Refine
Year of publication
- 2023 (598) (remove)
Document Type
- Journal article (313)
- Doctoral Thesis (218)
- Working Paper (25)
- Book article / Book chapter (21)
- Preprint (8)
- Conference Proceeding (4)
- Report (4)
- Book (2)
- Jahresbericht (1)
- Master Thesis (1)
Language
- English (598) (remove)
Keywords
- cultural studies (14)
- Kulturwissenschaften (12)
- machine learning (11)
- deep learning (9)
- COVID-19 (7)
- SARS-CoV-2 (6)
- Thrombozyt (6)
- anxiety (6)
- Biene (5)
- Deep learning (5)
- Germany (5)
- Globalisierung (5)
- India (5)
- Indien (5)
- Parkinson's disease (5)
- Tissue Engineering (5)
- Topologischer Isolator (5)
- inflammation (5)
- mental health (5)
- Angststörung (4)
- Funktionelle Kernspintomografie (4)
- Hall, Stuart (4)
- Lehrerbildung (4)
- Maschinelles Lernen (4)
- Mikroskopie (4)
- Sentinel-2 (4)
- Virtuelle Realität (4)
- Williams, Raymond (4)
- Zellzyklus (4)
- animal behaviour (4)
- artificial intelligence (4)
- global warming (4)
- globalization (4)
- human behaviour (4)
- mRNA (4)
- metabolism (4)
- neuroinflammation (4)
- neuroscience (4)
- platelets (4)
- psychology (4)
- quality of life (4)
- ARPES (3)
- CRISPR/Cas9 (3)
- Candida albicans (3)
- Chemische Synthese (3)
- Digitalisierung (3)
- EEG (3)
- Feminismus (3)
- Internationalität (3)
- Künstliche Intelligenz (3)
- Maus (3)
- Modellierung (3)
- P4 (3)
- Pflanzen (3)
- Platelet (3)
- Sentinel-1 (3)
- Small RNA (3)
- Zellskelett (3)
- bee (3)
- black holes (3)
- breast cancer (3)
- cancer (3)
- climate change (3)
- education (3)
- fMRI (3)
- feminism (3)
- heart failure (3)
- neuroimmunology (3)
- optogenetics (3)
- prognosis (3)
- stroke (3)
- surgery (3)
- tissue engineering (3)
- toe (3)
- tomography (3)
- topological insulators (3)
- virtual reality (3)
- winter wheat (3)
- 3D printing (2)
- 3D tissue model (2)
- 5G (2)
- ADHD (2)
- Alltagskultur (2)
- Alps (2)
- Alzheimerkrankheit (2)
- Apis mellifera (2)
- Aufmerksamkeit (2)
- Augmented Reality (2)
- Bildverarbeitung (2)
- Biofabrication (2)
- Biomarker (2)
- Blut-Hirn-Schranke (2)
- Borane (2)
- Borylation (2)
- Brain-derived neurotrophic factor (2)
- CD117 (2)
- CORDEX Africa (2)
- CRISPR/Cas-Methode (2)
- Campylobacter jejuni (2)
- Carbene (2)
- Cement (2)
- Chemie (2)
- Cytokine (2)
- Cytoskeleton (2)
- DFT (2)
- Datenfusion (2)
- Digital Religions (2)
- Digital Religions Education (2)
- Elektrochemie (2)
- Ernteertrag (2)
- Expansion Microscopy (2)
- Expositionstherapie (2)
- Extended Reality (2)
- Exziton (2)
- Fibromyalgie (2)
- Fluoreszenz (2)
- Fotophysik (2)
- Fotovoltaik (2)
- Gefühl (2)
- Gephyrin (2)
- Google Earth Engine (2)
- Immunologie (2)
- Immunsuppression (2)
- Induzierte pluripotente Stammzelle (2)
- Inhibitorische Synapse (2)
- Inhibitory synapse (2)
- Katalyse (2)
- Kognition (2)
- Kohlenstoff (2)
- Kondo-Effekt (2)
- Krebs <Medizin> (2)
- Kulturpolitik (2)
- Kulturtheorie (2)
- Kulturwissenschaft (2)
- Landwirtschaft / Nachhaltigkeit (2)
- MAP-Kinase (2)
- MMB (2)
- Marxismus (2)
- Marxist theory (2)
- Mediendidaktik (2)
- Medienkompetenz (2)
- Mensch-Maschine-Kommunikation (2)
- Merkel cell carcinoma (2)
- Methyltransferase (2)
- Molekül (2)
- Monarchfalter (2)
- NK cells (2)
- NLRP3 (2)
- Nationale Minderheiten (2)
- Neurodegeneration (2)
- Neuronales Netz (2)
- Nucleinsäuren (2)
- OLED (2)
- Organische Chemie (2)
- Organische Solarzelle (2)
- Orientierung (2)
- Peptidsynthese (2)
- Perovskite (2)
- Perowskit (2)
- Photoelektronenspektroskopie (2)
- Photophysics (2)
- Platelets (2)
- Polymere (2)
- Pädagogik (2)
- Quantenspinsystem (2)
- Quantum information (2)
- RNA (2)
- Rassismus (2)
- Rastertunnelmikroskop (2)
- Regulatorischer T-Lymphozyt (2)
- Religionsunterricht (2)
- Religious Education (2)
- Religiöse Bildung (2)
- Renormierungsgruppe (2)
- Ribosom (2)
- Ruthenium complexes (2)
- SDN (2)
- SPECT (2)
- Schlaganfall (2)
- Simulation (2)
- Social VR (2)
- Social Virtual Reality (2)
- Sozialphilosophie (2)
- Spinale Muskelatrophie (2)
- Spivak, Gayatri Chakravorty (2)
- Supraleitung (2)
- Supramolekulare Chemie (2)
- Synthese (2)
- Synthesis (2)
- Tanzania (2)
- Theoretische Chemie (2)
- Ultraschall (2)
- Virtual Reality (2)
- Winterweizen (2)
- Zambia (2)
- Zement (2)
- abandonment (2)
- accretion (2)
- altitudinal gradient (2)
- amino acid transporter (2)
- angiogenesis (2)
- animal model (2)
- attention (2)
- basic mental models (2)
- biomarker (2)
- blood gas analysis (2)
- blood-brain barrier (2)
- bone (2)
- brain (2)
- cancer microenvironment (2)
- cell biology (2)
- cell migration (2)
- central complex (2)
- cognitive impairment (2)
- connected mobility applications (2)
- cosmology (2)
- critical illness (2)
- crystallization (2)
- cultural politics (2)
- cultural theory (2)
- cytokines (2)
- dSTORM (2)
- decision making (2)
- decision-making (2)
- decoherence (2)
- deep brain stimulation (2)
- dementia (2)
- depression (2)
- diagnosis (2)
- digital change (2)
- diseases of the nervous system (2)
- division of labor (2)
- doctoral graduates (2)
- eHealth (2)
- earth observation (2)
- editorial (2)
- emergent time (2)
- endoscopy (2)
- extracellular vesicles (2)
- follow-up (2)
- free electron laser (2)
- gene expression (2)
- general relativity (2)
- genetics (2)
- genomics (2)
- gephyrin (2)
- glioblastoma (2)
- global change (2)
- grading (2)
- guard cells (2)
- health policy (2)
- honeybee (2)
- imaging (2)
- immunotherapy (2)
- infection (2)
- innate immunity (2)
- insulin resistance (2)
- internationalism (2)
- ischemic stroke (2)
- local field potentials (2)
- magnetic resonance imaging (2)
- media literacy (2)
- miRNA (2)
- migration (2)
- minorities (2)
- monitoring (2)
- mortality (2)
- multipath scheduling (2)
- network calculus (2)
- neural network (2)
- neurological disorders (2)
- neurology (2)
- neuromuscular junction (2)
- obesity (2)
- object detection (2)
- oncology (2)
- ordinary culture (2)
- organoids (2)
- osteoporosis (2)
- oxidative stress (2)
- pancreatic cancer (2)
- perception (2)
- peripheral nervous system (2)
- permafrost (2)
- photon-counting (2)
- platelet aggregation (2)
- politics of representation (2)
- polyomavirus (2)
- preclinical research (2)
- preterm infants (2)
- protease inhibitors (2)
- protein kinase (2)
- qubit (2)
- racism (2)
- recovery (2)
- regenerative medicine (2)
- relativistic jets (2)
- remote sensing (2)
- renewable energy (2)
- secondary structure (2)
- self-assembly (2)
- sepsis (2)
- signaling pathway (2)
- social philosophy (2)
- software (2)
- sphingolipids (2)
- spinal muscular atrophy (2)
- spine (2)
- survival (2)
- sustainable agriculture (2)
- tapeworm (2)
- the rich (2)
- three-dimensional imaging (2)
- transcription (2)
- translational research (2)
- transnationalism (2)
- tumor microenvironment (2)
- urbanization (2)
- very-long-baseline interferometry (2)
- vitamin C (2)
- vitamin D (2)
- wind speed (2)
- Übergangsmetallkomplexe (2)
- (approximate) functional equation (1)
- 1,2-azaborinine (1)
- 18S rRNA (1)
- 19. Jahrhundert (1)
- 223Ra (1)
- 224Ra (1)
- 2PI Formalism (1)
- 2n+3 (1)
- 2ϕ\(_0\) periodicity (1)
- 3 D bioprinting (1)
- 3 dimensional cell culture model (1)
- 3D (1)
- 3D Gewebemodelle (1)
- 3D Printing (1)
- 3D Reconstruction (1)
- 3D cell culture (1)
- 3D in vitro model (1)
- 3D model generation (1)
- 3D organoids (1)
- 3D-Druck (1)
- 3D-Rekonstruktion (1)
- 3D-Zellkultur (1)
- 4D-GIS (1)
- 5G core network (1)
- 6G (1)
- 77-LH-28-1 (1)
- 9-borafluorene (1)
- A. thaliana (1)
- ABA (1)
- ACC/AHA classification (1)
- ADSCs (1)
- AGP (1)
- AKT1 (1)
- ALMT (1)
- AMPK (1)
- ATPase activity (1)
- ATR-FTIR (1)
- ATSSSS (1)
- Ab-initio-Rechnung (1)
- Ableitung (1)
- Academic Skills (1)
- Accessibility (1)
- Accurate crop monitoring (1)
- Achilles tendinopathy (1)
- Ackerschmalwand (1)
- Actin cytoskeleton-related protein (1)
- Activist Scholarship (1)
- AdS-CFT-Korrespondenz (1)
- AdS/CFT correspondence (1)
- Add-on-Miss (1)
- Additive Fertigung (1)
- Adiabatic Perturbation Theory (1)
- Adjuvans (1)
- Adrenocortical Carcinoma (1)
- Affinity probe (1)
- Agentenbasierte Modellierung (1)
- Aggression (1)
- Agoraphobie (1)
- Agrobacterium (1)
- Aktivierungsenergie (1)
- Aktivist (1)
- Akzeptanz (1)
- Akzeptanz- und Commitment Therapie (1)
- Aldehyde Bioconjugation (1)
- Alkyltransferase Ribozyme SAMURI (1)
- Allogenic hematopoietic stem cell transplantation (1)
- Allorhizobium vitis (1)
- Altern (1)
- Alzheimer's Dementia (1)
- Alzheimer's disease (1)
- AmGr1 (1)
- AmGr1, AmGr2, AmGr3 (1)
- AmGr2 (1)
- AmGr3 (1)
- American Studies (1)
- American Thyroid Association (1)
- Amerikanistik (1)
- Amygdala (1)
- Analogschaltung (1)
- Analytical Quality by Design (1)
- Anderson impurity model (1)
- Angewandte Mathematik (1)
- Angst (1)
- Angst als Zustand (1)
- Angsterkrankung (1)
- Animal model (1)
- Anode (1)
- Anrege-Abfrage-Spektroskopie (1)
- Antibiotikum (1)
- Antiferromagnet (1)
- Antiferromagnetikum (1)
- Antiferromagnetismus (1)
- Antikörper (1)
- Antimikrobieller Wirkstoff (1)
- Anxiety disorder (1)
- Anxiety disorders (1)
- Apoptosis (1)
- Arbeitsmarkt (1)
- Arctic (1)
- Argentina (1)
- Artificial Intelligence (1)
- Arzneimittelüberwachung (1)
- Arzneistoffanalytik (1)
- Asc-1 transporter (1)
- Astrochemie (1)
- Atemwege (1)
- Atemwegsschleimhaut (1)
- Aufmerksamkeitsdefizit-Syndrom (1)
- Auger-Spektroskopie (1)
- Augmented Lagrangian methods (1)
- Ausschreibungen (1)
- Autoantikörper (1)
- Autoinhibition (1)
- Autonomer Roboter (1)
- Autonomie (1)
- B-MYB (1)
- B-Zell-Lymphom (1)
- BDNF stimulation (1)
- BMP signaling (1)
- BOLD signal (1)
- BPM (1)
- BPMN (1)
- BRET (1)
- Bacterial infection (1)
- Baghdadite (1)
- Bakterielle Infektion (1)
- Bamboo-branch songs (1)
- Bandstruktur (1)
- Bandwürmer (1)
- Bank credit (1)
- Bank-led Growth (1)
- Barbituric Acid Merocyanines (1)
- Baryogenesis (1)
- Baryonenasymmetrie (1)
- Batterie (1)
- Bauchspeicheldrüse (1)
- Bauchspeicheldrüsenkrebs (1)
- Baumhöhle (1)
- Bed nucleus of stria terminalis (1)
- Begabtenförderung (1)
- Behinderung (1)
- Benutzererlebnis (1)
- Benutzerforschung (1)
- Benzimidazolderivate (1)
- Bereaved Parents (1)
- Bericht (1)
- Berufserfolg (1)
- Bestärkendes Lernen <Künstliche Intelligenz> (1)
- Bestäubung (1)
- Bias correction (1)
- Bias-Korrektur (1)
- Biene <Gattung> (1)
- Bienenkrankheiten (1)
- Bienenschwarm (1)
- Bilderzeugung (1)
- Bildgebendes Verfahren (1)
- Bildung (1)
- Bilharziose (1)
- Bimolekulare Lipidschicht (1)
- Bindegewebe (1)
- Bioconjugate (1)
- Bioinformatics (1)
- Biologie (1)
- Biologische Aktivität (1)
- Biomacromolecular Sensing (1)
- Biomechanics (1)
- Biomechanik (1)
- Bioorthogonal Tag (1)
- Bioreactor (1)
- Biosensor (1)
- Biosphere Reserves (1)
- Biosphärenreservat (1)
- Bioverfügbarkeit (1)
- Bismut (1)
- Bismuthene (1)
- Bispecific T-cell engager (1)
- Bitopische Liganden (1)
- Blei (1)
- Bleiakkumulator (1)
- BlessU2 (1)
- Blick (1)
- Bloch-Floquet Theorem (1)
- Blood nerve barrier (1)
- Bone-replacement (1)
- Boron (1)
- Boron Materials (1)
- Bortezomib (1)
- Brassicaceae (1)
- Brombeere (1)
- Brownsche Bewegung (1)
- Bruxismus (1)
- Bulk-boundary correspondence (1)
- Butyrate <Buttersäuresalze> (1)
- C-C coupling (1)
- C1q/TNF related protein (CTRP) (1)
- C5a (1)
- C5aR1 (1)
- CACO-2 (1)
- CAR-T cells (1)
- CCR2 (1)
- CCR4 (1)
- CD28 Superagonist (1)
- CHI Conference (1)
- CIDP (1)
- CIPK23 (1)
- CK5 (1)
- CMV (1)
- CNS disorders (1)
- CNS integrity (1)
- CNV (1)
- COVID-19 pandemic (1)
- COVID‐19 (1)
- CPFE (1)
- CVT (1)
- CXCL10 (1)
- CXorf44 (1)
- Ca2+ signal (1)
- Calcium (1)
- Calcium Phosphate (1)
- Calciumphosphat (1)
- Cambrian (1)
- Cancer (1)
- Candida auris (1)
- Carbocistein (1)
- Carbon additives (1)
- Carbon surface chemistry (1)
- Cas9 (1)
- Catalysis (1)
- Causality (1)
- Cayley graph (1)
- Cell adhesion (1)
- Cell cycle (1)
- Change Vector Analysis (1)
- Characterization (1)
- Charged Aerosol Detection (1)
- Charged aerosol detection (1)
- Chemical Synthesis (1)
- Chemical modification (1)
- Chemische Reinheit (1)
- China (1)
- Chinese Population Policy (1)
- Chinese state media (1)
- Chinolon <2-> (1)
- Chinolonamide (1)
- Chiralität <Chemie> (1)
- Christentum (1)
- Chromatin (1)
- Circadian (1)
- Circumpolar (1)
- Climate change (1)
- Clostridium difficile (1)
- Cloud Computing (1)
- Cognitive Remediation (1)
- Cognitive control (1)
- Coherent Multidimensional Spectroscopy (1)
- Coherent perfect absorption (1)
- Coisotropic reduction (1)
- Colorectal Cancer (1)
- Combustion (1)
- Comorbidity (1)
- Composite optimization problems (1)
- Compressed Sensing (1)
- Computational Chemistry (1)
- Computer Vision (1)
- Concealed Information Test (CIT) (1)
- Conformal field theory (1)
- Conical Intersections (1)
- Contactin-1 (1)
- Containerization (1)
- Contributors (1)
- Corpus amygdaloideum (1)
- Correlated Fermions (1)
- Correlation Effects (1)
- Correlative microscopy (1)
- Covalent Organic Framework (1)
- Covid-19 (1)
- Coxiella burnetii (1)
- Crop Growth Models (1)
- Crop YIelds (1)
- Crop growth models (CGMs) (1)
- Crop yield estimations (1)
- Crosslinker (1)
- Crosstalk (1)
- CuMnSb (1)
- Cyclotrimerization (1)
- Cytomegalie-Virus (1)
- Cytotoxic T cell (1)
- Cytotoxicity (1)
- Cytotoxizität (1)
- DAS28 (1)
- DASH (1)
- DBS biomarkers (1)
- DBS programming (1)
- DEUQUA (1)
- DHX30 (1)
- DMARD (1)
- DNA (1)
- DNA damage repair (1)
- DNA methylation (1)
- DNA recognition (1)
- DNA storage (1)
- DNA-Sensor (1)
- DNA-based nanostructures (1)
- DNA-processing enzymes (1)
- DNS-Reparatur (1)
- DNS-Schädigung (1)
- Daily life (1)
- Danaus plexippus (1)
- Darmepithel (1)
- Darmparasit (1)
- Darmparasiten (1)
- Data Fusion (1)
- Datenanalyse (1)
- Dauerfrostboden (1)
- Decision Support Systems (1)
- Deep Learning (1)
- Deep-sequencing (1)
- Deformationsquantisierung (1)
- Degradation (1)
- Demethylase (1)
- Demethylierung (1)
- Density of states (1)
- Dephosphorylierung (1)
- Depression (1)
- Design-Based-Research (1)
- Desinformation (1)
- Deutschland (1)
- Development (1)
- Diabetic painful neuropathy (1)
- Diagnostik (1)
- Diboryne (1)
- Dichtefunktionalformalismus (1)
- Dickdarmkrebs (1)
- Differentialgeometrie (1)
- Differentialgleichung (1)
- Diffusion coefficient (1)
- Digital Humanities (1)
- Digitale Signalverarbeitung (1)
- Diine (1)
- Dijkstra’s algorithm (1)
- Diorganobismut-Spezies (1)
- Dirac Halbmetalle (1)
- Dirac semimetals (1)
- Directional emission (1)
- Dodecaborane (1)
- Domänenspezifische Sprache (1)
- Dorsal root ganglion (1)
- Drahtloses vermaschtes Netzwerk (1)
- Dreidimensionale Rekonstruktion (1)
- Dreiecksgitter (1)
- Drift-Diffusion (1)
- Drosophila melanogaster (1)
- Dual-setting (1)
- Dunkle Persönlichkeitsmerkmale (1)
- Dye (1)
- Dynamic charge acceptance (1)
- Dynamics of ribosome assembly (1)
- Dynamische Molekularfeldtheorie (1)
- Dünndarm (1)
- Dünnschichtsolarzelle (1)
- EGFR (1)
- EHT (1)
- ER dynamics in axon terminals (1)
- EUROASPIRE (1)
- Echinococcus (1)
- Echtzeit (1)
- Ecological Momentary Assessment (1)
- Economic development (1)
- Economic growth (1)
- Edge-MEC-Cloud (1)
- Editorial Principles (1)
- Eeriness (1)
- Eigenstate Thermalization Hypothesis (1)
- Einfühlung (1)
- Einfühlung <Motiv> (1)
- Einsamkeit (1)
- Einzelzellanalyse (1)
- Electronic spectroscopy (1)
- Elektromyographie (1)
- Elektronenkorrelation (1)
- Elektronische Spektroskopie (1)
- Elektrophysiologie (1)
- Elementarteilchenphysik (1)
- Embryonalentwicklung (1)
- Emission Policy (1)
- Emotion (1)
- Emotion inference (1)
- Emotionserkennung (1)
- Emotionsinterpretation (1)
- Emotionsregulation (1)
- Empathy (1)
- Enantioselektivität (1)
- Endocytose (1)
- Endocytosis (1)
- Endophänotypen (1)
- Endoplasmatisches Retikulum (1)
- Endosomes (1)
- Endothel (1)
- Endothelium (1)
- Enhanced Vegetation Index (1)
- Enterobacteriaceae (1)
- Enterococcus faecalis (1)
- Enterococcus faecium (1)
- Entscheidungsunterstützungssystem (1)
- Entwicklung (1)
- Entzündung (1)
- Environmental (1)
- Ephedrin (1)
- Epigenetik (1)
- Epistemic Network Analysis (1)
- Epistemische Überzeugungen (1)
- Epitranskriptom (1)
- Erdbeobachtung (1)
- Erde (1)
- Erfahrung (1)
- Erneuerbare Energien (1)
- Erosion (1)
- Erregbarkeit (1)
- Erziehungswissenschaften (1)
- Erzählung (1)
- Euler equations (1)
- Euler-Lagrange-Gleichung (1)
- European orchard bee (Osmia cornuta) (1)
- Exact Diagonalization (1)
- Excitatory/inhibitory imbalance (1)
- Exciton–exciton annihilation (1)
- Experimentelle Psychologie (1)
- Explainable Artificial Intelligence (1)
- Exposure treatment (1)
- Extinktion (1)
- Extrazellulärmatrix (1)
- Exziton-Exziton-Annihilierung (1)
- FAM104A (1)
- FAM104B (1)
- FAT10ylation (1)
- FGF signaling (1)
- FIFO caching strategies (1)
- FLJ14775 (1)
- FLJ20434 (1)
- FOXP2 (1)
- FRET (1)
- FTIR spectroscopy (1)
- Fabaceae (1)
- Fabry disease (1)
- Fabry-Krankheit (1)
- Fake News (1)
- Falschmeldung (1)
- Farbstoff (1)
- Feelings of agency (1)
- Feminist (1)
- Feng Menglong (1)
- Fermionensystem (1)
- Fernerkundung (1)
- Festphasensynthese (1)
- Fibromyalgia syndrome (1)
- Fibromyalgiesyndrom (1)
- Film (1)
- Finance (1)
- Finance-growth nexus (1)
- Finite-Differenzen-Methode (1)
- Flavonoids (1)
- Flight muscle (1)
- Floquet-Theorie (1)
- Flugzeitmassenspektrometrie (1)
- FluidFM (1)
- Fluorescence Microscopy (1)
- Fluorescence and Crosslinking (1)
- Fluorescence microscopy (1)
- Fluorescent probes (1)
- Fluoreszenz-Resonanz-Energie-Transfer (1)
- Fluoreszenzmikroskopie (1)
- Fluoreszenzpolarisation (1)
- Fluoreszenzsonde (1)
- Fluoreszierender Stoff (1)
- Forkhead Transcription Factors (1)
- Forkhead-Box-Proteine (1)
- Formulierungsentwicklung (1)
- FoxO transcription factors (1)
- Fragebogen (1)
- Free Electron Laser (1)
- Freies Molekül (1)
- Fructosebisphosphat-Aldolase (1)
- Frühe Gene (1)
- Frühstudium (1)
- Fulminsäure (1)
- Functional Renormalization Group (1)
- Functional properties (1)
- Funknetz (1)
- Fusobacterium nucleatum (1)
- Förster Resonanz Energie Transfer (1)
- G-Protein gekoppelter Rezeptor (1)
- G2/M genes (1)
- GAD1 (1)
- GC1 cells (1)
- GEDI (1)
- GIS (1)
- GLA KO mouse model (1)
- GPCR (1)
- GPVI (1)
- GRAPPA (1)
- GRM8 (1)
- GSK3 (1)
- GTP-bindende Proteine (1)
- Galectin 1 (1)
- Galectine (1)
- Galle (1)
- Ganzkörperbestrahlung (1)
- Gas chromatography (1)
- Gaschromatographie (1)
- Gattungstheorie (1)
- Gehirn (1)
- Geld (1)
- Geldpolitik (1)
- Genetic etiology (1)
- Genexpression (1)
- Genomics (1)
- Genotyping (1)
- Genregulation (1)
- Geoinformationssystem (1)
- Geometric constraints (1)
- Geospatial (1)
- Gerichtete Abstrahlung (1)
- German population (1)
- Geschlecht (1)
- Gewalt / Frau (1)
- Gewebemodell (1)
- Gewebemodelle (1)
- Gilroy, Paul: The Black Atlantic (1)
- Glioblastoma (1)
- Global Ecosystem Dynamics Investigation (1)
- Glucocorticoids (1)
- Glut1DS (1)
- Glycocalyx (1)
- Glykobiologie (1)
- Glykokalyx (1)
- Grad-seq (1)
- Graft-versus-host-disease (1)
- Graft-versus-leukemia (1)
- Gram points (1)
- Gram-positive (1)
- Gram’s law (1)
- Granulozyten (1)
- Graptolithoidea (1)
- Graßmannians (1)
- Grundvorstellung (1)
- Grünland (1)
- Grünlandnutzung (1)
- Guanine nucleotide exchange factor (GEF) (1)
- HAQ (1)
- HASH (1)
- HCMV (1)
- HCW (1)
- HER2 conversion (1)
- HER2 targeted therapy (1)
- HER2-low (1)
- HNSCC (1)
- HPLC (1)
- HPLC-MS (1)
- HPβCD (1)
- Habituationstraining (1)
- Handlungserleben (1)
- Handlungsregulation (1)
- Handlungssteuerung (1)
- Hautleitfähigkeit (1)
- Hecke L-functions (1)
- Hecke eigenforms (1)
- Heisenberg-Modell (1)
- Helicene diimide (1)
- Helicobacter pylori (1)
- Hemibodies (1)
- Hemibody (1)
- Herpes (1)
- Herzfrequenz (1)
- Herzfunktion (1)
- Herzinfarkt (1)
- Herzmuskel (1)
- Heterogenität von Mikroorganismen (1)
- Heusler (1)
- Heuslersche Legierung (1)
- Hfq (1)
- High-performance liquid chromatography (1)
- Higher-order Transient Absorption Spectroscopy (1)
- Hispanoamerikanisch (1)
- History (1)
- Hochbegabung (1)
- Homing (1)
- Honeybee (1)
- Hubbard model (1)
- Human Computer Interaction (1)
- Human-centered computing / Access (1)
- Human-centered computing / Human computer interaction (HCI) / Interaction paradigms / Mixed / augmented reality (1)
- Human-centered computing / Human computer interaction (HCI) / Interaction paradigms / Virtual reality (1)
- Human-centered computing / Human computer interaction (HCI) / Interactiondevices (1)
- Human-centered computing / Human computerinteraction (HCI) / Interaction techniques (1)
- Humane Afrikanische Trypanosomiasis (1)
- Humanoider Roboter (1)
- Humanparasitologie (1)
- Hurwitz zeta function (1)
- Hybrid-Molecules (1)
- Hybridliganden (1)
- Hydroarylation (1)
- Hyperactivity (1)
- Hyperbolische Differentialgleichung (1)
- Hypophosphatemia (1)
- Hypothalamus (1)
- Hülsenfrüchte (1)
- ICM cells (1)
- IE3 (1)
- IFNG (1)
- IL-2 (1)
- IL-4 antagonists (1)
- ILEX (1)
- IP6 (1)
- IR spectroscopy (1)
- IR/UV Ion Dip Spectroscopy (1)
- IT security (1)
- Ibrutinib (1)
- Image Quality (1)
- Imkerei (1)
- Immune Checkpoint Therapy (1)
- Immune System (1)
- Immunkardiologie (1)
- Immunocardiology (1)
- Immunotherapy (1)
- Immunreaktion (1)
- Immunsystem (1)
- Immuntherapie (1)
- Impulsivität (1)
- Impurity Profiling (1)
- In-vitro-Kultur (1)
- InSAR (1)
- Income (1)
- Indium (1)
- Induced pluripotent stem cells (1)
- Industrial Policy (1)
- Industrie (1)
- Industrie-Roboter (1)
- Industriepolitik (1)
- Infection models (1)
- Infektion (1)
- Infektionsmodell (1)
- Infektionsstudien (1)
- Infrarotspektroskopie (1)
- Inhibitor (1)
- Inhibitory-postsynapse (1)
- Injectability (1)
- Insekten (1)
- Insektensterben (1)
- Instrumentelle Analytik (1)
- Integrin (1)
- Interaktion (1)
- Interferon <alpha-2a-> (1)
- Interkulturalität (1)
- Interkulturelle Kompetenz (1)
- Interkulturelles Lernen (1)
- Interleukin 2 (1)
- Interleukin 4 (1)
- Interleukin-4 (IL-4) (1)
- Intermolecular Interactions (1)
- Intermolekulare Wechselwirkungen (1)
- Internet of Things (1)
- IoT (1)
- IoT-driven processes (1)
- Isolation and Characterization (1)
- JCAS (1)
- JOL reactivity (1)
- Jahresbericht (1)
- Jameson, Frederic (1)
- Janus fibers (1)
- Japan (1)
- Josephson junctions (1)
- Journal of Nuclear Cardiology (1)
- Judgements of agency (1)
- Julius-Maximilians-Universität Würzburg (1)
- K band ranging (KBR) (1)
- K+ channels (1)
- K-Ras (1)
- KEA (1)
- KIT (1)
- Kabellose Netzwerke (1)
- Kakao (1)
- Kardiologie (1)
- Karriere (1)
- Kaste (1)
- Kathará (1)
- Keratinozyt (1)
- Kernspintomografie (1)
- Ketamin (1)
- KhpB protein (1)
- Ki67 (1)
- Kinaseinhibitor (1)
- Kinetische Gleichung (1)
- Klima (1)
- Klinische Studie (1)
- Knochenersatz (1)
- Knochenmark (1)
- Knochenmarktransplantation (1)
- Knowledge Acquisition (1)
- Kognitionspsychologie (1)
- Kognitive Psychologie (1)
- Kohärente perfekte Absorption (1)
- Kolloid (1)
- Kolorektales Karzinom (1)
- Komorbidität (1)
- Komplexe (1)
- Konjugation (1)
- Koordinationsverbindungen (1)
- Korrelative Mikroskopie (1)
- Kosmochemie (1)
- Krankenhaus (1)
- Kreatives Schreiben (1)
- Krebsforschung (1)
- Kristallzüchtung (1)
- Kryoelektronenmikroskopie (1)
- Kultur (1)
- Kurdyka--{\L}ojasiewicz property (1)
- Kutikula (1)
- LC-Oszillator (1)
- LCB (1)
- LCNEC (1)
- LFU (1)
- LPS (1)
- LRU (1)
- LUMEN (1)
- Land Use/Land Cover (1)
- Land use diversity (1)
- Landsat 8 (1)
- Landschaftspflege (1)
- Lead Time (1)
- Lead-acid batteries (1)
- Lead-free double perovskite (1)
- Lebensmittelchemie (1)
- Lebensmittelprodukte (1)
- LeishBASEedit (1)
- Leishmania (1)
- Leistungsbewertung (1)
- Leistungsentwicklung (1)
- Lepidoptera (1)
- Leptogenesis (1)
- Lerch zeta function (1)
- Lerneffekt (1)
- Lernkurve (1)
- Lernwirksamkeit (1)
- Lewis acidity (1)
- Lewis-Azidität (1)
- Lewis-Säure (1)
- Library of Phytochemicals (1)
- Library of plant species (1)
- Lidschlag (1)
- Lie group actions (1)
- Lie groups (1)
- Lie n-algebroids (1)
- Lieferzeit (1)
- Lifetime Imaging (1)
- Liganden (1)
- Light use efficiency (LUE) model (1)
- Lineare Optimierung (1)
- Linux (1)
- Literary and Cultural Studies (1)
- Literaturwissenschaft (1)
- Lithium-Ionen-Akkumulator (1)
- Lithium-Ionen-Batterie (1)
- Lithium-ion Battery (1)
- Local (1)
- Local Gazetteer (1)
- Local Lipschitz continuity (1)
- Locomotor activity (1)
- Lokales Wissen (1)
- Lungenembolie (1)
- Lungenkrebs (1)
- Luttinger Materialien (1)
- Luttinger materials (1)
- Lysosome (1)
- Löslichkeit (1)
- M2 (1)
- M4 (1)
- MATQ-seq (1)
- MCMV (1)
- MEK5/ERK5 cascade (1)
- MGL (1)
- MHD equations (1)
- MOD13Q1 (1)
- MODIS (1)
- MP-DCCP (1)
- MSC 11M35 (1)
- MSC: 14M15 (1)
- MSC: 49M37 (1)
- MSC: 53C22 (1)
- MSC: 53C35 (1)
- MSC: 65K05 (1)
- MSC: 90C30 (1)
- MSC: 90C40 (1)
- MYC (1)
- MYCNv (1)
- Machine Learning (1)
- Macrophages (1)
- Magnetische Anregung (1)
- Magnetische Störstelle (1)
- Magnetismus (1)
- Magnetohydrodynamische Gleichung (1)
- Majorana-Nullmoden (1)
- Makrophage (1)
- Malignant melanoma (1)
- Mamestra brassicae (1)
- Mantle cell lymphoma (1)
- Maschinelles Sehen (1)
- Massenmedien + Wirkung (1)
- Massenspektrometrie (1)
- Masspectrometry (1)
- Mathematical Optimization (1)
- Mathematische Modellierung (1)
- Media Literacy (1)
- Medical Image Analysis (1)
- Medien (1)
- Medien + Psychologie (1)
- Medienpädagogik (1)
- Medienwirkungsforschung (1)
- Megakaryozyt (1)
- Mehta, Deepa (1)
- Melanom (1)
- Melt electrowriting (1)
- Mensch-Maschine-Interaktion (1)
- Mental Representations (1)
- Metabolic Glycoengineering (1)
- Metallosupramolecular chemistry (1)
- Metallosupramolekulare Chemie (1)
- Metamaterial (1)
- Metaverse (1)
- Meteorologische Muster (1)
- Methode (1)
- Methylierung (1)
- Microscopy (1)
- Microwave Assisted Extraction (1)
- Mig1 (1)
- Mikrotubuli (1)
- Mikrotubuli-assoziiertes Protein (MAP) (1)
- Milieu (1)
- Ming dynasty (1)
- Mingdynastie (1)
- Mip (1)
- Mip Inhibitoren (1)
- Mitose (1)
- Modell (1)
- Moderator (1)
- Modification (1)
- ModulationTregs (1)
- Molekularbiologie (1)
- Molekulare Bildgebung (1)
- Molekularstrahlepitaxie (1)
- Money (1)
- Monitoring (1)
- Monoklonaler bispezifischer Antikörper (1)
- Monolage (1)
- Monolayer (1)
- Monoschicht (1)
- Morbus Fabry (1)
- Motoneuron (1)
- Motoneuron-Krankheit (1)
- Mott-Übergang (1)
- Multi-Loop (1)
- Multi-Unit Aufnahmen (1)
- Multidrugresistant (1)
- Multilayered skin tissue model (1)
- Multiple Myeloma (1)
- Multisensory integration (1)
- Muscarinrezeptor (1)
- Muscle (1)
- Muskarinrezeptor (1)
- Myc (1)
- Mycoplasma pneumoniae (1)
- Myeloid-derived suppressor cells (1)
- Myocardial infarction (1)
- Myosin IIA (1)
- Mähen (1)
- N ligands (1)
- N-functionalization (1)
- N-heterocyclic carbenes (1)
- N-heterozyklische Carbene (1)
- NA (1)
- NAFLD (1)
- NAS (1)
- NDVI (1)
- NEDMIAL (1)
- NF-κB (1)
- NFATc1 (1)
- NHX1 (1)
- NIR chromophore (1)
- NMDAR (1)
- NMR-Spektroskopie (1)
- NOTCH (1)
- NaCl transport (1)
- NaV1.9 (1)
- Nachbefragung (1)
- Nachhaltigkeit (1)
- Nahrung (1)
- Nanooptik (1)
- Nanophotonik (1)
- Narrow escape problem (1)
- Nationale Traditionen (1)
- Natriumkanal (1)
- Nature Conservation (1)
- Nature-Insipired Synthesis (1)
- Naturschutz (1)
- Naturstoff (1)
- Nebenniere (1)
- Nebennierenrindenkarzinom (1)
- Nebennierentumor (1)
- Neisseria gonorrhoeae (1)
- Nervenstimulation (1)
- Network Emulator (1)
- Neurodevelopmental diseases (1)
- Neuroepigenomics (1)
- Neurofascin (1)
- Neuromodulation (1)
- Neuropathic pain (1)
- Neuroprotection (1)
- Neuroscience (1)
- Neurowissenschaften (1)
- Neutral rate of interest (1)
- Neutrino (1)
- Neutrophils (1)
- Nicht-Fulleren Akzeptor (1)
- Nicht-kleinzelliges Bronchialkarzinom (NSCLC) (1)
- Nichtlineare Spektroskopie (1)
- Nickel-Complexes (1)
- Niedervalente Spezies (1)
- Nigeria (1)
- Nineteenth Century (1)
- Nisthöhle (1)
- Nociceptor (1)
- Non-Fullerene Acceptor (1)
- Non-Hermitian skin effect (1)
- Non-coding RNA (1)
- Nucleobase Surrogate Incorporation (1)
- Nucleoside (1)
- OLC (1)
- OLFM4 (1)
- OST1 (1)
- Oberflächenphysik (1)
- Oberflächenzustand (1)
- Object Detection (1)
- Octopamin (1)
- Octopamine (1)
- Octopaminergic signaling (1)
- Oldenburg burnout inventory (1)
- Olfaktorik (1)
- Oligonucleotide (1)
- Onchocerca volvulus (1)
- Onchozerkose (1)
- Oncogenes (1)
- Open Quantum System (1)
- Optical antenna (1)
- Optische Antenne (1)
- Optogenetics (1)
- Optogenetik (1)
- Orbital (1)
- Organische Synthese (1)
- Organischer Halbleiter (1)
- Organoid (1)
- Orphans (1)
- Osmolarität (1)
- Oxytocin (1)
- P4-INT (1)
- PAH formation (1)
- PAR-CLIP (1)
- PCD (1)
- PCL (1)
- PCR (1)
- PEDOT (1)
- PEG (1)
- PER (1)
- PFA in ethanol (1)
- PLGA (1)
- PROLOG <Programmiersprache> (1)
- PROM’s (1)
- PSMC2 (1)
- PSP (1)
- PT-Transformation (1)
- PTH1R (1)
- Panikstörung (1)
- Pankreas (1)
- Parasitology (1)
- Parkinson-Krankheit (1)
- Parkinson’s disease (1)
- Pathogenesis (1)
- Pathogenität (1)
- Pathophysiologie (1)
- Peptide (1)
- Perceived Usefulness (1)
- Perceived Wealth (1)
- Perception (1)
- Perceptions, Attitudes, and Values (1)
- Peripheral eosinophils (1)
- Peripheres Nervensystem (1)
- Permafrost (1)
- Perturbative (1)
- Perylenbisdicarboximide <Perylen-3,4:9,10-bis(dicarboximide)> (1)
- Pesticide (1)
- Pharmaceutical Analysis (1)
- Pharmakometrie (1)
- Pharmazeutischer Hilfsstoff (1)
- Phase diagrams (1)
- Phosphoglykolatphosphatase (1)
- Phospholipide (1)
- Phosphoramidite (1)
- Phosphorane (1)
- Photodissoziation (1)
- Photoluminescence (1)
- Photophysik (1)
- Photoresponsive DNA Crosslinker (1)
- Photoviltaics (1)
- Photovoltaik (1)
- Phylogenie (1)
- Phylogeny (1)
- Physics beyond the Standard Model (1)
- Physikalische Chemie (1)
- Physikalische Konsistenz (1)
- Pilocarpin (1)
- Pilokarpin (1)
- Place (1)
- Planetary Health (1)
- Planetary Health Education (1)
- Plant extracts (1)
- Plants (1)
- Plasmonik (1)
- Plastin 3 (1)
- Poisson algebras (1)
- PolSAR (1)
- Policy Implementation in China (1)
- Politische Ethik (1)
- Polycaprolacton (1)
- Polycyclic Aromatic Hydrocarbons (1)
- Polyethylenglykole (1)
- Polyglycerol (1)
- Polyine (1)
- Polylactid-co-Glycolid (1)
- Polymers (1)
- Polyneuropathie (1)
- Populism (1)
- Populismus (1)
- Porosität (1)
- Porous Materials (1)
- Postmarxismus (1)
- Praxis (1)
- Pre-service Teachers (1)
- Prognose (1)
- Programmed Cell Death 1 (1)
- Programmed Cell Death Ligand 1 (1)
- Proliferation (1)
- Promotion (1)
- Prosoziales Verhalten (1)
- Proteasom (1)
- Proteasome (1)
- Proteinbindung (1)
- Proteine (1)
- Protozoa (1)
- Protozoen (1)
- Pruno-Rubion sprengelii (1)
- Pseudo-Fermions (1)
- Pseudouridin (1)
- Psychologie (1)
- Pump-Probe-Technik (1)
- Pump–probe spectroscopy (1)
- Punktwolke (1)
- Pyrochlore (1)
- Quality Management (1)
- Qualitätsmanagement (1)
- Quanten-Hall-Effekt (1)
- Quantenfeldtheorie (1)
- Quanteninformation (1)
- Quantenthermodynamik (1)
- Quantenzustand (1)
- QuantiFERON\(^®\)-TB Gold Plus (1)
- Quantum Magnetism (1)
- Quantum many-body systems (1)
- Quantum spin lattices (1)
- Quinolone Amides (1)
- R-type currents (1)
- RAKI (1)
- RAMP (1)
- RCC (1)
- RCK domain (1)
- RCT (1)
- RIL-seq (1)
- RNA Labelling (1)
- RNA helicase (1)
- RNA labeling (1)
- RNA metabolism (1)
- RNA modifications (1)
- RNA recognition (1)
- RNA transport (1)
- RNA-Protein Interaktom (1)
- RNA-RNA interactions (1)
- RNA-Sequenzierung (1)
- RNA-bindendes Protein (1)
- RNA-binding proteins (1)
- RNA-protein interactome (1)
- RNS-Bindungsproteine (1)
- RNS-Viren (1)
- RT-qPCR (1)
- Radikal <Chemie> (1)
- Random Forest (1)
- Random Matrix Theory (1)
- Random forest (RF) model (1)
- Random-phase-Approximation (1)
- Random-walk simulations (1)
- Ranvier-Schnürring (1)
- Rapid Prototyping <Fertigung> (1)
- Rastertunnelmikroskopie (1)
- Rbm8a (1)
- Reaktive Sauerstoffspezies (1)
- Receptor Dynamics (1)
- Reduced density matrix (1)
- Referenzrahmen (1)
- Regenerative Medizin (1)
- Regierung (1)
- Regionale Klimamodelle (1)
- Regression (1)
- Regulation (1)
- Regulatory T Cells (1)
- Rekonsolidierung (1)
- Religion (1)
- Religious Practice (1)
- Remote sensing (RS) (1)
- Renormierung (1)
- Representation (1)
- Reproducibility challenges (1)
- Reprogrammming (1)
- Repräsentation (1)
- Research Station (1)
- Resonance Stabilized Radicals (1)
- Reticular Chemistry (1)
- Revenge (1)
- Rezeptionsforschung (1)
- Rezeptor (1)
- Rezeptor-Tyrosinkinasen (1)
- Rhamno-Prunetea (1)
- Rheology (1)
- Rheumatoid Arthritis (1)
- Rho GTPasw (1)
- Ribozym (1)
- Ribozyme (1)
- Robotics (1)
- Rodents (1)
- Roman (1)
- Routing (1)
- Roux-en-Y Gastric Bypass (1)
- Ruthenium Komplexe (1)
- Röntgenspektroskopie (1)
- SAH (1)
- SCCHN (1)
- SELEX (1)
- SIB (1)
- SLAC1 (1)
- SLC-family (1)
- SNF1 (1)
- SPECT/CT (1)
- STAT3 (1)
- STM (1)
- SUMOylation (1)
- Saccharomyces cerevisiae (1)
- Salmonella (1)
- Salmonella Typhimurium (1)
- Salmonella enterica (1)
- Salt Overly Sensitive pathway (1)
- Satellit (1)
- Satellite Earth Observation (1)
- Satellite Remote Sensing (1)
- Satellite glial cell (1)
- Scherstress (1)
- Schistosomiasis (1)
- Schlaf (1)
- Schmerz (1)
- Schmerzforschung (1)
- Schmetterlinge (1)
- Schulerfolg (1)
- Schädlingsbekämpfung (1)
- Scotogenic Model (1)
- Second coordination sphere engineering (1)
- Sehen (1)
- Sekundärkrankheit (1)
- Selbstkalibrierung (1)
- Selbstmordgefährdung (1)
- Selbstorganisation (1)
- Self-calibration (1)
- Sense of agency (1)
- Sensing-aaS (1)
- Sequence-Structure (1)
- Sequenzdaten (1)
- Serotonin (1)
- Setting Control (1)
- Shannon entropy (1)
- Shear Stress (1)
- Signaltransduktion (1)
- Silica precursor (1)
- Siliciumcarbid (1)
- Silicon carbide (1)
- Siliziumcarbid (1)
- Siliziumkarbid (1)
- Single-cell RNA-sequencing (1)
- Single-molecule microscopy (1)
- Singlett Oxygen (1)
- Singulettsauerstoff (1)
- Sinusthrombose (1)
- Site-specific RNA labelling (1)
- Skin Tissue Engineering (1)
- Sleep (1)
- Social Buffering (1)
- Social Circle (1)
- Social Distancing (1)
- Socrates (1)
- Soil-transmitted helminths (1)
- Sol-gel (1)
- Solar cell (1)
- Solar-Cell (1)
- Solid-phase peptide synthesis (1)
- Solubilisation (1)
- Solubility (1)
- South Indian Ocean (1)
- Soziale Robotik (1)
- Sozialer Kontakt (1)
- Soziales Umfeld (1)
- Spatiotemporal fusion (1)
- Spechte (1)
- Specialized pro resolving mediators (1)
- Spektroskopie (1)
- Sphingolipids (1)
- Spin-Bahn-Wechselwirkung (1)
- Spin-Orbit interaction (1)
- Spinal Muscular Atrophy (1)
- Spinalganglion (1)
- Spinflüssigkeit (1)
- Spo0A (1)
- Sporenbildung (1)
- Sporulation (1)
- Sprachgebrauch (1)
- Squaraine (1)
- Staat (1)
- Stability Maintenance (1)
- Stabilitätsstudien (1)
- Starke Kopplung (1)
- State Estimation (1)
- Statine (1)
- Status Threat (1)
- Steroide (1)
- Steroidhormon (1)
- Stochastische Matrix (1)
- Stomata (1)
- Strategic Emerging Industries (1)
- Street children (1)
- Strongyloides (1)
- Strongyloides stercoralis (1)
- Structure-from-Motion (1)
- Struktur (1)
- Struktur-Aktivitäts-Beziehung (1)
- Strumpellin (1)
- Su-Schrieffer-Heeger chain (1)
- Su-Schrieffer-Heeger-Kette (1)
- Subjektivität (1)
- Suizidalität (1)
- Super-Resolution Microscopy (1)
- Supercap (1)
- Superkondensator (1)
- Supply Chain Design (1)
- Supply Chain Management (1)
- Support Vector Regression (1)
- Sustainable Agriculture (1)
- Sustainable Development (1)
- Symplektische Geometrie (1)
- Synthetic Aperture RADAR (1)
- Synthetic RS data (1)
- Synthetische Apertur (1)
- T Helper Cell (1)
- T Lymphocyte (1)
- T antigen (1)
- T cells (1)
- T-Lymphozyt (1)
- T-Track\(^®\) TB (1)
- T-cell engager (1)
- T-shaped π–π stacking (1)
- TB (1)
- TDM (1)
- TETC (1)
- TKA (1)
- TLR3 (1)
- TNFα (1)
- TPACK (1)
- TRRAP (1)
- TTL validation of data consistency (1)
- Tagesrhythmus (1)
- Talententwicklung (1)
- Tansania (1)
- Targeted therapy (1)
- Temporal binding (1)
- Temporal predictability (1)
- Testinstrument (1)
- Text analysis (1)
- Textanalyse (1)
- Theoretical Chemistry (1)
- Theorie (1)
- Theory of Mind (1)
- Therapeutisches Drug Monitoring (1)
- Therapie (1)
- Therapieresistenz (1)
- Thermal equilibrium (1)
- Thermalisierung (1)
- Thermogenesis (1)
- Thigmotaxis (1)
- Thrombose (1)
- Thrombosis (1)
- Thrombozytenaggregation (1)
- Ti plasmids (1)
- Tian Rucheng (1)
- Tierversuche (1)
- Tissue staining (1)
- Tjap1 (1)
- Tolane-Modified Fluorescent Nucleosides (1)
- Toll-like receptor signaling (1)
- Tomografie (1)
- Topolectrics (1)
- Topological Pumping (1)
- Topological metamaterial (1)
- Topological semimetals (1)
- Topological superconductivity (1)
- Topologische Halbmetalle (1)
- Topologische Phase (1)
- Topologische Supraleitung (1)
- Transkription <Genetik> (1)
- Transkriptionelle Regulierung (1)
- Transkriptomanalyse (1)
- Transnationalismus (1)
- Traumatic neuropathy (1)
- Traveling culture (1)
- Treg (1)
- Trem2 (1)
- Triangular lattice (1)
- Triarylborane (1)
- TruD (1)
- Trypanosoma (1)
- Trypanosoma brucei (1)
- Trypanosomiase (1)
- Trypanosomiasis (1)
- Tumor (1)
- Tumor Treating Fields (TTFields) (1)
- Tumor-Treating Fields (TTFields) (1)
- UBA6 (1)
- UBE2Z (1)
- UNESCO designations (1)
- Ubiquitylation (1)
- Ultrafast spectroscopy (1)
- Ultrakurzzeitspektroskopie (1)
- Ultraschallprüfung (1)
- Umwelt (1)
- Umweltpolitik / Kompensation (1)
- Uncanny Valley of Mind (1)
- Unconventional/Topological superconductivity (1)
- Underwater Mapping (1)
- Underwater Scanning (1)
- Universal Two-Child Policy (1)
- Unterernährung (1)
- Ureaplasma parvum (1)
- VLA-1 (1)
- Vaccinia (1)
- Vaccinia-virus (1)
- Vasopressin (1)
- Velocity-Map-Imaging (1)
- Venezuela (1)
- Venus (1)
- Vereinigte Staaten (1)
- Vernacular poety (1)
- Vernacular story (1)
- Verschwörungstheorie (1)
- Verwundbarkeit (1)
- Vicia faba (L.) (1)
- Virus infection (1)
- Visualized Kathará (1)
- Visuelle Orientierung (1)
- Visuelle Wahrnehmung (1)
- Vitis vinifera (1)
- Volatile Organic Compound (VOC) (1)
- Vorhersage (1)
- WASH complex (1)
- Wahrgenommener Reichtum (1)
- Wahrnehmung (1)
- Waiting Impulsivity (1)
- Wald (1)
- Wallace, Michele (1)
- Wasseroxidation (1)
- Water Oxidation (1)
- Weakly chromophore impurities (1)
- Web services (1)
- Wechsler intelligence scale (WISC-IV) (1)
- West African refugee crisis (1)
- West Gondwana (1)
- West Lake (1)
- Western Europe (1)
- Weyl Halbmetalle (1)
- Weyl semimetals (1)
- WhatsApp (1)
- Widerstand (1)
- Wilde Honigbienen (1)
- Wiliams, Raymond (1)
- Willams, Raymond (1)
- Winter wheat (1)
- Wirtschaftsentwicklung (1)
- Wirtschaftswachstum (1)
- Wissenschaft (1)
- Wissenschaftliche Beobachtung (1)
- Wissenserwerb (1)
- Wuerzburg (1)
- Wurzburg (1)
- X-ray computed (1)
- XLH (1)
- XMCD (1)
- Xanomeline (1)
- Xinjiang (1)
- YAP (1)
- YAP5SA (1)
- YouTube (1)
- Ypk1 (1)
- Yu-Shiba-Rusinov-Zustände (1)
- Zebrafish (1)
- Zeitreihe (1)
- Zelldifferenzierung (1)
- Zellkern (1)
- Zellmigration (1)
- Zellteilung (Zytokinese) (1)
- Zhang Dai (1)
- Zinc phthalocyanine (1)
- Zinkphthalocyanin (1)
- Zins (1)
- Zustandsdichte (1)
- Zustandserkennung (1)
- Zweidimensionale konforme Feldtheorie (1)
- Zweidimensionales Material (1)
- Zwergfadenwurm (1)
- Zytotoxizität (1)
- \(^1\)H-NMR spectroscopy (1)
- abdominal imaging (1)
- abiotic stress (1)
- academia (1)
- academic domains (1)
- acceptance-based strategies (1)
- accuracy (1)
- acid value (1)
- action control (1)
- action prepotency (1)
- active TB (1)
- active galactic nuclei (1)
- active zone (1)
- actors (1)
- additive manufacturing (1)
- adiponectin (1)
- adjoint and coadjoint representations (1)
- adjuvant therapy (1)
- adolescence (1)
- adrenal incidentaloma (1)
- adrenal tumours (1)
- adrenocortical adenoma (1)
- adrenocortical carcinoma (1)
- adrenocortical carcinoma (ACC) (1)
- adverse drug reaction (1)
- adverse effects (1)
- affluence (1)
- age (1)
- age determination by skeleton (1)
- aggression (1)
- aging (1)
- agricultural landscape (1)
- akademische Domänen (1)
- algebraic degree (1)
- algorithms (1)
- alkene-alkyne [2+2] photocycloaddition (1)
- allografts (1)
- alpha-IIb beta-3 (1)
- alternating management (1)
- alternative pig farming (1)
- alveolar bone loss (1)
- amber light (1)
- amino acid restriction (1)
- amygdala (1)
- anaemia (1)
- anaerobe (1)
- anaesthesiology (1)
- anatomy (1)
- anchoring (1)
- anesthesia (1)
- anesthesiology (1)
- angle-resolved photoelectron spectroscopy (1)
- animal models (1)
- animal physiology (1)
- animal studies (1)
- anion channels (1)
- annotation (1)
- annual report (1)
- antenna phase center calibration (1)
- anterior insula (1)
- anthropomorphism (1)
- anti-thrombotic therapies (1)
- anti-tumor agents (1)
- antidepressants (1)
- antifungal drug (1)
- antigen-presenting cells (1)
- antimicrobial resistance (1)
- antimicrobial responses (1)
- antioxidant (1)
- anxiety disorders (1)
- aortic valve stenosis (1)
- apexification (1)
- apoptosis (1)
- aquaporins (1)
- aqueous humor outflow (1)
- arabidopsis thaliana (1)
- aromaticity (1)
- arousal inhibition (1)
- arthroscopic simulator training (1)
- artificial human skin (1)
- artificial photosynthesis (1)
- assembloid (1)
- asymptotic preserving (1)
- atopic diseases (1)
- atrial fibrillation (1)
- auctions (1)
- auditory pathway (1)
- autobiographical memory (1)
- automation (1)
- autonomic (1)
- autonomy (1)
- autophagy (1)
- availability (1)
- axial vascularization (1)
- axons (1)
- azapeptide nitriles (1)
- azido-ceramides (1)
- azobenzenes (1)
- background knowledge (1)
- bacterial community (1)
- bacterial migration (1)
- bacterial virulence (1)
- baseline detection (1)
- bedingte elektrische Stimulation (1)
- bee diseases (1)
- bee-lining (1)
- bees (1)
- behavior (1)
- benzimidazole (1)
- beta cell (1)
- beta power (1)
- bioceramic (1)
- biocompatible materials (1)
- biodiversity conservation (1)
- biodosimetry (1)
- bioelectronics (1)
- biofabrication (1)
- bioink (1)
- bioinorganic (1)
- biological scaffold (1)
- biology (1)
- biomedical engineering (1)
- bioorthogonal SAM analogue ProSeDMA (1)
- biophysics (1)
- biostratigraphy (1)
- biosynthetic glycosylation (1)
- bipartite metabolism (1)
- bipolar disorder (1)
- bit (1)
- bitopic hybrid ligands (1)
- bitopic ligands (1)
- bitter taste (1)
- blended learning (1)
- blood brain barrier (1)
- blood platelets (1)
- blood vessel (1)
- body size (1)
- bond activation (1)
- bond theory (1)
- bone conduction implant (1)
- bone imaging (1)
- bone marrow (1)
- bone metabolism (1)
- bone morphogenetic protein 9 (BMP9) (1)
- bone morphogenetic proteins (1)
- bone regeneration (1)
- boraselenone (1)
- borirane (1)
- boundary spanning (1)
- brain endothelium (1)
- brain signal complexity (1)
- branched-chain amino acids (1)
- breast cancer imaging (1)
- breed predisposition (1)
- burnout (1)
- business process anagement (1)
- butyrate (1)
- c-kit (1)
- calcium activity (1)
- calcium channels (1)
- calcium phosphate (1)
- calcium signaling (1)
- caloric restriction (1)
- calorimetry (1)
- calprotectin (1)
- camera orientation (1)
- cancellous bone (1)
- cancer immunotherapy (1)
- candidate gene (1)
- canine (1)
- canola (1)
- canopy height (1)
- capillary electrophoresis (1)
- carbon dioxide (CO2) (1)
- carbon emissions (1)
- carborane (1)
- carcinoma (1)
- cardiac arrest (1)
- cardiology (1)
- cardioprotective potential (1)
- cardiovascular diseases (1)
- caregiver (1)
- caregiver burden (1)
- caste system (1)
- catalase (1)
- catholicism (1)
- causality (1)
- cell (1)
- cell cycle (1)
- cell differentiation patterns (1)
- cell line specificity pyridyl indole carboxylates (1)
- cell velocimetry (1)
- cell vitality (1)
- cellmigration (1)
- cellular physiology (1)
- cellular signalling networks (1)
- central bank information (1)
- cephalometry (1)
- ceramides (1)
- cerebrovascular disorders (1)
- change vector analysis (1)
- charge transfer (1)
- charged aerosol detector (1)
- chemical bonding (1)
- chemical ecology (1)
- chemical glycosylation (1)
- chemical libraries (1)
- chemokine receptor (1)
- child development (1)
- children (1)
- chiral (1)
- chlorantraniliprole (1)
- chromatin (1)
- chromatin accessibility (1)
- chronic kidney disease (1)
- cine loop (1)
- circadian rhythm (1)
- circular dichroism (1)
- circulating (1)
- circulation types (1)
- circum-Arctic (1)
- cisplatin (1)
- classification (1)
- climate (1)
- climate policy (1)
- climate‐smart pest management (1)
- clinical decision support (1)
- clinical measurement in health technology (1)
- clinical outcome (1)
- clinical skills (1)
- clinical systems (1)
- closing of chromatin (1)
- closo-Borane (1)
- co-culture (1)
- coastal erosion (1)
- cocoa mapping (1)
- cognitive ability (1)
- cognitive bias (1)
- cognitive decline (1)
- cognitive deficits (1)
- cognitive load (1)
- cognitive neuroscience (1)
- cognitive profile (1)
- cognitive remediation (1)
- coherence (1)
- collagen (1)
- collybistin (1)
- color (1)
- colorectal cancer (1)
- combination (1)
- commensal bacteria (1)
- communication models (1)
- communication networks (1)
- comorbidity (1)
- comparability (1)
- complementary medicine (1)
- complex‐valued machine learning (1)
- computational chemistry (1)
- computational neural networks (1)
- computed tomography (1)
- computer modelling (1)
- computer navigation (1)
- computer performance evaluation (1)
- computer vision (1)
- conditionality (1)
- cone-beam computed tomography (1)
- conformational activation (1)
- conservation biology (1)
- content-based image retrieval (1)
- contingent electrical stimulation (1)
- control group (1)
- conventional imaging (1)
- convolution kernel (1)
- cooperation (1)
- coordination chemistry (1)
- cord blood (1)
- coronary artery disease (1)
- coronary heart disease (1)
- covalent inhibitors (1)
- covert retrieval (1)
- crop modeling (1)
- crop models (1)
- crop rotation (1)
- cross-sectional imaging (1)
- cryo-EM (1)
- cryo-ET (1)
- crystal growth (1)
- crystallographic analyses (1)
- curriculum development (1)
- cutaneous lymphomas (1)
- cyclic alkyl(amino)carbenes (1)
- cyclization reactions (1)
- cyclodextrins (1)
- cytochrome P450s (1)
- cytosine base editor (CBE) toolbox (1)
- cytoskeleton (1)
- cytosolic pH (1)
- cytotoxic T cells (1)
- cytotoxicity (1)
- damage control orthopedics (1)
- data analysis (1)
- data augmentation (1)
- data display (1)
- data storage (1)
- data warehouse (1)
- ddPCR (1)
- de Casteljau Algorithm (1)
- de novo sequenced genomes (1)
- decafluoroazobezene (1)
- decay (1)
- definite clause grammars (1)
- degradation (1)
- delay constrained (1)
- delay of therapy (1)
- deliberation (1)
- dens invaginatus (1)
- density functional calculations (1)
- density gradient centrifugation (1)
- dental education (1)
- derivative (1)
- dermal fibroblasts (1)
- design of experiments (1)
- developmental biology (1)
- developmental differentiation (1)
- dexamethasone (1)
- dexamethasone suppression test (1)
- diabetes mellitus (1)
- diagnostic correctness (1)
- diagnostic markers (1)
- dialysis adequacy (1)
- dicarboximide (1)
- dicoordinate borylene (1)
- diet (1)
- difference-in-differences (1)
- differential RNA-seq (1)
- differential centrifugation (1)
- differential expression (1)
- differential graded modules (1)
- differentiated thyroid cancer (1)
- digit (1)
- digital Health (1)
- digital age (1)
- digital medicine (1)
- digitalization (1)
- disability (1)
- discourse analysis (1)
- discourses of gender and ethnicity (1)
- discriminant analysis (1)
- disease score (1)
- disease severity (1)
- diseases (1)
- disengagement (1)
- dishonest responding (1)
- disjoint multi-paths (1)
- disorder of immunity (1)
- dog (1)
- dormancy (1)
- dosimetry (1)
- drift-diffusion model (1)
- drift-diffusion modeling (1)
- drought stress (1)
- drug delivery (1)
- drug resistance (1)
- drug safety (1)
- dual action benefits (1)
- dual targeting (1)
- dual-energy CT (1)
- dual-source CT (1)
- dualsteric ligands (1)
- dust microbiomes (1)
- dynamic protein-protein interactions (1)
- dynamics (1)
- dystonia (1)
- e-Government (1)
- e-Learning (1)
- early breast cancer (1)
- early detection (1)
- echinococcosis (1)
- echinocytes (1)
- ecology (1)
- ecosystem function (1)
- edge states (1)
- education for sustainable healthcare (1)
- electrical and electronic engineering (1)
- electrocution (1)
- electromyography (1)
- electronic health records (1)
- electronic properties and materials (1)
- electrophysiology (1)
- electroporation (1)
- emergency information (1)
- emotion (1)
- emotion measurement (1)
- emotion regulation (1)
- emotional shifts (1)
- emphysema (1)
- emulation (1)
- enantiomers (1)
- end-stage kidney disease (1)
- endoglin (1)
- endoscopic instruments (1)
- endoscopic intervention (1)
- endosomal trafficking (1)
- endpoint geodesics (1)
- energy efficiency (1)
- enhancers (1)
- entomology (1)
- environmental health (1)
- environmental impact (1)
- ephedrine (1)
- epidemiology (1)
- epigenetic modification (1)
- episodic binding (1)
- epitope mapping (1)
- equilibrium real interest rate (1)
- error (1)
- error processing (1)
- error-transfer (1)
- ester value (1)
- euglena (1)
- euglenids (1)
- evidence synthesis (1)
- evidence-based policy (1)
- evidence-based practice (1)
- evolutionary developmental biology (1)
- evolutionary genetics (1)
- exchange rate dynamics (1)
- exciton (1)
- excitonic chirality (1)
- exemplarity (1)
- exercise (1)
- exhaustion (1)
- experience (1)
- experimental models of disease (1)
- explainability of machine learning (1)
- exponent pairs (1)
- exponential growth (1)
- exposure therapy (1)
- extended reality (1)
- extinction (1)
- extracellular (1)
- extracellular matrix (1)
- eye contact (1)
- eye movement disorders (1)
- fMRI time series (1)
- fNIRS (1)
- fatigue (1)
- fatty acids (1)
- fear (1)
- feature analysis (1)
- feature matching (1)
- feature selection (1)
- fecal short-chain fatty acids (1)
- federated learning (1)
- feeding (1)
- femoral fracture (1)
- feral bees (1)
- fiber intake (1)
- fibrin (1)
- filamentous Salmonella Typhimurium (1)
- film analysis (1)
- fitness trackers (1)
- fixation (1)
- flowering plants (1)
- flowers (1)
- fluorescence (1)
- fluorescence resonance energy transfer (1)
- fluorescence resonance energy transfer (FRET) (1)
- fluorescent probe (1)
- fluoroscopy (1)
- fmri activity (1)
- focus of infection (1)
- fog computing (1)
- folded macrocyles (1)
- food cultures (1)
- forager (1)
- force (1)
- fordisc (1)
- forensic anthropology (1)
- forest (1)
- forest landscape (1)
- forest structure Germany (1)
- formalin (1)
- formulation development (1)
- fracture (1)
- free jet (1)
- free light chains (1)
- frontal bone (1)
- fully convolutional neural networks (1)
- functional neuroimaging (1)
- functional resting-state connectivity (1)
- funktionelle Kernspintomographie (1)
- funktionelle Magnetresonanztomographie (1)
- funktionelle Resting-State Konnektivität (1)
- fused boracycles (1)
- fusion (1)
- gait-phase prediction (1)
- gammadelta T cells (1)
- gastroenterology (1)
- gastrointestinal (1)
- gender (1)
- gene (1)
- gene editing (1)
- gene expression heterogeneity (1)
- general circulation model (1)
- general practice (1)
- genetic engineering (1)
- genetic modification (1)
- genetic screen (1)
- genotoxicity (1)
- genotypes (1)
- geographically weighted regression (1)
- geometric morphometrics (1)
- germanium (1)
- giant cell arteritis (1)
- global (action-inherent) (1)
- global IPX network (1)
- globus pallidus (1)
- glycine receptor (1)
- glycine uptake (1)
- glycoengineering (1)
- glycogen synthase kinase 3 (1)
- good clinical practice (1)
- gram-negative bacteria (1)
- grasshopper (1)
- gravity (1)
- grazing (1)
- group 10 element (1)
- group-based communication (1)
- growth cone (1)
- growth models (1)
- guideline-directed medical therapy (1)
- gustatory receptors (Grs) (1)
- haircoat (1)
- half-Heusler (1)
- haloacid dehalogenase phosphatase (1)
- halogenation (1)
- hand dominance (1)
- hardware-in-the-loop simulation (1)
- hardware-in-the-loop streaming system (1)
- head and neck cancer (1)
- health care (1)
- health sciences (1)
- health-care workers (1)
- health-related quality of life (1)
- hearing aids (1)
- heart rate (1)
- heat transfer (1)
- helical edge states (1)
- hematoma (1)
- hemodialysis (1)
- hemoglobin jet (1)
- hemolymph lipids (1)
- heparin binding sites (1)
- herpes virus (1)
- heuristics (1)
- high-frequency identification (1)
- high-pressure freezing/freeze substitution (1)
- higher plants (1)
- historical document analysis (1)
- historical images (1)
- historical psychology (1)
- history of psychology (1)
- hit ratio analysis and simulation (1)
- home isolation (1)
- homeostasis (1)
- homogeneous catalysis (1)
- honey bee density (1)
- honeybee taste perception (1)
- honeycomb lattice (1)
- hospital (1)
- hospital data (1)
- hospitalization (1)
- host-guest chemistry (1)
- human (1)
- human African trypanosomiasis (1)
- human brain microvascular endothelial cells (HBMVEC) (1)
- human cells (1)
- human induced pluripotent stem cells (1)
- human learning (1)
- human nutrition (1)
- human startle disease (1)
- human–computer interaction (1)
- hyaluronic acid (1)
- hybrid ligands (1)
- hybrid materials (1)
- hydrides (1)
- hydrogel (1)
- hymenoptera (1)
- hyperbolic partial differential equations (1)
- hyperpolarization (1)
- hypertension (1)
- hypoxia (1)
- iPSCs (1)
- illness experience (1)
- immature tooth (1)
- immaturity (1)
- immediate early genes (1)
- immune cell infiltration (1)
- immune evasion (1)
- immune infiltration (1)
- immunofluorescence (1)
- immunogenetics (1)
- immunoglobulin rearrangement (1)
- immunology (1)
- immunomodulation (1)
- immunosurveillance (1)
- implementation framework (1)
- implications of wealth (1)
- impression formation (1)
- in silico analysis (1)
- in vitro and in vivo thrombus formation (1)
- in vitro dissolution methods (1)
- in vitro dissolution testing (1)
- in vitro study (1)
- in vitro/in vivo Korrelation (1)
- in vitro/in vivo correlation (1)
- in vivo dissolution (1)
- inappropriate medication (1)
- inbound medical tourism (1)
- income wealth threshold estimations (1)
- individual drug responses (1)
- indoxacarb (1)
- inertial measurement units (1)
- infection detection (1)
- inferior frontal gyrus (1)
- inflammasome (1)
- inflammatory pain (1)
- infodemic (1)
- informal education (1)
- information extraction (1)
- information strategies (1)
- inherent chirality (1)
- inhibition failures (1)
- inhibitory postsynapse (1)
- insect conservation (1)
- insecticide (1)
- instrument design (1)
- insulin receptor (1)
- integral graph (1)
- intelligence (1)
- intelligent voice assistant (1)
- intensity analysis (1)
- intercultural pedagogy (1)
- interference pattern (1)
- interferometry (1)
- internal medicine (1)
- international trade (1)
- intervention strategies (1)
- interview study (1)
- intestinal barrier (1)
- intestinal enteroids (1)
- intestinal inflammation (1)
- intestinal parasites (1)
- intestinal permeability (1)
- intramuscular hemorrhage (1)
- intratumoral microbiota (1)
- iodine value (1)
- irony (1)
- isentropic Euler equations (1)
- job satisfaction (1)
- judgement (1)
- judgments of learning (1)
- junior studies (1)
- justice (1)
- juvenile hormone (1)
- ketamine (1)
- ketogenic dietary therapy (KDT) (1)
- key-insight extraction (1)
- kidney cancer (1)
- kinase (1)
- kinase inhibitor (1)
- kinetic equations (1)
- knee arthroplasty (1)
- knee replacement (1)
- knowledge representation (1)
- label-free quantification (1)
- laboratory and online studies (1)
- lactation (1)
- land surface temperature (1)
- land-use intensification (1)
- landsat (1)
- landscape complexity (1)
- landscape management (1)
- landwirtschaftlicher Betrieb (1)
- large T antigen (1)
- large‐scale atmospheric circulation modes (1)
- late enhancement (1)
- late gadolinium-enhancement (1)
- lateral neck abscesses (1)
- law (1)
- layered dissection (1)
- layout recognition (1)
- leaf response (1)
- learning (1)
- learning and memory (1)
- learning curve (1)
- learning effect (1)
- least cost (1)
- length of stay (1)
- level of evidence III (1)
- lidar (1)
- ligands (1)
- light-driven metabolism (1)
- light-induced interstrand DNA crosslinking (1)
- lipidomics (1)
- live-cell imaging (1)
- livestock-associated staphylococci (1)
- local (transient) (1)
- local cell neighborhood (1)
- local culture of knowledge (1)
- local farm management (1)
- local self‐governance (1)
- locomotor activity (1)
- logic programming (1)
- long-term analysis (1)
- long-term survivors (1)
- low back pain (1)
- low energy metabolism (1)
- lower extremity (1)
- lower extremity amputation (1)
- luciferase assay (1)
- lung fibrosis (1)
- lying (1)
- lying behavior (1)
- lymph node (1)
- lymph nodes (1)
- lymphatic metastasis (1)
- lymphocyte differentiation (1)
- lytic infection (1)
- mHealth (1)
- macrophages (1)
- magnesium stearate (1)
- magnetic (1)
- magnetic topological insulator (1)
- main group elements (1)
- major amputation (1)
- major depressive disorder (MDD) (1)
- malnourishment (1)
- management (1)
- marker (1)
- mass spectrometry (1)
- mathematical modelling (1)
- mathematics classrooms (1)
- maxillofacial surgery (1)
- mean first passage time (1)
- mechanical alignment (1)
- mechanical thrombectomy (1)
- mechanism of action (1)
- media analysis (1)
- medical device training (1)
- medical devices (1)
- medical education (1)
- medical imaging (1)
- medical nutrition therapy (1)
- medical records (1)
- medium cut-off dialyzer (1)
- megakaryocyte (1)
- membrane protein (1)
- membrane transporters (1)
- mental disorders (1)
- mesenchymal stem cells (1)
- mesenchymal stromal cells (1)
- mesodermal organoid (1)
- mesophyll cells (1)
- meta-data (1)
- metabolically unhealthy obesity (1)
- metabolite repair (1)
- metabolomics (1)
- metacomprehension (1)
- metagenomics (1)
- metastasis (1)
- meteorological patterns (1)
- methionine (1)
- methodological pluralism (1)
- methodology (1)
- miR (1)
- miRNA target (1)
- miRNS (1)
- micro-CT (1)
- micro-computed-tomography (1)
- microRNA (1)
- microbial diversity (1)
- microbial ecology (1)
- microbiology (1)
- microbiota-derived metabolites (1)
- micrometre level microwave ranging (1)
- micronuclei (1)
- micronutrients (1)
- microscopy (1)
- microstates (1)
- middle cerebral artery occlusion (1)
- mild cognitive impairment (1)
- mind-body-intervention (1)
- mindfulness (1)
- miniature schnauzer (1)
- minimally invasive surgery (1)
- minor amputation (1)
- misconceptions (1)
- mitochondrial calcium uniporter (1)
- mitotic disturbance (1)
- mixed methods (1)
- mobile instant messaging (1)
- mobile messaging application (1)
- mobility (1)
- model output statistics (1)
- model reduction (1)
- modelling (1)
- modified inflation (1)
- moisture convergence (1)
- molecular biology (1)
- molecular capsules (1)
- molecular evolution (1)
- molecular mechanism (1)
- molecular modeling (1)
- molecular modelling (1)
- molecular movie (1)
- molecular neuroscience (1)
- molekulares Modellieren (1)
- monarch butterfly (1)
- monetary policy rules (1)
- monocyte subsets (1)
- monocytes (1)
- monovalent cation:proton antiporter-2 (CPA2) family (1)
- moral elitism (1)
- morphology (1)
- motivation (1)
- motor neurons (1)
- mountain biodiversity (1)
- mouse blastocysts (1)
- mouse embryonic stem cells (1)
- mouse xenografts (1)
- movement disorder (1)
- multi-pinhole collimation (1)
- multi-unit recording (1)
- multicentric (1)
- multidisciplinary (1)
- multilayer perceptron model (1)
- multimodal intervention (1)
- multipath (1)
- multipath packet scheduling (1)
- multiple action control (1)
- multiscale encoder (1)
- multisensory navigation (1)
- multi‐model ensemble (1)
- murine cytomegalovirus (MCMV) (1)
- muscarinic (1)
- muscarinic acetylcholine receptors (1)
- muscarinic receptors (1)
- muscle (1)
- musculoskeletal system (1)
- mushroom body (1)
- mycoplasma (1)
- myelin biology and repair (1)
- myelination (1)
- myeloablation (1)
- myeloma (1)
- myocardial infarction (1)
- nanofibers (1)
- nanographene (1)
- nanoporous (1)
- nanotopography (1)
- nanotopology (1)
- narrative effects (1)
- narrative persuasion (1)
- national traditions (1)
- natural processing (1)
- navigation (1)
- near infrared chirality (1)
- near-surface geophysics (1)
- necrobiome (1)
- neighborhood movement (1)
- neoadjuvant therapies (1)
- neonatal immunology (1)
- neonatal meningitis (1)
- network simulation (1)
- neural crest (1)
- neural networks (1)
- neural organoid (1)
- neural stem cell potential (1)
- neuroblastoma cell (1)
- neuroendocrine tumor (1)
- neurofibromatosis type 1 (1)
- neurologin-2 (1)
- neuronal and synaptic plasticity (1)
- neuronal excitability (1)
- neuronal silencing (1)
- neuronavigation (1)
- neuropaticher Schmerz (1)
- neurosphere (1)
- neutrophils (1)
- new media (1)
- news media reporting (1)
- ngEHT (1)
- nifedipine (1)
- non-SBI fungicide (1)
- non-aureus staphylococci (1)
- non-cancer controls (1)
- non-fullerene acceptor (1)
- non-fullerene acceptors (1)
- non-muscle myosin (1)
- non-small cell lung cancer (NSCLC) (1)
- non-small-cell lung (1)
- non-terrestrial networks (1)
- nonadiabatic Dynamics (1)
- nonradiative Relaxation (1)
- non‐fullerene acceptors (1)
- norepinephrine transporter (1)
- normal distribution transform (1)
- normal values (1)
- nuclear import (1)
- nurse bee (1)
- nursing home residents (1)
- nystagmus (1)
- o-carborane (1)
- obesity surgery (1)
- object reconstruction (1)
- occupational destinations (1)
- ocular anterior segment perfusion culture (1)
- oculomotor (1)
- oil seed rape (1)
- oil-seed rape (1)
- oilseed rape (1)
- olfaction (1)
- olfactomedin 4 (1)
- oncobiome (1)
- oncogenic YAP (1)
- oncologist (1)
- oncolytic virus (1)
- one-electron oxidation (1)
- one-health approach (1)
- ontology (1)
- opening of chromatin (1)
- ophthalmic artery (1)
- opsins (1)
- optic nerve (1)
- optogenetic (1)
- oral bioavailability (1)
- oral drug absorption (1)
- oral squamous cell carcinoma (1)
- orbit (1)
- orbital tomography (1)
- orchestration (1)
- order of growth (1)
- organellar mapping (1)
- organic (1)
- organic farming (1)
- organic light emitting diodes (1)
- organic photovoltaics (1)
- organic solar cell (1)
- organic solar cells (1)
- orientation (1)
- orienting response (1)
- oropharyngeal carcinoma (1)
- orthodontics (1)
- orthognathic surgery (1)
- orthopaedic surgery (1)
- orthopedic surgery (1)
- orthopedics (1)
- oscillation (1)
- osmotic effects (1)
- osteoarthritis (1)
- osteochondral lesion (1)
- ovarian cancer (1)
- ovarian tumor (1)
- oxygen/glucose deprivation (1)
- ozone (O3) (1)
- p38 MAPK (1)
- p53 (1)
- p97 VCP Cdc48 (1)
- pH (1)
- pN1 (1)
- packet reception method (1)
- paediatric patients (1)
- pain (1)
- pain regulation (1)
- pancreas (1)
- pancreatic differentiation (1)
- pandemic (1)
- papillary thyroid carcinoma (PTC) (1)
- parallel imaging (1)
- parasitoid (1)
- parasitology (1)
- parotid gland (1)
- partial knee arthroplasty (1)
- particle picking (1)
- path indistinguishability (1)
- patient data (1)
- patient reported outcome measures (1)
- patient-specific implant (1)
- patient-specific instruments (1)
- patients' experience (1)
- pedicle screws (1)
- peptide stapling (1)
- peptidomimetic sequence (1)
- peptidomimetics (1)
- perception and action (1)
- perfluoroarylation (1)
- performance (1)
- performance evaluation (1)
- performance monitoring (1)
- perfusion (1)
- perfusion culture (1)
- perfusion map (1)
- peripartum (1)
- permanent employment (1)
- peroxisome purification (1)
- peroxisomes (1)
- personalized medicine (1)
- perylene bisimide (1)
- perylene bisimide dyes (1)
- pesticide mixture (1)
- pharmacology (1)
- pharmacometrics (1)
- pharmacovigilance (1)
- phase space (1)
- phase transition (1)
- phenomenology (1)
- phenotype (1)
- phosphatidylcholines (1)
- phosphoglycolate phosphatase (1)
- photoacoustic (1)
- photocatalysis (1)
- photocontrol (1)
- photovoltaic (1)
- phthalazinone pyrazole (1)
- phylogenetics (1)
- physical consistency (1)
- physical therapy (1)
- physiology (1)
- pig farming methods (1)
- piquetero movement (1)
- plant development (1)
- plant molecular biology (1)
- plant physiology (1)
- plant signalling (1)
- plant-herbivore interactions (1)
- plant-insect interactions (1)
- plantaris tendinopathy (1)
- plant–herbivore interactions (1)
- platelet (1)
- platelet activation (1)
- platelet-derived growth factor (1)
- platelet-rich plasma (1)
- pneumoniae (1)
- point-of-care (1)
- point-of-care-testing (1)
- policy cycle (1)
- policy evaluation (1)
- policy lab (1)
- policy pilot (1)
- political regime (1)
- politische Institution (1)
- pollen beetle (1)
- pollen tubes (1)
- pollinator (1)
- pollution (1)
- poly(2-ethyl-2-oxazoline) (1)
- poly(2-oxazoline) (1)
- poly(lactic-co-glycolic acid) (1)
- polycaprolactone (1)
- polycyclic aromatic hydrocarbons (1)
- polymers (1)
- polyneuropathy (1)
- polypharmacy (1)
- polysorbate 80 (1)
- population-based (1)
- pore (1)
- pose tracking (1)
- positive nodal status (1)
- positron emission tomography (1)
- post Marxism (1)
- post-neoadjuvant therapies (1)
- post-transcriptional regulation (1)
- postdoctoral careers (1)
- postsynaptic potentials (1)
- posttranscriptional regulation (1)
- posture (1)
- potassium (1)
- potassium channel (1)
- potassium homeostasis (1)
- potenzielles therapeutisches Target (1)
- precision agriculture (1)
- precision medicine (1)
- precision-cut tumor slices (1)
- preclinical model (1)
- prediction (1)
- predictive process analytics (1)
- predictive process monitoring (1)
- preface (1)
- prefrontal cortex (1)
- pregnancy (1)
- prenatal paternal depression (1)
- prescribing omission (1)
- preterm birth (1)
- prevalence (1)
- prevention (1)
- preventive medicine (1)
- principal (1)
- principal component analysis (1)
- private chat groups (1)
- proboscis extension response (PER) (1)
- process mining (1)
- professional success (1)
- prognostic marker (1)
- programmed cell death (1)
- progression-free survival (1)
- project management (1)
- propeller flap (1)
- propofol (1)
- prospective (1)
- prospective study (1)
- proteasome inhibitors (1)
- proteasome system (1)
- protective behavior (1)
- protective factors (1)
- protein (1)
- protein analysis (1)
- protein binding (1)
- protein folding (1)
- protein localization (1)
- proteomics (1)
- proxy VAR (1)
- psychiatric rehabilitation (1)
- psycho-oncology (1)
- psychoeducation (1)
- psychometrics (1)
- psychopathology (1)
- psychotropic drugs (1)
- psychotropic medication (1)
- public health (1)
- pulmonary cancer (1)
- pulmonary embolism (1)
- punishment (1)
- push-pull stabilization (1)
- pyrene (1)
- pyrrolizidine alkaloids (1)
- qualitative research (1)
- quality control (1)
- quality of care (1)
- quantitative 1H NMR (1)
- quantum optics (1)
- quantum spin hall insulator (1)
- quaterrylene bisimide (1)
- qubit interaction (1)
- quiescence (1)
- rBAM2-labeled RNA strands (1)
- rRNA depletion (1)
- radiation dose (1)
- radical (1)
- radical reactions (1)
- radio astronomy (1)
- radiographic bone loss (1)
- radioiodine (1)
- radiology (1)
- radiotherapy (1)
- radiotherapy (RT) (1)
- rainfall (1)
- random forest (1)
- random forest regression (1)
- randomized controlled trial (1)
- range shifts (1)
- ransomware (1)
- rapid prototyping (1)
- reactivity and selectivity study (1)
- real-time (1)
- real-time imaging (1)
- real-world (1)
- reasoning (1)
- reciprocity (1)
- recognition (1)
- reconstruction (1)
- red fruit oil (1)
- reference data (1)
- reflections (1)
- regenerative cooling (1)
- regional climate model (1)
- regional climate models (1)
- regulation (1)
- regulatory RNA (1)
- regulatory T cells (1)
- rehabilitation (1)
- reinforcement learning (1)
- religion (1)
- remitted/acute phase (1)
- renewable energy policy (1)
- reperfusion injury (1)
- replica (1)
- replication crisis (1)
- reporter screen (1)
- representations up to homotopy (1)
- reproductive disorders (1)
- research integrity (1)
- resection (1)
- resilience (1)
- resolution (1)
- respiratory signs and symptoms (1)
- response fractionation (1)
- responsiveness (1)
- resting-state (1)
- restrained statehood (1)
- retrogressive thaw slump (1)
- reversible oxidation (1)
- review (1)
- revitalization (1)
- rheumatoid arthritis (1)
- ribosome biogenesis (1)
- rigidification (1)
- ring strain (1)
- risk pregnancy (1)
- risk stratification (1)
- robotic (1)
- robotic process automation (1)
- rocket engine (1)
- rodent model (1)
- rotations (1)
- sRNA (1)
- sacubitril-valsartan (1)
- salivary gland neoplasia (1)
- salt metathesis (1)
- salt stress (1)
- salt-and-pepper pattern (1)
- saponification Value (1)
- satellite (1)
- satellite communication (1)
- saturation transfer difference NMR (1)
- scaffold-free (1)
- scalability (1)
- scalability evaluation (1)
- scalable functional genomic screening (1)
- school (1)
- science–policy interface (1)
- scurvy (1)
- second line antibiotics (1)
- secondary infarct growth (1)
- secondary prevention (1)
- seed yield (1)
- selenium (1)
- self-governance (1)
- self-serving dishonesty (1)
- self-targeting CRISPR-Cas (1)
- selfcompassion (1)
- self‐organisation (1)
- selpercatinib (1)
- senescence (1)
- sensory ganglia (1)
- sensory neuron (1)
- sentinel (1)
- sentinel-2 (1)
- sequencing (1)
- serum (1)
- service-curve estimation (1)
- shape (1)
- shedding (1)
- shortest path routing (1)
- sigma factor (1)
- sigma-1 receptor-directed molecular imaging (1)
- signal transduction (1)
- signaling (1)
- signaling traffic (1)
- signalling pathways (1)
- singe crystal (1)
- single cell analysis (1)
- single particle tracking (1)
- single-cell RNA sequencing (1)
- single-cell RNA-seq (1)
- single-molecule localization microscopy (1)
- site mapping (1)
- situation awareness (1)
- situational awareness (1)
- skin equivalent (1)
- slice culture (1)
- small RNA (1)
- small RNA expression (1)
- small fiber neuropathy (1)
- small-animal SPECT (1)
- small-cell lung (1)
- smart journaling (1)
- smart speaker (1)
- social comparisons (1)
- social interaction (1)
- social media (1)
- social movements (1)
- social psychology (1)
- social relationship (1)
- social role (1)
- social self‐organization (1)
- social understanding (1)
- sodium (1)
- sodium-glucose co-transporter-2 inhibitors (1)
- software performance (1)
- solid-state emitter (1)
- solid‐state emission (1)
- somatic symptom burden (1)
- spatial error assessment (1)
- spatial proteomics (1)
- spatio-thematic coverage (1)
- spatiotemporal slump development (1)
- species range shifts (1)
- specific phobia (1)
- spectral CT (1)
- spectral shaping (1)
- speech motor impairment (1)
- speech recognition (1)
- spezifische Phobie (1)
- spider (1)
- spider phobia (1)
- spin physics (1)
- spin-resolved ARPES (1)
- spinning (1)
- spiral trajectory (1)
- spontaneous blinks (1)
- sports medicine (1)
- sports therapy (1)
- ssVEP (1)
- standard schnauzer (1)
- star products (1)
- state (1)
- state management (1)
- state–society relations (1)
- stationary preserving (1)
- statistical data (1)
- statistics and numerical data (1)
- stem cells (1)
- stem weevil (1)
- stereochemistry (1)
- stress (1)
- stress reduction (1)
- stress response (1)
- strong electronic correlations (1)
- strongyloides infection (1)
- structure (1)
- structured light illumination (1)
- structure–activity relationships (1)
- subcutaneous animal model (1)
- subjective perception of wealth (1)
- subjective wealth cues (1)
- subjectivity (1)
- sublethal effect (1)
- sublethal effects (1)
- subtropical Indian Ocean dipole (1)
- subversiveness (1)
- succession (1)
- suffering (1)
- sugar perception (fructose, sucrose) (1)
- sugar receptor (1)
- sugar responsiveness (1)
- sugars (1)
- suicidality (1)
- super-resolution microscopy (1)
- suppression of women (1)
- suppressive capacity (1)
- suppressor (1)
- supramolecular chemistry (1)
- surface model (1)
- surface scanner (1)
- surgical treatment (1)
- surrogate model (1)
- sustainability (1)
- sustainable development (1)
- swarming (1)
- sympathetic nervous system (1)
- synaptic transmission (1)
- synaptic vesicles (1)
- synergistic effect (1)
- synthesis (1)
- synthetic aperture RADAR (1)
- synthetic biology (1)
- systematic review (1)
- systemic inflammation (1)
- systems biology (1)
- table extraction (1)
- table understanding (1)
- talent development (1)
- tanzania (1)
- taxanes (1)
- technology (1)
- telehealth (1)
- telemedicine (1)
- telescopes (1)
- temperature (1)
- temporal binding (1)
- temporal processing (1)
- temporary employment (1)
- temporo-parietal junction (1)
- tendon tissue engineering (1)
- tenogenic differentiation (1)
- test instrument (1)
- tetany (1)
- text line detection (1)
- theory of science (1)
- therapy (1)
- threat (1)
- three-coordinate borane (1)
- thrombo-inflammation (1)
- thrombopoiesis (1)
- thrombosis (1)
- thyroid carcinoma (TC) (1)
- time frequency analyses (1)
- time-correlated single photon counting (TCSPC) (1)
- time-resolved (1)
- timestamping method (1)
- tin (1)
- tin prefiltration (1)
- tissue preparation (1)
- tools overview (1)
- tooth (1)
- tooth extraction (1)
- total recall (1)
- toxicity (1)
- trARPES (1)
- trabecular meshwork (1)
- trace elements (1)
- traditional almond orchard (1)
- traditional land use (1)
- trafficking (1)
- training (1)
- transcriptional termination site (1)
- transcriptome (1)
- transformative education (1)
- transportation (1)
- trastuzumab (1)
- trastuzumab deruxtecan (1)
- traumatic brain injury (1)
- tree cavity (1)
- tremor (1)
- triarylborane (1)
- triple-negative breast cancer (1)
- triplet excitons (1)
- trispecific (1)
- truth (1)
- tuber (1)
- tuberculosis (1)
- tumor (1)
- tumor microenvironment (TME) (1)
- tumormicroenvironment (1)
- tumors (1)
- tumour (1)
- tumour immunology (1)
- two-dimensional topological insulator (1)
- ubiquitin proteasome system (1)
- ultra-low-dose CT (1)
- ultrafiltration (1)
- uncooperative space rendezvous (1)
- underutilized legumes (1)
- underwater 3D scanning (1)
- unicompartmental knee arthroplasty (1)
- upslope shift (1)
- urinary calculi (1)
- urinary tract infections (1)
- usability (1)
- user-centered design (1)
- user-centred design (1)
- vDEUQUA2021 (1)
- vacuolar calcium sensor (1)
- vacuum processable (1)
- valence framing (1)
- vasculature (1)
- vasp (1)
- vegetation (1)
- venous infiltration (1)
- verbal n-back (1)
- vertebral pedicles (1)
- very long baseline interferometry (1)
- video object detection (1)
- videooculography (1)
- vineyard terrace (1)
- viral genome packaging (1)
- viral miRNAs (1)
- virology (1)
- virtual non-contrast (1)
- vision (1)
- visual cue (1)
- visual memory (1)
- visual perception (1)
- visual processes (1)
- visual proteomics (1)
- vitamins (1)
- voltage gating (1)
- waggle dance decoding (1)
- warhead (1)
- wax (1)
- weak statehood (1)
- wealth estimation (1)
- weight-bearing (1)
- well-balanced scheme (1)
- white blood cells (1)
- white matter disease (1)
- wild honey bees (1)
- wild-living honey bees (1)
- wildlife-friendly farming (1)
- women (1)
- workshop (1)
- wrong labelling (1)
- x-ray spectroscopy (1)
- yam (1)
- zentrale Spindel und Mittelkörper (1)
- zinc (1)
- zonulin (1)
- zoology (1)
- Übergangsmetall (1)
- Übergangsmetalldichalkogenide (1)
Institute
- Graduate School of Life Sciences (102)
- Theodor-Boveri-Institut für Biowissenschaften (73)
- Institut für Informatik (43)
- Institut für Psychologie (30)
- Institut für Geographie und Geologie (25)
- Institut für Pharmazie und Lebensmittelchemie (24)
- Institut für Organische Chemie (21)
- Medizinische Klinik und Poliklinik II (21)
- Neurologische Klinik und Poliklinik (21)
- Neuphilologisches Institut - Moderne Fremdsprachen (20)
Schriftenreihe
Sonstige beteiligte Institutionen
- Helmholtz Institute for RNA-based Infection Research (HIRI) (2)
- Klinische Studienzentrale (Universitätsklinikum) (2)
- Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg (2)
- Anthropology Department University of Tennessee, Knoxville (1)
- CIBSS Centre for Integrative Biological Signalling Studies, University of Freiburg (1)
- Carl-Ludwig-Institut für Physiologie, Universität Leipzig (1)
- Chair of Experimental Biomedicine I (1)
- Charles University, Faculty of Mathematics and Physics, Ke Karlovu 5, 121 16 Prague, Czech Republic (1)
- DATE Lab, KITE Research Insititute, University Health Network, Toronto, Canada (1)
- Deutsches Zentrum für Luft- und Raumfahrt (DLR) (1)
The topological classification of electronic band structures is based on symmetry properties of Bloch eigenstates of single-particle Hamiltonians. In parallel, topological field theory has opened the doors to the formulation and characterization of non-trivial phases of matter driven by strong electron-electron interaction. Even though important examples of topological Mott insulators have been constructed, the relevance of the underlying non-interacting band topology to the physics of the Mott phase has remained unexplored. Here, we show that the momentum structure of the Green’s function zeros defining the “Luttinger surface" provides a topological characterization of the Mott phase related, in the simplest description, to the one of the single-particle electronic dispersion. Considerations on the zeros lead to the prediction of new phenomena: a topological Mott insulator with an inverted gap for the bulk zeros must possess gapless zeros at the boundary, which behave as a form of “topological antimatter” annihilating conventional edge states. Placing band and Mott topological insulators in contact produces distinctive observable signatures at the interface, revealing the otherwise spectroscopically elusive Green’s function zeros.
T cell exhaustion is a hallmark of cancer and persistent infections, marked by inhibitory receptor upregulation, diminished cytokine secretion, and impaired cytolytic activity. Terminally exhausted T cells are steadily replenished by a precursor population (Tpex), but the metabolic principles governing Tpex maintenance and the regulatory circuits that control their exhaustion remain incompletely understood. Using a combination of gene-deficient mice, single-cell transcriptomics, and metabolomic analyses, we show that mitochondrial insufficiency is a cell-intrinsic trigger that initiates the functional exhaustion of T cells. At the molecular level, we find that mitochondrial dysfunction causes redox stress, which inhibits the proteasomal degradation of hypoxia-inducible factor 1α (HIF-1α) and promotes the transcriptional and metabolic reprogramming of Tpex cells into terminally exhausted T cells. Our findings also bear clinical significance, as metabolic engineering of chimeric antigen receptor (CAR) T cells is a promising strategy to enhance the stemness and functionality of Tpex cells for cancer immunotherapy.
Axon degeneration and functional decline in myelin diseases are often attributed to loss of myelin but their relation is not fully understood. Perturbed myelinating glia can instigate chronic neuroinflammation and contribute to demyelination and axonal damage. Here we study mice with distinct defects in the proteolipid protein 1 gene that develop axonal damage which is driven by cytotoxic T cells targeting myelinating oligodendrocytes. We show that persistent ensheathment with perturbed myelin poses a risk for axon degeneration, neuron loss, and behavioral decline. We demonstrate that CD8\(^+\) T cell-driven axonal damage is less likely to progress towards degeneration when axons are efficiently demyelinated by activated microglia. Mechanistically, we show that cytotoxic T cell effector molecules induce cytoskeletal alterations within myelinating glia and aberrant actomyosin constriction of axons at paranodal domains. Our study identifies detrimental axon-glia-immune interactions which promote neurodegeneration and possible therapeutic targets for disorders associated with myelin defects and neuroinflammation.
Sharks occupy diverse ecological niches and play critical roles in marine ecosystems, often acting as apex predators. They are considered a slow-evolving lineage and have been suggested to exhibit exceptionally low cancer rates. These two features could be explained by a low nuclear mutation rate. Here, we provide a direct estimate of the nuclear mutation rate in the epaulette shark (Hemiscyllium ocellatum). We generate a high-quality reference genome, and resequence the whole genomes of parents and nine offspring to detect de novo mutations. Using stringent criteria, we estimate a mutation rate of 7×10\(^{−10}\) per base pair, per generation. This represents one of the lowest directly estimated mutation rates for any vertebrate clade, indicating that this basal vertebrate group is indeed a slowly evolving lineage whose ability to restore genetic diversity following a sustained population bottleneck may be hampered by a low mutation rate.
Butyrophilin (BTN)–3A and BTN2A1 molecules control the activation of human Vγ9Vδ2 T cells during T cell receptor (TCR)-mediated sensing of phosphoantigens (PAg) derived from microbes and tumors. However, the molecular rules governing PAg sensing remain largely unknown. Here, we establish three mechanistic principles of PAg-mediated γδ T cell activation. First, in humans, following PAg binding to the intracellular BTN3A1-B30.2 domain, Vγ9Vδ2 TCR triggering involves the extracellular V-domain of BTN3A2/BTN3A3. Moreover, the localization of both protein domains on different chains of the BTN3A homo-or heteromers is essential for efficient PAg-mediated activation. Second, the formation of BTN3A homo-or heteromers, which differ in intracellular trafficking and conformation, is controlled by molecular interactions between the juxtamembrane regions of the BTN3A chains. Finally, the ability of PAg not simply to bind BTN3A-B30.2, but to promote its subsequent interaction with the BTN2A1-B30.2 domain, is essential for T-cell activation. Defining these determinants of cooperation and the division of labor in BTN proteins improves our understanding of PAg sensing and elucidates a mode of action that may apply to other BTN family members.
Tropical forest recovery is fundamental to addressing the intertwined climate and biodiversity loss crises. While regenerating trees sequester carbon relatively quickly, the pace of biodiversity recovery remains contentious. Here, we use bioacoustics and metabarcoding to measure forest recovery post-agriculture in a global biodiversity hotspot in Ecuador. We show that the community composition, and not species richness, of vocalizing vertebrates identified by experts reflects the restoration gradient. Two automated measures – an acoustic index model and a bird community composition derived from an independently developed Convolutional Neural Network - correlated well with restoration (adj-R² = 0.62 and 0.69, respectively). Importantly, both measures reflected composition of non-vocalizing nocturnal insects identified via metabarcoding. We show that such automated monitoring tools, based on new technologies, can effectively monitor the success of forest recovery, using robust and reproducible data.
Neural processing of a desired moving direction requires the continuous comparison between the current heading and the goal direction. While the neural basis underlying the current heading is well-studied, the coding of the goal direction remains unclear in insects. Here, we used tetrode recordings in tethered flying monarch butterflies to unravel how a goal direction is represented in the insect brain. While recording, the butterflies maintained robust goal directions relative to a virtual sun. By resetting their goal directions, we found neurons whose spatial tuning was tightly linked to the goal directions. Importantly, their tuning was unaffected when the butterflies changed their heading after compass perturbations, showing that these neurons specifically encode the goal direction. Overall, we here discovered invertebrate goal-direction neurons that share functional similarities to goal-direction cells reported in mammals. Our results give insights into the evolutionarily conserved principles of goal-directed spatial orientation in animals.
Herpes simplex virus 1 (HSV-1) infection and stress responses disrupt transcription termination by RNA Polymerase II (Pol II). In HSV-1 infection, but not upon salt or heat stress, this is accompanied by a dramatic increase in chromatin accessibility downstream of genes. Here, we show that the HSV-1 immediate-early protein ICP22 is both necessary and sufficient to induce downstream open chromatin regions (dOCRs) when transcription termination is disrupted by the viral ICP27 protein. This is accompanied by a marked ICP22-dependent loss of histones downstream of affected genes consistent with impaired histone repositioning in the wake of Pol II. Efficient knock-down of the ICP22-interacting histone chaperone FACT is not sufficient to induce dOCRs in ΔICP22 infection but increases dOCR induction in wild-type HSV-1 infection. Interestingly, this is accompanied by a marked increase in chromatin accessibility within gene bodies. We propose a model in which allosteric changes in Pol II composition downstream of genes and ICP22-mediated interference with FACT activity explain the differential impairment of histone repositioning downstream of genes in the wake of Pol II in HSV-1 infection.
Immune checkpoint blockade therapy is beneficial and even curative for some cancer patients. However, the majority don’t respond to immune therapy. Across different tumor types, pre-existing T cell infiltrates predict response to checkpoint-based immunotherapy. Based on in vitro pharmacological studies, mouse models and analyses of human melanoma patients, we show that the cytokine GDF-15 impairs LFA-1/β2-integrin-mediated adhesion of T cells to activated endothelial cells, which is a pre-requisite of T cell extravasation. In melanoma patients, GDF-15 serum levels strongly correlate with failure of PD-1-based immune checkpoint blockade therapy. Neutralization of GDF-15 improves both T cell trafficking and therapy efficiency in murine tumor models. Thus GDF-15, beside its known role in cancer-related anorexia and cachexia, emerges as a regulator of T cell extravasation into the tumor microenvironment, which provides an even stronger rationale for therapeutic anti-GDF-15 antibody development.
The neuronal RNA-binding protein Ptbp2 regulates neuronal differentiation by modulating alternative splicing programs in the nucleus. Such programs contribute to axonogenesis by adjusting the levels of protein isoforms involved in axon growth and branching. While its functions in alternative splicing have been described in detail, cytosolic roles of Ptbp2 for axon growth have remained elusive. Here, we show that Ptbp2 is located in the cytosol including axons and growth cones of motoneurons, and that depletion of cytosolic Ptbp2 affects axon growth. We identify Ptbp2 as a major interactor of the 3’ UTR of Hnrnpr mRNA encoding the RNA-binding protein hnRNP R. Axonal localization of Hnrnpr mRNA and local synthesis of hnRNP R protein are strongly reduced when Ptbp2 is depleted, leading to defective axon growth. Ptbp2 regulates hnRNP R translation by mediating the association of Hnrnpr with ribosomes in a manner dependent on the translation factor eIF5A2. Our data thus suggest a mechanism whereby cytosolic Ptbp2 modulates axon growth by fine-tuning the mRNA transport and local synthesis of an RNA-binding protein.
Elevated and low blood pressure (BP) may lead to poor functional outcome after ischemic stroke, which is conflicting. Hence, there must be another factor—such as cerebral small vessel disease (cSVD) -interacting with BP and thus, affecting outcome. Here, we investigate the relationship between BP and cSVD regarding outcome after stroke. Data of 423/503 stroke patients were prospectively analyzed. Diastolic (DBP) and systolic BP (SBP) were collected on hospital admission (BP\(_{ad}\)) and over the first 72 h (BP\(_{72h}\)). cSVD-burden was determined on MR-scans. Good functional outcome was defined as a modified Rankin Scale score ≤ 2 at hospital discharge and 12 months thereafter. cSVD was a predictor of poor outcome (OR 2.8; p < 0.001). SBPad, DBP\(_{ad}\) and SBP\(_{72h}\) were not significantly associated with outcome at any time. A significant relationship was found between DBP\(_{72h}\), (p < 0.01), cSVD (p = 0.013) and outcome at discharge. At 12 months, we found a relationship between outcome and DBP\(_{72h}\) (p = 0.018) and a statistical tendency regarding cSVD (p = 0.08). Changes in DBP72h were significantly related with outcome. There was a U-shaped relationship between DBP\(_{72h}\) and outcome at discharge. Our results suggest an individualized stroke care by either lowering or elevating DBP depending on cSVD-burden in order to influence functional outcome.
Air pollution is associated with morbidity and mortality worldwide. We investigated the impact of improved air quality during the economic lockdown during the SARS-Cov2 pandemic on emergency room (ER) admissions in Germany. Weekly aggregated clinical data from 33 hospitals were collected in 2019 and 2020. Hourly concentrations of nitrogen and sulfur dioxide (NO2, SO2), carbon and nitrogen monoxide (CO, NO), ozone (O3) and particulate matter (PM10, PM2.5) measured by ground stations and meteorological data (ERA5) were selected from a 30 km radius around the corresponding ED. Mobility was assessed using aggregated cell phone data. A linear stepwise multiple regression model was used to predict ER admissions. The average weekly emergency numbers vary from 200 to over 1600 cases (total n = 2,216,217). The mean maximum decrease in caseload was 5 standard deviations. With the enforcement of the shutdown in March, the mobility index dropped by almost 40%. Of all air pollutants, NO2 has the strongest correlation with ER visits when averaged across all departments. Using a linear stepwise multiple regression model, 63% of the variation in ER visits is explained by the mobility index, but still 6% of the variation is explained by air quality and climate change.
The question of how behavior is represented in the mind lies at the core of psychology as the science of mind and behavior. While a long-standing research tradition has established two opposing fundamental views of perceptual representation, Structuralism and Gestalt psychology, we test both accounts with respect to action representation: Are multiple actions (characterizing human behavior in general) represented as the sum of their component actions (Structuralist view) or holistically (Gestalt view)? Using a single-/dual-response switch paradigm, we analyzed switches between dual ([A + B]) and single ([A], [B]) responses across different effector systems and revealed comparable performance in partial repetitions and full switches of behavioral requirements (e.g., in [A + B] → [A] vs. [B] → [A], or [A] → [A + B] vs. [B] → [A + B]), but only when the presence of dimensional overlap between responses allows for Gestalt formation. This evidence for a Gestalt view of behavior in our paradigm challenges some fundamental assumptions in current (tacitly Structuralist) action control theories (in particular the idea that all actions are represented compositionally with reference to their components), provides a novel explanatory angle for understanding complex, highly synchronized human behavior (e.g., dance), and delimitates the degree to which complex behavior can be analyzed in terms of its basic components.
Automated analysis of the inner ear anatomy in radiological data instead of time-consuming manual assessment is a worthwhile goal that could facilitate preoperative planning and clinical research. We propose a framework encompassing joint semantic segmentation of the inner ear and anatomical landmark detection of helicotrema, oval and round window. A fully automated pipeline with a single, dual-headed volumetric 3D U-Net was implemented, trained and evaluated using manually labeled in-house datasets from cadaveric specimen (N = 43) and clinical practice (N = 9). The model robustness was further evaluated on three independent open-source datasets (N = 23 + 7 + 17 scans) consisting of cadaveric specimen scans. For the in-house datasets, Dice scores of 0.97 and 0.94, intersection-over-union scores of 0.94 and 0.89 and average Hausdorf distances of 0.065 and 0.14 voxel units were achieved. The landmark localization task was performed automatically with an average localization error of 3.3 and 5.2 voxel units. A robust, albeit reduced performance could be
attained for the catalogue of three open-source datasets. Results of the ablation studies with 43 mono-parametric variations of the basal architecture and training protocol provided task-optimal parameters for both categories. Ablation studies against single-task variants of the basal architecture showed a clear performance beneft of coupling landmark localization with segmentation and a dataset-dependent performance impact on segmentation ability.
Neuroanatomical variations across the visual field of human observers go along with corresponding variations of the perceived coarseness of visual stimuli. Here we show that horizontal gratings are perceived as having lower spatial frequency than vertical gratings when occurring along the horizontal meridian of the visual field, whereas gratings occurring along the vertical meridian show the exact opposite effect. This finding indicates a new peculiarity of processes operating along the cardinal axes of the visual field.
This study evaluated the influence of different vascular reconstruction kernels on the image quality of CT angiographies of the lower extremity runoff using a 1st-generation photon-counting-detector CT (PCD-CT) compared with dose-matched examinations on a 3rd-generation energy-integrating-detector CT (EID-CT). Inducing continuous extracorporeal perfusion in a human cadaveric model, we performed CT angiographies of eight upper leg arterial runoffs with radiation dose-equivalent 120 kVp acquisition protocols (CTDIvol 5 mGy). Reconstructions were executed with different vascular kernels, matching the individual modulation transfer functions between scanners. Signal-to-noise-ratios (SNR) and contrast-to-noise-ratios (CNR) were computed to assess objective image quality. Six radiologists evaluated image quality subjectively using a forced-choice pairwise comparison tool. Interrater agreement was determined by calculating Kendall’s concordance coefficient (W). The intraluminal attenuation of PCD-CT images was significantly higher than of EID-CT (414.7 ± 27.3 HU vs. 329.3 ± 24.5 HU; p < 0.001). Using comparable kernels, image noise with PCD-CT was significantly lower than with EID-CT (p ≤ 0.044). Correspondingly, SNR and CNR were approximately twofold higher for PCD-CT (p < 0.001). Increasing the spatial frequency for PCD-CT reconstructions by one level resulted in similar metrics compared to EID-CT (CNRfat; EID-CT Bv49: 21.7 ± 3.7 versus PCD-CT Bv60: 21.4 ± 3.5). Overall image quality of PCD-CTA achieved ratings superior to EID-CTA irrespective of the used reconstruction kernels (best: PCD-CT Bv60; worst: EID-CT Bv40; p < 0.001). Interrater agreement was good (W = 0.78). Concluding, PCD-CT offers superior intraluminal attenuation, SNR, and CNR compared to EID-CT in angiographies of the upper leg arterial runoff. Combined with improved subjective image quality, PCD-CT facilitates the use of sharper convolution kernels and ultimately bears the potential of improved vascular structure assessability.
Psychosocial factors affect mental health and health-related quality of life (HRQL) in a complex manner, yet gender differences in these interactions remain poorly understood. We investigated whether psychosocial factors such as social support and personal and work-related concerns impact mental health and HRQL differentially in women and men during the first year of the COVID-19 pandemic. Between June and October 2020, the first part of a COVID-19-specific program was conducted within the “Characteristics and Course of Heart Failure Stages A-B and Determinants of Progression (STAAB)” cohort study, a representative age- and gender-stratified sample of the general population of Würzburg, Germany. Using psychometric networks, we first established the complex relations between personal social support, personal and work-related concerns, and their interactions with anxiety, depression, and HRQL. Second, we tested for gender differences by comparing expected influence, edge weight differences, and stability of the networks. The network comparison revealed a significant difference in the overall network structure. The male (N = 1370) but not the female network (N = 1520) showed a positive link between work-related concern and anxiety. In both networks, anxiety was the most central variable. These findings provide further evidence that the complex interplay of psychosocial factors with mental health and HRQL decisively depends on gender. Our results are relevant for the development of gender-specific interventions to increase resilience in times of pandemic crisis.
Minimally invasive endovascular interventions have become an important tool for the treatment of cardiovascular diseases such as ischemic heart disease, peripheral artery disease, and stroke. X-ray fluoroscopy and digital subtraction angiography are used to precisely guide these procedures, but they are associated with radiation exposure for patients and clinical staff. Magnetic Particle Imaging (MPI) is an emerging imaging technology using time-varying magnetic fields combined with magnetic nanoparticle tracers for fast and highly sensitive imaging. In recent years, basic experiments have shown that MPI has great potential for cardiovascular applications. However, commercially available MPI scanners were too large and expensive and had a small field of view (FOV) designed for rodents, which limited further translational research. The first human-sized MPI scanner designed specifically for brain imaging showed promising results but had limitations in gradient strength, acquisition time and portability. Here, we present a portable interventional MPI (iMPI) system dedicated for real-time endovascular interventions free of ionizing radiation. It uses a novel field generator approach with a very large FOV and an application-oriented open design enabling hybrid approaches with conventional X-ray-based angiography. The feasibility of a real-time iMPI-guided percutaneous transluminal angioplasty (PTA) is shown in a realistic dynamic human-sized leg model.
Social buffering, a phenomenon where social presence can reduce anxiety and fear-related autonomic responses, has been studied in numerous laboratory settings. The results suggest that the familiarity of the interaction partner influences social buffering while also providing some evidence for gender effects. In the laboratory, however, it is difficult to mimic the complexity of real-life social interactions. Consequently, the social modulation of anxiety and related autonomic responses in everyday life remains poorly understood. We used smartphone-based Ecological Momentary Assessment (EMA) combined with wearable electrocardiogram sensors to investigate how everyday-life social interactions affect state anxiety and related cardiac changes in women and men. On five consecutive days, 96 healthy young participants (53% women) answered up to six EMA surveys per day, indicating characteristics of their most recent social interaction and the respective interaction partner(s). In women, our results showed lower heart rate in the presence of a male interaction partner. Men showed the same effect with female interaction partners. Moreover, only women showed decreased heart rate and increased heart rate variability with increasing interaction partner familiarity. These findings specify the conditions under which social interactions reduce anxiety-related responses in women and men.
Formic acid is the main component of the ant’s major weapon against enemies. Being mainly used as a chemical defense, the acid is also exploited for recruitment and trail marking. The repelling effect of the organic acid is used by some mammals and birds which rub themselves in the acid to eliminate ectoparasites. Beekeepers across the world rely on this effect to control the parasitic mite Varroa destructor. Varroa mites are considered the most destructive pest of honey bees worldwide and can lead to the loss of entire colonies. Formic acid is highly effective against Varroa mites but can also kill the honeybee queen and worker brood. Whether formic acid can also affect the behavior of honey bees is unknown. We here study the effect of formic acid on sucrose responsiveness and cognition of honey bees treated at different live stages in field-relevant doses. Both behaviors are essential for survival of the honey bee colony. Rather unexpectedly, formic acid clearly improved the learning performance of the bees in appetitive olfactory conditioning, while not affecting sucrose responsiveness. This exciting side effect of formic acid certainly deserves further detailed investigations.
Photon-counting detector (PCD) CT allows for ultra-high-resolution (UHR) examinations of the shoulder without requiring an additional post-patient comb filter to narrow the detector aperture. This study was designed to compare the PCD performance with a high-end energy-integrating detector (EID) CT. Sixteen cadaveric shoulders were examined with both scanners using dose-matched 120 kVp acquisition protocols (low-dose/full-dose: CTDI\(_{vol}\) = 5.0/10.0 mGy). Specimens were scanned in UHR mode with the PCD-CT, whereas EID-CT examinations were conducted in accordance with the clinical standard as “non-UHR”. Reconstruction of EID data employed the sharpest kernel available for standard-resolution scans (ρ\(_{50}\) = 12.3 lp/cm), while PCD data were reconstructed with both a comparable kernel (11.8 lp/cm) and a sharper dedicated bone kernel (16.5 lp/cm). Six radiologists with 2–9 years of experience in musculoskeletal imaging rated image quality subjectively. Interrater agreement was analyzed by calculation of the intraclass correlation coefficient in a two-way random effects model. Quantitative analyses comprised noise recording and calculating signal-to-noise ratios based on attenuation measurements in bone and soft tissue. Subjective image quality was higher in UHR-PCD-CT than in EID-CT and non-UHR-PCD-CT datasets (all p < 0.001). While low-dose UHR-PCD-CT was considered superior to full-dose non-UHR studies on either scanner (all p < 0.001), ratings of low-dose non-UHR-PCD-CT and full-dose EID-CT examinations did not differ (p > 0.99). Interrater reliability was moderate, indicated by a single measures intraclass correlation coefficient of 0.66 (95% confidence interval: 0.58–0.73; p < 0.001). Image noise was lowest and signal-to-noise ratios were highest in non-UHR-PCD-CT reconstructions at either dose level (p < 0.001). This investigation demonstrates that superior depiction of trabecular microstructure and considerable denoising can be realized without additional radiation dose by employing a PCD for shoulder CT imaging. Allowing for UHR scans without dose penalty, PCD-CT appears as a promising alternative to EID-CT for shoulder trauma assessment in clinical routine.
Changes in body perception often arise when observers are confronted with related yet discrepant multisensory signals. Some of these effects are interpreted as outcomes of sensory integration of various signals, whereas related biases are ascribed to learning-dependent recalibration of coding individual signals. The present study explored whether the same sensorimotor experience entails changes in body perception that are indicative of multisensory integration and those that indicate recalibration. Participants enclosed visual objects by a pair of visual cursors controlled by finger movements. Then either they judged their perceived finger posture (indicating multisensory integration) or they produced a certain finger posture (indicating recalibration). An experimental variation of the size of the visual object resulted in systematic and opposite biases of the perceived and produced finger distances. This pattern of results is consistent with the assumption that multisensory integration and recalibration had a common origin in the task we used.
Long-term sequelae in hospitalized Coronavirus Disease 2019 (COVID-19) patients may result in limited quality of life. The current study aimed to determine health-related quality of life (HRQoL) after COVID-19 hospitalization in non-intensive care unit (ICU) and ICU patients. This is a single-center study at the University Hospital of Wuerzburg, Germany. Patients eligible were hospitalized with COVID-19 between March 2020 and December 2020. Patients were interviewed 3 and 12 months after hospital discharge. Questionnaires included the European Quality of Life 5 Dimensions 5 Level (EQ-5D-5L), patient health questionnaire-9 (PHQ-9), the generalized anxiety disorder 7 scale (GAD-7), FACIT fatigue scale, perceived stress scale (PSS-10) and posttraumatic symptom scale 10 (PTSS-10). 85 patients were included in the study. The EQ5D-5L-Index significantly differed between non-ICU (0.78 ± 0.33 and 0.84 ± 0.23) and ICU (0.71 ± 0.27; 0.74 ± 0.2) patients after 3- and 12-months. Of non-ICU 87% and 80% of ICU survivors lived at home without support after 12 months. One-third of ICU and half of the non-ICU patients returned to work. A higher percentage of ICU patients was limited in their activities of daily living compared to non-ICU patients. Depression and fatigue were present in one fifth of the ICU patients. Stress levels remained high with only 24% of non-ICU and 3% of ICU patients (p = 0.0186) having low perceived stress. Posttraumatic symptoms were present in 5% of non-ICU and 10% of ICU patients. HRQoL is limited in COVID-19 ICU patients 3- and 12-months post COVID-19 hospitalization, with significantly less improvement at 12-months compared to non-ICU patients. Mental disorders were common highlighting the complexity of post-COVID-19 symptoms as well as the necessity to educate patients and primary care providers about monitoring mental well-being post COVID-19.
Topological differences and confounders of mental rotation in cervical dystonia and blepharospasm
(2023)
Mental rotation (mR) bases on imagination of actual movements. It remains unclear whether there is a specific pattern of mR impairment in focal dystonia. We aimed to investigate mR in patients with cervical dystonia (CD) and blepharospasm (BS) and to assess potential confounders. 23 CD patients and 23 healthy controls (HC) as well as 21 BS and 19 hemifacial spasm (HS) patients were matched for sex, age, and education level. Handedness, finger dexterity, general reaction time, and cognitive status were assessed. Disease severity was evaluated by clinical scales. During mR, photographs of body parts (head, hand, or foot) and a non-corporal object (car) were displayed at different angles rotated within their plane. Subjects were asked to judge laterality of the presented image by keystroke. Both speed and correctness were evaluated. Compared to HC, CD and HS patients performed worse in mR of hands, whereas BS group showed comparable performance. There was a significant association of prolonged mR reaction time (RT) with reduced MoCA scores and with increased RT in an unspecific reaction speed task. After exclusion of cognitively impaired patients, increased RT in the mR of hands was confined to CD group, but not HS. While the question of whether specific patterns of mR impairment reliably define a dystonic endophenotype remains elusive, our findings point to mR as a useful tool, when used carefully with control measures and tasks, which may be capable of identifying specific deficits that distinguish between subtypes of dystonia.
Seasonal plasticity in insects is often triggered by temperature and photoperiod changes. When climatic conditions become sub-optimal, insects might undergo reproductive diapause, a form of seasonal plasticity delaying the development of reproductive organs and activities. During the reproductive diapause, the cuticular hydrocarbon (CHC) profile, which covers the insect body surface, might also change to protect insects from desiccation and cold temperature. However, CHCs are often important cues and signals for mate recognition and changes in CHC composition might affect mate recognition. In the present study, we investigated the CHC profile composition and the mating success of Drosophila suzukii in 1- and 5-day-old males and females of summer and winter morphs. CHC compositions differed with age and morphs. However, no significant differences were found between the sexes of the same age and morph. The results of the behavioral assays show that summer morph pairs start to mate earlier in their life, have a shorter mating duration, and have more offspring compared to winter morph pairs. We hypothesize that CHC profiles of winter morphs are adapted to survive winter conditions, potentially at the cost of reduced mate recognition cues.
A substantial number of people refused to get vaccinated against COVID-19, which prompts the question as to why. We focus on the role of individual worldviews about the nature and generation of knowledge (epistemic beliefs). We propose a model that includes epistemic beliefs, their relationship to the Dark Factor of Personality (D), and their mutual effect on the probability of having been vaccinated against COVID-19. Based on a US nationally representative sample (N = 1268), we show that stronger endorsement of post-truth epistemic beliefs was associated with a lower probability of having been vaccinated against COVID-19. D was also linked to a lower probability of having been vaccinated against COVID-19, which can be explained by post-truth epistemic beliefs. Our results indicate that the more individuals deliberately refrain from adhering to the better argument, the less likely they are vaccinated. More generally, post-truth epistemic beliefs pose a challenge for rational communication.
Seed amplification assays (SAA) are becoming commonly used in synucleinopathies to detect α-synuclein aggregates. Studies in Parkinson’s disease (PD) and isolated REM-sleep behavior disorder (iRBD) have shown a considerably lower sensitivity in the olfactory epithelium than in CSF or skin. To get an insight into α-synuclein (α-syn) distribution within the nervous system and reasons for low sensitivity, we compared SAA assessment of nasal brushings and skin biopsies in PD (n = 27) and iRBD patients (n = 18) and unaffected controls (n = 30). α-syn misfolding was overall found less commonly in the olfactory epithelium than in the skin, which could be partially explained by the nasal brushing matrix exerting an inhibitory effect on aggregation. Importantly, the α-syn distribution was not uniform: there was a higher deposition of misfolded α-syn across all sampled tissues in the iRBD cohort compared to PD (supporting the notion of RBD as a marker of a more malignant subtype of synucleinopathy) and in a subgroup of PD patients, misfolded α-syn was detectable only in the olfactory epithelium, suggestive of the recently proposed brain-first PD subtype. Assaying α-syn of diverse origins, such as olfactory (part of the central nervous system) and skin (peripheral nervous system), could increase diagnostic accuracy and allow better stratification of patients.
Infected wounds pose a major mortality risk in animals. Injuries are common in the ant Megaponera analis, which raids pugnacious prey. Here we show that M. analis can determine when wounds are infected and treat them accordingly. By applying a variety of antimicrobial compounds and proteins secreted from the metapleural gland to infected wounds, workers reduce the mortality of infected individuals by 90%. Chemical analyses showed that wound infection is associated with specific changes in the cuticular hydrocarbon profile, thereby likely allowing nestmates to diagnose the infection state of injured individuals and apply the appropriate antimicrobial treatment. This study demonstrates that M. analis ant societies use antimicrobial compounds produced in the metapleural glands to treat infected wounds and reduce nestmate mortality.
Plants extract mineral nutrients from the soil, or from interactions with mutualistic soil microbes via their root systems. Adapting root architecture to nutrient availability enables efficient resource utilization, particularly in patchy and dynamic environments. Root growth responses to soil nitrogen levels are shoot-mediated, but the identity of shoot-derived mobile signals regulating root growth responses has remained enigmatic. Here we show that a shoot-derived micro RNA, miR2111, systemically steers lateral root initiation and nitrogen responsiveness through its root target TML (TOO MUCH LOVE) in the legume Lotus japonicus, where miR2111 and TML were previously shown to regulate symbiotic infections with nitrogen fixing bacteria. Intriguingly, systemic control of lateral root initiation by miR2111 and TML/HOLT (HOMOLOGUE OF LEGUME TML) was conserved in the nonsymbiotic ruderal Arabidopsis thaliana, which follows a distinct ecological strategy. Thus, the miR2111-TML/HOLT regulon emerges as an essential, conserved factor in adaptive shoot control of root architecture in dicots.
Inflammation in the brain and gut is a critical component of several neurological diseases, such as Parkinson’s disease (PD). One trigger of the immune system in PD is aggregation of the pre-synaptic protein, α-synuclein (αSyn). Understanding the mechanism of propagation of αSyn aggregates is essential to developing disease-modifying therapeutics. Using a brain-first mouse model of PD, we demonstrate αSyn trafficking from the brain to the ileum of male mice. Immunohistochemistry revealed that the ileal αSyn aggregations are contained within CD11c+ cells. Using single-cell RNA sequencing, we demonstrate that ileal CD11c\(^+\) cells are microglia-like and the same subtype of cells is activated in the brain and ileum of PD mice. Moreover, by utilizing mice expressing the photo-convertible protein, Dendra2, we show that CD11c\(^+\) cells traffic from the brain to the ileum. Together these data provide a mechanism of αSyn trafficking between the brain and gut.
Pain-associated approach and avoidance behaviours are critically involved in the development and maintenance of chronic pain. Empirical research suggests a key role of operant learning mechanisms, and first experimental paradigms were developed for their investigation within a controlled laboratory setting. We introduce a new Virtual Reality paradigm to the study of pain-related behaviour and investigate pain experiences on multiple dimensions. The paradigm evaluates the effects of three-tiered heat-pain stimuli applied contingent versus non-contingent with three types of arm movements in naturalistic virtual sceneries. Behaviour, self-reported pain-related fear, pain expectancy and electrodermal activity were assessed in 42 healthy participants during an acquisition phase (contingent movement-pain association) and a modification phase (no contingent movement-pain association). Pain-associated approach behaviour, as measured by arm movements followed by a severe heat stimulus, quickly decreased in-line with the arm movement-pain contingency. Slower effects were observed in fear of movement-related pain and pain expectancy ratings. During the subsequent modification phase, the removal of the pain contingencies modified all three indices. In both phases, skin conductance responses resemble the pattern observed for approach behaviour, while skin conductance levels equal the pattern observed for the self-ratings. Our findings highlight a fast reduction in approach behaviour in the face of acute pain and inform about accompanying psychological and physiological processes. We discuss strength and limitations of our paradigm for future investigations with the ultimate goal of gaining a comprehensive understanding of the mechanisms involved in chronic pain development, maintenance, and its therapy.
Pathogen-specific innate immune response patterns are distinctly affected by genetic diversity
(2023)
Innate immune responses vary by pathogen and host genetics. We analyze quantitative trait loci (eQTLs) and transcriptomes of monocytes from 215 individuals stimulated by fungal, Gram-negative or Gram-positive bacterial pathogens. We identify conserved monocyte responses to bacterial pathogens and a distinct antifungal response. These include 745 response eQTLs (reQTLs) and corresponding genes with pathogen-specific effects, which we find first in samples of male donors and subsequently confirm for selected reQTLs in females. reQTLs affect predominantly upregulated genes that regulate immune response via e.g., NOD-like, C-type lectin, Toll-like and complement receptor-signaling pathways. Hence, reQTLs provide a functional explanation for individual differences in innate response patterns. Our identified reQTLs are also associated with cancer, autoimmunity, inflammatory and infectious diseases as shown by external genome-wide association studies. Thus, reQTLs help to explain interindividual variation in immune response to infection and provide candidate genes for variants associated with a range of diseases.
Bioimages frequently exhibit low signal-to-noise ratios due to experimental conditions, specimen characteristics, and imaging trade-offs. Reliable segmentation of such ambiguous images is difficult and laborious. Here we introduce deepflash2, a deep learning-enabled segmentation tool for bioimage analysis. The tool addresses typical challenges that may arise during the training, evaluation, and application of deep learning models on ambiguous data. The tool’s training and evaluation pipeline uses multiple expert annotations and deep model ensembles to achieve accurate results. The application pipeline supports various use-cases for expert annotations and includes a quality assurance mechanism in the form of uncertainty measures. Benchmarked against other tools, deepflash2 offers both high predictive accuracy and efficient computational resource usage. The tool is built upon established deep learning libraries and enables sharing of trained model ensembles with the research community. deepflash2 aims to simplify the integration of deep learning into bioimage analysis projects while improving accuracy and reliability.
The Fischer carbene synthesis, involving the conversion of a transition metal (TM)-bound CO ligand to a carbene ligand of the form [=C(OR’)R] (R, R’ = organyl groups), is one of the seminal reactions in the history of organometallic chemistry. Carbonyl complexes of p-block elements, of the form [E(CO)n] (E = main-group fragment), are much less abundant than their TM cousins; this scarcity and the general instability of low-valent p-block species means that replicating the historical reactions of TM carbonyls is often very difficult. Here we present a step-for-step replica of the Fischer carbene synthesis at a borylene carbonyl involving nucleophilic attack at the carbonyl carbon followed by electrophilic quenching at the resultant acylate oxygen atom. These reactions provide borylene acylates and alkoxy-/silyloxy-substituted alkylideneboranes, main-group analogues of the archetypal transition metal acylate and Fischer carbene families, respectively. When either the incoming electrophile or the boron center has a modest steric profile, the electrophile instead attacks at the boron atom, leading to carbene-stabilized acylboranes – boron analogues of the well-known transition metal acyl complexes. These results constitute faithful main-group replicas of a number of historical organometallic processes and pave the way to further advances in the field of main-group metallomimetics.
The discrimination of enantiomers by natural receptors is a well-established phenomenon. In contrast the number of synthetic receptors with the capability for enantioselective molecular recognition of chiral substrates is scarce and for chiral cyclophanes indicative for a preferential binding of homochiral guests. Here we introduce a cyclophane composed of two homochiral core-twisted perylene bisimide (PBI) units connected by p-xylylene spacers and demonstrate its preference for the complexation of [5]helicene of opposite helicity compared to the PBI units of the host. The pronounced enantio-differentiation of this molecular receptor for heterochiral guests can be utilized for the enrichment of the P-PBI-M-helicene-P-PBI epimeric bimolecular complex. Our experimental results are supported by DFT calculations, which reveal that the sterically demanding bay substituents attached to the PBI chromophores disturb the helical shape match of the perylene core and homochiral substrates and thereby enforce the formation of syndiotactic host-guest complex structures. Hence, the most efficient substrate binding is observed for those aromatic guests, e. g. perylene, [4]helicene, phenanthrene and biphenyl, that can easily adapt in non-planar axially chiral conformations due to their inherent conformational flexibility. In all cases the induced chirality for the guest is opposed to those of the embedding PBI units, leading to heterochiral host-guest structures.
Ferroptosis is a form of cell death characterized by phospholipid peroxidation, where numerous studies have suggested that the induction of ferroptosis is a therapeutic strategy to target therapy refractory cancer entities. Ferroptosis suppressor protein 1 (FSP1), an NAD(P)H-ubiquinone reductase, is a key determinant of ferroptosis vulnerability, and its pharmacological inhibition was shown to strongly sensitize cancer cells to ferroptosis. A first generation of FSP1 inhibitors, exemplified by the small molecule iFSP1, has been reported; however, the molecular mechanisms underlying inhibition have not been characterized in detail. In this study, we explore the species-specific inhibition of iFSP1 on the human isoform to gain insights into its mechanism of action. Using a combination of cellular, biochemical, and computational methods, we establish a critical contribution of a species-specific aromatic architecture that is essential for target engagement. The results described here provide valuable insights for the rational development of second-generation FSP1 inhibitors combined with a tracer for screening the druggable pocket. In addition, we pose a cautionary notice for using iFSP1 in animal models, specifically murine models.
Present surgical situations require a bone adhesive which has not yet been developed for use in clinical applications. Recently, phosphoserine modified cements (PMC) based on mixtures of o-phosphoserine (OPLS) and calcium phosphates, such as tetracalcium phosphate (TTCP) or α-tricalcium phosphate (α-TCP) as well as chelate setting magnesium phosphate cements have gained increasing popularity for their use as mineral bone adhesives. Here, we investigated new mineral-organic bone cements based on phosphoserine and magnesium phosphates or oxides, which possess excellent adhesive properties. These were analyzed by X-ray diffraction, Fourier infrared spectroscopy and electron microscopy and subjected to mechanical tests to determine the bond strength to bone after ageing at physiological conditions. The novel biomineral adhesives demonstrate excellent bond strength to bone with approximately 6.6–7.3 MPa under shear load. The adhesives are also promising due to their cohesive failure pattern and ductile character. In this context, the new adhesive cements are superior to currently prevailing bone adhesives. Future efforts on bone adhesives made from phosphoserine and Mg2+ appear to be very worthwhile.
Purpose
To compare the performance of the dominant and nondominant hand during fundamental arthroscopic simulator training.
Methods
Surgical trainees who participated in a 2-day simulator training course between 2021 and 2023 were classified, according to their arthroscopic experience in beginners and competents. Only right-handed individuals with complete data sets were included in the study. Ambidexterity was trained using a box trainer (Fundamentals of Arthroscopic Surgery Training, Virtamed AG, Schlieren, Switzerland).Two tasks, periscoping for learning camera guidance and triangulation for additional instrument handling, were performed 4 times with the camera in the dominant hand and then in the nondominant hand. For each task, exercise time, camera path length, and instrument path length were recorded and analyzed.
Results
Out of 94 participants 74 right-handed individuals (22 females, 52 males) were classified to novices (n = 43, less than 10 independently performed arthroscopies) and competents (n = 31, more than 10 independently performed arthroscopies). Competents performed significantly better than novices. No significant difference was found after changing the guiding hand for the camera from the dominant to the nondominant hand regarding the camera path length and the instrument path length. Notably, tasks were performed even faster when using the camera in the nondominant hand.
Conclusions
Our data demonstrate that the learned manual skills during basic arthroscopic training are quickly transferred to the contralateral side. In consequence, additional fundamental skills training for camera guidance and instrument handling of the nondominant hand are not necessary.
Clinical Relevance
For skillful arthroscopy, camera guidance and instrument handing must be equally mastered with both hands. It is important to understand how hand dominance may affect learning during arthroscopic simulator training.
Highlights
• Beta-Guided programming is an innovative approach that may streamline the programming process for PD patients with STN DBS.
• While preliminary findings from our study suggest that Beta Titration may potentially mitigate STN overstimulation and enhance symptom control,
• Our results demonstrate that beta-guided programming significantly reduces programming time, suggesting it could be efficiently integrated into routine clinical practice using a commercially available patient programmer.
Background
Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment for advanced Parkinson's disease (PD). Clinical outcomes after DBS can be limited by poor programming, which remains a clinically driven, lengthy and iterative process. Electrophysiological recordings in PD patients undergoing STN-DBS have shown an association between STN spectral power in the beta frequency band (beta power) and the severity of clinical symptoms. New commercially-available DBS devices now enable the recording of STN beta oscillations in chronically-implanted PD patients, thereby allowing investigation into the use of beta power as a biomarker for DBS programming.
Objective
To determine the potential advantages of beta-guided DBS programming over clinically and image-guided programming in terms of clinical efficacy and programming time.
Methods
We conducted a randomized, blinded, three-arm, crossover clinical trial in eight Parkinson's patients with STN-DBS who were evaluated three months after DBS surgery. We compared clinical efficacy and time required for each DBS programming paradigm, as well as DBS parameters and total energy delivered between the three strategies (beta-, clinically- and image-guided).
Results
All three programming methods showed similar clinical efficacy, but the time needed for programming was significantly shorter for beta- and image-guided programming compared to clinically-guided programming (p < 0.001).
Conclusion
Beta-guided programming may be a useful and more efficient approach to DBS programming in Parkinson's patients with STN-DBS. It takes significantly less time to program than traditional clinically-based programming, while providing similar symptom control. In addition, it is readily available within the clinical DBS programmer, making it a valuable tool for improving current clinical practice.
Human startle disease is associated with mutations in distinct genes encoding glycine receptors, transporters or interacting proteins at glycinergic synapses in spinal cord and brainstem. However, a significant number of diagnosed patients does not carry a mutation in the common genes GLRA1, GLRB, and SLC6A5. Recently, studies on solute carrier 7 subfamily 10 (SLC7A10; Asc-1, alanine-serine-cysteine transporter) knock-out (KO) mice displaying a startle disease-like phenotype hypothesized that this transporter might represent a novel candidate for human startle disease. Here, we screened 51 patients from our patient cohort negative for the common genes and found three exonic (one missense, two synonymous), seven intronic, and single nucleotide changes in the 5′ and 3′ untranslated regions (UTRs) in Asc-1. The identified missense mutation Asc-1\(^{G307R}\) from a patient with startle disease and developmental delay was investigated in functional studies. At the molecular level, the mutation Asc-1\(^{G307R}\) did not interfere with cell-surface expression, but disrupted glycine uptake. Substitution of glycine at position 307 to other amino acids, e.g., to alanine or tryptophan did not affect trafficking or glycine transport. By contrast, G307K disrupted glycine transport similar to the G307R mutation found in the patient. Structurally, the disrupted function in variants carrying positively charged residues can be explained by local structural rearrangements because of the large positively charged side chain. Thus, our data suggest that SLC7A10 may represent a rare but novel gene associated with human startle disease and developmental delay.
Background
Medical resource management can be improved by assessing the likelihood of prolonged length of stay (LOS) for head and neck cancer surgery patients. The objective of this study was to develop predictive models that could be used to determine whether a patient's LOS after cancer surgery falls within the normal range of the cohort.
Methods
We conducted a retrospective analysis of a dataset consisting of 300 consecutive patients who underwent head and neck cancer surgery between 2017 and 2022 at a single university medical center. Prolonged LOS was defined as LOS exceeding the 75th percentile of the cohort. Feature importance analysis was performed to evaluate the most important predictors for prolonged LOS. We then constructed 7 machine learning and deep learning algorithms for the prediction modeling of prolonged LOS.
Results
The algorithms reached accuracy values of 75.40 (radial basis function neural network) to 97.92 (Random Trees) for the training set and 64.90 (multilayer perceptron neural network) to 84.14 (Random Trees) for the testing set. The leading parameters predicting prolonged LOS were operation time, ischemia time, the graft used, the ASA score, the intensive care stay, and the pathological stages. The results revealed that patients who had a higher number of harvested lymph nodes (LN) had a lower probability of recurrence but also a greater LOS. However, patients with prolonged LOS were also at greater risk of recurrence, particularly when fewer (LN) were extracted. Further, LOS was more strongly correlated with the overall number of extracted lymph nodes than with the number of positive lymph nodes or the ratio of positive to overall extracted lymph nodes, indicating that particularly unnecessary lymph node extraction might be associated with prolonged LOS.
Conclusions
The results emphasize the need for a closer follow-up of patients who experience prolonged LOS. Prospective trials are warranted to validate the present results.
Learning about informal fallacies and the detection of fake news: an experimental intervention
(2023)
The philosophical concept of informal fallacies–arguments that fail to provide sufficient support for a claim–is introduced and connected to the topic of fake news detection. We assumed that the ability to identify informal fallacies can be trained and that this ability enables individuals to better distinguish between fake news and real news. We tested these assumptions in a two-group between-participants experiment (N = 116). The two groups participated in a 30-minute-long text-based learning intervention: either about informal fallacies or about fake news. Learning about informal fallacies enhanced participants’ ability to identify fallacious arguments one week later. Furthermore, the ability to identify fallacious arguments was associated with a better discernment between real news and fake news. Participants in the informal fallacy intervention group and the fake news intervention group performed equally well on the news discernment task. The contribution of (identifying) informal fallacies for research and practice is discussed.
To fire action-potential-like electrical signals, the vacuole membrane requires the two-pore channel TPC1, formerly called SV channel. The TPC1/SV channel functions as a depolarization-stimulated, non-selective cation channel that is inhibited by luminal Ca\(^{2+}\). In our search for species-dependent functional TPC1 channel variants with different luminal Ca\(^{2+}\) sensitivity, we found in total three acidic residues present in Ca\(^{2+}\) sensor sites 2 and 3 of the Ca\(^{2+}\)-sensitive AtTPC1 channel from Arabidopsis thaliana that were neutral in its Vicia faba ortholog and also in those of many other Fabaceae. When expressed in the Arabidopsis AtTPC1-loss-of-function background, wild-type VfTPC1 was hypersensitive to vacuole depolarization and only weakly sensitive to blocking luminal Ca\(^{2+}\). When AtTPC1 was mutated for these VfTPC1-homologous polymorphic residues, two neutral substitutions in Ca\(^{2+}\) sensor site 3 alone were already sufficient for the Arabidopsis At-VfTPC1 channel mutant to gain VfTPC1-like voltage and luminal Ca\(^{2+}\) sensitivity that together rendered vacuoles hyperexcitable. Thus, natural TPC1 channel variants exist in plant families which may fine-tune vacuole excitability and adapt it to environmental settings of the particular ecological niche.
Interleukin-4 (IL-4) plays a key role in atopic diseases. It coordinates T-helper cell differentiation to subtype 2, thereby directing defense toward humoral immunity. Together with Interleukin-13, IL-4 further induces immunoglobulin class switch to IgE. Antibodies of this type activate mast cells and basophilic and eosinophilic granulocytes, which release pro-inflammatory mediators accounting for the typical symptoms of atopic diseases. IL-4 and IL-13 are thus major targets for pharmaceutical intervention strategies to treat atopic diseases. Besides neutralizing antibodies against IL-4, IL-13, or its receptors, IL-4 antagonists can present valuable alternatives. Pitrakinra, an Escherichia coli-derived IL-4 antagonist, has been evaluated in clinical trials for asthma treatment in the past; however, deficits such as short serum lifetime and potential immunogenicity among others stopped further development. To overcome such deficits, PEGylation of therapeutically important proteins has been used to increase the lifetime and proteolytic stability. As an alternative, glycoengineering is an emerging strategy used to improve pharmacokinetics of protein therapeutics. In this study, we have established different strategies to attach glycan moieties to defined positions in IL-4. Different chemical attachment strategies employing thiol chemistry were used to attach a glucose molecule at amino acid position 121, thereby converting IL-4 into a highly effective antagonist. To enhance the proteolytic stability of this IL-4 antagonist, additional glycan structures were introduced by glycoengineering utilizing eucaryotic expression. IL-4 antagonists with a combination of chemical and biosynthetic glycoengineering could be useful as therapeutic alternatives to IL-4 neutralizing antibodies already used to treat atopic diseases.
Recent studies link increased ozone (O\(_3\)) and carbon dioxide (CO\(_2\)) levels to alteration of plant performance and plant-herbivore interactions, but their interactive effects on plant-pollinator interactions are little understood. Extra floral nectaries (EFNs) are essential organs used by some plants for stimulating defense against herbivory and for the attraction of insect pollinators, e.g., bees. The factors driving the interactions between bees and plants regarding the visitation of bees to EFNs are poorly understood, especially in the face of global change driven by greenhouse gases. Here, we experimentally tested whether elevated levels of O\(_3\) and CO\(_2\) individually and interactively alter the emission of Volatile Organic Compound (VOC) profiles in the field bean plant (Vicia faba, L., Fabaceae), EFN nectar production and EFN visitation by the European orchard bee (Osmia cornuta, Latreille, Megachilidae). Our results showed that O\(_3\) alone had significant negative effects on the blends of VOCs emitted while the treatment with elevated CO\(_2\) alone did not differ from the control. Furthermore, as with O\(_3\) alone, the mixture of O\(_3\) and CO\(_2\) also had a significant difference in the VOCs’ profile. O\(_3\) exposure was also linked to reduced nectar volume and had a negative impact on EFN visitation by bees. Increased CO\(_2\) level, on the other hand, had a positive impact on bee visits. Our results add to the knowledge of the interactive effects of O\(_3\) and CO\(_2\) on plant volatiles emitted by Vicia faba and bee responses. As greenhouse gas levels continue to rise globally, it is important to take these findings into consideration to better prepare for changes in plant-insect interactions.
Natural DNA storage allows cellular differentiation, evolution, the growth of our children and controls all our ecosystems. Here, we discuss the fundamental aspects of DNA storage and recent advances in this field, with special emphasis on natural processes and solutions that can be exploited. We point out new ways of efficient DNA and nucleotide storage that are inspired by nature. Within a few years DNA-based information storage may become an attractive and natural complementation to current electronic data storage systems. We discuss rapid and directed access (e.g. DNA elements such as promotors, enhancers), regulatory signals and modulation (e.g. lncRNA) as well as integrated high-density storage and processing modules (e.g. chromosomal territories). There is pragmatic DNA storage for use in biotechnology and human genetics. We examine DNA storage as an approach for synthetic biology (e.g. light-controlled nucleotide processing enzymes). The natural polymers of DNA and RNA offer much for direct storage operations (read-in, read-out, access control). The inbuilt parallelism (many molecules at many places working at the same time) is important for fast processing of information. Using biology concepts from chromosomal storage, nucleic acid processing as well as polymer material sciences such as electronical effects in enzymes, graphene, nanocellulose up to DNA macramé , DNA wires and DNA-based aptamer field effect transistors will open up new applications gradually replacing classical information storage methods in ever more areas over time (decades).
Objectives
To evaluate whether a multimodal intervention in general practice reduces the proportion of second line antibiotic prescriptions and the overall proportion of antibiotic prescriptions for uncomplicated urinary tract infections in women.
Design
Parallel, cluster randomised, controlled trial.
Setting
General practices in five regions in Germany. Data were collected between 1 April 2021 and 31 March 2022.
Participants
General practitioners from 128 randomly assigned practices.
Interventions
Multimodal intervention consisting of guideline recommendations for general practitioners and patients, provision of regional data for antibiotic resistance, and quarterly feedback, which included individual first line and second line proportions of antibiotic prescribing, benchmarking with regional or supra-regional practices, and telephone counselling. Participants in the control group received no information on the intervention.
Main outcome measures
Primary outcome was the proportion of second line antibiotics prescribed by general practices, in relation to all antibiotics prescribed, for uncomplicated urinary tract infections after one year between the intervention and control group. General practices were randomly assigned in blocks (1:1), with a block size of four, into the intervention or control group using SAS version 9.4; randomisation was stratified by region. The secondary outcome was the prescription proportion of all antibiotics, relative within all cases (instances of UTI diagnosis), for the treatment of urinary tract infections after one year between the groups. Adverse events were assessed as exploratory outcomes.
Results
110 practices with full datasets identified 10 323 cases during five quarters (ie, 15 months). The mean proportion of second line antibiotics prescribed was 0.19 (standard deviation 0.20) in the intervention group and 0.35 (0.25) in the control group after 12 months. After adjustment for preintervention proportions, the mean difference was −0.13 (95% confidence interval −0.21 to −0.06, P<0.001). The overall proportion of all antibiotic prescriptions for urinary tract infections over 12 months was 0.74 (standard deviation 0.22) in the intervention and 0.80 (0.15) in the control group with a mean difference of −0.08 (95% confidence interval −0.15 to −0.02, P<0.029). No differences were noted in the number of complications (ie, pyelonephritis, admission to hospital, or fever) between the groups.
Conclusions
The multimodal intervention in general practice significantly reduced the proportion of second line antibiotics and all antibiotic prescriptions for uncomplicated urinary tract infections in women.
Trial registration
German Clinical Trials Register (DRKS), DRKS00020389