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Calcium fluoride based multifunctional nanoparticles for multimodal imaging

Please always quote using this URN: urn:nbn:de:bvb:20-opus-170657
  • New multifunctional nanoparticles (NPs) that can be used as contrast agents (CA) in different imaging techniques, such as photoluminescence (PL) microscopy and magnetic resonance imaging (MRI), open new possibilities for medical imaging, e.g., in the fields of diagnostics or tissue characterization in regenerative medicine. The focus of this study is on the synthesis and characterization of CaF\(_{2}\):(Tb\(^{3+}\),Gd\(^{3+}\)) NPs. Fabricated in a wet-chemical procedure, the spherical NPs with a diameter of 5–10 nm show a crystallineNew multifunctional nanoparticles (NPs) that can be used as contrast agents (CA) in different imaging techniques, such as photoluminescence (PL) microscopy and magnetic resonance imaging (MRI), open new possibilities for medical imaging, e.g., in the fields of diagnostics or tissue characterization in regenerative medicine. The focus of this study is on the synthesis and characterization of CaF\(_{2}\):(Tb\(^{3+}\),Gd\(^{3+}\)) NPs. Fabricated in a wet-chemical procedure, the spherical NPs with a diameter of 5–10 nm show a crystalline structure. Simultaneous doping of the NPs with different lanthanide ions, leading to paramagnetism and fluorescence, makes them suitable for MR and PL imaging. Owing to the Gd\(^{3+}\) ions on the surface, the NPs reduce the MR T\(_{1}\) relaxation time constant as a function of their concentration. Thus, the NPs can be used as a MRI CA with a mean relaxivity of about r = 0.471 mL·mg\(^{−1}\)·s\(^{−1}\). Repeated MRI examinations of four different batches prove the reproducibility of the NP synthesis and determine the long-term stability of the CAs. No cytotoxicity of NP concentrations between 0.5 and 1 mg·mL\(^{−1}\) was observed after exposure to human dermal fibroblasts over 24 h. Overall this study shows, that the CaF\(_{2}\):(Tb\(^{3+}\),Gd\(^{3+}\)) NPs are suitable for medical imaging.show moreshow less

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Metadaten
Author: Marion Straßer, Joachim H. X. Schrauth, Sofia Dembski, Daniel Haddad, Bernd Ahrens, Stefan Schweizer, Bastian Christ, Alevtina Cubukova, Marco Metzger, Heike Walles, Peter M. Jakob, Gerhard Sextl
URN:urn:nbn:de:bvb:20-opus-170657
Document Type:Journal article
Faculties:Fakultät für Physik und Astronomie / Physikalisches Institut
Fakultät für Chemie und Pharmazie / Lehrstuhl für Chemische Technologie der Materialsynthese
Medizinische Fakultät / Lehrstuhl für Tissue Engineering und Regenerative Medizin
Language:English
Parent Title (English):Beilstein Journal of Nanotechnology
Year of Completion:2017
Volume:8
Pagenumber:1484–1493
Source:Beilstein Journal of Nanotechnology 2017, 8, 1484-1493. DOI: 10.3762/bjnano.8.148
DOI:https://doi.org/10.3762/bjnano.8.148
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=28900602
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften
Tag:calcium fluoride nanoparticles; magnetic resonance imaging (MRI); multifunctional nanoparticles; multimodal imaging; photoluminescence
Release Date:2019/10/02
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International