1)
- Prednisolon (1)
- Predominant polarity (1)
- Pregnancy (1)
- Premna (1)
- Preserved Ejection Fraction (1)
- Preterm birth (1)
- Pre‐Ligand Assembly Domain (PLAD) (1)
- Prfa-mediated virulence (1)
- Primary care (1)
- Primary cell lines (1)
- Primary endosymbiont (1)
- Primary hyperparathyroidism (pHPT) (1)
- Primitive neuroectodermal (1)
- ProQ (1)
- Probabilities (1)
- Probenecid (1)
- Problem size (1)
- Process Model Comprehension (1)
- Prodigy (1)
- Production Cross-Section (1)
- Production cross-section (1)
- Proenzyme (1)
- Professionalism (1)
- Profile distances (1)
- Profilierung (1)
- Profiling (1)
- Progenitor cells (1)
- Prognosis (1)
- Prognostic impact (1)
- Prognostic markers (1)
- Prognostic scoring system (1)
- Programm (1)
- Programmed Cell Death 1 Receptor (1)
- Programmed cell-death (1)
- Programmierbare logische Anordnung (1)
- Progression (1)
- Progressive motor neuronopathy (1)
- Progressive multifocal leukoencephalopathy (1)
- Progressive supranuclear palsy (1)
- Prolactin (1)
- Promoter prediction (1)
- Promotor (1)
- Propagation (1)
- Propeller flap (1)
- Property rights approach (1)
- Proprioception (1)
- Prosaccade (1)
- Prostaglandins (1)
- Prostata (1)
- Prostatakrebs (1)
- Prostate carcinoma (1)
- Prostate-cancer (1)
- Protease inhibition (1)
- Proteasen (1)
- Protection (1)
- Protein binding (1)
- Protein coding (1)
- Protein folding (1)
- Protein function prediction (1)
- Protein kinase B (1)
- Protein kinase D3 (PKD3) (1)
- Protein transduction (1)
- Proteine (1)
- Proteins (1)
- Proteogenomics (1)
- Proteomanalyse (1)
- Proteus vulgaris (1)
- Proton-Proton- Collisions (1)
- Protons (1)
- Protoonkogen (1)
- Protopterus annectens (1)
- Protoscolex (1)
- Prototype (1)
- Pruno-Rubion sprengelii (1)
- Prunus-africana (1)
- Präferenz (1)
- Pseudo-allergy (1)
- Pseudomonas (1)
- Pseudomonas-aeruginosa (1)
- Pseudorapidity (1)
- Pseudotsuga menziesii (1)
- Psychisch Kranker (1)
- Psychological distress (1)
- Psychology (1)
- Psychometrics (1)
- Psychomotor Performance/physiology (1)
- Psychopathology (1)
- Psychopharmakologie (1)
- Psychotherapie (1)
- Pt (1)
- Pteromalidae (1)
- Pulmonary Embolism (1)
- Pulmonary function (1)
- Pulmonary function tests (1)
- Pulmonary hypertension (1)
- Puls-pressure variation (1)
- Pulse shaping (1)
- Purification (1)
- Purpureocillium (1)
- Pycnogenol (1)
- Pyrrinol (1)
- Pädagogische Psychologie (1)
- Q. brantii (1)
- QCD Corrections (1)
- QCD background (1)
- QCM (1)
- QGP-1 (1)
- QIVIVE (1)
- QKD (1)
- QM/MM (1)
- QTL analysis (1)
- QUAC (1)
- QW interface profile (1)
- Qb-Test (1)
- Qi gong (1)
- QoE fundamentals (1)
- QoS-QoE mapping functions (1)
- Qualitative representation and reasoning (1)
- Quality-control (1)
- QuantiFERON\(^®\)-TB Gold Plus (1)
- Quantitative risk assessment (1)
- Quantitative structure-property relationship modeling (QSPR) (1)
- Quantum chromodynamics (1)
- Quantum chronodynamics (1)
- Quantum electrodynamics (1)
- Quantum optics with artificial atoms (1)
- Quantum wells (1)
- Quantum-well, -wire and -dot devices (1)
- Quark (1)
- Quark & gluon jets (1)
- Quark pair procuction (1)
- Quarkonium Production (1)
- Quarks (1)
- Quercus petraea (1)
- Question format (1)
- Questionnaire (1)
- Quetiapine (1)
- R (1)
- R factor = 0.018 (1)
- R factor = 0.025 (1)
- R package (1)
- R-715 (1)
- R-CHOP (1)
- R-GECO1 cytosolic Ca\(^{2+}\) reporter (1)
- R-loop (1)
- R-sneutrino (1)
- R-type (1)
- R. sphaeroidesl (1)
- R0 (1)
- RAB GTPases (1)
- RAD51C (1)
- RADARSAT Constellation Mission (1)
- RADARSAT-2 (1)
- RAF1 (1)
- RAKI (1)
- RAP (1)
- RARRES2 (1)
- RAS (1)
- RBCL (1)
- RBCL Gene-sequences (1)
- RBM8A (1)
- RCK domain (1)
- RDoC (1)
- RECK (1)
- RECOLA (1)
- REMO-iMOVE (1)
- RESP model (1)
- RET6 (1)
- RFP (1)
- RGB-D (1)
- RHE (1)
- RHO-associated kinease (1)
- RIG-I (1)
- RIM-binding protein (1)
- RIM1α (1)
- RINEX Format (1)
- RIP1 (1)
- RLQ analysis (1)
- RLT (1)
- RMnO3 (1)
- RNA CHAPERONE HFQ (1)
- RNA Enzymes (1)
- RNA Expression (1)
- RNA Labelling (1)
- RNA Methyltransferase (1)
- RNA Modification (1)
- RNA aptamers (1)
- RNA binding protein (1)
- RNA chaperone Hfq (1)
- RNA denaturation (1)
- RNA export (1)
- RNA expression (1)
- RNA in situ hybridization (1)
- RNA isolation (1)
- RNA labeling (1)
- RNA ligation (1)
- RNA metabolism (1)
- RNA polymerase (1)
- RNA probe (1)
- RNA recognition (1)
- RNA sequence (1)
- RNA sequence analyses (1)
- RNA sequencing (RNA-Seq) (1)
- RNA structures (1)
- RNA transport (1)
- RNA virus (1)
- RNA-Aptamere (1)
- RNA-Dependent RNA Polymerase (1)
- RNA-Seq analysis (1)
- RNA-binding protein (1)
- RNA-polymerase-I (1)
- RNA-seq transcriptome (1)
- RNAPOL1 (1)
- RNAScope (1)
- RNAi (1)
- RNAlater (1)
- RNR (1)
- RNase E (1)
- RNase III (1)
- ROCK (1)
- ROI (1)
- ROK-alpha (1)
- ROR1 (1)
- RP11 (1)
- RQQ domain (1)
- RRID: AB_2315425 (1)
- RRID: AB_2337244 (1)
- RRM2 (1)
- RS-13 (1)
- RSK2 (1)
- RSV-A ON1 (1)
- RT -PCR (1)
- RT-qPCT (1)
- RTK (1)
- RTMS (1)
- RTPS1 (1)
- RTPS2 (1)
- RTS,S/AS01 malaria vaccine (1)
- RTX-Toxins (1)
- RU(CO)(3)CL(GLYCINATE) (1)
- RU-(II) complexes (1)
- RYGB (1)
- Ra-224 (1)
- Rab (1)
- Rac1 (1)
- Racial differences (1)
- Radiation (1)
- Radiation biology (1)
- Radiation calculations (1)
- Radiation exposure (1)
- Radiation inactivation (1)
- Radiation sensitivity (1)
- Radical prostatectomy (1)
- Radical-ion pair (1)
- Radicals (1)
- Radiochemotherapy (1)
- Radiofluorine (1)
- Radiographs (1)
- Radioiodine Therapy (1)
- Radioligand binding - 86Rb + -efflux (1)
- Radioligands (1)
- Radioligauds (1)
- Radionuclide therapy (1)
- Radiopharmacy (1)
- Radiosensitivity (1)
- Radiotherapy treatment planning (1)
- Radiotracer (1)
- Radium (1)
- Rain-forest (1)
- Ramadan (1)
- Raman (1)
- Raman micro-spectroscopy (1)
- Raman probes (1)
- Raman spectroscopy (1)
- Raman-scattering (1)
- Ramsar Convention on Wetlands (1)
- Random Forests (1)
- Random-Walk (1)
- Ranidae (1)
- Rapid evolution (1)
- Rapidity (1)
- Rashba-Splitting (1)
- Rat Iiver microsomes (1)
- Rat Sensory Neurons (1)
- Rat hippocampus (1)
- Rat liver peroxisome (1)
- Rat mynteric plexus (1)
- Rat spinal-cord (1)
- Rat-brain (1)
- Rating scale (1)
- Razumikhin method (1)
- RbdB (1)
- Re-irradiation (1)
- Reachability matrix (1)
- Real-time (1)
- Real-time Kinematics (RTK) (1)
- Real-time PCR (1)
- Rearrangement of carbocations (1)
- RecQ4 (1)
- Receptor (1)
- Receptor kinase (1)
- Receptor ytva (1)
- Receptors (1)
- Rechtschreibung (1)
- Reciprocity (1)
- Recognition of depression (1)
- Recombinant (1)
- Recombinant DNA (1)
- Recombinant DNA ; Growth hormone gene ; PCR; Silver carp ; Fish (1)
- Recombinant DNA ; polymerase chain reaction ; metallothionein gene ; rainbow trout ; fish (1)
- Recombinant protein expression (1)
- Recombinant vaccinia (1)
- Recombination directionality factor (1)
- Recurrent medulloblastoma (1)
- Recurrent neural-networks (1)
- Red Sea (1)
- Red sea (1)
- Redox environment (1)
- Reflexa Roxb (1)
- Regenerative medicine (1)
- Regimes (1)
- Regional differences (1)
- Regulation of protease activity (1)
- Regulatory T-cells (1)
- Regulatory-cells (1)
Institut
- Theodor-Boveri-Institut für Biowissenschaften (1307)
- Physikalisches Institut (353)
- Institut für Psychologie (335)
- Neurologische Klinik und Poliklinik (323)
- Medizinische Klinik und Poliklinik I (317)
- Medizinische Klinik und Poliklinik II (317)
- Institut für Molekulare Infektionsbiologie (288)
- Institut für Anorganische Chemie (251)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (233)
- Institut für Organische Chemie (226)
Schriftenreihe
Sonstige beteiligte Institutionen
- Johns Hopkins School of Medicine (11)
- IZKF Nachwuchsgruppe Geweberegeneration für muskuloskelettale Erkrankungen (7)
- Clinical Trial Center (CTC) / Zentrale für Klinische Studien Würzburg (ZKSW) (5)
- Wilhelm-Conrad-Röntgen-Forschungszentrum für komplexe Materialsysteme (5)
- Bernhard-Heine-Centrum für Bewegungsforschung (4)
- Johns Hopkins University School of Medicine (4)
- Zentraleinheit Klinische Massenspektrometrie (3)
- Center for Interdisciplinary Clinical Research, Würzburg University, Würzburg, Germany (2)
- Interdisciplinary Center for Clinical Research (2)
- Klinische Studienzentrale (Universitätsklinikum) (2)
ResearcherID
- D-1221-2009 (1)
Alpine bumble bees are the most important pollinators in temperate mountain ecosystems. Although they are used to encounter small-scale successions of very different climates in the mountains, many species respond sensitively to climatic changes, reflected in spatial range shifts and declining populations worldwide. Cuticular hydrocarbons (CHCs) mediate climate adaptation in some insects. However, whether they predict the elevational niche of bumble bees or their responses to climatic changes remains poorly understood. Here, we used three different approaches to study the role of bumble bees’ CHCs in the context of climate adaptation: using a 1,300 m elevational gradient, we first investigated whether the overall composition of CHCs, and two potentially climate-associated chemical traits (proportion of saturated components, mean chain length) on the cuticle of six bumble bee species were linked to the species’ elevational niches. We then analyzed intraspecific variation in CHCs of Bombus pascuorum along the elevational gradient and tested whether these traits respond to temperature. Finally, we used a field translocation experiment to test whether CHCs of Bombus lucorum workers change, when translocated from the foothill of a cool and wet mountain region to (a) higher elevations, and (b) a warm and dry region. Overall, the six species showed distinctive, species-specific CHC profiles. We found inter- and intraspecific variation in the composition of CHCs and in chemical traits along the elevational gradient, but no link to the elevational distribution of species and individuals. According to our expectations, bumble bees translocated to a warm and dry region tended to express longer CHC chains than bumble bees translocated to cool and wet foothills, which could reflect an acclimatization to regional climate. However, chain lengths did not further decrease systematically along the elevational gradient, suggesting that other factors than temperature also shape chain lengths in CHC profiles. We conclude that in alpine bumble bees, CHC profiles and traits respond at best secondarily to the climate conditions tested in this study. While the functional role of species-specific CHC profiles in bumble bees remains elusive, limited plasticity in this trait could restrict species’ ability to adapt to climatic changes.
Introduction: Grasslands cover one third of the agricultural area in Germany and are mainly used for fodder production. However, grasslands fulfill many other ecosystem functions, like carbon storage, water filtration and the provision of habitats. In Germany, grasslands are mown and/or grazed multiple times during the year. The type and timing of management activities and the use intensity vary strongly, however co-determine grassland functions. Large-scale spatial information on grassland activities and use intensity in Germany is limited and not openly provided. In addition, the cause for patterns of varying mowing intensity are usually not known on a spatial scale as data on the incentives of farmers behind grassland management decisions is not available.
Methods: We applied an algorithm based on a thresholding approach utilizing Sentinel-2 time series to detect grassland mowing events to investigate mowing dynamics in Germany in 2018–2021. The detected mowing events were validated with an independent dataset based on the examination of public webcam images. We analyzed spatial and temporal patterns of the mowing dynamics and relationships to climatic, topographic, soil or socio-political conditions.
Results: We found that most intensively used grasslands can be found in southern/south-eastern Germany, followed by areas in northern Germany. This pattern stays the same among the investigated years, but we found variations on smaller scales. The mowing event detection shows higher accuracies in 2019 and 2020 (F1 = 0.64 and 0.63) compared to 2018 and 2021 (F1 = 0.52 and 0.50). We found a significant but weak (R2 of 0–0.13) relationship for a spatial correlation of mowing frequency and climate as well as topographic variables for the grassland areas in Germany. Further results indicate a clear value range of topographic and climatic conditions, characteristic for intensive grassland use. Extensive grassland use takes place everywhere in Germany and on the entire spectrum of topographic and climatic conditions in Germany. Natura 2000 grasslands are used less intensive but this pattern is not consistent among all sites.
Discussion: Our findings on mowing dynamics and relationships to abiotic and socio-political conditions in Germany reveal important aspects of grassland management, including incentives of farmers.
Xiphophorus fish exhibit a clear phenotypic polymorphism in puberty onset and reproductive strategies of males. In X. nigrensis and X. multilineatus, puberty onset is genetically determined and linked to a melanocortin 4 receptor (Mc4r) polymorphism of wild-type and mutant alleles on the sex chromosomes. We hypothesized that Mc4r mutant alleles act on wild-type alleles by a dominant negative effect through receptor dimerization, leading to differential intracellular signaling and effector gene activation. Depending on signaling strength, the onset of puberty either occurs early or is delayed. Here, we show by Förster Resonance Energy Transfer (FRET) that wild-type Xiphophorus Mc4r monomers can form homodimers, but also heterodimers with mutant receptors resulting in compromised signaling which explains the reduced Mc4r signaling in large males. Thus, hetero- vs. homo- dimerization seems to be the key molecular mechanism for the polymorphism in puberty onset and body size in male fish.
Background
Adrenal incidentalomas with cortisol autonomy are associated with increased cardiovascular morbidity and mortality. Specific data on the clinical and biochemical course of affected patients are lacking.
Methods
Retrospective study from a tertiary referral centre in Germany. After exclusion of overt hormone excess, malignancy and glucocorticoid medication, patients with adrenal incidentalomas were stratified according to serum cortisol after 1 mg dexamethasone: autonomous cortisol secretion (ACS), >5.0; possible ACS (PACS), 1.9-5.0; non-functioning adenomas (NFA), ≤1.8 µg/dl.
Results
A total of 260 patients were enrolled (147 women (56.5%), median follow-up 8.8 (2.0-20.8) years). At initial diagnosis, median age was 59.5 (20-82) years, and median tumour size was 27 (10-116) mm. Bilateral tumours were more prevalent in ACS (30.0%) and PACS (21.9%) than in NFA (8.1%). Over time, 40/124 (32.3%) patients had a shift of their hormonal secretion pattern (NFA to PACS/ACS, n=15/53; PACS to ACS, n=6/47; ACS to PACS, n=11/24; PACS to NFA, n=8/47). However, none of the patients developed overt Cushing’s syndrome. Sixty-one patients underwent adrenalectomy (NFA, 17.9%; PACS, 24.0%; ACS, 39.0%). When non-operated patients with NFA were compared to PACS and ACS at last follow-up, arterial hypertension (65.3% vs. 81.9% and 92.0%; p<0.05), diabetes (23.8% vs. 35.6% and 40.0%; p<0.01), and thromboembolic events (PACS: HR 3.43, 95%-CI 0.89-13.29; ACS: HR 5.96, 95%-CI 1.33-26.63; p<0.05) were significantly less frequent, along with a trend towards a higher rate of cardiovascular events in case of cortisol autonomy (PACS: HR 2.23, 95%-CI 0.94-5.32; ACS: HR 2.60, 95%-CI 0.87-7.79; p=0.1). Twenty-five (12.6%) of the non-operated patients died, with higher overall mortality in PACS (HR 2.6, 95%-CI 1.0-4.7; p=0.083) and ACS (HR 4.7, 95%-CI 1.6-13.3; p<0.005) compared to NFA. In operated patients, prevalence of arterial hypertension decreased significantly (77.0% at diagnosis to 61.7% at last follow-up; p<0.05). The prevalence of cardiovascular events and mortality did not differ significantly between operated and non-operated patients, whereas thromboembolic events were significantly less frequent in the surgical treatment group.
Conclusion
Our study confirms relevant cardiovascular morbidity in patients with adrenal incidentalomas (especially those with cortisol autonomy). These patients should therefore be monitored carefully, including adequate treatment of typical cardiovascular risk factors. Adrenalectomy was associated with a significantly decreased prevalence of hypertension. However, more than 30% of patients required reclassification according to repeated dexamethasone suppression tests. Thus, cortisol autonomy should ideally be confirmed before making any relevant treatment decision (e.g. adrenalectomy).
The transition to school is a key juncture in an individual’s educational trajectory, with far-reaching effects on the development of children and their families. Successful transitions require flexibility in the design of the transition process, addressing the needs of the persons involved in an adaptive manner. Adaptivity is also considered crucial for the success of inclusive transitions. However, a systematic breakdown of the aspects that characterize the concept of adaptivity in the context of inclusive school entry is not available at this point. This article therefore provides a conceptualization of adaptivity in the inclusive transition to school as well as a review of the current literature focusing this topic. The goal is to develop a model that structures the various aspects of adaptivity at school entry and offers an overview of the way these aspects are important to design the transition successfully according to current findings of empirical research. Building on a concept of transitions informed by ecological systems theory, we are guided by the assumption that adaptivity at transition to school may occur in three forms: as a feature of the persons involved in the transition; as a feature of the processes that moderate the course of the transition; and as a feature of the structures that frame the transition. Based on this distinction, we develop a model that presents adaptivity in the inclusive transition to school.
Providing adaptive, independence-preserving and theory-guided support to students in dealing with real-world problems in mathematics lessons is a major challenge for teachers in their professional practice. This paper examines this challenge in the context of simulations and mathematical modelling with digital tools: in addition to mathematical difficulties when autonomously working out individual solutions, students may also experience challenges when using digital tools. These challenges need to be closely examined and diagnosed, and might – if necessary – have to be overcome by intervention in such a way that the students can subsequently continue working independently. Thus, if a difficulty arises in the working process, two knowledge dimensions are necessary in order to provide adapted support to students. For teaching simulations and mathematical modelling with digital tools, more specifically, these knowledge dimensions are: pedagogical content knowledge about simulation and modelling processes supported by digital tools (this includes knowledge about phases and difficulties in the working process) and pedagogical content knowledge about interventions during the mentioned processes (focussing on characteristics of suitable interventions as well as their implementation and effects on the students’ working process). The two knowledge dimensions represent cognitive dispositions as the basis for the conceptualisation and operationalisation of a so-called adaptive intervention competence for teaching simulations and mathematical modelling with digital tools. In our article, we present a domain-specific process model and distinguish different types of teacher interventions. Then we describe the design and content of a university course at two German universities aiming to promote this domain-specific professional adaptive intervention competence, among others. In a study using a quasi-experimental pre-post design (N = 146), we confirm that the structure of cognitive dispositions of adaptive intervention competence for teaching simulations and mathematical modelling with digital tools can be described empirically by a two-dimensional model. In addition, the effectiveness of the course is examined and confirmed quantitatively. Finally, the results are discussed, especially against the background of the sample and the research design, and conclusions are derived for possibilities of promoting professional adaptive intervention competence in university courses.
Following the implementation of 2018’s laws on the rights of persons with disabilities (PWDs) in Egypt, students with disabilities (SWDs) have both legal and moral rights to meaningful learning opportunities and inclusive education. Despite that, SWDs still have very limited education resources which limit their career aspirations and quality of life. In this respect, education whether as part of formal education or lifelong learning is central to the museum’s mission. Museums, as part of non-formal education, are being acknowledged for their educative powers and investments in the development of quality formal, non-formal, and informal learning experiences. Further, phrases such as “inclusivity,” “accessibility,” and “diversity” were notably included in the newly approved museum definition by ICOM (2022) emphasizing museums’ obligations to embrace societal issues and shape a cultural attitude concerning disability rights, diversity, and equality together with overcoming exclusionary educational practices. The study seeks to investigate the existing resources and inclusive practices in Egyptian museums to achieve non-formal education for SWDs. Qualitative research approaches have been employed to answer a specific question: How can Egyptian museums work within their governing systems to support the learning of SWDs beyond their formal education system? The study aims to assess the potential of Egyptian museums in facilitating learning for SWDs. Further, it examines the capability of Egyptian museums in contributing to informal and non-formal learning for SWDs and striving for inclusive education inspired by the social model of disability that fosters inclusive educational programs and adopts a human rights-based approach. The results revealed that Egyptian museums contributed to the learning of SWDs, yet small-scale programs and individual efforts, but they are already engaged in active inclusive practices that address the learning of SWDs. The study suggests that they need to be acknowledged and supported by the government as state instruments and direct actors in advancing inclusive education and implementing appropriate pedagogies in favor of SWDs.
Ultra-high field cardiac MRI in large animals and humans for translational cardiovascular research
(2023)
A key step in translational cardiovascular research is the use of large animal models to better understand normal and abnormal physiology, to test drugs or interventions, or to perform studies which would be considered unethical in human subjects. Ultrahigh field magnetic resonance imaging (UHF-MRI) at 7 T field strength is becoming increasingly available for imaging of the heart and, when compared to clinically established field strengths, promises better image quality and image information content, more precise functional analysis, potentially new image contrasts, and as all in-vivo imaging techniques, a reduction of the number of animals per study because of the possibility to scan every animal repeatedly. We present here a solution to the dual use problem of whole-body UHF-MRI systems, which are typically installed in clinical environments, to both UHF-MRI in large animals and humans. Moreover, we provide evidence that in such a research infrastructure UHF-MRI, and ideally combined with a standard small-bore UHF-MRI system, can contribute to a variety of spatial scales in translational cardiovascular research: from cardiac organoids, Zebra fish and rodent hearts to large animal models such as pigs and humans. We present pilot data from serial CINE, late gadolinium enhancement, and susceptibility weighted UHF-MRI in a myocardial infarction model over eight weeks. In 14 pigs which were delivered from a breeding facility in a national SARS-CoV-2 hotspot, we found no infection in the incoming pigs. Human scanning using CINE and phase contrast flow measurements provided good image quality of the left and right ventricle. Agreement of functional analysis between CINE and phase contrast MRI was excellent. MRI in arrested hearts or excised vascular tissue for MRI-based histologic imaging, structural imaging of myofiber and vascular smooth muscle cell architecture using high-resolution diffusion tensor imaging, and UHF-MRI for monitoring free radicals as a surrogate for MRI of reactive oxygen species in studies of oxidative stress are demonstrated. We conclude that UHF-MRI has the potential to become an important precision imaging modality in translational cardiovascular research.
Over the past years, scholars have explored eudaimonic video game experiences—profound entertainment responses that include meaningfulness, reflection, and others. In a comparatively short time, a plethora of explanations for the formation of such eudaimonic gaming experiences has been developed across multiple disciplines, making it difficult to keep track of the state of theory development. Hence, we present a theoretical overview of these explanations. We first provide a working definition of eudaimonic gaming experiences (i.e., experiences that reflect human virtues and encourage players to develop their potential as human beings fully) and outline four layers of video games—agency, narrative, sociality, and aesthetics—that form the basis for theorizing. Subsequently, we provide an overview of the theoretical approaches, categorizing them based on which of the four game layers their explanation mainly rests upon. Finally, we suggest the contingency of the different theoretical approaches for explaining eudaimonic experiences by describing how their usefulness varies as a function of interactivity. As different types of games offer players various levels of interactivity, our overview suggests which theories and which game layers should be considered when examining eudaimonic experiences for specific game types.
Fungal infections are a major global health burden where Candida albicans is among the most common fungal pathogen in humans and is a common cause of invasive candidiasis. Fungal phenotypes, such as those related to morphology, proliferation and virulence are mainly driven by gene expression, which is primarily regulated by kinase signaling cascades. Serine-arginine (SR) protein kinases are highly conserved among eukaryotes and are involved in major transcriptional processes in human and S. cerevisiae. Candida albicans harbors two SR protein kinases, while Sky2 is important for metabolic adaptation, Sky1 has similar functions as in S. cerevisiae. To investigate the role of these SR kinases for the regulation of transcriptional responses in C. albicans, we performed RNA sequencing of sky1Δ and sky2Δ and integrated a comprehensive phosphoproteome dataset of these mutants. Using a Systems Biology approach, we study transcriptional regulation in the context of kinase signaling networks. Transcriptomic enrichment analysis indicates that pathways involved in the regulation of gene expression are downregulated and mitochondrial processes are upregulated in sky1Δ. In sky2Δ, primarily metabolic processes are affected, especially for arginine, and we observed that arginine-induced hyphae formation is impaired in sky2Δ. In addition, our analysis identifies several transcription factors as potential drivers of the transcriptional response. Among these, a core set is shared between both kinase knockouts, but it appears to regulate different subsets of target genes. To elucidate these diverse regulatory patterns, we created network modules by integrating the data of site-specific protein phosphorylation and gene expression with kinase-substrate predictions and protein-protein interactions. These integrated signaling modules reveal shared parts but also highlight specific patterns characteristic for each kinase. Interestingly, the modules contain many proteins involved in fungal morphogenesis and stress response. Accordingly, experimental phenotyping shows a higher resistance to Hygromycin B for sky1Δ. Thus, our study demonstrates that a combination of computational approaches with integration of experimental data can offer a new systems biological perspective on the complex network of signaling and transcription. With that, the investigation of the interface between signaling and transcriptional regulation in C. albicans provides a deeper insight into how cellular mechanisms can shape the phenotype.
The signals that coordinate and control movement in vertebrates are transmitted from motoneurons (MNs) to their target muscle cells at neuromuscular junctions (NMJs). Human NMJs display unique structural and physiological features, which make them vulnerable to pathological processes. NMJs are an early target in the pathology of motoneuron diseases (MND). Synaptic dysfunction and synapse elimination precede MN loss suggesting that the NMJ is the starting point of the pathophysiological cascade leading to MN death. Therefore, the study of human MNs in health and disease requires cell culture systems that enable the connection to their target muscle cells for NMJ formation. Here, we present a human neuromuscular co-culture system consisting of induced pluripotent stem cell (iPSC)-derived MNs and 3D skeletal muscle tissue derived from myoblasts. We used self-microfabricated silicone dishes combined with Velcro hooks to support the formation of 3D muscle tissue in a defined extracellular matrix, which enhances NMJ function and maturity. Using a combination of immunohistochemistry, calcium imaging, and pharmacological stimulations, we characterized and confirmed the function of the 3D muscle tissue and the 3D neuromuscular co-cultures. Finally, we applied this system as an in vitro model to study the pathophysiology of Amyotrophic Lateral Sclerosis (ALS) and found a decrease in neuromuscular coupling and muscle contraction in co-cultures with MNs harboring ALS-linked SOD1 mutation. In summary, the human 3D neuromuscular cell culture system presented here recapitulates aspects of human physiology in a controlled in vitro setting and is suitable for modeling of MND.
Diagnosing any of the more than 30 types of T-cell lymphomas is considered a challenging task for many pathologists and currently requires morphological expertise as well as the integration of clinical data, immunophenotype, flow cytometry and clonality analyses. Even considering all available information, some margin of doubt might remain using the current diagnostic procedures. In recent times, the genetic landscape of most T-cell lymphomas has been elucidated, showing a number of diagnostically relevant mutations. In addition, recent data indicate that some of these genetic alterations might bear prognostic and predictive value. Extensive genetic analyses, such as whole exome or large panel sequencing are still expensive and time consuming, therefore limiting their application in routine diagnostic. We therefore devoted our effort to develop a lean approach for genetic analysis of T-cell lymphomas, focusing on maximum efficiency rather than exhaustively covering all possible targets. Here we report the results generated with our small amplicon-based panel that could be used routinely on paraffin-embedded and even decalcified samples, on a single sample basis in parallel with other NGS-panels used in our routine diagnostic lab, in a relatively short time and with limited costs. We tested 128 available samples from two German reference centers as part of our routine work up (among which 116 T-cell lymphomas), which is the largest routine diagnostic series reported to date. Our results showed that this assay had a very high rate of technical success (97%) and could detect mutations in the majority (79%) of tested T-cell lymphoma samples.
The execution of voluntary movements is primarily governed by the cerebral hemisphere contralateral to the moving limb. Previous research indicates that the ipsilateral motor network, comprising the primary motor cortex (M1), supplementary motor area (SMA), and premotor cortex (PM), plays a crucial role in the planning and execution of limb movements. However, the precise functions of this network and its interplay in different task contexts have yet to be fully understood. Twenty healthy right-handed participants (10 females, mean age 26.1 ± 4.6 years) underwent functional MRI scans while performing biceps brachii representations such as bilateral, unilateral flexion, and bilateral flexion-extension. Ipsilateral motor evoked potentials (iMEPs) were obtained from the identical set of participants in a prior study using transcranial magnetic stimulation (TMS) targeting M1 while employing the same motor tasks. The voxel time series was extracted based on the region of interest (M1, SMA, ventral PM and dorsal PM). Directed functinal connectivity was derived from the extracted time series using time-resolved partial directed coherence. We found increased connectivity from left-PMv to both sides M1, as well as right-PMv to both sides SMA, in unilateral flexion compared to bilateral flexion. Connectivity from left M1 to left-PMv, and left-SMA to right-PMd, also increased in both unilateral flexion and bilateral flexion-extension compared to bilateral flexion. However, connectivity between PMv and right-M1 to left-PMd decreased during bilateral flexion-extension compared to unilateral flexion. Additionally, during bilateral flexion-extension, the connectivity from right-M1 to right-SMA had a negative relationship with the area ratio of iMEP in the dominant side. Our results provide corroborating evidence for prior research suggesting that the ipsilateral motor network is implicated in the voluntary movements and underscores its involvement in cognitive processes such as movement planning and coordination. Moreover, ipsilateral connectivity from M1 to SMA on the dominant side can modulate the degree of ipsilateral M1 activation during bilateral antagonistic contraction.
Introduction: National and international guidelines recommend early integration of evidence-based multimodal interventions and programs, especially with a focus on relaxation techniques and other Mind–Body-based methods to maintain the quality of life of oncology patients, improve treatment tolerability, and promote healthy lifestyle behaviors. Consequently, we aim to understand what drives patients and how they navigate integrative medicine to best advise them. This study aimed to detect possible topics of particular interest to patients and identify the patient groups that could benefit most from further programs. Furthermore, we aimed to investigate if patients are open-minded toward integrative oncology concepts and learn about their motivational level to maintain or change behavior.
Methods: Between August 2019 and October 2020 we surveyed patients undergoing oncological therapy in a university oncological outpatient center using a custom-developed questionnaire based on established Mind–Body Medicine concepts.
Results: We included 294 patients with various cancers. More than half reported problems sleeping through (61%) and 42% felt stressed frequently, invariably rating this as detrimental to their health. Moreover, a slight majority (52%) felt physically limited due to their disease and only 30% performed defined exercise programs. Women were significantly more likely to feel stressed and reported with alarming frequency that they often feel “everything was up to them.” The 40–65-year-olds reported significantly less restful sleep, more stress and were more dissatisfied with their situation. However, this group already used natural remedies most frequently and was most often motivated to use relaxation techniques in the next 6 months. The lower the perceived individual energy level (EL), the less frequently patients did sport, the more frequently they felt their disease impaired their activity, mostly feeling stressed and tense. We also found significant associations between negative emotions/thoughts and the variables “sleep,” “use of relaxation techniques,” “personal stress perception,” and “successful lifestyle modification.”
Conclusion: Mind–Body programs that focus on patient’s individual resources, with tools to explore impairing patterns of self-perception and cognitive biases, can be a valuable resource for oncology patients and should therefore be part of an integrative medical treatment concept.
Introduction: In this study, we investigated the impact of age on mate selection preferences in males and females, and explored how the formation and duration of committed relationships depend on the sex of the person making the selection.
Methods: To this end, we utilized data from the television dating shows The Bachelor and The Bachelorette. In these programs, either a single man (“bachelor”) or a woman (“bachelorette”) has the opportunity to select a potential long-term partner from a pool of candidates. Our analysis encompassed a total of n = 169 seasons from 23 different countries, beginning with the first airing in 2002.
Results: We found that the likelihood of the final couple continuing their relationship beyond the broadcast was higher in The Bachelorette than in The Bachelor, although the duration of these relationships was not significantly influenced by the type of show. On average, women were younger, both when selecting their partner and when being chosen. However, men exhibited a greater preference for larger age differences than women. Furthermore, the age of the chosen male partners significantly increased with the age of the “bachelorettes,” whereas “bachelors” consistently favored women around 25.5 years old, regardless of their own age.
Discussion: We discuss these findings within the context of parental investment theory and sexual strategies theory.
Aim: The climate and ecological crises are considered fundamental threats to human health. Healthcare workers in general and doctors in particular can contribute as change agents in mitigation and adaptation. Planetary health education (PHE) aims to harness this potential. This study explores perspectives among stakeholders involved in PHE at German medical schools on the characteristics of high-quality PHE and compares them to existing PHE frameworks.
Methods: In 2021, we conducted a qualitative interview study with stakeholders from German medical schools involved in PHE. Three different groups were eligible: faculty members, medical students actively involved in PHE, and study deans of medical schools. Recruitment was performed through national PHE networks and snowball sampling. Thematic qualitative text analysis according to Kuckartz was used for the analysis. Results were systematically compared to three existing PHE frameworks.
Results: A total of 20 participants (13 female) from 15 different medical schools were interviewed. Participants covered a wide range of professional backgrounds and experience in PHE education. The analysis revealed ten key themes: (1) Complexity and systems thinking, (2) inter- and transdisciplinarity, (3) ethical dimension, (4) responsibility of health professionals, (5) transformative competencies including practical skills, (6) space for reflection and resilience building, (7) special role of students, (8) need for curricular integration, (9) innovative and proven didactic methods, and (10) education as a driver of innovation. Six of our themes showed substantial overlap with existing PHE frameworks. Two of our themes were only mentioned in one of the frameworks, and two others were not explicitly mentioned. Few important elements of the frameworks did not emerge from our data.
Conclusions: In the light of increased attention regarding the connections of the climate and ecological crises and health, our results can be useful for anyone working toward the integration of planetary health into medical schools' and any health professions' curricula and should be considered when designing and implementing new educational activities.
Background: According to socio-ecological theories, physical activity behaviors are linked to the physical and social neighborhood environment. Reliable and contextually adapted instruments are needed to assess environmental characteristics related to physical activity. This work aims to develop an audit toolbox adapted to the German context, to urban and rural settings, for different population groups, and different types of physical activity; and to evaluate its inter-rater reliability.
Methods: We conducted a systematic literature search to collect existing audit tools and to identify the latest evidence of environmental factors influencing physical activity in general, as well as in German populations. The results guided the construction of a category system for the toolbox. Items were assigned to the categories based on their relevance to physical activity and to the German context as well as their comprehensibility. We piloted the toolbox in different urban and rural areas (100 street segments, 15 parks, and 21 playgrounds) and calculated inter-rater reliability by Cohen's Kappa.
Results: The audit toolbox comprises a basic streetscape audit with seven categories (land use and destinations, traffic safety, pedestrian infrastructure, cycling infrastructure, attractiveness, social environment, and subjective assessment), as well as supplementary tools for children and adolescents, seniors and people with impaired mobility, parks and public open spaces, playgrounds, and rural areas. 76 % of all included items had moderate, substantial, or almost perfect inter-rater reliability (κ > 0.4).
Conclusions: The audit toolbox is an innovative and reliable instrument for the assessment of the physical activity friendliness of urban and rural environments in Germany.
Stress experiences of healthcare assistants in family practice at the onset of the COVID-19 pandemic
(2023)
Background: At the beginning of the pandemic in 2020, healthcare assistants in general practices were confronted with numerous new challenges. The aim of the study was to investigate the stress factors of healthcare assistants in March/April 2020 as well as in the further course of the pandemic in 2020.
Methods: From August to December 2020, 6,300 randomly selected healthcare assistants in four German states were invited to participate in the study. We performed a mixed methods design using semi-structured telephone interviews and a cross-sectional survey with quantitative and open questions. The feeling of psychological burden was assessed on a 6-point likert-scale. We defined stress factors and categorized them in patient, non-patient and organizational stress factors. The results of the three data sets were compared within a triangulation protocol.
Results: One thousand two hundred seventy-four surveys were analyzed and 28 interviews with 34 healthcare assistants were conducted. Of the participants, 29.5% reported experiences of a very high or high feeling of psychological burden in March/April 2020. Worries about the patients’ health and an uncertainty around the new disease were among the patient-related stress factors. Non-patient-related stress factors were problems with the compatibility of work and family, and the fear of infecting relatives with COVID-19. Organizational efforts and dissatisfaction with governmental pandemic management were reported as organizational stress factors. Support from the employer and team cohesion were considered as important resources.
Discussion: It is necessary to reduce stress among healthcare assistants by improving their working conditions and to strengthen their resilience to ensure primary healthcare delivery in future health crises.
Introduction: This paper addresses the need for reliable user identification in Extended Reality (XR), focusing on the scarcity of public datasets in this area.
Methods: We present a new dataset collected from 71 users who played the game “Half-Life: Alyx” on an HTC Vive Pro for 45 min across two separate sessions. The dataset includes motion and eye-tracking data, along with physiological data from a subset of 31 users. Benchmark performance is established using two state-of-the-art deep learning architectures, Convolutional Neural Networks (CNN) and Gated Recurrent Units (GRU).
Results: The best model achieved a mean accuracy of 95% for user identification within 2 min when trained on the first session and tested on the second.
Discussion: The dataset is freely available and serves as a resource for future research in XR user identification, thereby addressing a significant gap in the field. Its release aims to facilitate advancements in user identification methods and promote reproducibility in XR research.
Rationale: Social factors are considered important for the initiation and maintenance of drug abuse. Virtual reality (VR) research on cue reactivity and exposure frequently incorporates social stimuli as part of complex drug-intake scenarios. Attempts are rarely made to dissect the impact of the different components and their interactive effects. The present study critically extends this line of research by investigating the modulatory effects of social context on the reactivity evoked by proximal smoking cues.
Methods: Thirty-two smokers and 33 never-smokers were presented in VR with proximal cues and neutral stimuli, embedded in a social context or a neutral context. A virtual hand model was used to translate real hand movements into VR. Each trial started with the presentation of the different stimulus–context combinations. Discrete stimuli were presented on the table in front of the participants, and contextual stimuli were presented at the end of the table. Afterward, participants were instructed to grasp the target stimulus (a cigarette vs. a pencil) in front of them. After successful contact, the stimulus appeared in the virtual hand. Modulation of cue reactivity by social context was assessed by self-report, physiological measures, and overt approach behavior.
Results: The results revealed modulatory effects of social context on the responses to proximal smoking cues in smokers. In contrast to never-smokers, smoking cues evoked craving in smokers, which was attenuated in a social context. Furthermore, social context increased the latency to approach and contact the cigarette in the group of smokers but did not affect behavioral approach responses in never-smokers. Other data provided indications for interactive, but also main effects of cues and contexts. Interestingly, cue-evoked craving was increased after contact with the virtual cigarette.
Conclusion: The present study critically extends previous research by providing evidence for the modulation of cue reactivity by social context. The results are particularly important given the well-established role of drug-associated environmental contexts in the stimulus control of addictive behaviors. Our results emphasize the need to address social context effects on cue reactivity in basic research and treatment and further suggest that changes in the perceived availability of smoking might enhance or inhibit cue-evoked reactivity.
Objective: This study aims to critically evaluate the effectiveness and accuracy of a time safing and cost-efficient open-source algorithm for in-house planning of mandibular reconstructions using the free osteocutaneous fibula graft. The evaluation focuses on quantifying anatomical accuracy and assessing the impact on ischemia time.
Methods: A pilot study was conducted, including patients who underwent in-house planned computer-aided design and manufacturing (CAD/CAM) of free fibula flaps between 2021 and 2023. Out of all patient cases, we included all with postoperative 3D imaging in the study. The study utilized open-source software tools for the planning step, and three-dimensional (3D) printing techniques. The Hausdorff distance and Dice coefficient metrics were used to evaluate the accuracy of the planning procedure.
Results: The study assessed eight patients (five males and three females, mean age 61.75 ± 3.69 years) with different diagnoses such as osteoradionecrosis and oral squamous cell carcinoma. The average ischemia time was 68.38 ± 27.95 min. For the evaluation of preoperative planning vs. the postoperative outcome, the mean Hausdorff Distance was 1.22 ± 0.40. The Dice Coefficients yielded a mean of 0.77 ± 0.07, suggesting a satisfactory concordance between the planned and postoperative states. Dice Coefficient and Hausdorff Distance revealed significant correlations with ischemia time (Spearman's rho = −0.810, p = 0.015 and Spearman's rho = 0.762, p = 0.028, respectively). Linear regression models adjusting for disease type further substantiated these findings.
Conclusions: The in-house planning algorithm not only achieved high anatomical accuracy, as reflected by the Dice Coefficients and Hausdorff Distance metrics, but this accuracy also exhibited a significant correlation with reduced ischemia time. This underlines the critical role of meticulous planning in surgical outcomes. Additionally, the algorithm's open-source nature renders it cost-efficient, easy to learn, and broadly applicable, offering promising avenues for enhancing both healthcare affordability and accessibility.
Recently, Tummino et al. reported that 34 compounds, including Chloroquine and Fluoxetine, inhibit SARS-CoV-2 replication by inducing phospholipidosis, although Chloroquine failed to suppress viral replication in Calu-3 cells and patients. In contrast, Fluoxetine represses viral replication in human precision-cut lung slices (PCLS) and Calu-3 cells. Thus, it is unlikely that these compounds have similar mechanisms of action. Here, we analysed a subset of these compounds in the viral replication and phospholipidosis assays using the Calu-3 cells and PCLS as the patient-near system. Trimipramine and Chloroquine induced phospholipidosis but failed to inhibit SARS-CoV-2 replication in Calu-3 cells, which contradicts the reported findings and the proposed mechanism. Fluoxetine, only slightly induced phospholipidosis in Calu-3 cells but reduced viral replication by 2.7 orders of magnitude. Tilorone suppressed viral replication by 1.9 orders of magnitude in Calu-3 cells without causing phospholipidosis. Thus, induction of phospholipidosis is not correlated with the inhibition of SARS-CoV-2, and the compounds act via other mechanisms. However, we show that compounds, such as Amiodarone, Tamoxifen and Tilorone, with antiviral activity on Calu-3 cells, also inhibited viral replication in human PCLS. Our results indicate that antiviral assays against SARS-CoV-2 are cell-line specific. Data from Vero E6 can lead to non-transferable results, underlining the importance of an appropriate cell system for analysing antiviral compounds against SARS-CoV-2. We observed a correlation between the active compounds in Calu-3 cells and PCLS.
Tumor necrosis factor (TNF) receptor 1 (TNFR1), TNFR2 and fibroblast growth factor-inducible 14 (Fn14) belong to the TNF receptor superfamily (TNFRSF). From a structural point of view, TNFR1 is a prototypic death domain (DD)-containing receptor. In contrast to other prominent death receptors, such as CD95/Fas and the two TRAIL death receptors DR4 and DR5, however, liganded TNFR1 does not instruct the formation of a plasma membrane-associated death inducing signaling complex converting procaspase-8 into highly active mature heterotetrameric caspase-8 molecules. Instead, liganded TNFR1 recruits the DD-containing cytoplasmic signaling proteins TRADD and RIPK1 and empowers these proteins to trigger cell death signaling by cytosolic complexes after their release from the TNFR1 signaling complex. The activity and quality (apoptosis versus necroptosis) of TNF-induced cell death signaling is controlled by caspase-8, the caspase-8 regulatory FLIP proteins, TRAF2, RIPK1 and the RIPK1-ubiquitinating E3 ligases cIAP1 and cIAP2. TNFR2 and Fn14 efficiently recruit TRAF2 along with the TRAF2 binding partners cIAP1 and cIAP2 and can thereby limit the availability of these molecules for other TRAF2/cIAP1/2-utilizing proteins including TNFR1. Accordingly, at the cellular level engagement of TNFR2 or Fn14 inhibits TNFR1-induced RIPK1-mediated effects reaching from activation of the classical NFκB pathway to induction of apoptosis and necroptosis. In this review, we summarize the effects of TNFR2- and Fn14-mediated depletion of TRAF2 and the cIAP1/2 on TNFR1 signaling at the molecular level and discuss the consequences this has in vivo.
Introduction: Distributed ledger networks, chiefly those based on blockchain technologies, currently are heralding a next-generation of computer systems that aims to suit modern users’ demands. Over the recent years, several technologies for blockchains, off-chaining strategies, as well as decentralised and respectively self-sovereign identity systems have shot up so fast that standardisation of the protocols is lagging behind, severely hampering the interoperability of different approaches. Moreover, most of the currently available solutions for distributed ledgers focus on either home users or enterprise use case scenarios, failing to provide integrative solutions addressing the needs of both.
Methods: Herein, we introduce the OpenDSU platform that allows to interoperate generic blockchain technologies, organised–and possibly cascaded in a hierarchical fashion–in domains. To achieve this flexibility, we seamlessly integrated a set of well conceived components that orchestrate off-chain data and provide granularly resolved and cryptographically secure access levels, intrinsically nested with sovereign identities across the different domains. The source code and extensive documentation of all OpenDSU components described herein are publicly available under the MIT open-source licence at https://opendsu.com.
Results: Employing our platform to PharmaLedger, an inter-European network for the standardisation of data handling in the pharmaceutical industry and in healthcare, we demonstrate that OpenDSU can cope with generic demands of heterogeneous use cases in both, performance and handling substantially different business policies.
Discussion: Importantly, whereas available solutions commonly require a predefined and fixed set of components, no such vendor lock-in restrictions on the blockchain technology or identity system exist in OpenDSU, making systems built on it flexibly adaptable to new standards evolving in the future.
Purpose: This study analyses a large number of cancer patients with CIEDs for device malfunction and premature battery depletion by device interrogation after each radiotherapy fraction and compares different guidelines in regard to patient safety. Methods: From 2007 to 2022, a cohort of 255 patients was analyzed for CIED malfunctions via immediate device interrogation after every RT fraction. Results: Out of 324 series of radiotherapy treatments, with a total number of 5742 CIED interrogations, nine device malfunctions (2.8%) occurred. Switching into back-up/safety mode and software errors occurred four times each. Once, automatic read-out could not be performed. The median prescribed cumulative dose at planning target volume (PTV) associated with CIED malfunction was 45.0 Gy (IQR 36.0–64.0 Gy), with a median dose per fraction of 2.31 Gy (IQR 2.0–3.0 Gy). The median maximum dose at the CIED at time of malfunction was 0.3 Gy (IQR 0.0–1.3 Gy). No correlation between CIED malfunction and maximum photon energy (p = 0.07), maximum dose at the CIED (p = 0.59) nor treatment localization (p = 0.41) could be detected. After excluding the nine malfunctions, premature battery depletion was only observed three times (1.2%). Depending on the national guidelines, 1–9 CIED malfunctions in this study would have been detected on the day of occurrence and in none of the cases would patient safety have been compromised. Conclusion: Radiation-induced malfunctions of CIEDs and premature battery depletion are rare. If recommendations of national safety guidelines are followed, only a portion of the malfunctions would be detected directly after occurrence. Nevertheless, patient safety would not be compromised.
The topological classification of electronic band structures is based on symmetry properties of Bloch eigenstates of single-particle Hamiltonians. In parallel, topological field theory has opened the doors to the formulation and characterization of non-trivial phases of matter driven by strong electron-electron interaction. Even though important examples of topological Mott insulators have been constructed, the relevance of the underlying non-interacting band topology to the physics of the Mott phase has remained unexplored. Here, we show that the momentum structure of the Green’s function zeros defining the “Luttinger surface" provides a topological characterization of the Mott phase related, in the simplest description, to the one of the single-particle electronic dispersion. Considerations on the zeros lead to the prediction of new phenomena: a topological Mott insulator with an inverted gap for the bulk zeros must possess gapless zeros at the boundary, which behave as a form of “topological antimatter” annihilating conventional edge states. Placing band and Mott topological insulators in contact produces distinctive observable signatures at the interface, revealing the otherwise spectroscopically elusive Green’s function zeros.
T cell exhaustion is a hallmark of cancer and persistent infections, marked by inhibitory receptor upregulation, diminished cytokine secretion, and impaired cytolytic activity. Terminally exhausted T cells are steadily replenished by a precursor population (Tpex), but the metabolic principles governing Tpex maintenance and the regulatory circuits that control their exhaustion remain incompletely understood. Using a combination of gene-deficient mice, single-cell transcriptomics, and metabolomic analyses, we show that mitochondrial insufficiency is a cell-intrinsic trigger that initiates the functional exhaustion of T cells. At the molecular level, we find that mitochondrial dysfunction causes redox stress, which inhibits the proteasomal degradation of hypoxia-inducible factor 1α (HIF-1α) and promotes the transcriptional and metabolic reprogramming of Tpex cells into terminally exhausted T cells. Our findings also bear clinical significance, as metabolic engineering of chimeric antigen receptor (CAR) T cells is a promising strategy to enhance the stemness and functionality of Tpex cells for cancer immunotherapy.
Axon degeneration and functional decline in myelin diseases are often attributed to loss of myelin but their relation is not fully understood. Perturbed myelinating glia can instigate chronic neuroinflammation and contribute to demyelination and axonal damage. Here we study mice with distinct defects in the proteolipid protein 1 gene that develop axonal damage which is driven by cytotoxic T cells targeting myelinating oligodendrocytes. We show that persistent ensheathment with perturbed myelin poses a risk for axon degeneration, neuron loss, and behavioral decline. We demonstrate that CD8\(^+\) T cell-driven axonal damage is less likely to progress towards degeneration when axons are efficiently demyelinated by activated microglia. Mechanistically, we show that cytotoxic T cell effector molecules induce cytoskeletal alterations within myelinating glia and aberrant actomyosin constriction of axons at paranodal domains. Our study identifies detrimental axon-glia-immune interactions which promote neurodegeneration and possible therapeutic targets for disorders associated with myelin defects and neuroinflammation.
Sharks occupy diverse ecological niches and play critical roles in marine ecosystems, often acting as apex predators. They are considered a slow-evolving lineage and have been suggested to exhibit exceptionally low cancer rates. These two features could be explained by a low nuclear mutation rate. Here, we provide a direct estimate of the nuclear mutation rate in the epaulette shark (Hemiscyllium ocellatum). We generate a high-quality reference genome, and resequence the whole genomes of parents and nine offspring to detect de novo mutations. Using stringent criteria, we estimate a mutation rate of 7×10\(^{−10}\) per base pair, per generation. This represents one of the lowest directly estimated mutation rates for any vertebrate clade, indicating that this basal vertebrate group is indeed a slowly evolving lineage whose ability to restore genetic diversity following a sustained population bottleneck may be hampered by a low mutation rate.
Butyrophilin (BTN)–3A and BTN2A1 molecules control the activation of human Vγ9Vδ2 T cells during T cell receptor (TCR)-mediated sensing of phosphoantigens (PAg) derived from microbes and tumors. However, the molecular rules governing PAg sensing remain largely unknown. Here, we establish three mechanistic principles of PAg-mediated γδ T cell activation. First, in humans, following PAg binding to the intracellular BTN3A1-B30.2 domain, Vγ9Vδ2 TCR triggering involves the extracellular V-domain of BTN3A2/BTN3A3. Moreover, the localization of both protein domains on different chains of the BTN3A homo-or heteromers is essential for efficient PAg-mediated activation. Second, the formation of BTN3A homo-or heteromers, which differ in intracellular trafficking and conformation, is controlled by molecular interactions between the juxtamembrane regions of the BTN3A chains. Finally, the ability of PAg not simply to bind BTN3A-B30.2, but to promote its subsequent interaction with the BTN2A1-B30.2 domain, is essential for T-cell activation. Defining these determinants of cooperation and the division of labor in BTN proteins improves our understanding of PAg sensing and elucidates a mode of action that may apply to other BTN family members.
Tropical forest recovery is fundamental to addressing the intertwined climate and biodiversity loss crises. While regenerating trees sequester carbon relatively quickly, the pace of biodiversity recovery remains contentious. Here, we use bioacoustics and metabarcoding to measure forest recovery post-agriculture in a global biodiversity hotspot in Ecuador. We show that the community composition, and not species richness, of vocalizing vertebrates identified by experts reflects the restoration gradient. Two automated measures – an acoustic index model and a bird community composition derived from an independently developed Convolutional Neural Network - correlated well with restoration (adj-R² = 0.62 and 0.69, respectively). Importantly, both measures reflected composition of non-vocalizing nocturnal insects identified via metabarcoding. We show that such automated monitoring tools, based on new technologies, can effectively monitor the success of forest recovery, using robust and reproducible data.
Neural processing of a desired moving direction requires the continuous comparison between the current heading and the goal direction. While the neural basis underlying the current heading is well-studied, the coding of the goal direction remains unclear in insects. Here, we used tetrode recordings in tethered flying monarch butterflies to unravel how a goal direction is represented in the insect brain. While recording, the butterflies maintained robust goal directions relative to a virtual sun. By resetting their goal directions, we found neurons whose spatial tuning was tightly linked to the goal directions. Importantly, their tuning was unaffected when the butterflies changed their heading after compass perturbations, showing that these neurons specifically encode the goal direction. Overall, we here discovered invertebrate goal-direction neurons that share functional similarities to goal-direction cells reported in mammals. Our results give insights into the evolutionarily conserved principles of goal-directed spatial orientation in animals.
Herpes simplex virus 1 (HSV-1) infection and stress responses disrupt transcription termination by RNA Polymerase II (Pol II). In HSV-1 infection, but not upon salt or heat stress, this is accompanied by a dramatic increase in chromatin accessibility downstream of genes. Here, we show that the HSV-1 immediate-early protein ICP22 is both necessary and sufficient to induce downstream open chromatin regions (dOCRs) when transcription termination is disrupted by the viral ICP27 protein. This is accompanied by a marked ICP22-dependent loss of histones downstream of affected genes consistent with impaired histone repositioning in the wake of Pol II. Efficient knock-down of the ICP22-interacting histone chaperone FACT is not sufficient to induce dOCRs in ΔICP22 infection but increases dOCR induction in wild-type HSV-1 infection. Interestingly, this is accompanied by a marked increase in chromatin accessibility within gene bodies. We propose a model in which allosteric changes in Pol II composition downstream of genes and ICP22-mediated interference with FACT activity explain the differential impairment of histone repositioning downstream of genes in the wake of Pol II in HSV-1 infection.
Immune checkpoint blockade therapy is beneficial and even curative for some cancer patients. However, the majority don’t respond to immune therapy. Across different tumor types, pre-existing T cell infiltrates predict response to checkpoint-based immunotherapy. Based on in vitro pharmacological studies, mouse models and analyses of human melanoma patients, we show that the cytokine GDF-15 impairs LFA-1/β2-integrin-mediated adhesion of T cells to activated endothelial cells, which is a pre-requisite of T cell extravasation. In melanoma patients, GDF-15 serum levels strongly correlate with failure of PD-1-based immune checkpoint blockade therapy. Neutralization of GDF-15 improves both T cell trafficking and therapy efficiency in murine tumor models. Thus GDF-15, beside its known role in cancer-related anorexia and cachexia, emerges as a regulator of T cell extravasation into the tumor microenvironment, which provides an even stronger rationale for therapeutic anti-GDF-15 antibody development.
The neuronal RNA-binding protein Ptbp2 regulates neuronal differentiation by modulating alternative splicing programs in the nucleus. Such programs contribute to axonogenesis by adjusting the levels of protein isoforms involved in axon growth and branching. While its functions in alternative splicing have been described in detail, cytosolic roles of Ptbp2 for axon growth have remained elusive. Here, we show that Ptbp2 is located in the cytosol including axons and growth cones of motoneurons, and that depletion of cytosolic Ptbp2 affects axon growth. We identify Ptbp2 as a major interactor of the 3’ UTR of Hnrnpr mRNA encoding the RNA-binding protein hnRNP R. Axonal localization of Hnrnpr mRNA and local synthesis of hnRNP R protein are strongly reduced when Ptbp2 is depleted, leading to defective axon growth. Ptbp2 regulates hnRNP R translation by mediating the association of Hnrnpr with ribosomes in a manner dependent on the translation factor eIF5A2. Our data thus suggest a mechanism whereby cytosolic Ptbp2 modulates axon growth by fine-tuning the mRNA transport and local synthesis of an RNA-binding protein.
Elevated and low blood pressure (BP) may lead to poor functional outcome after ischemic stroke, which is conflicting. Hence, there must be another factor—such as cerebral small vessel disease (cSVD) -interacting with BP and thus, affecting outcome. Here, we investigate the relationship between BP and cSVD regarding outcome after stroke. Data of 423/503 stroke patients were prospectively analyzed. Diastolic (DBP) and systolic BP (SBP) were collected on hospital admission (BP\(_{ad}\)) and over the first 72 h (BP\(_{72h}\)). cSVD-burden was determined on MR-scans. Good functional outcome was defined as a modified Rankin Scale score ≤ 2 at hospital discharge and 12 months thereafter. cSVD was a predictor of poor outcome (OR 2.8; p < 0.001). SBPad, DBP\(_{ad}\) and SBP\(_{72h}\) were not significantly associated with outcome at any time. A significant relationship was found between DBP\(_{72h}\), (p < 0.01), cSVD (p = 0.013) and outcome at discharge. At 12 months, we found a relationship between outcome and DBP\(_{72h}\) (p = 0.018) and a statistical tendency regarding cSVD (p = 0.08). Changes in DBP72h were significantly related with outcome. There was a U-shaped relationship between DBP\(_{72h}\) and outcome at discharge. Our results suggest an individualized stroke care by either lowering or elevating DBP depending on cSVD-burden in order to influence functional outcome.
Air pollution is associated with morbidity and mortality worldwide. We investigated the impact of improved air quality during the economic lockdown during the SARS-Cov2 pandemic on emergency room (ER) admissions in Germany. Weekly aggregated clinical data from 33 hospitals were collected in 2019 and 2020. Hourly concentrations of nitrogen and sulfur dioxide (NO2, SO2), carbon and nitrogen monoxide (CO, NO), ozone (O3) and particulate matter (PM10, PM2.5) measured by ground stations and meteorological data (ERA5) were selected from a 30 km radius around the corresponding ED. Mobility was assessed using aggregated cell phone data. A linear stepwise multiple regression model was used to predict ER admissions. The average weekly emergency numbers vary from 200 to over 1600 cases (total n = 2,216,217). The mean maximum decrease in caseload was 5 standard deviations. With the enforcement of the shutdown in March, the mobility index dropped by almost 40%. Of all air pollutants, NO2 has the strongest correlation with ER visits when averaged across all departments. Using a linear stepwise multiple regression model, 63% of the variation in ER visits is explained by the mobility index, but still 6% of the variation is explained by air quality and climate change.
The question of how behavior is represented in the mind lies at the core of psychology as the science of mind and behavior. While a long-standing research tradition has established two opposing fundamental views of perceptual representation, Structuralism and Gestalt psychology, we test both accounts with respect to action representation: Are multiple actions (characterizing human behavior in general) represented as the sum of their component actions (Structuralist view) or holistically (Gestalt view)? Using a single-/dual-response switch paradigm, we analyzed switches between dual ([A + B]) and single ([A], [B]) responses across different effector systems and revealed comparable performance in partial repetitions and full switches of behavioral requirements (e.g., in [A + B] → [A] vs. [B] → [A], or [A] → [A + B] vs. [B] → [A + B]), but only when the presence of dimensional overlap between responses allows for Gestalt formation. This evidence for a Gestalt view of behavior in our paradigm challenges some fundamental assumptions in current (tacitly Structuralist) action control theories (in particular the idea that all actions are represented compositionally with reference to their components), provides a novel explanatory angle for understanding complex, highly synchronized human behavior (e.g., dance), and delimitates the degree to which complex behavior can be analyzed in terms of its basic components.
Automated analysis of the inner ear anatomy in radiological data instead of time-consuming manual assessment is a worthwhile goal that could facilitate preoperative planning and clinical research. We propose a framework encompassing joint semantic segmentation of the inner ear and anatomical landmark detection of helicotrema, oval and round window. A fully automated pipeline with a single, dual-headed volumetric 3D U-Net was implemented, trained and evaluated using manually labeled in-house datasets from cadaveric specimen (N = 43) and clinical practice (N = 9). The model robustness was further evaluated on three independent open-source datasets (N = 23 + 7 + 17 scans) consisting of cadaveric specimen scans. For the in-house datasets, Dice scores of 0.97 and 0.94, intersection-over-union scores of 0.94 and 0.89 and average Hausdorf distances of 0.065 and 0.14 voxel units were achieved. The landmark localization task was performed automatically with an average localization error of 3.3 and 5.2 voxel units. A robust, albeit reduced performance could be
attained for the catalogue of three open-source datasets. Results of the ablation studies with 43 mono-parametric variations of the basal architecture and training protocol provided task-optimal parameters for both categories. Ablation studies against single-task variants of the basal architecture showed a clear performance beneft of coupling landmark localization with segmentation and a dataset-dependent performance impact on segmentation ability.
Neuroanatomical variations across the visual field of human observers go along with corresponding variations of the perceived coarseness of visual stimuli. Here we show that horizontal gratings are perceived as having lower spatial frequency than vertical gratings when occurring along the horizontal meridian of the visual field, whereas gratings occurring along the vertical meridian show the exact opposite effect. This finding indicates a new peculiarity of processes operating along the cardinal axes of the visual field.
This study evaluated the influence of different vascular reconstruction kernels on the image quality of CT angiographies of the lower extremity runoff using a 1st-generation photon-counting-detector CT (PCD-CT) compared with dose-matched examinations on a 3rd-generation energy-integrating-detector CT (EID-CT). Inducing continuous extracorporeal perfusion in a human cadaveric model, we performed CT angiographies of eight upper leg arterial runoffs with radiation dose-equivalent 120 kVp acquisition protocols (CTDIvol 5 mGy). Reconstructions were executed with different vascular kernels, matching the individual modulation transfer functions between scanners. Signal-to-noise-ratios (SNR) and contrast-to-noise-ratios (CNR) were computed to assess objective image quality. Six radiologists evaluated image quality subjectively using a forced-choice pairwise comparison tool. Interrater agreement was determined by calculating Kendall’s concordance coefficient (W). The intraluminal attenuation of PCD-CT images was significantly higher than of EID-CT (414.7 ± 27.3 HU vs. 329.3 ± 24.5 HU; p < 0.001). Using comparable kernels, image noise with PCD-CT was significantly lower than with EID-CT (p ≤ 0.044). Correspondingly, SNR and CNR were approximately twofold higher for PCD-CT (p < 0.001). Increasing the spatial frequency for PCD-CT reconstructions by one level resulted in similar metrics compared to EID-CT (CNRfat; EID-CT Bv49: 21.7 ± 3.7 versus PCD-CT Bv60: 21.4 ± 3.5). Overall image quality of PCD-CTA achieved ratings superior to EID-CTA irrespective of the used reconstruction kernels (best: PCD-CT Bv60; worst: EID-CT Bv40; p < 0.001). Interrater agreement was good (W = 0.78). Concluding, PCD-CT offers superior intraluminal attenuation, SNR, and CNR compared to EID-CT in angiographies of the upper leg arterial runoff. Combined with improved subjective image quality, PCD-CT facilitates the use of sharper convolution kernels and ultimately bears the potential of improved vascular structure assessability.
Psychosocial factors affect mental health and health-related quality of life (HRQL) in a complex manner, yet gender differences in these interactions remain poorly understood. We investigated whether psychosocial factors such as social support and personal and work-related concerns impact mental health and HRQL differentially in women and men during the first year of the COVID-19 pandemic. Between June and October 2020, the first part of a COVID-19-specific program was conducted within the “Characteristics and Course of Heart Failure Stages A-B and Determinants of Progression (STAAB)” cohort study, a representative age- and gender-stratified sample of the general population of Würzburg, Germany. Using psychometric networks, we first established the complex relations between personal social support, personal and work-related concerns, and their interactions with anxiety, depression, and HRQL. Second, we tested for gender differences by comparing expected influence, edge weight differences, and stability of the networks. The network comparison revealed a significant difference in the overall network structure. The male (N = 1370) but not the female network (N = 1520) showed a positive link between work-related concern and anxiety. In both networks, anxiety was the most central variable. These findings provide further evidence that the complex interplay of psychosocial factors with mental health and HRQL decisively depends on gender. Our results are relevant for the development of gender-specific interventions to increase resilience in times of pandemic crisis.
Minimally invasive endovascular interventions have become an important tool for the treatment of cardiovascular diseases such as ischemic heart disease, peripheral artery disease, and stroke. X-ray fluoroscopy and digital subtraction angiography are used to precisely guide these procedures, but they are associated with radiation exposure for patients and clinical staff. Magnetic Particle Imaging (MPI) is an emerging imaging technology using time-varying magnetic fields combined with magnetic nanoparticle tracers for fast and highly sensitive imaging. In recent years, basic experiments have shown that MPI has great potential for cardiovascular applications. However, commercially available MPI scanners were too large and expensive and had a small field of view (FOV) designed for rodents, which limited further translational research. The first human-sized MPI scanner designed specifically for brain imaging showed promising results but had limitations in gradient strength, acquisition time and portability. Here, we present a portable interventional MPI (iMPI) system dedicated for real-time endovascular interventions free of ionizing radiation. It uses a novel field generator approach with a very large FOV and an application-oriented open design enabling hybrid approaches with conventional X-ray-based angiography. The feasibility of a real-time iMPI-guided percutaneous transluminal angioplasty (PTA) is shown in a realistic dynamic human-sized leg model.
Social buffering, a phenomenon where social presence can reduce anxiety and fear-related autonomic responses, has been studied in numerous laboratory settings. The results suggest that the familiarity of the interaction partner influences social buffering while also providing some evidence for gender effects. In the laboratory, however, it is difficult to mimic the complexity of real-life social interactions. Consequently, the social modulation of anxiety and related autonomic responses in everyday life remains poorly understood. We used smartphone-based Ecological Momentary Assessment (EMA) combined with wearable electrocardiogram sensors to investigate how everyday-life social interactions affect state anxiety and related cardiac changes in women and men. On five consecutive days, 96 healthy young participants (53% women) answered up to six EMA surveys per day, indicating characteristics of their most recent social interaction and the respective interaction partner(s). In women, our results showed lower heart rate in the presence of a male interaction partner. Men showed the same effect with female interaction partners. Moreover, only women showed decreased heart rate and increased heart rate variability with increasing interaction partner familiarity. These findings specify the conditions under which social interactions reduce anxiety-related responses in women and men.
Formic acid is the main component of the ant’s major weapon against enemies. Being mainly used as a chemical defense, the acid is also exploited for recruitment and trail marking. The repelling effect of the organic acid is used by some mammals and birds which rub themselves in the acid to eliminate ectoparasites. Beekeepers across the world rely on this effect to control the parasitic mite Varroa destructor. Varroa mites are considered the most destructive pest of honey bees worldwide and can lead to the loss of entire colonies. Formic acid is highly effective against Varroa mites but can also kill the honeybee queen and worker brood. Whether formic acid can also affect the behavior of honey bees is unknown. We here study the effect of formic acid on sucrose responsiveness and cognition of honey bees treated at different live stages in field-relevant doses. Both behaviors are essential for survival of the honey bee colony. Rather unexpectedly, formic acid clearly improved the learning performance of the bees in appetitive olfactory conditioning, while not affecting sucrose responsiveness. This exciting side effect of formic acid certainly deserves further detailed investigations.
Photon-counting detector (PCD) CT allows for ultra-high-resolution (UHR) examinations of the shoulder without requiring an additional post-patient comb filter to narrow the detector aperture. This study was designed to compare the PCD performance with a high-end energy-integrating detector (EID) CT. Sixteen cadaveric shoulders were examined with both scanners using dose-matched 120 kVp acquisition protocols (low-dose/full-dose: CTDI\(_{vol}\) = 5.0/10.0 mGy). Specimens were scanned in UHR mode with the PCD-CT, whereas EID-CT examinations were conducted in accordance with the clinical standard as “non-UHR”. Reconstruction of EID data employed the sharpest kernel available for standard-resolution scans (ρ\(_{50}\) = 12.3 lp/cm), while PCD data were reconstructed with both a comparable kernel (11.8 lp/cm) and a sharper dedicated bone kernel (16.5 lp/cm). Six radiologists with 2–9 years of experience in musculoskeletal imaging rated image quality subjectively. Interrater agreement was analyzed by calculation of the intraclass correlation coefficient in a two-way random effects model. Quantitative analyses comprised noise recording and calculating signal-to-noise ratios based on attenuation measurements in bone and soft tissue. Subjective image quality was higher in UHR-PCD-CT than in EID-CT and non-UHR-PCD-CT datasets (all p < 0.001). While low-dose UHR-PCD-CT was considered superior to full-dose non-UHR studies on either scanner (all p < 0.001), ratings of low-dose non-UHR-PCD-CT and full-dose EID-CT examinations did not differ (p > 0.99). Interrater reliability was moderate, indicated by a single measures intraclass correlation coefficient of 0.66 (95% confidence interval: 0.58–0.73; p < 0.001). Image noise was lowest and signal-to-noise ratios were highest in non-UHR-PCD-CT reconstructions at either dose level (p < 0.001). This investigation demonstrates that superior depiction of trabecular microstructure and considerable denoising can be realized without additional radiation dose by employing a PCD for shoulder CT imaging. Allowing for UHR scans without dose penalty, PCD-CT appears as a promising alternative to EID-CT for shoulder trauma assessment in clinical routine.
Changes in body perception often arise when observers are confronted with related yet discrepant multisensory signals. Some of these effects are interpreted as outcomes of sensory integration of various signals, whereas related biases are ascribed to learning-dependent recalibration of coding individual signals. The present study explored whether the same sensorimotor experience entails changes in body perception that are indicative of multisensory integration and those that indicate recalibration. Participants enclosed visual objects by a pair of visual cursors controlled by finger movements. Then either they judged their perceived finger posture (indicating multisensory integration) or they produced a certain finger posture (indicating recalibration). An experimental variation of the size of the visual object resulted in systematic and opposite biases of the perceived and produced finger distances. This pattern of results is consistent with the assumption that multisensory integration and recalibration had a common origin in the task we used.
Long-term sequelae in hospitalized Coronavirus Disease 2019 (COVID-19) patients may result in limited quality of life. The current study aimed to determine health-related quality of life (HRQoL) after COVID-19 hospitalization in non-intensive care unit (ICU) and ICU patients. This is a single-center study at the University Hospital of Wuerzburg, Germany. Patients eligible were hospitalized with COVID-19 between March 2020 and December 2020. Patients were interviewed 3 and 12 months after hospital discharge. Questionnaires included the European Quality of Life 5 Dimensions 5 Level (EQ-5D-5L), patient health questionnaire-9 (PHQ-9), the generalized anxiety disorder 7 scale (GAD-7), FACIT fatigue scale, perceived stress scale (PSS-10) and posttraumatic symptom scale 10 (PTSS-10). 85 patients were included in the study. The EQ5D-5L-Index significantly differed between non-ICU (0.78 ± 0.33 and 0.84 ± 0.23) and ICU (0.71 ± 0.27; 0.74 ± 0.2) patients after 3- and 12-months. Of non-ICU 87% and 80% of ICU survivors lived at home without support after 12 months. One-third of ICU and half of the non-ICU patients returned to work. A higher percentage of ICU patients was limited in their activities of daily living compared to non-ICU patients. Depression and fatigue were present in one fifth of the ICU patients. Stress levels remained high with only 24% of non-ICU and 3% of ICU patients (p = 0.0186) having low perceived stress. Posttraumatic symptoms were present in 5% of non-ICU and 10% of ICU patients. HRQoL is limited in COVID-19 ICU patients 3- and 12-months post COVID-19 hospitalization, with significantly less improvement at 12-months compared to non-ICU patients. Mental disorders were common highlighting the complexity of post-COVID-19 symptoms as well as the necessity to educate patients and primary care providers about monitoring mental well-being post COVID-19.
Topological differences and confounders of mental rotation in cervical dystonia and blepharospasm
(2023)
Mental rotation (mR) bases on imagination of actual movements. It remains unclear whether there is a specific pattern of mR impairment in focal dystonia. We aimed to investigate mR in patients with cervical dystonia (CD) and blepharospasm (BS) and to assess potential confounders. 23 CD patients and 23 healthy controls (HC) as well as 21 BS and 19 hemifacial spasm (HS) patients were matched for sex, age, and education level. Handedness, finger dexterity, general reaction time, and cognitive status were assessed. Disease severity was evaluated by clinical scales. During mR, photographs of body parts (head, hand, or foot) and a non-corporal object (car) were displayed at different angles rotated within their plane. Subjects were asked to judge laterality of the presented image by keystroke. Both speed and correctness were evaluated. Compared to HC, CD and HS patients performed worse in mR of hands, whereas BS group showed comparable performance. There was a significant association of prolonged mR reaction time (RT) with reduced MoCA scores and with increased RT in an unspecific reaction speed task. After exclusion of cognitively impaired patients, increased RT in the mR of hands was confined to CD group, but not HS. While the question of whether specific patterns of mR impairment reliably define a dystonic endophenotype remains elusive, our findings point to mR as a useful tool, when used carefully with control measures and tasks, which may be capable of identifying specific deficits that distinguish between subtypes of dystonia.
Seasonal plasticity in insects is often triggered by temperature and photoperiod changes. When climatic conditions become sub-optimal, insects might undergo reproductive diapause, a form of seasonal plasticity delaying the development of reproductive organs and activities. During the reproductive diapause, the cuticular hydrocarbon (CHC) profile, which covers the insect body surface, might also change to protect insects from desiccation and cold temperature. However, CHCs are often important cues and signals for mate recognition and changes in CHC composition might affect mate recognition. In the present study, we investigated the CHC profile composition and the mating success of Drosophila suzukii in 1- and 5-day-old males and females of summer and winter morphs. CHC compositions differed with age and morphs. However, no significant differences were found between the sexes of the same age and morph. The results of the behavioral assays show that summer morph pairs start to mate earlier in their life, have a shorter mating duration, and have more offspring compared to winter morph pairs. We hypothesize that CHC profiles of winter morphs are adapted to survive winter conditions, potentially at the cost of reduced mate recognition cues.
A substantial number of people refused to get vaccinated against COVID-19, which prompts the question as to why. We focus on the role of individual worldviews about the nature and generation of knowledge (epistemic beliefs). We propose a model that includes epistemic beliefs, their relationship to the Dark Factor of Personality (D), and their mutual effect on the probability of having been vaccinated against COVID-19. Based on a US nationally representative sample (N = 1268), we show that stronger endorsement of post-truth epistemic beliefs was associated with a lower probability of having been vaccinated against COVID-19. D was also linked to a lower probability of having been vaccinated against COVID-19, which can be explained by post-truth epistemic beliefs. Our results indicate that the more individuals deliberately refrain from adhering to the better argument, the less likely they are vaccinated. More generally, post-truth epistemic beliefs pose a challenge for rational communication.
Seed amplification assays (SAA) are becoming commonly used in synucleinopathies to detect α-synuclein aggregates. Studies in Parkinson’s disease (PD) and isolated REM-sleep behavior disorder (iRBD) have shown a considerably lower sensitivity in the olfactory epithelium than in CSF or skin. To get an insight into α-synuclein (α-syn) distribution within the nervous system and reasons for low sensitivity, we compared SAA assessment of nasal brushings and skin biopsies in PD (n = 27) and iRBD patients (n = 18) and unaffected controls (n = 30). α-syn misfolding was overall found less commonly in the olfactory epithelium than in the skin, which could be partially explained by the nasal brushing matrix exerting an inhibitory effect on aggregation. Importantly, the α-syn distribution was not uniform: there was a higher deposition of misfolded α-syn across all sampled tissues in the iRBD cohort compared to PD (supporting the notion of RBD as a marker of a more malignant subtype of synucleinopathy) and in a subgroup of PD patients, misfolded α-syn was detectable only in the olfactory epithelium, suggestive of the recently proposed brain-first PD subtype. Assaying α-syn of diverse origins, such as olfactory (part of the central nervous system) and skin (peripheral nervous system), could increase diagnostic accuracy and allow better stratification of patients.
Infected wounds pose a major mortality risk in animals. Injuries are common in the ant Megaponera analis, which raids pugnacious prey. Here we show that M. analis can determine when wounds are infected and treat them accordingly. By applying a variety of antimicrobial compounds and proteins secreted from the metapleural gland to infected wounds, workers reduce the mortality of infected individuals by 90%. Chemical analyses showed that wound infection is associated with specific changes in the cuticular hydrocarbon profile, thereby likely allowing nestmates to diagnose the infection state of injured individuals and apply the appropriate antimicrobial treatment. This study demonstrates that M. analis ant societies use antimicrobial compounds produced in the metapleural glands to treat infected wounds and reduce nestmate mortality.
Plants extract mineral nutrients from the soil, or from interactions with mutualistic soil microbes via their root systems. Adapting root architecture to nutrient availability enables efficient resource utilization, particularly in patchy and dynamic environments. Root growth responses to soil nitrogen levels are shoot-mediated, but the identity of shoot-derived mobile signals regulating root growth responses has remained enigmatic. Here we show that a shoot-derived micro RNA, miR2111, systemically steers lateral root initiation and nitrogen responsiveness through its root target TML (TOO MUCH LOVE) in the legume Lotus japonicus, where miR2111 and TML were previously shown to regulate symbiotic infections with nitrogen fixing bacteria. Intriguingly, systemic control of lateral root initiation by miR2111 and TML/HOLT (HOMOLOGUE OF LEGUME TML) was conserved in the nonsymbiotic ruderal Arabidopsis thaliana, which follows a distinct ecological strategy. Thus, the miR2111-TML/HOLT regulon emerges as an essential, conserved factor in adaptive shoot control of root architecture in dicots.
Inflammation in the brain and gut is a critical component of several neurological diseases, such as Parkinson’s disease (PD). One trigger of the immune system in PD is aggregation of the pre-synaptic protein, α-synuclein (αSyn). Understanding the mechanism of propagation of αSyn aggregates is essential to developing disease-modifying therapeutics. Using a brain-first mouse model of PD, we demonstrate αSyn trafficking from the brain to the ileum of male mice. Immunohistochemistry revealed that the ileal αSyn aggregations are contained within CD11c+ cells. Using single-cell RNA sequencing, we demonstrate that ileal CD11c\(^+\) cells are microglia-like and the same subtype of cells is activated in the brain and ileum of PD mice. Moreover, by utilizing mice expressing the photo-convertible protein, Dendra2, we show that CD11c\(^+\) cells traffic from the brain to the ileum. Together these data provide a mechanism of αSyn trafficking between the brain and gut.
Pain-associated approach and avoidance behaviours are critically involved in the development and maintenance of chronic pain. Empirical research suggests a key role of operant learning mechanisms, and first experimental paradigms were developed for their investigation within a controlled laboratory setting. We introduce a new Virtual Reality paradigm to the study of pain-related behaviour and investigate pain experiences on multiple dimensions. The paradigm evaluates the effects of three-tiered heat-pain stimuli applied contingent versus non-contingent with three types of arm movements in naturalistic virtual sceneries. Behaviour, self-reported pain-related fear, pain expectancy and electrodermal activity were assessed in 42 healthy participants during an acquisition phase (contingent movement-pain association) and a modification phase (no contingent movement-pain association). Pain-associated approach behaviour, as measured by arm movements followed by a severe heat stimulus, quickly decreased in-line with the arm movement-pain contingency. Slower effects were observed in fear of movement-related pain and pain expectancy ratings. During the subsequent modification phase, the removal of the pain contingencies modified all three indices. In both phases, skin conductance responses resemble the pattern observed for approach behaviour, while skin conductance levels equal the pattern observed for the self-ratings. Our findings highlight a fast reduction in approach behaviour in the face of acute pain and inform about accompanying psychological and physiological processes. We discuss strength and limitations of our paradigm for future investigations with the ultimate goal of gaining a comprehensive understanding of the mechanisms involved in chronic pain development, maintenance, and its therapy.
Pathogen-specific innate immune response patterns are distinctly affected by genetic diversity
(2023)
Innate immune responses vary by pathogen and host genetics. We analyze quantitative trait loci (eQTLs) and transcriptomes of monocytes from 215 individuals stimulated by fungal, Gram-negative or Gram-positive bacterial pathogens. We identify conserved monocyte responses to bacterial pathogens and a distinct antifungal response. These include 745 response eQTLs (reQTLs) and corresponding genes with pathogen-specific effects, which we find first in samples of male donors and subsequently confirm for selected reQTLs in females. reQTLs affect predominantly upregulated genes that regulate immune response via e.g., NOD-like, C-type lectin, Toll-like and complement receptor-signaling pathways. Hence, reQTLs provide a functional explanation for individual differences in innate response patterns. Our identified reQTLs are also associated with cancer, autoimmunity, inflammatory and infectious diseases as shown by external genome-wide association studies. Thus, reQTLs help to explain interindividual variation in immune response to infection and provide candidate genes for variants associated with a range of diseases.
Bioimages frequently exhibit low signal-to-noise ratios due to experimental conditions, specimen characteristics, and imaging trade-offs. Reliable segmentation of such ambiguous images is difficult and laborious. Here we introduce deepflash2, a deep learning-enabled segmentation tool for bioimage analysis. The tool addresses typical challenges that may arise during the training, evaluation, and application of deep learning models on ambiguous data. The tool’s training and evaluation pipeline uses multiple expert annotations and deep model ensembles to achieve accurate results. The application pipeline supports various use-cases for expert annotations and includes a quality assurance mechanism in the form of uncertainty measures. Benchmarked against other tools, deepflash2 offers both high predictive accuracy and efficient computational resource usage. The tool is built upon established deep learning libraries and enables sharing of trained model ensembles with the research community. deepflash2 aims to simplify the integration of deep learning into bioimage analysis projects while improving accuracy and reliability.
The Fischer carbene synthesis, involving the conversion of a transition metal (TM)-bound CO ligand to a carbene ligand of the form [=C(OR’)R] (R, R’ = organyl groups), is one of the seminal reactions in the history of organometallic chemistry. Carbonyl complexes of p-block elements, of the form [E(CO)n] (E = main-group fragment), are much less abundant than their TM cousins; this scarcity and the general instability of low-valent p-block species means that replicating the historical reactions of TM carbonyls is often very difficult. Here we present a step-for-step replica of the Fischer carbene synthesis at a borylene carbonyl involving nucleophilic attack at the carbonyl carbon followed by electrophilic quenching at the resultant acylate oxygen atom. These reactions provide borylene acylates and alkoxy-/silyloxy-substituted alkylideneboranes, main-group analogues of the archetypal transition metal acylate and Fischer carbene families, respectively. When either the incoming electrophile or the boron center has a modest steric profile, the electrophile instead attacks at the boron atom, leading to carbene-stabilized acylboranes – boron analogues of the well-known transition metal acyl complexes. These results constitute faithful main-group replicas of a number of historical organometallic processes and pave the way to further advances in the field of main-group metallomimetics.
The discrimination of enantiomers by natural receptors is a well-established phenomenon. In contrast the number of synthetic receptors with the capability for enantioselective molecular recognition of chiral substrates is scarce and for chiral cyclophanes indicative for a preferential binding of homochiral guests. Here we introduce a cyclophane composed of two homochiral core-twisted perylene bisimide (PBI) units connected by p-xylylene spacers and demonstrate its preference for the complexation of [5]helicene of opposite helicity compared to the PBI units of the host. The pronounced enantio-differentiation of this molecular receptor for heterochiral guests can be utilized for the enrichment of the P-PBI-M-helicene-P-PBI epimeric bimolecular complex. Our experimental results are supported by DFT calculations, which reveal that the sterically demanding bay substituents attached to the PBI chromophores disturb the helical shape match of the perylene core and homochiral substrates and thereby enforce the formation of syndiotactic host-guest complex structures. Hence, the most efficient substrate binding is observed for those aromatic guests, e. g. perylene, [4]helicene, phenanthrene and biphenyl, that can easily adapt in non-planar axially chiral conformations due to their inherent conformational flexibility. In all cases the induced chirality for the guest is opposed to those of the embedding PBI units, leading to heterochiral host-guest structures.
Ferroptosis is a form of cell death characterized by phospholipid peroxidation, where numerous studies have suggested that the induction of ferroptosis is a therapeutic strategy to target therapy refractory cancer entities. Ferroptosis suppressor protein 1 (FSP1), an NAD(P)H-ubiquinone reductase, is a key determinant of ferroptosis vulnerability, and its pharmacological inhibition was shown to strongly sensitize cancer cells to ferroptosis. A first generation of FSP1 inhibitors, exemplified by the small molecule iFSP1, has been reported; however, the molecular mechanisms underlying inhibition have not been characterized in detail. In this study, we explore the species-specific inhibition of iFSP1 on the human isoform to gain insights into its mechanism of action. Using a combination of cellular, biochemical, and computational methods, we establish a critical contribution of a species-specific aromatic architecture that is essential for target engagement. The results described here provide valuable insights for the rational development of second-generation FSP1 inhibitors combined with a tracer for screening the druggable pocket. In addition, we pose a cautionary notice for using iFSP1 in animal models, specifically murine models.
Context
Habitat loss and degradation impose serious threats on biodiversity. However, not all habitats receive the attention commensurate with their ecological importance. Shrub ecotones (successional stages between grasslands and forests) can be highly species-diverse but are often restricted to small areas as prevalent management practices either promote open grassland or forest habitats, threatening the effective conservation of ecotone species.
Objectives
In this study, we assessed the importance of habitat and landscape features of shrub ecotones for the rarely studied true bugs (Heteroptera), a functionally diverse taxon that comprises highly specialized species and broad generalists.
Methods
True bugs were sampled with a beating tray in 118 spatially independent shrub ecotones in a region of 45,000 square kilometers in Germany. In addition to habitat area and landscape context, we used a hedge index to evaluate habitat quality.
Results
Shrub ecotones in open habitats harbored a greater species richness and abundance compared to shaded ones in later seral stages, and species composition differed. Richness and abundance were positively affected by increasing habitat area and quality, whereas an increase in the proportion of semi-natural habitats within 1 km only enhanced richness. While feeding and habitat specialists were more sensitive to habitat area reduction than generalists, this was not the case for weak dispersers and carnivores.
Conclusions
Our findings emphasize the importance of large and high-quality ecotones that form a patchy mosaic of shrubs and herbaceous plants. Such ecotones can benefit both grassland species and species depending on woody plants. Conservation authorities should balance between promoting shrubs and keeping such habitats open to maximize species diversity.
Long-term monitoring of the ANTARES optical module efficiencies using \(^{40}\)K decays in sea water
(2018)
Cherenkov light induced by radioactive decay products is one of the major sources of background light for deep-sea neutrino telescopes such as ANTARES. These decays are at the same time a powerful calibration source. Using data collected by the ANTARES neutrino telescope from mid 2008 to 2017, the time evolution of the photon detection efficiency of optical modules is studied. A modest loss of only 20% in 9 years is observed. The relative time calibration between adjacent modules is derived as well.
Present surgical situations require a bone adhesive which has not yet been developed for use in clinical applications. Recently, phosphoserine modified cements (PMC) based on mixtures of o-phosphoserine (OPLS) and calcium phosphates, such as tetracalcium phosphate (TTCP) or α-tricalcium phosphate (α-TCP) as well as chelate setting magnesium phosphate cements have gained increasing popularity for their use as mineral bone adhesives. Here, we investigated new mineral-organic bone cements based on phosphoserine and magnesium phosphates or oxides, which possess excellent adhesive properties. These were analyzed by X-ray diffraction, Fourier infrared spectroscopy and electron microscopy and subjected to mechanical tests to determine the bond strength to bone after ageing at physiological conditions. The novel biomineral adhesives demonstrate excellent bond strength to bone with approximately 6.6–7.3 MPa under shear load. The adhesives are also promising due to their cohesive failure pattern and ductile character. In this context, the new adhesive cements are superior to currently prevailing bone adhesives. Future efforts on bone adhesives made from phosphoserine and Mg2+ appear to be very worthwhile.
One of the main objectives of the ANTARES telescope is the search for point- like neutrino sources. Both the pointing accuracy and the angular resolution of the detector are important in this context and a reliableway to evaluate this performance is needed. In order to measure the pointing accuracy of the detector, one possibility is to study the shadow of the Moon, i. e. the deficit of the atmospheric muon flux from the direction of the Moon induced by the absorption of cosmic rays. Analysing the data taken between 2007 and 2016, theMoon shadow is observed with 3.5s statistical significance. The detector angular resolution for downwardgoing muons is 0.73. +/- 0.14.. The resulting pointing performance is consistent with the expectations. An independent check of the telescope pointing accuracy is realised with the data collected by a shower array detector onboard of a ship temporarily moving around the ANTARES location.
Purpose
To compare the performance of the dominant and nondominant hand during fundamental arthroscopic simulator training.
Methods
Surgical trainees who participated in a 2-day simulator training course between 2021 and 2023 were classified, according to their arthroscopic experience in beginners and competents. Only right-handed individuals with complete data sets were included in the study. Ambidexterity was trained using a box trainer (Fundamentals of Arthroscopic Surgery Training, Virtamed AG, Schlieren, Switzerland).Two tasks, periscoping for learning camera guidance and triangulation for additional instrument handling, were performed 4 times with the camera in the dominant hand and then in the nondominant hand. For each task, exercise time, camera path length, and instrument path length were recorded and analyzed.
Results
Out of 94 participants 74 right-handed individuals (22 females, 52 males) were classified to novices (n = 43, less than 10 independently performed arthroscopies) and competents (n = 31, more than 10 independently performed arthroscopies). Competents performed significantly better than novices. No significant difference was found after changing the guiding hand for the camera from the dominant to the nondominant hand regarding the camera path length and the instrument path length. Notably, tasks were performed even faster when using the camera in the nondominant hand.
Conclusions
Our data demonstrate that the learned manual skills during basic arthroscopic training are quickly transferred to the contralateral side. In consequence, additional fundamental skills training for camera guidance and instrument handling of the nondominant hand are not necessary.
Clinical Relevance
For skillful arthroscopy, camera guidance and instrument handing must be equally mastered with both hands. It is important to understand how hand dominance may affect learning during arthroscopic simulator training.
Introduction:
Fibromyalgia syndrome (FMS) and small fiber neuropathy (SFN) are distinct pain conditions that share commonalities and may be challenging as for differential diagnosis.
Objective:
To comprehensively investigate clinical characteristics of women with FMS and SFN to determine clinically applicable parameters for differentiation.
Methods:
We retrospectively analyzed medical records of 158 women with FMS and 53 with SFN focusing on pain-specific medical and family history, accompanying symptoms, additional diseases, and treatment. We investigated data obtained using standardized pain, depression, and anxiety questionnaires. We further analyzed test results and findings obtained in standardized small fiber tests.
Results:
FMS patients were on average ten years younger at symptom onset, described higher pain intensities requiring frequent change of pharmaceutics, and reported generalized pain compared to SFN. Pain in FMS was accompanied by irritable bowel or sleep disturbances, and in SFN by paresthesias, numbness, and impaired glucose metabolism (P < 0.01 each). Family history was informative for chronic pain and affective disorders in FMS (P < 0.001) and for neurological disorders in SFN patients (P < 0.001). Small fiber pathology in terms of skin denervation and/or thermal sensory threshold elevation was present in 110/158 (69.7 %) FMS patients and 39/53 (73.6 %) SFN patients. FMS patients mainly showed proximally reduced skin innervation and higher corneal nerve branch densities (p<0.001) whereas SFN patients were characterized by reduced cold detection and prolonged electrical A-delta conduction latencies (P < 0.05).
Conclusions:
Our data show that FMS and SFN differ substantially. Detailed pain, drug and family history, investigating blood glucose metabolism, and applying differential small fiber tests may help to improve diagnostic differentiation and targeted therapy.
Highlights
• The GLA variant S126G is not associated with Fabry symptoms in the presented case
• S126G has no effect on α-GAL A activity or Gb3 levels in this patient
• S126G sensory neurons show no electrophysiological abnormalities
Abstract
Fabry disease (FD) is a life-limiting disorder characterized by intracellular globotriaosylceramide (Gb3) accumulations. The underlying α-galactosidase A (α-GAL A) deficiency is caused by variants in the gene GLA. Variants of unknown significance (VUS) are frequently found in GLA and challenge clinical management. Here, we investigated a 49-year old man with cryptogenic lacunar cerebral stroke and the chance finding of the VUS S126G, who was sent to our center for diagnosis and initiation of a costly and life-long FD-specific treatment. We combined clinical examination with in vitro investigations of dermal fibroblasts (HDF), induced pluripotent stem cells (iPSC), and iPSC-derived sensory neurons. We analyzed α-GAL A activity in iPSC, Gb3 accumulation in all three cell types, and action potential firing in sensory neurons. Neurological examination and small nerve fiber assessment was normal except for reduced distal skin innervation. S126G iPSC showed normal α-GAL A activity compared to controls and no Gb3 deposits were found in all three cell types. Baseline electrophysiological characteristics of S126G neurons showed no difference compared to healthy controls as investigated by patch-clamp recordings. We pioneer multi-level cellular characterization of the VUS S126G using three cell types derived from a patient and provide further evidence for the benign nature of S126G in GLA, which is of great importance in the management of such cases in clinical practice.
Highlights
• Beta-Guided programming is an innovative approach that may streamline the programming process for PD patients with STN DBS.
• While preliminary findings from our study suggest that Beta Titration may potentially mitigate STN overstimulation and enhance symptom control,
• Our results demonstrate that beta-guided programming significantly reduces programming time, suggesting it could be efficiently integrated into routine clinical practice using a commercially available patient programmer.
Background
Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment for advanced Parkinson's disease (PD). Clinical outcomes after DBS can be limited by poor programming, which remains a clinically driven, lengthy and iterative process. Electrophysiological recordings in PD patients undergoing STN-DBS have shown an association between STN spectral power in the beta frequency band (beta power) and the severity of clinical symptoms. New commercially-available DBS devices now enable the recording of STN beta oscillations in chronically-implanted PD patients, thereby allowing investigation into the use of beta power as a biomarker for DBS programming.
Objective
To determine the potential advantages of beta-guided DBS programming over clinically and image-guided programming in terms of clinical efficacy and programming time.
Methods
We conducted a randomized, blinded, three-arm, crossover clinical trial in eight Parkinson's patients with STN-DBS who were evaluated three months after DBS surgery. We compared clinical efficacy and time required for each DBS programming paradigm, as well as DBS parameters and total energy delivered between the three strategies (beta-, clinically- and image-guided).
Results
All three programming methods showed similar clinical efficacy, but the time needed for programming was significantly shorter for beta- and image-guided programming compared to clinically-guided programming (p < 0.001).
Conclusion
Beta-guided programming may be a useful and more efficient approach to DBS programming in Parkinson's patients with STN-DBS. It takes significantly less time to program than traditional clinically-based programming, while providing similar symptom control. In addition, it is readily available within the clinical DBS programmer, making it a valuable tool for improving current clinical practice.
Glycine receptor β–targeting autoantibodies contribute to the pathology of autoimmune diseases
(2024)
Background and Objectives
Stiff-person syndrome (SPS) and progressive encephalomyelitis with rigidity and myoclonus (PERM) are rare neurologic disorders of the CNS. Until now, exclusive GlyRα subunit–binding autoantibodies with subsequent changes in function and surface numbers were reported. GlyR autoantibodies have also been described in patients with focal epilepsy. Autoimmune reactivity against the GlyRβ subunits has not yet been shown. Autoantibodies against GlyRα1 target the large extracellular N-terminal domain. This domain shares a high degree of sequence homology with GlyRβ making it not unlikely that GlyRβ-specific autoantibody (aAb) exist and contribute to the disease pathology.
Methods
In this study, we investigated serum samples from 58 patients for aAb specifically detecting GlyRβ. Studies in microarray format, cell-based assays, and primary spinal cord neurons and spinal cord tissue immunohistochemistry were performed to determine specific GlyRβ binding and define aAb binding to distinct protein regions. Preadsorption approaches of aAbs using living cells and the purified extracellular receptor domain were further used. Finally, functional consequences for inhibitory neurotransmission upon GlyRβ aAb binding were resolved by whole-cell patch-clamp recordings.
Results
Among 58 samples investigated, cell-based assays, tissue analysis, and preadsorption approaches revealed 2 patients with high specificity for GlyRβ aAb. Quantitative protein cluster analysis demonstrated aAb binding to synaptic GlyRβ colocalized with the scaffold protein gephyrin independent of the presence of GlyRα1. At the functional level, binding of GlyRβ aAb from both patients to its target impair glycine efficacy.
Discussion
Our study establishes GlyRβ as novel target of aAb in patients with SPS/PERM. In contrast to exclusively GlyRα1-positive sera, which alter glycine potency, aAbs against GlyRβ impair receptor efficacy for the neurotransmitter glycine. Imaging and functional analyses showed that GlyRβ aAbs antagonize inhibitory neurotransmission by affecting receptor function rather than localization.
Human startle disease is associated with mutations in distinct genes encoding glycine receptors, transporters or interacting proteins at glycinergic synapses in spinal cord and brainstem. However, a significant number of diagnosed patients does not carry a mutation in the common genes GLRA1, GLRB, and SLC6A5. Recently, studies on solute carrier 7 subfamily 10 (SLC7A10; Asc-1, alanine-serine-cysteine transporter) knock-out (KO) mice displaying a startle disease-like phenotype hypothesized that this transporter might represent a novel candidate for human startle disease. Here, we screened 51 patients from our patient cohort negative for the common genes and found three exonic (one missense, two synonymous), seven intronic, and single nucleotide changes in the 5′ and 3′ untranslated regions (UTRs) in Asc-1. The identified missense mutation Asc-1\(^{G307R}\) from a patient with startle disease and developmental delay was investigated in functional studies. At the molecular level, the mutation Asc-1\(^{G307R}\) did not interfere with cell-surface expression, but disrupted glycine uptake. Substitution of glycine at position 307 to other amino acids, e.g., to alanine or tryptophan did not affect trafficking or glycine transport. By contrast, G307K disrupted glycine transport similar to the G307R mutation found in the patient. Structurally, the disrupted function in variants carrying positively charged residues can be explained by local structural rearrangements because of the large positively charged side chain. Thus, our data suggest that SLC7A10 may represent a rare but novel gene associated with human startle disease and developmental delay.
Background
Medical resource management can be improved by assessing the likelihood of prolonged length of stay (LOS) for head and neck cancer surgery patients. The objective of this study was to develop predictive models that could be used to determine whether a patient's LOS after cancer surgery falls within the normal range of the cohort.
Methods
We conducted a retrospective analysis of a dataset consisting of 300 consecutive patients who underwent head and neck cancer surgery between 2017 and 2022 at a single university medical center. Prolonged LOS was defined as LOS exceeding the 75th percentile of the cohort. Feature importance analysis was performed to evaluate the most important predictors for prolonged LOS. We then constructed 7 machine learning and deep learning algorithms for the prediction modeling of prolonged LOS.
Results
The algorithms reached accuracy values of 75.40 (radial basis function neural network) to 97.92 (Random Trees) for the training set and 64.90 (multilayer perceptron neural network) to 84.14 (Random Trees) for the testing set. The leading parameters predicting prolonged LOS were operation time, ischemia time, the graft used, the ASA score, the intensive care stay, and the pathological stages. The results revealed that patients who had a higher number of harvested lymph nodes (LN) had a lower probability of recurrence but also a greater LOS. However, patients with prolonged LOS were also at greater risk of recurrence, particularly when fewer (LN) were extracted. Further, LOS was more strongly correlated with the overall number of extracted lymph nodes than with the number of positive lymph nodes or the ratio of positive to overall extracted lymph nodes, indicating that particularly unnecessary lymph node extraction might be associated with prolonged LOS.
Conclusions
The results emphasize the need for a closer follow-up of patients who experience prolonged LOS. Prospective trials are warranted to validate the present results.
Learning about informal fallacies and the detection of fake news: an experimental intervention
(2023)
The philosophical concept of informal fallacies–arguments that fail to provide sufficient support for a claim–is introduced and connected to the topic of fake news detection. We assumed that the ability to identify informal fallacies can be trained and that this ability enables individuals to better distinguish between fake news and real news. We tested these assumptions in a two-group between-participants experiment (N = 116). The two groups participated in a 30-minute-long text-based learning intervention: either about informal fallacies or about fake news. Learning about informal fallacies enhanced participants’ ability to identify fallacious arguments one week later. Furthermore, the ability to identify fallacious arguments was associated with a better discernment between real news and fake news. Participants in the informal fallacy intervention group and the fake news intervention group performed equally well on the news discernment task. The contribution of (identifying) informal fallacies for research and practice is discussed.
Highlights
• Loss of DNAJC19's DnaJ domain disrupts cardiac mitochondrial structure, leading to abnormal cristae formation in iPSC-CMs.
• Impaired mitochondrial structures lead to an increased mitochondrial respiration, ROS and an elevated membrane potential.
• Mutant iPSC-CMs show sarcomere dysfunction and a trend to more arrhythmias, resembling DCMA-associated cardiomyopathy.
Background
Dilated cardiomyopathy with ataxia (DCMA) is an autosomal recessive disorder arising from truncating mutations in DNAJC19, which encodes an inner mitochondrial membrane protein. Clinical features include an early onset, often life-threatening, cardiomyopathy associated with other metabolic features. Here, we aim to understand the metabolic and pathophysiological mechanisms of mutant DNAJC19 for the development of cardiomyopathy.
Methods
We generated induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) of two affected siblings with DCMA and a gene-edited truncation variant (tv) of DNAJC19 which all lack the conserved DnaJ interaction domain. The mutant iPSC-CMs and their respective control cells were subjected to various analyses, including assessments of morphology, metabolic function, and physiological consequences such as Ca\(^{2+}\) kinetics, contractility, and arrhythmic potential. Validation of respiration analysis was done in a gene-edited HeLa cell line (DNAJC19tv\(_{HeLa}\)).
Results
Structural analyses revealed mitochondrial fragmentation and abnormal cristae formation associated with an overall reduced mitochondrial protein expression in mutant iPSC-CMs. Morphological alterations were associated with higher oxygen consumption rates (OCRs) in all three mutant iPSC-CMs, indicating higher electron transport chain activity to meet cellular ATP demands. Additionally, increased extracellular acidification rates suggested an increase in overall metabolic flux, while radioactive tracer uptake studies revealed decreased fatty acid uptake and utilization of glucose. Mutant iPSC-CMs also showed increased reactive oxygen species (ROS) and an elevated mitochondrial membrane potential. Increased mitochondrial respiration with pyruvate and malate as substrates was observed in mutant DNAJC19tv HeLa cells in addition to an upregulation of respiratory chain complexes, while cellular ATP-levels remain the same. Moreover, mitochondrial alterations were associated with increased beating frequencies, elevated diastolic Ca\(^{2+}\) concentrations, reduced sarcomere shortening and an increased beat-to-beat rate variability in mutant cell lines in response to β-adrenergic stimulation.
Conclusions
Loss of the DnaJ domain disturbs cardiac mitochondrial structure with abnormal cristae formation and leads to mitochondrial dysfunction, suggesting that DNAJC19 plays an essential role in mitochondrial morphogenesis and biogenesis. Moreover, increased mitochondrial respiration, altered substrate utilization, increased ROS production and abnormal Ca\(^{2+}\) kinetics provide insights into the pathogenesis of DCMA-related cardiomyopathy.
To fire action-potential-like electrical signals, the vacuole membrane requires the two-pore channel TPC1, formerly called SV channel. The TPC1/SV channel functions as a depolarization-stimulated, non-selective cation channel that is inhibited by luminal Ca\(^{2+}\). In our search for species-dependent functional TPC1 channel variants with different luminal Ca\(^{2+}\) sensitivity, we found in total three acidic residues present in Ca\(^{2+}\) sensor sites 2 and 3 of the Ca\(^{2+}\)-sensitive AtTPC1 channel from Arabidopsis thaliana that were neutral in its Vicia faba ortholog and also in those of many other Fabaceae. When expressed in the Arabidopsis AtTPC1-loss-of-function background, wild-type VfTPC1 was hypersensitive to vacuole depolarization and only weakly sensitive to blocking luminal Ca\(^{2+}\). When AtTPC1 was mutated for these VfTPC1-homologous polymorphic residues, two neutral substitutions in Ca\(^{2+}\) sensor site 3 alone were already sufficient for the Arabidopsis At-VfTPC1 channel mutant to gain VfTPC1-like voltage and luminal Ca\(^{2+}\) sensitivity that together rendered vacuoles hyperexcitable. Thus, natural TPC1 channel variants exist in plant families which may fine-tune vacuole excitability and adapt it to environmental settings of the particular ecological niche.
Interleukin-4 (IL-4) plays a key role in atopic diseases. It coordinates T-helper cell differentiation to subtype 2, thereby directing defense toward humoral immunity. Together with Interleukin-13, IL-4 further induces immunoglobulin class switch to IgE. Antibodies of this type activate mast cells and basophilic and eosinophilic granulocytes, which release pro-inflammatory mediators accounting for the typical symptoms of atopic diseases. IL-4 and IL-13 are thus major targets for pharmaceutical intervention strategies to treat atopic diseases. Besides neutralizing antibodies against IL-4, IL-13, or its receptors, IL-4 antagonists can present valuable alternatives. Pitrakinra, an Escherichia coli-derived IL-4 antagonist, has been evaluated in clinical trials for asthma treatment in the past; however, deficits such as short serum lifetime and potential immunogenicity among others stopped further development. To overcome such deficits, PEGylation of therapeutically important proteins has been used to increase the lifetime and proteolytic stability. As an alternative, glycoengineering is an emerging strategy used to improve pharmacokinetics of protein therapeutics. In this study, we have established different strategies to attach glycan moieties to defined positions in IL-4. Different chemical attachment strategies employing thiol chemistry were used to attach a glucose molecule at amino acid position 121, thereby converting IL-4 into a highly effective antagonist. To enhance the proteolytic stability of this IL-4 antagonist, additional glycan structures were introduced by glycoengineering utilizing eucaryotic expression. IL-4 antagonists with a combination of chemical and biosynthetic glycoengineering could be useful as therapeutic alternatives to IL-4 neutralizing antibodies already used to treat atopic diseases.
Recent studies link increased ozone (O\(_3\)) and carbon dioxide (CO\(_2\)) levels to alteration of plant performance and plant-herbivore interactions, but their interactive effects on plant-pollinator interactions are little understood. Extra floral nectaries (EFNs) are essential organs used by some plants for stimulating defense against herbivory and for the attraction of insect pollinators, e.g., bees. The factors driving the interactions between bees and plants regarding the visitation of bees to EFNs are poorly understood, especially in the face of global change driven by greenhouse gases. Here, we experimentally tested whether elevated levels of O\(_3\) and CO\(_2\) individually and interactively alter the emission of Volatile Organic Compound (VOC) profiles in the field bean plant (Vicia faba, L., Fabaceae), EFN nectar production and EFN visitation by the European orchard bee (Osmia cornuta, Latreille, Megachilidae). Our results showed that O\(_3\) alone had significant negative effects on the blends of VOCs emitted while the treatment with elevated CO\(_2\) alone did not differ from the control. Furthermore, as with O\(_3\) alone, the mixture of O\(_3\) and CO\(_2\) also had a significant difference in the VOCs’ profile. O\(_3\) exposure was also linked to reduced nectar volume and had a negative impact on EFN visitation by bees. Increased CO\(_2\) level, on the other hand, had a positive impact on bee visits. Our results add to the knowledge of the interactive effects of O\(_3\) and CO\(_2\) on plant volatiles emitted by Vicia faba and bee responses. As greenhouse gas levels continue to rise globally, it is important to take these findings into consideration to better prepare for changes in plant-insect interactions.
Idiopathic Parkinson’s disease (PD) is characterized by a progredient degeneration of the brain, starting at deep subcortical areas such as the dorsal motor nucleus of the glossopharyngeal and vagal nerves (DM) (stage 1), followed by the coeruleus–subcoeruleus complex; (stage 2), the substantia nigra (SN) (stage 3), the anteromedial temporal mesocortex (MC) (stage 4), high-order sensory association areas and prefrontal fields (HC) (stage 5) and finally first-order sensory association areas, premotor areas, as well as primary sensory and motor field (FC) (stage 6). Autoimmunity might play a role in PD pathogenesis. Here we analyzed whether anti-brain autoantibodies differentially recognize different human brain areas and identified autoantigens that correlate with the above-described dissemination of PD pathology in the brain. Brain tissue was obtained from deceased individuals with no history of neurological or psychiatric disease and no neuropathological abnormalities. Tissue homogenates from different brain regions (DM, SN, MC, HC, FC) were subjected to SDS-PAGE and Western blot. Blots were incubated with plasma samples from 30 PD patients and 30 control subjects and stained with anti-IgG antibodies to detect anti-brain autoantibodies. Signals were quantified. Prominent autoantigens were identified by 2D-gel-coupled mass spectrometry sequencing. Anti-brain autoantibodies are frequent and occur both in healthy controls and individuals with PD. Glial fibrillary acidic protein (GFAP) was identified as a prominent autoantigen recognized in all plasma samples. GFAP immunoreactivity was highest in DM areas and lowest in FC areas with no significant differences in anti-GFAP autoantibody titers between healthy controls and individuals with PD. The anti-GFAP autoimmunoreactivity of different brain areas correlates with the dissemination of histopathological neurodegeneration in PD. We hypothesize that GFAP autoantibodies are physiological but might be involved as a cofactor in PD pathogenesis secondary to a leakage of the blood–brain barrier.
Background
Labelled with lutetium-177, the urea-based small molecules PSMA I&T and PSMA-617 are the two agents most frequently used for radioligand therapy (RLT) in patients with advanced metastatic castration-resistant and prostate-specific membrane antigen (PSMA) expressing prostate cancer (mCRPC). In this matched-pair analysis, we aimed to compare the toxicity and efficacy of both agents for PSMA-directed RLT.
Materials and methods
A total of 110 mCRPC patients from two centres were accrued, 55 individuals treated with [\(^{177}\)Lu]Lu-PSMA I&T, and a matched cohort of 55 patients treated with [\(^{177}\)Lu]Lu-PSMA-617. Matching criteria included age at the first cycle, Gleason score, prostate-specific antigen (PSA) values, and previous taxane-based chemotherapy. Using common terminology criteria for adverse events (CTCAE v. 5.0), toxicity profiles were investigated (including bone marrow and renal toxicity). Overall survival (OS) between both groups was compared.
Results
Toxicity assessment revealed grade III anaemia in a single patient (1.8%) for [\(^{177}\)Lu]Lu-PSMA I&T and five (9.1%) for [\(^{177}\)Lu]Lu-PSMA-617. In addition, one (1.9%) grade III thrombopenia for [\(^{177}\)Lu]Lu-PSMA-617 was recorded. Apart from that, no other grade III/IV toxicities were present. A median OS of 12 months for patients treated with [\(^{177}\)Lu]Lu-PSMA I&T did not differ significantly when compared to patients treated with [\(^{177}\)Lu]Lu-PSMA-617 (median OS, 13 months; P = 0.89).
Conclusion
In this matched-pair analysis of patients receiving one of the two agents most frequently applied for PSMA RLT, the rate of clinically relevant toxicities was low for both compounds. In addition, no relevant differences for OS were observed.
Natural DNA storage allows cellular differentiation, evolution, the growth of our children and controls all our ecosystems. Here, we discuss the fundamental aspects of DNA storage and recent advances in this field, with special emphasis on natural processes and solutions that can be exploited. We point out new ways of efficient DNA and nucleotide storage that are inspired by nature. Within a few years DNA-based information storage may become an attractive and natural complementation to current electronic data storage systems. We discuss rapid and directed access (e.g. DNA elements such as promotors, enhancers), regulatory signals and modulation (e.g. lncRNA) as well as integrated high-density storage and processing modules (e.g. chromosomal territories). There is pragmatic DNA storage for use in biotechnology and human genetics. We examine DNA storage as an approach for synthetic biology (e.g. light-controlled nucleotide processing enzymes). The natural polymers of DNA and RNA offer much for direct storage operations (read-in, read-out, access control). The inbuilt parallelism (many molecules at many places working at the same time) is important for fast processing of information. Using biology concepts from chromosomal storage, nucleic acid processing as well as polymer material sciences such as electronical effects in enzymes, graphene, nanocellulose up to DNA macramé , DNA wires and DNA-based aptamer field effect transistors will open up new applications gradually replacing classical information storage methods in ever more areas over time (decades).
Objectives
To evaluate whether a multimodal intervention in general practice reduces the proportion of second line antibiotic prescriptions and the overall proportion of antibiotic prescriptions for uncomplicated urinary tract infections in women.
Design
Parallel, cluster randomised, controlled trial.
Setting
General practices in five regions in Germany. Data were collected between 1 April 2021 and 31 March 2022.
Participants
General practitioners from 128 randomly assigned practices.
Interventions
Multimodal intervention consisting of guideline recommendations for general practitioners and patients, provision of regional data for antibiotic resistance, and quarterly feedback, which included individual first line and second line proportions of antibiotic prescribing, benchmarking with regional or supra-regional practices, and telephone counselling. Participants in the control group received no information on the intervention.
Main outcome measures
Primary outcome was the proportion of second line antibiotics prescribed by general practices, in relation to all antibiotics prescribed, for uncomplicated urinary tract infections after one year between the intervention and control group. General practices were randomly assigned in blocks (1:1), with a block size of four, into the intervention or control group using SAS version 9.4; randomisation was stratified by region. The secondary outcome was the prescription proportion of all antibiotics, relative within all cases (instances of UTI diagnosis), for the treatment of urinary tract infections after one year between the groups. Adverse events were assessed as exploratory outcomes.
Results
110 practices with full datasets identified 10 323 cases during five quarters (ie, 15 months). The mean proportion of second line antibiotics prescribed was 0.19 (standard deviation 0.20) in the intervention group and 0.35 (0.25) in the control group after 12 months. After adjustment for preintervention proportions, the mean difference was −0.13 (95% confidence interval −0.21 to −0.06, P<0.001). The overall proportion of all antibiotic prescriptions for urinary tract infections over 12 months was 0.74 (standard deviation 0.22) in the intervention and 0.80 (0.15) in the control group with a mean difference of −0.08 (95% confidence interval −0.15 to −0.02, P<0.029). No differences were noted in the number of complications (ie, pyelonephritis, admission to hospital, or fever) between the groups.
Conclusions
The multimodal intervention in general practice significantly reduced the proportion of second line antibiotics and all antibiotic prescriptions for uncomplicated urinary tract infections in women.
Trial registration
German Clinical Trials Register (DRKS), DRKS00020389
Summary
Blood oxygen saturation is an important clinical parameter, especially in postoperative hospitalized patients, monitored in clinical practice by arterial blood gas (ABG) and/or pulse oximetry that both are not suitable for a long-term continuous monitoring of patients during the entire hospital stay, or beyond. Technological advances developed recently for consumer-grade fitness trackers could—at least in theory—help to fill in this gap, but benchmarks on the applicability and accuracy of these technologies in hospitalized patients are currently lacking. We therefore conducted at the postanaesthesia care unit under controlled settings a prospective clinical trial with 201 patients, comparing in total >1,000 oxygen blood saturation measurements by fitness trackers of three brands with the ABG gold standard and with pulse oximetry. Our results suggest that, despite of an overall still tolerable measuring accuracy, comparatively high dropout rates severely limit the possibilities of employing fitness trackers, particularly during the immediate postoperative period of hospitalized patients.
Highlights
•The accuracy of O2 measurements by fitness trackers is tolerable (RMSE ≲4%)
•Correlation with arterial blood gas measurements is fair to moderate (PCC = [0.46; 0.64])
•Dropout rates of fitness trackers during O2 monitoring are high (∼1/3 values missing)
•Fitness trackers cannot be recommended for O2 measuring during critical monitoring
Summary
Here we describe a novel neuro-mesodermal assembloid model that recapitulates aspects of peripheral nervous system (PNS) development such as neural crest cell (NCC) induction, migration, and sensory as well as sympathetic ganglion formation. The ganglia send projections to the mesodermal as well as neural compartment. Axons in the mesodermal part are associated with Schwann cells. In addition, peripheral ganglia and nerve fibers interact with a co-developing vascular plexus, forming a neurovascular niche. Finally, developing sensory ganglia show response to capsaicin indicating their functionality.
The presented assembloid model could help to uncover mechanisms of human NCC induction, delamination, migration, and PNS development. Moreover, the model could be used for toxicity screenings or drug testing. The co-development of mesodermal and neuroectodermal tissues and a vascular plexus along with a PNS allows us to investigate the crosstalk between neuroectoderm and mesoderm and between peripheral neurons/neuroblasts and endothelial cells.
Highlights
•Novel neuro-mesodermal assembloid model of peripheral nervous system development
•Model covers neural crest cell induction, migration, and ganglion formation
•Ganglia send projections to the mesodermal as well as neural compartment
•Peripheral ganglia and nerve fibers interact with a co-developing vascular plexus
Background
Haemophilus influenzae (Hi) is a Gram-negative bacterium that may cause sepsis or meningitis, treatment of which mainly includes β-lactam antibiotics. Since 2019 EUCAST breakpoints for piperacillin/tazobactam have been available. Little is known about the prevalence and mechanisms of piperacillin/tazobactam resistance in Hi.
Objectives
To provide reliable prevalence data for piperacillin/tazobactam resistance in Hi in Germany, to evaluate different antibiotic susceptibility testing methods and to examine possible resistance mechanisms.
Methods
According to EUCAST breakpoints, the MIC for piperacillin/tazobactam resistance is >0.25 mg/L. All invasive Hi in Germany from 2019 were examined by gradient agar diffusion (GAD) for piperacillin/tazobactam susceptibility. Piperacillin/tazobactam broth microdilution (BMD), piperacillin GAD on tazobactam-containing agar [piperacillin GAD on Mueller–Hinton agar with horse blood (MH-F)/tazobactam) and piperacillin/tazobactam agar dilution (AD) were used for confirmation. Phenotypic testing was complemented by ftsI sequencing.
Results
Piperacillin/tazobactam GAD resulted in 2.9% (21/726) resistant Hi. BMD did not confirm piperacillin/tazobactam resistance. Two strains were found resistant by AD, of which one was also resistant using piperacillin GAD on MH-F/tazobactam. Overall, we found two strains with a piperacillin/tazobactam MIC >0.25 mg/L in at least two different tests (0.3%). Both were β-lactamase-producing amoxicillin/clavulanate-resistant with PBP3 mutations characterized as group III-like+. Relevant PBP3 mutations occurred in six strains without phenotypic piperacillin/tazobactam resistance. These mutations suggest a reduced efficacy of β-lactam antibiotics in these isolates.
Conclusions
Piperacillin/tazobactam resistance prevalence in invasive Hi is low in Germany. Reduced susceptibility was correlated with PBP3 mutations, in particular with group III mutations.
The genomes of both human cytomegalovirus (HCMV) and murine cytomegalovirus (MCMV) were first sequenced over 20 years ago. Similar to HCMV, the MCMV genome had initially been proposed to harbor ≈170 open reading frames (ORFs). More recently, omics approaches revealed HCMV gene expression to be substantially more complex comprising several hundred viral ORFs. Here, we provide a state-of-the art reannotation of lytic MCMV gene expression based on integrative analysis of a large set of omics data. Our data reveal 365 viral transcription start sites (TiSS) that give rise to 380 and 454 viral transcripts and ORFs, respectively. The latter include 200 small ORFs, some of which represented the most highly expressed viral gene products. By combining TiSS profiling with metabolic RNA labelling and chemical nucleotide conversion sequencing (dSLAM-seq), we provide a detailed picture of the expression kinetics of viral transcription. This not only resulted in the identification of a novel MCMV immediate early transcript encoding the m166.5 ORF, which we termed ie4, but also revealed a group of well-expressed viral transcripts that are induced later than canonical true late genes and contain an initiator element (Inr) but no TATA- or TATT-box in their core promoters. We show that viral upstream ORFs (uORFs) tune gene expression of longer viral ORFs expressed in cis at translational level. Finally, we identify a truncated isoform of the viral NK-cell immune evasin m145 arising from a viral TiSS downstream of the canonical m145 mRNA. Despite being ≈5-fold more abundantly expressed than the canonical m145 protein it was not required for downregulating the NK cell ligand, MULT-I. In summary, our work will pave the way for future mechanistic studies on previously unknown cytomegalovirus gene products in an important virus animal model.
Background
To cover soft tissue defects, the perforator-based propeller flap offers the option to rotate healthy tissue into complex wounds. By rotating the flap, the perforator is torqued. As a result, perfusion changes are possible.
Methods
A retrospective data analysis of patients was done, who received a propeller flap to cover soft tissue defects of the lower extremity as well as a peri- and postoperative perfusion monitoring with a laser-Doppler-spectrophotometry system. Additionally, patient-specific data were collected.
Results
Seven patients were identified. Four patients experienced early complications, two epidermolysis of the distal flap areas, three wound healing disorders, and one partial flap necrosis. Intraoperative perfusion monitoring showed a decline of blood flow after incision of the flap, especially at distal flap site. In case of complications, there were prolonged blood flow declines up to the first postoperative day.
Conclusion
Torqueing the perforator by rotating the flap can cause an impairment in inflow and outflow. If the impairment is prolonged, perfusion-associated complications are possible. The identification of a viable perforator is particularly important. In addition, a conservative postoperative mobilization is necessary to compensate for the impaired and adapting outflow.
Background
Healthcare workers and medical students faced new challenges during the COVID-19 pandemic. Processes within many hospitals were completely disrupted. In addition, the face to face teaching of medical students was drastically reduced. Those at risk of developing mental health problems appear to be younger health care workers and women.
Objective
To investigate potential COVID-19 pandemic-related gender differences in psychological distress among medical students and physicians in their first years of practice.
Design and setting
An anonymous survey was carried out online between December 1, 2021, and March 31, 2022, at the Mannheim Medical Faculty and the Würzburg Medical Faculty, Germany, after obtaining informed consent. Primary outcome measures were changes in anxiety and depression symptoms using the Hospital Anxiety and Depression Scale (HADS), and changes in participants' current quality of life using the WHO Quality of Life BREF.
Results
The results show wave-like courses for perceived anxiety and burden overlapping with the course of the COVID-19 incidence. In comparison to men, women showed a significant higher increase in HADS (p = 0.005) and a reduced life quality (p = 0.007) after COVID-19. Both sexes showed different frequencies of the factors influencing quality of life, with the presence of a previous mental illness and mean anxiety having a significant higher negative impact in women.
Conclusion
Future and young female physicians reported a disproportionate higher burden during COVID-19 compared to their male colleges. These observations suggest an increased need for support and prevention efforts especially in this vulnerable population.
Background
Guideline-directed medical therapy (GDMT) is the cornerstone in the treatment of patients with heart failure and reduced ejection fraction (HFrEF) and novel substances such as sacubitril/valsartan (S/V) and sodium-glucose co-transporter-2 inhibitors (SGLT2i) have demonstrated marked clinical benefits. We investigated their implementation into real-world HF care in Germany before, during, and after the COVID-19 pandemic period.
Methods
The IQVIA LRx data set is based on ∼80% of 73 million people covered by the German statutory health insurance. Prescriptions of S/V were used as a proxy for HFrEF. Time trends were analysed between Q1/2016 and Q2/2023 for prescriptions for S/V alone and in combination therapy with SGLT2i.
Findings
The number of patients treated with S/V increased from 5260 in Q1/2016 to 351,262 in Q2/2023. The share of patients with combination therapy grew from 0.6% (29 of 5260) to 14.2% (31,128 of 219,762) in Q2/2021, and then showed a steep surge up to 54.8% (192,429 of 351,262) in Q2/2023, coinciding with the release of the European Society of Cardiology (ESC) guidelines for HF in Q3/2021. Women and patients aged >80 years were treated less often with combined therapy than men and younger patients. With the start of the COVID-19 pandemic, the number of patients with new S/V prescriptions dropped by 17.5% within one quarter, i.e., from 26,855 in Q1/2020 to 22,145 in Q2/2020, and returned to pre-pandemic levels only in Q1/2021.
Interpretation
The COVID-19 pandemic was associated with a 12-month deceleration of S/V uptake in Germany. Following the release of the ESC HF guidelines, the combined prescription of S/V and SGLT2i was readily adopted. Further efforts are needed to fully implement GDMT and strengthen the resilience of healthcare systems during public health crises.
We have investigated optical properties of hybrid two-dimensional-zero-dimensional (2D-0D) tunnel structures containing strongly elongated InAs/InP(001) quantum dots (called quantum dashes), emitting at 1.55 μm. These quantum dashes (QDashes) are separated by a 2.3 nm-width barrier from an InGaAs quantum well (QW), lattice matched to InP. We have tailored quantum-mechanical coupling between the states confined in QDashes and a QW by changing the QW thickness. By combining modulation spectroscopy and photoluminescence excitation, we have determined the energies of all relevant optical transitions in the system and proven the carrier transfer from the QW to the QDashes, which is the fundamental requirement for the tunnel injection scheme. A transformation between 0D and mixed-type 2D-0D character of an electron and a hole confinement in the ground state of the hybrid system have been probed by time-resolved photoluminescence that revealed considerable changes in PL decay time with the QW width changes. The experimental discoveries have been explained by band structure calculations in the framework of the eight-band k·p model showing that they are driven by delocalization of the lowest energy hole state. The hole delocalization process from the 0D QDash confinement is unfavorable for optical devices based on such tunnel injection structures.
While there is abounding literature on virus-induced pathology in general and coronavirus in particular, recent evidence accumulates showing distinct and deleterious brain affection. As the respiratory tract connects to the brain without protection of the blood–brain barrier, SARS-CoV-2 might in the early invasive phase attack the cardiorespiratory centres located in the medulla/pons areas, giving rise to disturbances of respiration and cardiac problems. Furthermore, brainstem regions are at risk to lose their functional integrity. Therefore, long-term neurological as well as psychiatric symptomatology and eventual respective disorders cannot be excluded as evidenced from influenza-A triggered post-encephalitic Parkinsonism and HIV-1 triggered AIDS–dementia complex. From the available evidences for coronavirus-induced brain pathology, this review concludes a number of unmet needs for further research strategies like human postmortem brain analyses. SARS-CoV-2 mirroring experimental animal brain studies, characterization of time-dependent and region-dependent spreading behaviours of coronaviruses, enlightening of pathological mechanisms after coronavirus infection using long-term animal models and clinical observations of patients having had COVID-19 infection are calling to develop both protective strategies and drug discoveries to avoid early and late coronavirus-induced functional brain disturbances, symptoms and eventually disorders. To fight SARS-CoV-2, it is an urgent need to enforce clinical, molecular biological, neurochemical and genetic research including brain-related studies on a worldwide harmonized basis.
Purpose
The purpose of this study is to investigate changes over time in quality of life (QoL) in incurable lung cancer patients and the impact of determinants like molecular alterations (MA).
Methods
In a prospective, longitudinal, multicentric study, we assessed QoL, symptom burden, psychological distress, unmet needs, and prognostic understanding of patients diagnosed with incurable lung cancer at the time of the diagnosis (T0) and after 3 (T1), 6 (T2) and 12 months (T3) using validated questionnaires like FACT-L, National Comprehensive Cancer Network (NCCN) Distress Thermometer (DT), PHQ-4, SCNS-SF-34, and SEIQoL.
Results
Two hundred seventeen patients were enrolled, 22 (10%) with reported MA. QoL scores improved over time, with a significant trend for DT, PHQ-4, and SCNS-SF-34. Significant determinants for stable or improving scores over time were survival > 6 months, performance status at the time of diagnosis, and presence of MA. Patients with MA showed better QoL scores (FACT-L at T1 104.4 vs 86.3; at T2 107.5 vs 90.0; at T3 100.9 vs 92.8) and lower psychological distress (NCCN DT at T1 3.3 vs 5; at T2 2.7 vs 4.5; at T3 3.7 vs 4.5; PHQ-4 at T1 2.3 vs 4.1; at T2 1.7 vs 3.6; at T3 2.2 vs 3.6), but also a worsening of the scores at 1 year and a higher percentage of inaccurate prognostic understanding (27 vs 17%) compared to patients without MA.
Conclusion
Patients with tumors harboring MA are at risk of QoL deterioration during the course of the disease. Physicians should adapt their communication strategies in order to maintain or improve QoL.
Background
The psychometric properties of an instrument, the Activity Scale for Kids-performance (ASKp), were assessed which was proposed to capture physical functioning after allogeneic hematopoietic stem cell transplantation (HSCT). Additionally, this multicenter observational prospective study investigated the influence of clinical correlates focusing on chronic graft-versus-host disease (cGVHD).
Methods
Patient-reported ASKp, clinician-reported Karnofsky/Lansky status (KPS/PSS), patient characteristics and cGVHD details were assessed of 55 patients with a median age of 12 years at baseline after day +100 post-HSCT and every 3 months during the next 18 months. The psychometric properties were evaluated and ASKp and KPS/PSS status was compared using ANOVAS and multiple regression models.
Results
The German version of the ASKp showed good psychometric properties except for ceiling effects. Discrimination ability of the ASKp was good regarding the need for devices but failed to predict cGVHD patients. Both the ASKp and the KPS/PSS were associated with patients after adoptive cell therapy being in need for devices, suffering from overlap cGVHD and from steroid side effects but not with patients’ age and gender. In contrast to the KPS/PSS the ASKp only showed significant differences after merging moderate and severe cGHVD patients when comparing them to No-cGVHD (F = 4.050; p = 0.049), being outperformed by the KPS/PSS (F = 20.082; p < 0.001).
Conclusion
The ASKp showed no clear advantages compared to KPS/PSS even though economical and patients’ effort was higher. Further application range may be limited through ceiling effects. Both should be taken into consideration. Therefore, the results may not support the usage of ASKp after HSCT and rather suggest KPS/PSS, both patient and clinician reported.
Key message
Mobile laser scanning and geometrical analysis revealed relationships between tree geometry and seed dispersal mechanism, latitude of origin, as well as growth.
Abstract
The structure and dynamics of a forest are defined by the architecture and growth patterns of its individual trees. In turn, tree architecture and growth result from the interplay between the genetic building plans and environmental factors. We set out to investigate whether (1) latitudinal adaptations of the crown shape occur due to characteristic solar elevation angles at a species’ origin, (2) architectural differences in trees are related to seed dispersal strategies, and (3) tree architecture relates to tree growth performance. We used mobile laser scanning (MLS) to scan 473 trees and generated three-dimensional data of each tree. Tree architectural complexity was then characterized by fractal analysis using the box-dimension approach along with a topological measure of the top heaviness of a tree. The tree species studied originated from various latitudinal ranges, but were grown in the same environmental settings in the arboretum. We found that trees originating from higher latitudes had significantly less top-heavy geometries than those from lower latitudes. Therefore, to a certain degree, the crown shape of tree species seems to be determined by their original habitat. We also found that tree species with wind-dispersed seeds had a higher structural complexity than those with animal-dispersed seeds (p < 0.001). Furthermore, tree architectural complexity was positively related to the growth performance of the trees (p < 0.001). We conclude that the use of 3D data from MLS in combination with geometrical analysis, including fractal analysis, is a promising tool to investigate tree architecture.
Background
Research in the field of surgery is mainly driven by aiming for trauma reduction as well as for personalized treatment concepts. Beyond laparoscopy, other proposed approaches for further reduction of the therapeutic trauma have failed to achieve clinical translation, with few notable exceptions. We believe that this is mainly due to a lack of flexibility and high associated costs. We aimed at addressing these issues by developing a novel minimally invasive operating platform and a preoperative design workflow for patient-individual adaptation and cost-effective rapid manufacturing of surgical manipulators. In this article, we report on the first in-vitro cholecystectomy performed with our operating platform.
Methods
The single-port overtube (SPOT) is a snake-like surgical manipulator for minimally invasive interventions. The system layout is highly flexible and can be adapted in design and dimensions for different kinds of surgery, based on patient- and disease-specific parameters. For collecting and analyzing this data, we developed a graphical user interface, which assists clinicians during the preoperative planning phase. Other major components of our operating platform include an instrument management system and a non-sterile user interface. For the trial surgery, we used a validated phantom which was further equipped with a porcine liver including the gallbladder.
Results
Following our envisioned preoperative design workflow, a suitable geometry of the surgical manipulator was determined for our trial surgery and rapidly manufactured by means of 3D printing. With this setup, we successfully performed a first in-vitro cholecystectomy, which was completed in 78 min.
Conclusions
By conducting the trial surgery, we demonstrated the effectiveness of our PLAFOKON operating platform. While some aspects – especially regarding usability and ergonomics – can be further optimized, the overall performance of the system is highly promising, with sufficient flexibility and strength for conducting the necessary tissue manipulations.
Climate change is increasing the frequency and intensity of warming and drought periods around the globe, currently representing a threat to many plant species. Understanding the resistance and resilience of plants to climate change is, therefore, urgently needed. As date palm (Phoenix dactylifera) evolved adaptation mechanisms to a xeric environment and can tolerate large diurnal and seasonal temperature fluctuations, we studied the protein expression changes in leaves, volatile organic compound emissions, and photosynthesis in response to variable growth temperatures and soil water deprivation. Plants were grown under controlled environmental conditions of simulated Saudi Arabian summer and winter climates challenged with drought stress. We show that date palm is able to counteract the harsh conditions of the Arabian Peninsula by adjusting the abundances of proteins related to the photosynthetic machinery, abiotic stress and secondary metabolism. Under summer climate and water deprivation, these adjustments included efficient protein expression response mediated by heat shock proteins and the antioxidant system to counteract reactive oxygen species formation. Proteins related to secondary metabolism were downregulated, except for the P. dactylifera isoprene synthase (PdIspS), which was strongly upregulated in response to summer climate and drought. This study reports, for the first time, the identification and functional characterization of the gene encoding for PdIspS, allowing future analysis of isoprene functions in date palm under extreme environments. Overall, the current study shows that reprogramming of the leaf protein profiles confers the date palm heat- and drought tolerance. We conclude that the protein plasticity of date palm is an important mechanism of molecular adaptation to environmental fluctuations.